Spinal cord最新文献

{"title":"Bibliometric analysis of the inflammation expression after spinal cord injury: current research status and emerging frontiers.","authors":"Xiaoyu Li, Kun Jiao, Chen Liu, Xiongfei Li, Shanhe Wang, Ye Tao, Yajun Cheng, Xiaoyi Zhou, Xianzhao Wei, Ming Li","doi":"10.1038/s41393-024-01038-w","DOIUrl":"https://doi.org/10.1038/s41393-024-01038-w","url":null,"abstract":"<p><strong>Study design: </strong>Bibliometric analysis.</p><p><strong>Objective: </strong>To analyze literature on inflammatory expression following spinal cord injury, highlighting development trends, current research status, and potential emerging frontiers.</p><p><strong>Setting: </strong>Not applicable.</p><p><strong>Methods: </strong>Articles were retrieved using terms related to spinal cord injury and inflammatory responses from the Web of Science Core Collection, covering January 1, 1980, to May 23, 2024. Tools like CiteSpace and VOSviewer assessed the research landscape, evaluating core authors, journals, and contributing countries. Keyword co-occurrence analyses identified research trends.</p><p><strong>Results: </strong>A total of 2504 articles were retrieved, showing a consistent increase in publications. The Journal of Neurotrauma had the highest publication volume and influence. The most prolific author was Cuzzocrea S, with Popovich PG having the highest H-index. China led in the number of publications, followed closely by the United States, which had the highest impact and extensive international collaboration. Research mainly focused on nerve function recovery, glial scar formation, and oxidative stress. Future research is expected to investigate cellular autophagy, vesicular transport, and related signaling pathways.</p><p><strong>Conclusion: </strong>The growing interest in inflammation caused by spinal cord injury is evident, with current research focusing on oxidative stress, glial scar, and neurological recovery. Future directions include exploring autophagy and extracellular vesicles for new therapies. Interdisciplinary research and extensive clinical trials are essential for validating new treatments. Biomarker discovery is crucial for diagnosis and monitoring, while understanding autophagy and signaling pathways is vital for drug development. Global cooperation is needed to accelerate the application of scientific findings, improving spinal cord injury treatment.</p>","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tract-specific magnetization transfer ratio provides insights into the severity of degenerative cervical myelopathy.","authors":"Grace Haynes, Fauziyya Muhammad, Kenneth A Weber, Ali F Khan, Sanaa Hameed, Hakeem Shakir, Michael Van Hal, Douglas Dickson, Michael Rohan, Yasin Dhaher, Todd Parrish, Lei Ding, Zachary A Smith","doi":"10.1038/s41393-024-01036-y","DOIUrl":"https://doi.org/10.1038/s41393-024-01036-y","url":null,"abstract":"<p><strong>Study design: </strong>Cross-sectional study.</p><p><strong>Objectives: </strong>This study's goal is to report whether Magnetization Transfer Ratio (MTR) can evaluate the severity of white matter (WM) injury in degenerative cervical myelopathy (DCM).</p><p><strong>Setting: </strong>Laureate Institute of Brain Research, USA; Department of Neurosurgery, University of Oklahoma Health Sciences Center, USA.</p><p><strong>Methods: </strong>27 DCM patients were aged-matched with 20 healthy controls (HC) and categorized into treatment groups based on modified Japanese Orthopedic Association (mJOA) severity (11 mild and 16 moderate/severe). Regional and tract MTRs were extracted from the two vertebral levels containing maximum compression within magnetization transfer images. MTR differences between groups were assessed using a one-way ANOVA or Kruskal-Wallis test. The association between MTR and mJOA measures was evaluated using Spearman's correlation.</p><p><strong>Results: </strong>Significant decreases in MTR were found between HC and moderate/severe groups in the overall (p = 0.0065) and ventral (p = 0.0009) WM regions; and ventral corticospinal (p = 0.0101), ventral reticulospinal (p = 0.0084), spinal lemniscus (p = 0.0079), and fasciculus cuneatus (p = 0.0219) tracts. The spinal lemniscus MTR also significantly decreased between HC and mild groups (p = 0.038). Ventral reticulospinal tract MTR correlated with upper (r = 0.439; p = 0.022) and lower (r = 0.386; p = 0.047) limb motor mJOA scores.</p><p><strong>Conclusions: </strong>Significant tract-based MTR changes and correlations align with known DCM symptoms, are demonstrated to be lost at the regional level, and display the inhomogeneous compressive damage occurring within DCM spinal cords.