Spinal cord最新文献_第10页

Maximal detrusor pressure can be predicted using technetium-99m-mertcaptoacetyltriglycine renal scintigraphy in the early stages of spinal cord injury 在脊髓损伤的早期阶段，可以使用锝-99m-巯基乙酰三甘氨酸肾闪烁扫描来预测最大逼尿肌压力。

IF 2.2 4区医学

Spinal cord Pub Date : 2024-03-07 DOI: 10.1038/s41393-024-00967-w

Su Ji Lee, Ji Cheol Shin

{"title":"Maximal detrusor pressure can be predicted using technetium-99m-mertcaptoacetyltriglycine renal scintigraphy in the early stages of spinal cord injury","authors":"Su Ji Lee, Ji Cheol Shin","doi":"10.1038/s41393-024-00967-w","DOIUrl":"10.1038/s41393-024-00967-w","url":null,"abstract":"Retrospective cohort study. To investigate the potential of technetium-99m-mercaptoacetyltriglycine (99mTc-MAG-3) renal scintigraphy for predicting maximal detrusor pressure in the early stages of spinal cord injury (SCI). Tertiary rehabilitation facility. Medical records of individuals with SCI admitted between January 2020 and April 2023 who underwent both 99mTc-MAG-3 renal scintigraphy and urodynamic study within 90 days of SCI onset were retrospectively reviewed. Pearson’s coefficient analysis was performed to determine the relationship between 99mTc-MAG-3 renal scintigraphy findings and urodynamic study findings. A multivariate linear regression analysis was performed to determine the best predictors of maximal detrusor pressure. A multivariate logistic regression analysis was performed to determine risk factors for high detrusor pressure. Ninety-four participants were enrolled in this study. Pearson’s correlation analysis showed that effective renal plasma flow (ERPF) and ERPF (% predicted) were significantly correlated with maximal detrusor pressure. The multivariate linear regression analysis demonstrated that ERPF (% predicted) was a significant predictor of maximal detrusor pressure. The multivariate logistic regression analysis showed that ERPF (% predicted) was significantly associated with high detrusor pressure. The receiver operating characteristic curve demonstrated that the predictive model had an area under the curve of 0.725, with an ERPF (% predicted) cut-off of 64.05%, sensitivity 1.000, and specificity 0.429. These results suggest that 99mTc-MAG-3 renal scintigraphy may be useful for predicting high detrusor pressure in early SCI and may guide the timing of urodynamic studies in individuals with early SCI for appropriate management of neurogenic lower urinary tract dysfunction.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"62 5","pages":"207-213"},"PeriodicalIF":2.2,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge, perceptions, and beliefs about urinary tract infections in persons with neurogenic bladder and impacts on interventions to promote person-centered care 关于神经源性膀胱患者尿路感染的知识、看法和信念，以及对促进以人为本的护理的干预措施的影响

IF 2.2 4区医学

Spinal cord Pub Date : 2024-03-07 DOI: 10.1038/s41393-024-00972-z

Margaret A. Fitzpatrick, Pooja Solanki, Marissa Wirth, Frances M. Weaver, Katie J. Suda, Stephen P. Burns, Nasia Safdar, Eileen Collins, Charlesnika T. Evans

