Spinal cord最新文献

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Prevalence, causes, and risk profile of rehospitalizations in persons with spinal cord injury within the first 10 years after primary rehabilitation 脊髓损伤患者在初级康复后头 10 年内再次住院的发生率、原因和风险概况。
IF 2.1 4区 医学
Spinal cord Pub Date : 2024-09-05 DOI: 10.1038/s41393-024-01028-y
Inge E. Eriks-Hoogland, Lea Studer, Lorena L. Müller, Benjamin Hirsch, Jürgen Pannek, Armin Gemperli, Cristina Ehrmann
{"title":"Prevalence, causes, and risk profile of rehospitalizations in persons with spinal cord injury within the first 10 years after primary rehabilitation","authors":"Inge E. Eriks-Hoogland, Lea Studer, Lorena L. Müller, Benjamin Hirsch, Jürgen Pannek, Armin Gemperli, Cristina Ehrmann","doi":"10.1038/s41393-024-01028-y","DOIUrl":"10.1038/s41393-024-01028-y","url":null,"abstract":"Retrospective cohort study. This study aims to identify the prevalence, causes, time pattern and risk profile of rehospitalizations in persons with spinal cord injury (SCI) within a 10-year period following primary rehabilitation and identify most common secondary health conditions (SHCs) and risk profile leading to rehospitalizations. Specialized hospital and rehabilitation center for SCI in Switzerland. A retrospective analysis was conducted on clinical data from persons with SCI, discharged from initial rehabilitation between January 1, 2010, and December 31, 2012, and followed up over a period of ten years post-discharge. Descriptive statistical methods were utilized to compute the rehospitalization prevalence and to identify the primary reasons. 225 participants were included, 70% were male (n = 179), and the mean age was 50 years (SD 19, Range 17–88). 54% were classified as having paraplegia (n = 122), and 77% incomplete injuries (n = 180). Over the 10-year observation period post-discharge, 120 were readmitted at least once, (prevalence 53%). In total, 66 persons (29%) were rehospitalized once or twice, while 54 persons (24%) were rehospitalized three or more times, with a maximum of 14 times. In the 10-year period, the most common SHCs leading to rehospitalization were infections (19%), pressure injuries (18%), and gastrointestinal problems (16%). During the study period, 57 persons (25%) passed away. Rehospitalization after primary rehabilitation is frequent and in the majority of the cases due to SHCs. The study findings are valuable for resource planning in healthcare and can guide the implementation of preventive measures to avoid SHCs.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"62 11","pages":"625-633"},"PeriodicalIF":2.1,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of exercise on autonomic cardiovascular control in individuals with chronic, motor-complete spinal cord injury: an exploratory randomised clinical trial 运动对慢性完全性运动性脊髓损伤患者自律性心血管控制的影响:一项探索性随机临床试验。
IF 2.1 4区 医学
Spinal cord Pub Date : 2024-08-31 DOI: 10.1038/s41393-024-01019-z
Tristan W. Dorey, Tom E. Nightingale, Abdullah A. Alrashidi, Stefan Thomas, Katharine D. Currie, Michèle Hubli, Shane J. T. Balthazaar, Andrei V. Krassioukov
{"title":"Effects of exercise on autonomic cardiovascular control in individuals with chronic, motor-complete spinal cord injury: an exploratory randomised clinical trial","authors":"Tristan W. Dorey, Tom E. Nightingale, Abdullah A. Alrashidi, Stefan Thomas, Katharine D. Currie, Michèle Hubli, Shane J. T. Balthazaar, Andrei V. Krassioukov","doi":"10.1038/s41393-024-01019-z","DOIUrl":"10.1038/s41393-024-01019-z","url":null,"abstract":"Secondary analysis of a clinical trial. To assess the impact of 6 months of arm cycle ergometry training (ACET), or body weight-supported treadmill training (BWSTT), on autonomic cardiovascular responses to a laboratory sit-up test (SUT) in individuals with chronic (≥1-year post-injury) spinal cord injury (SCI). Tertiary Rehabilitation Centre, Vancouver, Canada. Sixteen individuals with motor-complete (American Spinal Injury Association Impairment Scale A-B) SCI between the fourth cervical and sixth thoracic spinal cord segments, aged 39 ± 11 years, were assessed. Participants were randomized to receive 72 sessions of moderate-to-vigorous intensity ACET (n = 8) or passive BWSTT (n = 8). Changes in mean arterial pressure (finger plethysmography), hemodynamics (Modelflow® method), and heart rate/heart rate variability (HR/HRV; electrocardiography) were measured in response to a  SUT before and after 6 months of exercise training. Spontaneous cardiovagal baroreflex sensitivity (cvBRS) was assessed using the sequence method. Neither ACET nor BWSTT impacted hemodynamic responses to SUT or the incidence of orthostatic hypotension (all P > 0.36). ACET increased HR (P < 0.01, ηp2 = 0.34) and high frequency (HF) power HRV responses (P < 0.01, ηp2 = 0.42) to SUT following 6 months of training while BWSTT did not. Consistent with this, cvBRS improved (P < 0.05, ηp2 = 0.16) only following ACET. Improvements in cvBRS were correlated with both the HR (r = 0.726, P < 0.0001) and HF power (r = −0.484, P < 0.01) responses to SUT. Six months of ACET, but not BWSTT, improved cardiovagal baroreflex control of HR but had no effect on BP responses to SUT in individuals with chronic, motor-complete SCI. Canadian Institutes of Health Research (CIHR) NCT01718977","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"62 10","pages":"597-604"},"PeriodicalIF":2.1,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
White matter spinal tracts impairment in patients with degenerative cervical myelopathy evaluated with the magnetization transfer saturation MRI technique 利用磁化转移饱和磁共振成像技术评估退行性颈椎病患者的脊髓白质束损伤情况。
IF 2.1 4区 医学
Spinal cord Pub Date : 2024-08-28 DOI: 10.1038/s41393-024-01025-1
Elena Filimonova, Mars Abdaev, Ivan Vasilenko, Yulij Kubetskij, Oleg Prokhorov, Jamil Rzaev
{"title":"White matter spinal tracts impairment in patients with degenerative cervical myelopathy evaluated with the magnetization transfer saturation MRI technique","authors":"Elena Filimonova, Mars Abdaev, Ivan Vasilenko, Yulij Kubetskij, Oleg Prokhorov, Jamil Rzaev","doi":"10.1038/s41393-024-01025-1","DOIUrl":"10.1038/s41393-024-01025-1","url":null,"abstract":"Prospective case-control study. We investigated the use of the magnetization transfer saturation (MTsat) technique to assess the structural integrity of the spinal cord tracts in individuals with clinically significant degenerative cervical myelopathy (DCM) and associated disability. Novosibirsk Neurosurgery Centre, Russia. A total of 53 individuals diagnosed with DCM and 41 patients with cervical radiculopathy underwent high-resolution MRI of the cervical spinal cord via the magnetization transfer technique. The MRI data were processed using the Spinal Cord Toolbox (v5.5), with MTsat values determined for each spinal tract and compared between the two groups. Furthermore, associations between MTsat values and the clinical disability rates of patients were investigated. A significant decrease in the MTsat of the ventral spinocerebellar tract was observed in the DCM group compared to the control group (adjusted p < 0.001). There was a trend towards lower MTsat values in the rubrospinal tract in the DCM group (adjusted p = 0.08). Additionally, a decrease in MTsat values in the lateral funiculi of the spinal cord was found in patients with DCM (adjusted p < 0.01). Furthermore, a trend toward a positive correlation was observed between the JOA score and the MTsat values within the ventral spinocerebellar tract (R = 0.33, adjusted p = 0.051). The findings of our study indicate that demyelination in patients with DCM affects mainly the ventral spinocerebellar and rubrospinal tracts, and the extent of changes in the ventral spinocerebellar tract is related to the severity of the condition.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"62 10","pages":"590-596"},"PeriodicalIF":2.1,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41393-024-01025-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142081544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychological screening of significant others during spinal cord injury rehabilitation 脊髓损伤康复期间重要他人的心理筛查。
IF 2.1 4区 医学
Spinal cord Pub Date : 2024-08-27 DOI: 10.1038/s41393-024-01024-2
Tijn van Diemen, Eline W. M. Scholten, Nelleke G. Langerak, Ilse J. W. van Nes