</p>","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The spinal cord injury (SCI) peer support evaluation tool: the development of a tool to assess outcomes of peer support programs within SCI community-based organizations.","authors":"Shane N Sweet, Zhiyang Shi, Olivia Pastore, Robert B Shaw, Jacques Comeau, Heather L Gainforth, Christopher B McBride, Vanessa K Noonan, Launel Scott, Haley Flaro, Sheila Casemore, Lubna Aslam, Teren Clarke, Kathleen A Martin Ginis","doi":"10.1038/s41393-024-01033-1","DOIUrl":"10.1038/s41393-024-01033-1","url":null,"abstract":"<p><strong>Study design: </strong>Guided by the 4-step process outlined in the Consensus-based Standards for the selection of health Measurement INstruments (COSMIN) guideline, multiple methodologies were used: Delphi, literature reviews, ratings with consensus, think-aloud, and test-retest.</p><p><strong>Objectives: </strong>The purpose of this study was to develop and test a spinal cord injury (SCI) peer support evaluation tool that meets the needs of community-based SCI organizations in Canada.</p><p><strong>Setting: </strong>Peer support programs for people with SCI delivered by community-based SCI organizations.</p><p><strong>Methods: </strong>This research was co-constructed with executives and staff from SCI community-based organizations, people with SCI, researchers, and students. Given the multiple steps of this study, sample size and characteristics varied based on each step. Participants included people with SCI who received peer support (mentees) or provided peer support (mentors/supporters) and staff of community-based organizations.</p><p><strong>Results: </strong>In step 1, the 20 most important outcomes for SCI peer support were identified. In step 2 and 3, the 97 items were identified to assess the outcomes and by using rating and multiple consensus methodologies 20 items, one to assess each outcome, were selected. In step 4, content and face validity and test-retest reliability were achieved. The resulting SCI Peer Support Evaluation Tool consists of 20 single-item questions to assess 20 outcomes of SCI peer support.</p><p><strong>Conclusion: </strong>Through a systematic process, the SCI Peer Support Evaluation Tool is now ready to be implemented to assess outcomes of SCI peer support programs delivered by community-based SCI organizations.</p>","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive assessment during inpatient rehabilitation after spinal cord injury, a retrospective cross-sectional study","authors":"Anneke A. W. Welkamp, Christel C. M. v. Leeuwen, Marcel W. M. Post, Janneke M. Stolwijk-Swüste","doi":"10.1038/s41393-024-01035-z","DOIUrl":"https://doi.org/10.1038/s41393-024-01035-z","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Study design</h3><p>Cross-sectional study.</p><h3 data-test=\"abstract-sub-heading\">Objectives</h3><p>Cognitive screening is underdeveloped in spinal cord injury (SCI). Therefore, the objectives of our study were: (1) to evaluate cognitive functioning of rehabilitation inpatients with recently acquired spinal cord injury (SCI) with the Montreal Cognitive Assessment (MoCA); (2) to analyse associations between patient and lesion characteristics and the MoCA scores and (3) to compare the MoCA with the cognitive domain of the Utrecht scale for Evaluation of Rehabilitation (USER).</p><h3 data-test=\"abstract-sub-heading\">Setting</h3><p>Inpatient rehabilitation in a specialized rehabilitation centre in the Netherlands.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>MOCA and USER data of inpatients between November 2020 and December 2021 were used. Correlation and regression analysis were used.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Included were 98 adults aged (median) 61.6 years (range 19.5–83.6), 66% male, 26.5% traumatic SCI, 63% persons with paraplegia. MoCA and USER scores were available for 83 and 92 individuals, respectively. In 44.6% of the participants, the MoCA score was below the cut-off. Age (r = 0.31, <i>p</i> = 0.005) and educational level (r = 0.54 <i>P</i> &lt; 0.00) were significantly correlated to the MoCA score. The MoCA and the cognitive domain of the USER were moderately correlated (r = 0.25, <i>p</i> = 0.03).</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>Almost half of the inpatients scored below the cut-off score on the MoCA. Since the MoCA is a validated cognitive screening tool, the moderate correlation of the MoCA and the cognitive domain of the USER suggests that the USER alone is not sufficient in detecting cognitive deficits. We recommend to screen for cognitive deficits in all people with new SCI.</p><h3 data-test=\"abstract-sub-heading\">Sponsorship</h3><p>None.