{"title":"Knowledge, perceptions, and beliefs about urinary tract infections in persons with neurogenic bladder and impacts on interventions to promote person-centered care","authors":"Margaret A. Fitzpatrick, Pooja Solanki, Marissa Wirth, Frances M. Weaver, Katie J. Suda, Stephen P. Burns, Nasia Safdar, Eileen Collins, Charlesnika T. Evans","doi":"10.1038/s41393-024-00972-z","DOIUrl":"10.1038/s41393-024-00972-z","url":null,"abstract":"Qualitative study. To explore how knowledge, perceptions, and beliefs about urinary tract infections (UTIs) among persons with neurogenic bladder (NB) may impact health behaviors and provider management and enhance person-centeredness of interventions to improve UTI management. Three Veterans Affairs (VA) medical centers. Adults with NB due to spinal cord injury/disorder (SCI/D) or multiple sclerosis (MS) with UTI diagnoses in the prior year participated in focus groups. Transcripts were coded using deductive codes linked to the Health Belief Model and inductive codes informed by grounded theory. Twenty-three Veterans (SCI/D, 78%; MS: 18.5%) participated in discussions. Three themes emerged: (1) UTI knowledge; (2) factors affecting the intervention environment; and (3) factors affecting modes of delivery. Knowledge gaps included UTI prevention, specific symptoms most indicative of UTI, and antibiotic side effects. Poor perceptions of providers lacking knowledge about NB and ineffective patient–provider communication were common in the Emergency Department and non-VA facilities, whereas participants had positive perceptions of home-based care. Participants perceived lower severity and frequency of antibiotic risks compared to UTI risks. Participant preferences for education included caregiver involvement, verbal and written materials, and diverse settings like peer groups. Identifying patient perspectives enhances person-centeredness and allows for novel interventions improving patient knowledge and behaviors about UTIs. Partnering with trusted providers and home-based caregivers and improving NB knowledge and communication in certain care settings were important. Patient education should address mental risk representations and incorporate preferences for content delivery to optimize self-efficacy and strengthen cues to action.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"62 5","pages":"221-227"},"PeriodicalIF":2.2,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140054133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurodegeneration within the rostral spinal cord is associated with brain gray matter volume atrophy in the early stage of cervical spondylotic myelopathy 喙突脊髓内的神经变性与颈椎病早期脑灰质体积萎缩有关。

IF 2.2 4区医学

Spinal cord Pub Date : 2024-03-07 DOI: 10.1038/s41393-024-00971-0

Cuili Kuang, Yunfei Zha

{"title":"Neurodegeneration within the rostral spinal cord is associated with brain gray matter volume atrophy in the early stage of cervical spondylotic myelopathy","authors":"Cuili Kuang, Yunfei Zha","doi":"10.1038/s41393-024-00971-0","DOIUrl":"10.1038/s41393-024-00971-0","url":null,"abstract":"Case-control study. Investigating the association between neurodegeneration within rostral spinal cord and brain gray matter volume (GMV) and assessing the relationship between remote neurodegenerative changes and clinical outcomes at the early phase of Cervical Spondylotic Myelopathy (CSM). University/hospital. Using Spinal Cord Toolbox, spinal cord morphometrics (cross-sectional area [CSA], gray matter area [GMA], white matter area [WMA]) of 40 patients with CSM and 28 healthy controls (HCs) were computed and compared using two-sample t test. Brain GMV of the two groups was analyzed using voxel-based morphometry approach. Pearson’s correlation between spinal cord morphometrics and altered brain GMV and Spearman’s relationship between remote neurodegenerations and clinical outcomes were conducted in CSM group. Compared to HCs, CSA and WMA at C2/3 and GMV in right postcentral gyrus (PoCG.R) and left supplementary motor area (SMA.L) were significantly decreased in patients with CSM. CSA and WMA at C2/3 were associated with GMV in SMA.L and MCG.R in patients with CSM. CSA at C2/3 and GMV in PoCG.R were related to modified Japanese Orthopedic Association score in patients with CSM. The associations between CSA and WMA at C2/3 and GMV in SMA.L and MCG.R suggest a concordant change pattern and adaptive mechanisms for neuronal plasticity underlying remote neurodegeneration in early CSM. The atrophy of CSA at C2/3 and GMV loss in PoCG.R can serve as potential neuroimaging biomarkers of early structural changes within spinal cord and brain preceding marked clinical disabilities in patients with CSM.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"62 5","pages":"214-220"},"PeriodicalIF":2.2,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reprogramming of astrocytes to neuronal-like cells in spinal cord injury: a systematic review 脊髓损伤中星形胶质细胞向神经元样细胞的重编程：系统综述。

