Spinal cord最新文献

{"title":"Racial differences in serological markers across the first year of injury in spinal cord injury: responses to the letter to editor.","authors":"Jia Li, Matthew Farrow, Kerollos Ibrahim, Dana M McTigue, John Kramer, Bobo Tong, Catherine Jutzeler, Linda Jones, Ceren Yarar-Fisher","doi":"10.1038/s41393-025-01096-8","DOIUrl":"https://doi.org/10.1038/s41393-025-01096-8","url":null,"abstract":"","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Racial differences in serological markers across the first year of injury in spinal cord injury: a retrospective analysis of a multicenter interventional study by Jia Li et al.","authors":"Vishal Kumar, Sharath Raj","doi":"10.1038/s41393-025-01095-9","DOIUrl":"https://doi.org/10.1038/s41393-025-01095-9","url":null,"abstract":"","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges and strategies for spinal cord injury research recruitment in rehabilitation hospitals: a single center perspective.","authors":"Steven Kirshblum, Brittany Snider, Einat Engel-Haber","doi":"10.1038/s41393-025-01094-w","DOIUrl":"https://doi.org/10.1038/s41393-025-01094-w","url":null,"abstract":"<p><strong>Study design: </strong>A narrative review and perspective based on the experience of a single site in the U.S recruiting participants for clinical trials during the subacute phase (2 weeks to 3 months) following a traumatic spinal cord injury (SCI).</p><p><strong>Objectives: </strong>To discuss challenges and propose strategies for enrolling individuals with SCI in research during the subacute phase within a comprehensive inpatient rehabilitation program.</p><p><strong>Setting: </strong>Acute rehabilitation hospitals where patients with SCI typically spend part of the subacute post-injury period.</p><p><strong>Methods: </strong>This review draws on the authors' experience in research recruitment and retention. Key barriers and potential solutions are explored from both a practical and conceptual standpoint.</p><p><strong>Results: </strong>Challenges identified include heterogeneous impairments, older age, higher incidence of incomplete injuries, placement issues, competition among studies, limited patient volume, tight rehabilitation schedules, logistical and medical concerns, and misalignment of research measures with clinical practices. Based on experience and literature review, strategic planning including integration of individuals with lived experience into the study design team, patient education, simplified consent processes, flexible research protocols, collaboration between clinical and research teams, and patient-centered approaches can enhance recruitment efforts.</p><p><strong>Conclusions: </strong>Research recruitment during the subacute phase of SCI presents numerous medical, injury-specific, and systems-based challenges. However, this period remains critical for advancing research influencing long-term outcomes for individuals with SCI. We recommend a collaborative, patient-centered approach that integrates research within clinical care, guided by practical experience and informed by existing literature, which can improve recruitment efforts and ultimately support meaningful advancements in SCI rehabilitation research.</p>","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The incidence and trends of diving-related spine injuries in the United States and risk factors associated with spinal cord injury.","authors":"Anthony E Seddio, Sahir S Jabbouri, Rajiv S Vasudevan, Michael J Gouzoulis, Wesley Day, Gwyneth C Maloy, Arya G Varthi, Daniel R Rubio, Jonathan N Grauer","doi":"10.1038/s41393-025-01098-6","DOIUrl":"https://doi.org/10.1038/s41393-025-01098-6","url":null,"abstract":"<p><strong>Study design: </strong>Retrospective longitudinal cohort study.</p><p><strong>Objectives: </strong>To characterize: (1) incidence and trends of diving-related spine injuries (DRSI) and diving-related spinal cord injury (DRSCI) in the United States and (2) risk-factors associated with DRSCI.</p><p><strong>Setting: </strong>Using a large, national, multi-insurance administrative dataset of over 161 million patients, those who suffered a DRSIs were identified and characterized.</p><p><strong>Methods: </strong>Persons who suffered a DRSIs were analyzed from 2010-2021. Estimated annual percentage change (EAPC) was calculated by log-linear regression. For those with DRSCI, risk-factors were assessed by multivariable logistic regression.</p><p><strong>Results: </strong>Of 3829 persons who suffered DRSIs, the cervical spine was most frequently involved (53.0%). EAPCs of DRSIs at the cervical, thoracic, and lumbar spine significantly decreased over the studied years (-4.69, -6.81, and -4.88%, respectively; p < 0.05 for all), while DRSCI demonstrated a nonsignificant trend (p = 0.081). Among the 629 (16.4%) with DRSCI, risk-factors included: prior cervical spine surgery (OR 13.31, p < 0.001), history of cervical spondylolisthesis (OR 5.36, p < 0.001), male sex (OR 2.69, p < 0.001), history of cervical stenosis (OR 2.26, p < 0.001), coastal states (OR 1.38, p = 0.012), higher Elixhauser Comorbidity Index (OR 1.15, p < 0.001), and older age (OR 1.01, p = 0.029).