</p>","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142256092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-reported benzodiazepine use among adults with chronic spinal cord injury in the southeastern USA: associations with demographic, injury, and opioid use characteristics","authors":"Nicole D. DiPiro, Clara E. Dismuke-Greer, James S. Krause","doi":"10.1038/s41393-024-01030-4","DOIUrl":"https://doi.org/10.1038/s41393-024-01030-4","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Study design</h3><p>Cross-sectional cohort study.</p><h3 data-test=\"abstract-sub-heading\">Objectives</h3><p>To examine: (1) the self-reported frequency of specific prescription benzodiazepine use, (2) concurrent benzodiazepine and opioid use, and (3) sociodemographic, SCI, and opioid use factors associated with frequent benzodiazepine use.</p><h3 data-test=\"abstract-sub-heading\">Setting</h3><p>Community.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Participants included 918 community dwelling adults with chronic ( &gt; 1 year) traumatic SCI originally identified from a specialty hospital or a state-based surveillance system. Self-reported frequency of specific prescription benzodiazepines and opioids used, concurrent use, and factors associated with use were assessed.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Twenty percent reported any benzodiazepine use in the past year and 13% reported at least weekly use. Concurrent daily or weekly use of benzodiazepines and opioids was reported by 6.5%, with those individuals taking an average of 1.1 (0.4) benzodiazepines and 1.4 (0.6) opioids. Compared to younger adults, those 50–65 years old had lower odds of at least weekly benzodiazepine use (OR = 0.50, 95% CI, 0.29–0.89, <i>p</i>-value = 0.02). Non-Hispanic Blacks reported lower use of benzodiazepines compared to non-Hispanic whites (OR = 0.32, 95% CI, 0.15–0.68, <i>p</i>-value = &lt;0.01). Weekly opioid use was associated with higher odds of using benzodiazepines (OR = 3.10, 95%CI, 1.95–4.95, <i>p</i>-value = &lt;0.01).</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>Benzodiazepine use was commonly reported among those with SCI. Despite the potential risks, a high portion of those who reported benzodiazepine use also reported prescription opioid use. The findings highlight the need for monitoring of prescription medication use to avoid potentially risky concurrent use and adverse outcomes.</p>","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142224180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability of the Mini-BESTest and Brief-BESTest for assessing patients with incomplete spinal cord injury","authors":"Yusuke Morooka, Yasuyuki Takakura, Yosuke Kunisawa, Yuya Okubo, Shinta Araki, Shigeru Obayashi","doi":"10.1038/s41393-024-01032-2","DOIUrl":"https://doi.org/10.1038/s41393-024-01032-2","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Study design</h3><p>Single institution observational study.</p><h3 data-test=\"abstract-sub-heading\">Objectives</h3><p>To investigate the ceiling and floor effects of the Berg Balance Scale (BBS), Mini-Balance Evaluation Systems Test (BESTest), and Brief-BESTest, as well as to determine the intra- and inter-rater reliabilities and minimal detectable change (MDC) of the Mini-BESTest and Brief-BESTest in patients with acute and subacute incomplete cervical spinal cord injury (SCI) classified as AIS D.</p><h3 data-test=\"abstract-sub-heading\">Setting</h3><p>Advanced critical care center of our university hospital.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Twenty patients with incomplete cervical SCI who could stand without assistance were recruited. The floor and ceiling effects were evaluated by plotting histograms from the distribution of scores on the BBS, Mini-BESTest and Brief-BESTest, and calculating skewness. The Mini-BESTest and Brief-BESTest were evaluated and videotaped simultaneously, and intra- and inter-rater reliabilities were assessed. The MDC was also calculated.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The skewness of the BBS was −1.57, and the full score was 35%, indicating a ceiling effect. However, no ceiling or floor effect was observed for the Mini-BESTest and the Brief-BESTest. Intraclass correlation coefficients for intra-rater and inter-rater reliabilities were 0.98 and 0.97 for the Mini-BESTest and Brief-BESTest, respectively. Individual item reliability was moderate or better for the Mini-BESTest and excellent or better for the Brief-BESTest. The MDC of total scores ranged 3.14–3.84 and 2.92–3.60 for the Mini-BESTest and Brief-BESTest, respectively.