IF 2.2 4区医学

Spinal cord Pub Date : 2024-03-06 DOI: 10.1038/s41393-024-00969-8

Seyed Danial Alizadeh, Mohammad-Rasoul Jalalifar, Zahra Ghodsi, Mohsen Sadeghi-Naini, Hamid Malekzadeh, Golnoosh Rahimi, Kurosh Mojtabavi, Sina Shool, Zahra Eskandari, Rasoul Masoomi, Sahar Kiani, James Harrop, Vafa Rahimi-Movaghar

{"title":"Reprogramming of astrocytes to neuronal-like cells in spinal cord injury: a systematic review","authors":"Seyed Danial Alizadeh, Mohammad-Rasoul Jalalifar, Zahra Ghodsi, Mohsen Sadeghi-Naini, Hamid Malekzadeh, Golnoosh Rahimi, Kurosh Mojtabavi, Sina Shool, Zahra Eskandari, Rasoul Masoomi, Sahar Kiani, James Harrop, Vafa Rahimi-Movaghar","doi":"10.1038/s41393-024-00969-8","DOIUrl":"10.1038/s41393-024-00969-8","url":null,"abstract":"A Systematic Review To determine the therapeutic efficacy of in vivo reprogramming of astrocytes into neuronal-like cells in animal models of spinal cord injury (SCI). PRISMA 2020 guidelines were utilized, and search engines Medline, Web of Science, Scopus, and Embase until June 2023 were used. Studies that examined the effects of converting astrocytes into neuron-like cells with any vector in all animal models were included, while conversion from other cells except for spinal astrocytes, chemical mechanisms to provide SCI models, brain injury population, and conversion without in-vivo experience were excluded. The risk of bias was calculated independently. 5302 manuscripts were initially identified and after eligibility assessment, 43 studies were included for full-text analysis. After final analysis, 13 manuscripts were included. All were graded as high-quality assessments. The transduction factors Sox2, Oct4, Klf4, fibroblast growth factor 4 (Fgf4) antibody, neurogenic differentiation 1 (Neurod1), zinc finger protein 521 (Zfp521), ginsenoside Rg1, and small molecules (LDN193189, CHIR99021, and DAPT) could effectively reprogramme astrocytes into neuron-like cells. The process was enhanced by p21-p53, or Notch signaling knockout, valproic acid, or chondroitin sulfate proteoglycan inhibitors. The type of mature neurons was both excitatory and inhibitory. Astrocyte reprogramming to neuronal-like cells in an animal model after SCI appears promising. The molecular and functional improvements after astrocyte reprogramming were demonstrated in vivo, and further investigation is required in this field.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"62 4","pages":"133-142"},"PeriodicalIF":2.2,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140050369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of comprehensive rehabilitation in the care of degenerative cervical myelopathy 综合康复在治疗退行性颈椎脊髓病中的作用。

IF 2.2 4区医学

Spinal cord Pub Date : 2024-03-04 DOI: 10.1038/s41393-024-00965-y

Amiram Catz, Yaron Watts, Hagay Amir, Lilach Front, Ilana Gelernter, Dianne Michaeli, Vadim Bluvshtein, Elena Aidinoff