</p><p><strong>Conclusions: </strong>The rate of DRSIs of the cervical, thoracic, and lumbar spine has significantly decreased in recent years in the United States. However, the nonsignificant trend in DRSCI highlights the importance of continued public health initiatives. Among those with DRSCI, several unique risk-factors were identified, laying the foundation for the refinement of current diving injury prevention programs.</p>","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Focus on afferent sensory nervous pathways of the lower urinary tract after SCI. Tribute to Sir Ludwig Guttmann.","authors":"Jean Jacques Wyndaele","doi":"10.1038/s41393-025-01087-9","DOIUrl":"https://doi.org/10.1038/s41393-025-01087-9","url":null,"abstract":"<p><strong>Study design: </strong>Narrative Review.</p><p><strong>Objectives: </strong>To focus on the knowledge on afferent sensory nervous pathways related to the lower urinary tract (LUT), in individuals with spinal cord injury (SCI).</p><p><strong>Methods: </strong>We made a narrative review in which are summarized different primary studies from which conclusions may be drawn in a systematic way and from a holistic point of view, contributed by researcher's own experience and existing theories.</p><p><strong>Results: </strong>The knowledge on sensation in the LUT has grown during the last decade: advances in the basic science of bladder sensing relating to (a) the bladder wall-urothelial cells, sensory nerves, interstitial cells, and smooth muscle cells and (b) putative chemo/mechanosensors in the urethra-paraneurons or \"brush cells\" have helped to enlighten the different sensations related to bladder filling and voiding. Clinically there are diverse ways to evaluate the sensory function after SCI. After SCI, most patients retain the ability to be aware of the LUT, through bladder filling sensations, the feeling of passage through the urethra, pain and feeling unstable bladder contractions. They relate to different spinal afferent pathways, and their investigations permit valuable information on the spinal cord's condition and the completeness of its disruption. Therapeutic advantages to be explored may be to train the sensation awareness, to guide the frequency of CIC, to better determine the role of sacral stimulation.</p><p><strong>Conclusion: </strong>The knowledge on pelvic afferent sensory nervous pathways of the LUT after SCI, offers important diagnostic and therapeutic data.</p>","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Participation in activities among people with long-term spinal cord injury in Sweden and the USA - an explorative study using secondary data analysis.","authors":"Jessica L Dashner, Ulrica Antepohl","doi":"10.1038/s41393-025-01073-1","DOIUrl":"https://doi.org/10.1038/s41393-025-01073-1","url":null,"abstract":"<p><strong>Study design: </strong>Secondary data analysis.</p><p><strong>Objective: </strong>To explore differences in participation, secondary health complications, and the use of assistive devices and personal assistance among people with long-term SCI in Sweden and the USA.</p><p><strong>Setting: </strong>Community dwelling individuals with SCI in Sweden and USA.</p><p><strong>Methods: </strong>Secondary analysis of data collected via PARTS-Mv3 among individuals living with SCI in Sweden (n = 73) and in the USA (n = 45). Descriptive analyses provided information regarding the participants, their participation in activities, and secondary health complications, together with the use of assistive devices and personal assistance.</p><p><strong>Results: </strong>Both samples included more males than females. The mean ages for the Sweden and USA samples were 63.7 and 58, respectively. The mean time since injury was 36.3 years for Sweden and 35.9 for the USA. Perceived health was significantly higher in Sweden (3.80) than in the USA (2.89). The USA sample reported higher occurrence of secondary health complications than Sweden. The amount and type of participation in activities varied between countries, so also the use of assistive devices and personal assistance.</p><p><strong>Conclusions: </strong>Participation differences were identified when comparing individuals with long-term SCI living in Sweden and in the USA. Further explanatory work is needed to determine whether the differences can be attributed to the varying social and health care systems of the two countries. Understanding how cultural differences influence participation can provide valuable information to determine which system is more likely to positively influence the participation of individuals with long-term SCI.</p>","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction between injury severity and rehabilitation intervention on independence in activities of daily living in persons with spinal cord injury.","authors":"Ryuichiro Koga, Tatsuyuki Kakuma, Hiroaki Sakai, Tetsuo Hayashi, Kensuke Kubota, Satoko Matsumoto, Atsushi Sugyo, Ryosuke Ideta, Ryoichi Watanabe, Yoshito Ehara, Masaaki Yamamoto, Masaaki Kyoya, Yuto Ariji, Satoshi Murai, Ryusei Ifuku, Toru Ogata, Kota Suda, Takeshi Maeda","doi":"10.1038/s41393-025-01092-y","DOIUrl":"https://doi.org/10.1038/s41393-025-01092-y","url":null,"abstract":"<p><strong>Study design: </strong>Longitudinal secondary analysis of observational data.