</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>The Mini-BESTest and Brief-BESTest are reliable assessment tools for patients with acute and subacute incomplete SCI classified as AIS D. Clarified error ranges aid in estimating the treatment effect on balance abilities.</p>","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142227708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A home-based self-directed EEG neurofeedback intervention for people with chronic neuropathic pain following spinal cord injury (the StoPain Trial): description of the intervention","authors":"Negin Hesam-Shariati, Lara Alexander, Kevin Yi Chen, Ashley Craig, Paul A. Glare, Mark P. Jensen, Chin-Teng Lin, James H. McAuley, James W. Middleton, G. Lorimer Moseley, Toby Newton-John, Sebastian Restrepo, Ian W. Skinner, Pauline Zahara, Sylvia M. Gustin","doi":"10.1038/s41393-024-01031-3","DOIUrl":"https://doi.org/10.1038/s41393-024-01031-3","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Study design</h3><p>Randomised controlled trial.</p><h3 data-test=\"abstract-sub-heading\">Objectives</h3><p>The objective is to describe an electroencephalography (EEG) neurofeedback intervention that will be provided in a randomised controlled trial for people with neuropathic pain following spinal cord injury (SCI): the StoPain Trial. In this trial, participants in the treatment group will implement an EEG neurofeedback system as an analgesic intervention at home, while participants in the control group will continue with the treatments available to them in the community.</p><h3 data-test=\"abstract-sub-heading\">Setting</h3><p>University-based study in Sydney, Australia.</p><h3 data-test=\"abstract-sub-heading\">Methods/results</h3><p>This manuscript describes the rationale and components of the EEG neurofeedback intervention designed for individuals with SCI neuropathic pain and intended for home-based implementation. Our report is based on the criteria of the Template for Intervention Description and Replication (TIDieR) checklist, and includes why the efficacy of EEG neurofeedback will be investigated, what will be provided, who will administer it, and how, where, when, and how much the EEG neurofeedback intervention will be administered.</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>This manuscript provides a detailed description of a complex intervention used in a randomised controlled trial. This description will facilitate the subsequent interpretation of the trial results and allow for the replication of the intervention in clinical practice and future trials.</p><h3 data-test=\"abstract-sub-heading\">Sponsorship</h3><p>Australian Government Medical Research Future Fund (2020 Rare Cancers Rare Diseases and Unmet Needs Scheme: 2006020).</p>","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of wheelchair skills training during peer-led Active Rehabilitation Camps for people with spinal cord injury in Poland: a cohort study","authors":"Tomasz Tasiemski, Piotr Kazimierz Urbański, Sophie Jörgensen, Dawid Feder, Katarzyna Trok, Anestis Divanoglou","doi":"10.1038/s41393-024-01034-0","DOIUrl":"https://doi.org/10.1038/s41393-024-01034-0","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Study design</h3><p>Prospective cohort study.</p><h3 data-test=\"abstract-sub-heading\">Objectives</h3><p>To evaluate the effects of wheelchair skills training (WSTR) for participants with spinal cord injury (SCI) during peer-led Active Rehabilitation Camps (ARC) in Poland. We hypothesized that participation in ARC will improve wheelchair skill performance and self-efficacy in individuals with SCI. We also aimed to determine demographic and injury-related factors associated with greater improvements in wheelchair skill performance and self-efficacy.</p><h3 data-test=\"abstract-sub-heading\">Setting</h3><p>Thirteen consecutive ARCs in Poland.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Participants (<i>n</i> = 122) with traumatic or nontraumatic SCI older than 16 years were evaluated at the beginning (T1) and completion (T2) of ARC and at 3-month follow-up (T3) through the Queensland Evaluation of Wheelchair Skills (QEWS) and the Wheelchair Skills Test Questionnaire (WST-Q).</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>At T2, 43% of participants reached the threshold for substantial clinically meaningful change in QEWS, 73% in WST-Q capacity, and 67% in confidence, with approximately half of those reporting such gains at T3. At a group level, participants achieved small effect-size improvements (QEWS) at T2; large effects in wheelchair skills capacity at T2 and T3; large effects in wheelchair skill confidence at T2, and low effects at T3. Prior attendance to ARC was the only independent variable that explained 10% of variance in wheelchair capacity gains.