{"title":"The role of comprehensive rehabilitation in the care of degenerative cervical myelopathy","authors":"Amiram Catz, Yaron Watts, Hagay Amir, Lilach Front, Ilana Gelernter, Dianne Michaeli, Vadim Bluvshtein, Elena Aidinoff","doi":"10.1038/s41393-024-00965-y","DOIUrl":"10.1038/s41393-024-00965-y","url":null,"abstract":"Retrospective cohort study. To find out if comprehensive rehabilitation itself can improve daily performance in persons with DCM. The spinal department of a rehabilitation hospital. Data from 116 DCM inpatients who underwent comprehensive rehabilitation after spinal surgery were retrospectively analyzed. The definitions of the calculated outcome variables made possible analyses that distinguished the effect of rehabilitation from that of spinal surgery. Paired t-tests were used to compare admission with discharge outcomes and functional gains. Spearman’s correlations were used to assess relationships between performance gain during rehabilitation and between time from surgery to rehabilitation. The Spinal Cord Injury Ability Realization Measurement Index (SCI-ARMI) increased during rehabilitation from 57 (24) to 78 (19) (p < 0.001). The Spinal Cord Independence Measure 3rd version (SCIM III) gain attributed to neurological improvement (dSCIM-IIIn) was 6.3 (9.2), and that attributed to rehabilitation (dSCIM-IIIr) 16 (18.5) (p < 0.001). dSCIM-IIIr showed a rather weak negative correlation with time from spinal surgery to rehabilitation (r = −0.42, p < 0.001). The study showed, for the first time, that comprehensive rehabilitation can achieve considerable functional improvement for persons with DCM of any degree, beyond that of spinal surgery. Combined with previously published evidence, this indicates that comprehensive rehabilitation can be considered for persons with DCM of any functional degree, before surgery.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"62 5","pages":"200-206"},"PeriodicalIF":2.2,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41393-024-00965-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140029067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A nomogram for predicting the hospital-acquired infections in children with spinal cord injuries: a retrospective, multicenter, observational study 预测脊髓损伤儿童院内感染的提名图：一项回顾性多中心观察研究。

IF 2.2 4区医学

Spinal cord Pub Date : 2024-02-26 DOI: 10.1038/s41393-024-00966-x

Bo Wang, Pengfei Zheng, Yapeng Zhang, Wangmi Liu, Lei Liu, Yuntao Wang

{"title":"A nomogram for predicting the hospital-acquired infections in children with spinal cord injuries: a retrospective, multicenter, observational study","authors":"Bo Wang, Pengfei Zheng, Yapeng Zhang, Wangmi Liu, Lei Liu, Yuntao Wang","doi":"10.1038/s41393-024-00966-x","DOIUrl":"10.1038/s41393-024-00966-x","url":null,"abstract":"Retrospective cohort study. Hospital-acquired infections (HAIs) pose a significant risk for pediatric patients with spinal cord injuries (SCIs), potentially leading to extended hospital stays and increased morbidity. This study aims to identify patients at higher risk for HAIs. Hospitals from multiple areas in China. This retrospective study included 220 pediatric SCI patients from Jan 2005 to Dec 2023, divided into a training set (n = 154) and a validation set (n = 66). We conducted a multivariate logistic regression analysis to identify risk factors associated with HAIs and constructed a predictive nomogram. The model’s performance was assessed using receiver operating characteristic (ROC) curves, area under the ROC curve (AUC) and calibration plots, while decision curve analysis was utilized to determine clinical utility. The nomogram incorporated age, time from injury to the hospital, history of urinary and pulmonary infections, urobilinogen positivity, damaged segments, and admission American Spinal Injury Association (ASIA) scores. The model demonstrated excellent discrimination in the training set (AUC = 0.957) and good discrimination in the validation set (AUC = 0.919). Calibration plots indicated an acceptable fit between predicted probabilities and observed outcomes. Decision curve analysis confirmed the model’s net benefit over clinical decision thresholds in both sets. We developed and validated a predictive nomogram for HAIs in pediatric SCI patients that shows promise for clinical application. The model can assist healthcare providers in identifying patients at higher risk for HAIs, potentially facilitating early interventions and improved patient care strategies.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"62 4","pages":"183-191"},"PeriodicalIF":2.2,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139973515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between personality traits and depressive and anxiety symptoms among persons with spinal cord injury in first inpatient rehabilitation 首次住院康复的脊髓损伤患者的人格特质与抑郁和焦虑症状之间的关系。