</p><p><strong>Objectives: </strong>To examine the effectiveness of physical (PT) and occupational therapy (OT) interventions in improving Spinal Cord Independence Measure III (SCIM III) scores among individuals with spinal cord injury (SCI).</p><p><strong>Setting: </strong>Two SCI centers in Japan.</p><p><strong>Methods: </strong>The content and time of rehabilitation interventions, and International Standards for Neurological Classification of SCI and SCIM III scores, were recorded at nine time points (72 h; 2, 4, and 6 weeks; and 2, 3, 4, 5, and 6 months after injury) for hospitalized individuals with SCI. Overall, 204 participants were included and categorized into four groups based on admission severity. Using a linear mixed-effects model, the effectiveness of PT and OT interventions - defined by the International Spinal Cord Injury Physical Therapy-Occupational Therapy Basic Data Set - was assessed using the SCIM III score as the dependent variable.</p><p><strong>Results: </strong>The following items showed interaction effects between severity and treatment time for the SCIM III score: [Strength training] for PT and OT, and [Standing control activities] and [Gross motor upper extremity] for OT. Intervention effects were observed for [Bed/seated control activities], [Walking and stairs], and [Gross motor upper extremity] for PT, and [Fine motor upper extremity] for OT, regardless of severity.</p><p><strong>Conclusions: </strong>The results suggest that considering the interaction between injury severity and rehabilitation interventions is essential for optimizing treatment plans and determining appropriate intervention timing. These findings may support clinical decision-making and contribute to improving functional outcomes in individuals with SCI.</p>","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flap reconstruction of pressure ulcers in patients with spinal cord injury: a retrospective cohort study.","authors":"Ankit Mishra, Mohammed Eldolify, Rebecca Shirley, James K-K Chan","doi":"10.1038/s41393-025-01080-2","DOIUrl":"10.1038/s41393-025-01080-2","url":null,"abstract":"<p><strong>Study design: </strong>Retrospective case series.</p><p><strong>Objectives: </strong>To describe our five-year experience of surgical excision and flap reconstruction of pressure ulcers in individuals with spinal cord injury (SCI).</p><p><strong>Setting: </strong>Tertiary spinal centre in Stoke Mandeville, United Kingdom.</p><p><strong>Methods: </strong>All spinal injury patients that underwent surgical reconstruction of pressure ulcers at the Stoke Mandeville Hospital National Spinal Injury Centre between 2018 and 2022 inclusive were included. Ulcers underwent 'pseudotumour' excision followed by either immediate or staged flap reconstruction. The primary outcome was complete healing at one year. Secondary outcomes included flap loss, complications, and return to theatre.</p><p><strong>Results: </strong>52 cases were included across 44 patients. 43 cases (82.7%) underwent immediate debridement and reconstruction. The mean number of procedures was 1.9 (range 1-6). Local flaps were used in 22 (41.5%) cases. There was one (1.9%) free flap (anterolateral thigh), eight (15.4%) pedicled flaps, and 21 (39.6%) flaps based on single perforators. 49 cases completed follow-up; 41 (83.7%) were healed at one year after their initial surgery. Immediate reconstructions were 36.7% more likely to achieve healing at this time point than staged cases (P = .028, Fisher's exact). There was partial or total flap loss in 15 (28.8%) cases. Thirty-nine complications were seen in 24 (46.2%) cases. Twenty-three cases (44.2%) required returns to theatre.</p><p><strong>Conclusions: </strong>Surgical debridement with flap reconstruction is a safe and reliable treatment approach for pressure ulcers in those with SCI, with a complication rate comparable to existing literature. Immediate flap reconstruction and local flap designs may be associated with a lower risk of complications and higher healing rates.</p>","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":" ","pages":"292-297"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of disulfidptosis-related genes and subgroups in spinal cord injury.","authors":"Ye Tao, Shanhe Wang, Xiongfei Li, Letian Jin, Chen Liu, Kun Jiao, Xiaoyu Li, Yajun Cheng, Kehan Xu, Xiaoyi Zhou, Xianzhao Wei","doi":"10.1038/s41393-025-01081-1","DOIUrl":"10.1038/s41393-025-01081-1","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Study design: &lt;/strong&gt;Bioinformatics analysis and experimental validation study.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;To investigate the role and expression patterns of disulfidptosis-related genes in spinal cord injury (SCI), identify potential pivotal genes, and explore possible therapeutic targets.