</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>Peer-led WSTR during ARCs is highly effective at improving wheelchair skills in individuals with SCI. These improvements are largely retained after three months. Persons with SCI should have a chance to participate in more than one camp to maintain and further improve their wheelchair skills.</p>","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142224181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traumatic spinal cord injury and its correlation to risk of autoimmune/-inflammatory disease","authors":"Tim Damgaard Nielsen, Thomas Munk Laursen, Bodil Hammer Bech, Mikkel Mylius Rasmussen","doi":"10.1038/s41393-024-01026-0","DOIUrl":"https://doi.org/10.1038/s41393-024-01026-0","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Study design</h3><p>Nationwide epidemiological open cohort study.</p><h3 data-test=\"abstract-sub-heading\">Objectives</h3><p>To evaluate whether individuals with traumatic spinal cord injury (TSCI) are more prone to develop autoimmune diseases compared to a general non-TSCI population.</p><h3 data-test=\"abstract-sub-heading\">Setting</h3><p>Danish public national registries.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>An open nationwide cohort, including individuals born in Denmark from or alive during 1945-2018 was collected and the study period was 1980-2018. Poissons Log-linear regression estimated the incidence rate ratio (IRR) for developing eight groups of autoimmune diseases. A dose-response relationship based on the cervical/thoracic level of injury was assessed by stratification.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The cohort included 3,272 individuals with TSCI and 4.8 million background individuals, accounting for 50,865 and 140 million person-years respectively. The TSCI population had an overall IRR of 1.81 (95% CI, 1.59 to 2.05) of getting any autoimmune disease. Subgroup analysis found positive associations for; a) <i>Other neurologic</i> IRR 5.19 (95% CI, 2.79 to 9.65), b) <i>multiple sclerosis</i> IRR 3.70 (95% CI, 2.54 to 5.40), c) <i>Dermatologic</i> IRR 2.57 (95% CI, 1.86 to 3.55), d) Type 1 d<i>iabetes mellitus</i> IRR 2.01 (95% CI, 1.54 to 2.61), e) <i>Systemic</i> 1.92 (95% CI, 1.44 to 2.55), and f) <i>Gastroenterologic</i> IRR 1.42 (95% CI, 1.05 to 1.92). Cervical levels of TSCI showed an IRR of 1.70 (95% CI, 1.43 to 2.02), while thoracic levels had an IRR 1.98 (95% CI, 1.63 to 2.39).</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>TSCI may be an individual risk factor of developing an autoimmune disease. There does not appear to exist a dose-response relationship from the level of injury.</p><h3 data-test=\"abstract-sub-heading\">Sponsorship</h3><p>None.</p>","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric analysis of research on spinal cord and sacral neuromodulation in spinal cord injury","authors":"Jishi Ye, Jingli Chen, Juan Wang, Juan Ren, Yifan Jia, Zhongyuan Xia","doi":"10.1038/s41393-024-01029-x","DOIUrl":"https://doi.org/10.1038/s41393-024-01029-x","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Study design</h3><p>Qualitative studies.</p><h3 data-test=\"abstract-sub-heading\">Objectives</h3><p>Spinal cord injury (SCI) is one of the most devastating injuries to the central nervous system that places a major burden on society. Neuromodulation technology involving spinal cord stimulation (SCS) and sacral nerve modulation (SNM) is a promising technique for patients with SCI. However, there has been no bibliometric analysis of research in this field to date.</p><h3 data-test=\"abstract-sub-heading\">Setting</h3><p>Not applicable.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Systematic analyses of countries, institutions, authors, journals, co-cited documents, keywords, genes and diseases were performed. Related gene and disease data from the citexs platform were also reviewed. A total of 7437 articles on SCS and SNM in SCI were retrieved from the Web of Science database. The search time was limited to 1985-01-01 to 2022-12-31.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>We identified a significant increase in research output on SCS and SNM in SCI in recent years, with a concentrated period of high publication activity. Multiple publications were identified on neuropathic pain, electronic stimulation, TNF, BDNF and STAT3 gene expression, indicating that complications and potential therapeutic strategies for SCI are a key focus in the field.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Our study provides insights that may help to advance scientific research and potentially improve outcomes in patients with SCI.</p>","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}