IF 2.2 4区医学

Spinal cord Pub Date : 2024-02-23 DOI: 10.1038/s41393-024-00964-z

Christel M. C. van Leeuwen, Erika Papazoglou, Janske H. W. van Eersel, Janneke M. Stolwijk-Swüste, Marcel W. M. Post

{"title":"Associations between personality traits and depressive and anxiety symptoms among persons with spinal cord injury in first inpatient rehabilitation","authors":"Christel M. C. van Leeuwen, Erika Papazoglou, Janske H. W. van Eersel, Janneke M. Stolwijk-Swüste, Marcel W. M. Post","doi":"10.1038/s41393-024-00964-z","DOIUrl":"10.1038/s41393-024-00964-z","url":null,"abstract":"Retrospective analysis of medical records. To assess personality traits in persons with spinal cord injury (SCI) and compare these with the general population group. Moreover, to explore associations between personality traits and depressive and anxiety symptoms among persons with SCI in first inpatient rehabilitation. Specialized rehabilitation center in The Netherlands. Data were used from a routine psychological screening, administered in the first weeks of admission (N = 67). Measures included the Hospital Anxiety and Depression Scale and the Dutch Personality Questionnaire, which includes subscales measuring neuroticism, social inadequacy, rigidity, hostility, egoism, dominance, and self-esteem. Correlational and regression analyses were conducted. Mean age of the participants was 58 (SD 17) years. The majority (63%) were male, and had a low lesion (57%). The participants scored significantly higher on dominance and lower on social inadequacy, hostility, and egoism in comparison with the general population. In the bivariate regression analyses, high neuroticism (β = 0.42 and β = 0.53) and low self-esteem (β = -0.25 and β = -0.29) were significantly associated with increased depressive and anxiety symptoms. In the hierarchical regression analyses, only high neuroticism was significantly associated with increased depressive (β = 0.42, p < 0.05) and anxiety (β = 0.55, p < 0.001) symptoms. Personality traits are not the same between the SCI population and the general population. Assessment of personality traits early in inpatient rehabilitation can help to identify individuals at risk of mood problems and, thereby, facilitate interventions. Future research with a larger, representative SCI sample, is required to confirm these findings.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"62 4","pages":"178-182"},"PeriodicalIF":2.2,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139932963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Observations of cold-induced vasodilation in persons with spinal cord injuries 观察脊髓损伤者因寒冷引起的血管扩张。

IF 2.2 4区医学

Spinal cord Pub Date : 2024-02-22 DOI: 10.1038/s41393-024-00960-3

Yasuhisa Fujita, Yoshi-ichiro Kamijo, Tokio Kinoshita, Takamasa Hashizaki, Kouta Murai, Tatsuya Yoshikawa, Yasunori Umemoto, Chikako Kaminaka, Manabu Shibasaki, Fumihiro Tajima, Yukihide Nishimura

{"title":"Observations of cold-induced vasodilation in persons with spinal cord injuries","authors":"Yasuhisa Fujita, Yoshi-ichiro Kamijo, Tokio Kinoshita, Takamasa Hashizaki, Kouta Murai, Tatsuya Yoshikawa, Yasunori Umemoto, Chikako Kaminaka, Manabu Shibasaki, Fumihiro Tajima, Yukihide Nishimura","doi":"10.1038/s41393-024-00960-3","DOIUrl":"10.1038/s41393-024-00960-3","url":null,"abstract":"Acute experimental study. Cold-induced vasodilation is a local mechanism of protection against frostbite in non-injured persons. We assessed whether an increase in skin blood flow (SkBF) during local cooling (LC) was observed in individuals with spinal cord injuries (SCIs) and if the response patterns differed between region levels or sites. Laboratory of Wakayama Medical University and the affiliated clinics, Japan. A local cooler device (diameter 4 cm) was placed on the chest (sensate) and right thigh (non-sensate) in persons with cervical (SCIC; n = 9) and thoracolumbar SCIs (SCITL; n = 9). After the surface temperature under the device was controlled at 33 °C for 10 min (baseline), LC (−0.045 °C/s) was applied and the skin temperature was maintained at 15 and 8 °C for 15 min of each stage. SkBF (laser Doppler flowmetry) was monitored using a 1-mm needle-type probe inserted into its center. The percent change in SkBF (%ΔSkBF) on the chest remained unchanged until the end of 15 °C stage; thereafter, it increased to a level at least 70% greater than the baseline during the 8 °C stage in both groups. The %ΔSkBF on the thigh in both SCIC and SCITL notably increased from 8 and 6 min respectively, during the 8°C stage, compared to 1 min before the stage; however, it did not exceed the baseline level. An increase in SkBF during LC was observed both in the sensate and non-sensate areas in SCIs, although the magnitude was larger in the sensate area.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"62 4","pages":"170-177"},"PeriodicalIF":2.2,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41393-024-00960-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139932964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Examining the impact of COVID-19 on health care utilization among persons with chronic spinal cord injury/dysfunction: a population study 更正：研究 COVID-19 对慢性脊髓损伤/功能障碍患者使用医疗服务的影响：一项人口研究。