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Setting: &lt;/strong&gt;Shanghai, China.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Data acquisition and pre-processing: Screened 27 disulfidptosis-related genes based on literature and downloaded RNA-sequencing data of ASCI patients from GEO database (GSE151371); Identification of differentially expressed genes (DEGs): Used R package \"limma\" for differential gene expression analysis between ASCI samples and normal controls; Evaluating immune cell infiltration: Employed ssGSEA algorithm and CIBERSORT to determine immune cell abundance; Identification and functional verification of key genes: Intersected disulfidptosis-related genes with DEGs, and used machine learning techniques (Random Forest, Lasso, Support Vector Machine) to identify hub genes. Validated hub genes expression by real-time PCR; Construction of a diagnostic model: Developed a backpropagation neural network clinical prediction model based on hub genes and clinical features, and evaluated its performance using ROC curve. 6. Subcluster analysis: Performed consensus cluster analysis of ASCI samples and hub genes, and used GSVA to elucidate functional differences between subgroups.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Identified 7764 DEGs in ASCI, with GO and KEGG enrichment in inflammation and autophagy-related pathways; Found differences in immune cell infiltration between ASCI and control groups, and correlation between immune cells and DRGs; Determined seven hub genes (MYL6, NUBPL, CYFIP1, IQGAP1, FLNB, SLC7A11, CD2AP) through machine learning; Validated the expression of hub genes by qRT-PCR; Constructed a clinical diagnostic model with good predictive accuracy (overall dataset accuracy of 83.3%); Identified two subtypes of ASCI based on hub genes, with different immune infiltration and pathway activity.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Disulfidptosis is closely related to spinal cord injury. The identified hub genes and subtypes provide new insights for biomarker and therapeutic target research. The diagnostic model has potential for clinical application, but further studies are needed due to limitations such as small sample size.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Sponsorship: &lt;/strong&gt;This study was supported in part by the project of Youth Scientific and Technological Talents of PLA (2020QN06125), Changhong Talent Project in First affiliated hospital of Navy Medical University (Wei Xianzhao) and Basic Medical Research Project in First affiliated hospital of Navy Medical University (2023PY17). I want to reiterate that there is no prior publication of figures or tables and no conflict of interest in the submission of this manuscript. The graphical abstract is divided into two parts. The upper sect","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":" ","pages":"306-318"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors affecting return to work after spinal cord injury in Japan: a cross-sectional study.","authors":"Tetsuo Hayashi, Hiromitsu Kobayashi, Momo Irie, Hiroaki Sakai, Mayumi Takegawa, Ryota Takanami, Muneaki Masuda, Kensuke Kubota, Mari Sato, Osamu Kawano, Takeshi Maeda","doi":"10.1038/s41393-025-01083-z","DOIUrl":"10.1038/s41393-025-01083-z","url":null,"abstract":"<p><strong>Study design: </strong>Survey.</p><p><strong>Objectives: </strong>This study aimed to investigate the rate of return to work among individuals with spinal cord injuries in Japan and identify factors associated with their return.</p><p><strong>Setting: </strong>Returning to work is difficult for people with spinal cord injuries, although it contributes to their personal quality of life and society. Previous studies have examined various factors inhibiting return to work, but none have examined social participation.</p><p><strong>Methods: </strong>Questionnaires were sent to individuals of working age with spinal cord injuries. Their employment status, marital status, neurological status, activities of daily living, enjoyment of sports and/or hobbies post-injury, and whether they lived with family were examined using the visual analog scale for pain.</p><p><strong>Results: </strong>Among the 134 respondents, 61 (46%) were employed at the time of the survey. Multivariate logistic regression analysis revealed that mild paralysis and enjoyment of sports and/or hobbies were significant factors associated with return to work. Among those employed, 27% secured jobs through private job introductions, highlighting the role of social connections in facilitating employment.</p><p><strong>Conclusions: </strong>Besides mild paralysis, social participation in sports and/or hobbies was significantly associated with a return to work. As social connections can provide opportunities to obtain jobs, providing spaces for interaction through sports and hobbies, can create a conducive environment for returning to work.</p>","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":" ","pages":"279-284"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}