Increased risk of osteoarthritis in persons with spinal cord injury: a population-based longitudinal follow-up study in Taiwan

IF 2.2 4区医学 Q3 CLINICAL NEUROLOGY

Spinal cord Pub Date : 2025-08-09 DOI:10.1038/s41393-025-01112-x

Chien-Po Liu, Shin-Liang Pan

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Abstract

Retrospective cohort study. To assess the relative risk of osteoarthritis (OA) in individuals with newly diagnosed spinal cord injury (SCI) compared to a matched non-SCI group. Taiwan’s Longitudinal Health Insurance Database. We identified 1373 individuals aged 20–69 years with newly diagnosed SCI between 2002 and 2005 as the SCI group. A propensity-score-matched non-SCI group (N = 5492) with similar baseline demographic and clinical characteristics was selected for comparison. Both groups were followed until December 2011. OA-free survival was analyzed via Kaplan-Meier curves, and the association between SCI and OA risk was evaluated via stratified Cox proportional-hazards regression. To assess temporal risk variations, we performed landmark analysis with a 1-year cutoff, dividing follow-up into early (0–1 year) and long-term (≥1 year) periods. The respective incidence rates of OA for the SCI and non-SCI groups were 45.4 per 1000 person-years (95% confidence interval [CI], 40.1–50.1) and 31.6 per 1000 person-years (95% CI, 29.8–33.4). The hazard ratio of OA for the SCI group, as compared to the non-SCI group, was 1.52 (95% CI 1.34–1.72, p < 0.0001). This population-based longitudinal follow-up study indicates that there is an increased long-term risk of OA in persons with SCI, underscoring the need for clinical vigilance and early diagnostic measures in this population. Further research is needed to explore the mechanisms underlying the association between these two conditions.

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脊髓损伤患者骨关节炎风险增加：台湾一项以人群为基础的纵向随访研究。

研究设计：回顾性队列研究。目的：评估新诊断脊髓损伤（SCI）个体与匹配的非SCI组相比，骨关节炎（OA）的相对风险。设定：台湾健康保险纵向资料库。方法：选取2002 ~ 2005年间1373例20 ~ 69岁的新诊断SCI患者作为SCI组。选择具有相似基线人口学和临床特征的倾向评分匹配的非sci组（N = 5492）进行比较。这两组人都被跟踪到2011年12月。通过Kaplan-Meier曲线分析无OA生存率，通过分层Cox比例风险回归评估SCI与OA风险之间的相关性。为了评估时间风险变化，我们进行了1年的里程碑式分析，将随访分为早期（0-1年）和长期（≥1年）。结果：脊髓损伤组和非脊髓损伤组的OA发病率分别为45.4 / 1000人-年（95%可信区间[CI]， 40.1-50.1）和31.6 / 1000人-年（95% CI, 29.8-33.4）。与非SCI组相比，SCI组的OA风险比为1.52 （95% CI 1.34-1.72, p）。结论：这项基于人群的纵向随访研究表明，SCI患者患OA的长期风险增加，强调了在这一人群中需要临床警惕和早期诊断措施。需要进一步的研究来探索这两种情况之间关联的机制。

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来源期刊

Spinal cord 医学-临床神经学

CiteScore

4.50

自引率

9.10%

发文量

142

审稿时长

2 months

期刊介绍： Spinal Cord is a specialised, international journal that has been publishing spinal cord related manuscripts since 1963. It appears monthly, online and in print, and accepts contributions on spinal cord anatomy, physiology, management of injury and disease, and the quality of life and life circumstances of people with a spinal cord injury. Spinal Cord is multi-disciplinary and publishes contributions across the entire spectrum of research ranging from basic science to applied clinical research. It focuses on high quality original research, systematic reviews and narrative reviews. Spinal Cord''s sister journal Spinal Cord Series and Cases: Clinical Management in Spinal Cord Disorders publishes high quality case reports, small case series, pilot and retrospective studies perspectives, Pulse survey articles, Point-couterpoint articles, correspondences and book reviews. It specialises in material that addresses all aspects of life for persons with spinal cord injuries or disorders. For more information, please see the aims and scope of Spinal Cord Series and Cases.