IF 2.2 4区医学

Spinal cord Pub Date : 2024-02-15 DOI: 10.1038/s41393-024-00957-y

Arrani Senthinathan, Mina Tadrous, Swaleh Hussain, B. Catharine Craven, Susan B. Jaglal, Rahim Moineddin, John Shepherd, Lauren Cadel, Vanessa K. Noonan, Sandra McKay, Karen Tu, Sara J. T. Guilcher

引用次数: 0

The effect of level of injury on diabetes incidence and mortality after spinal cord injury – a longitudinal cohort study 损伤程度对脊髓损伤后糖尿病发病率和死亡率的影响--一项纵向队列研究。

IF 2.2 4区医学

Spinal cord Pub Date : 2024-02-14 DOI: 10.1038/s41393-024-00961-2

Sven Hoekstra, Michelle Trbovich, Wouter Koek, Michael Mader, Marzieh Salehi

{"title":"The effect of level of injury on diabetes incidence and mortality after spinal cord injury – a longitudinal cohort study","authors":"Sven Hoekstra, Michelle Trbovich, Wouter Koek, Michael Mader, Marzieh Salehi","doi":"10.1038/s41393-024-00961-2","DOIUrl":"10.1038/s41393-024-00961-2","url":null,"abstract":"Retrospective longitudinal cohort study of veterans with SCI. Spinal cord injury (SCI) is associated with an increased risk of developing diabetes mellitus (DM), likely due to body composition alterations and autonomic nervous system dysfunction. These factors are more pronounced in persons with tetraplegia (TP) versus paraplegia (PP). However, the effect of level of injury (LOI) on DM incidence is largely unknown. Therefore, the objective is to examine the effect of LOI on DM incidence in persons with SCI. South Texas Veterans Health Care System. We obtained electronic record data on age, sex, race/ethnicity, LOI and HbA1c concentration from January 1st 2001 through December 31st 2021. Cox proportional hazard regression analyses were used to assess the association between LOI, DM and all-cause mortality. Among 728 non-diabetic veterans with SCI (350 TP/ 378 PP, 52 ± 15 years, 690 male/38 female) 243 developed DM, of which 116 with TP and 127 with PP. Despite chronological variations between TP and PP, DM risk over the entire follow-up did not differ between the groups (hazard ratio (HR): 1.06, 95% CI: 0.82–1.38). Mortality was higher in TP versus PP (HR: 1.40, 95% CI: 1.09–1.78). However, developing DM did not increase the risk of death, regardless of LOI (HR: 1.07, 95% CI: 0.83–1.37). Despite chronological variations between both groups, the level of injury had minimal effect on long-term DM development in this cohort of veterans with SCI. Sponsorship NIH (DK105379; MS), RR&D SPiRE (I21RX003724-01A1; MT and SH).","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"62 4","pages":"164-169"},"PeriodicalIF":2.2,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0