{"title":"Psychological screening of significant others during spinal cord injury rehabilitation","authors":"Tijn van Diemen, Eline W. M. Scholten, Nelleke G. Langerak, Ilse J. W. van Nes","doi":"10.1038/s41393-024-01024-2","DOIUrl":"10.1038/s41393-024-01024-2","url":null,"abstract":"Retrospective cohort study. Determine the course of burden and psychological distress of significant others (SOs) during initial spinal cord injury (SCI) rehabilitation and to predict the caregiver’s burden at discharge with characteristics of SOs and persons with SCI (PSCIs) at the start of rehabilitation. Rehabilitation center Sint Maartenskliniek, Nijmegen, The Netherlands. All PSCIs admitted for initial rehabilitation between October 2020 and December 2022 were included. One of their SOs were asked to complete a set of screening questionnaires, collected in our routine context of care. A total of 181 PSCIs (62% male, average age 60 years, 80% incomplete SCI, 60% paraplegia and 32 days after injury) and 158 SOs (40% male, average age 57 years) were screened at admission, and 145 and 93 at discharge, respectively. For SOs, the average caregiver’s burden and feelings of depression and anxiety did not change during admission. The caregiver’s burden score at discharge was best predicted by the burden score at admission, explaining 20% (P < 0.001) of the variance. An additional 13% (P = 0.02) of the variance was explained by other SO and PSCI variables gathered in this study. The caregiver’s burden in this group of SOs during rehabilitation, was higher than that of a representative group in the chronic phase. On both assessments, around 20% scored above the cutoff. Scores of psychological distress are comparable to former studies. Standard screening of SOs during initial SCI rehabilitation is important to help the interdisciplinary team identify SOs at risk, and target their treatment during inpatient rehabilitation.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"62 10","pages":"584-589"},"PeriodicalIF":2.1,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142081543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combining clinically common drugs with hindlimb stretching in spinal cord injured rodents 将临床常用药物与脊髓损伤啮齿动物的后肢伸展相结合。
IF 2.1 4区 医学
Spinal cord Pub Date : 2024-08-26 DOI: 10.1038/s41393-024-01023-3
Morgan J. Forston, Savannah L. Jordan, Greta M. Cesarz, Darlene A. Burke, Alice Shum-Siu, Jeffrey C. Petruska, David S. K. Magnuson
{"title":"Combining clinically common drugs with hindlimb stretching in spinal cord injured rodents","authors":"Morgan J. Forston, Savannah L. Jordan, Greta M. Cesarz, Darlene A. Burke, Alice Shum-Siu, Jeffrey C. Petruska, David S. K. Magnuson","doi":"10.1038/s41393-024-01023-3","DOIUrl":"10.1038/s41393-024-01023-3","url":null,"abstract":"Preclinical pilot study. To explore peripheral and central nociceptive mechanisms that contribute to muscle stretch-induced locomotor deficits following spinal cord injury. Kentucky Spinal Cord Injury Research Center, Louisville, KY, USA. Ten female Sprague-Dawley rats received moderate, 25 g/cm T10 contusion injuries and recovered for 4 weeks. Rats were divided into three groups: Morphine/Ibuprofen-treated, Acetaminophen/Baclofen-treated, and saline control. Each group received daily hindlimb muscle stretching during weeks 4, 5, 9, and 10 post-injury and drugs were administered with stretching during weeks 4 and 9 only. Locomotor function was assessed throughout the experiment using the BBB Open Field Locomotor Scale. Hindlimb responses including spasticity, writhing, and clonic-like vibrations during muscle stretching were classified and scored. Consistent with our previous studies, hindlimb muscle stretching caused significant deficits in locomotor recovery following spinal cord injury. Baclofen and Ibuprofen partially mitigated the stretching effect, but none of the drugs significantly prevented the drop in locomotor function during stretching. Interestingly, treatment with Baclofen or Ibuprofen significantly reduced hindlimb responses such as spasticity and writhing during stretching, while Morphine exacerbated clonic-like vibrations in response to stretching maneuvers. These findings suggest that stretching may inhibit locomotor recovery through combined mechanisms of peripheral inflammation and sensitization of nociceptive afferents. When combined with central sprouting and loss of descending controls after SCI, this results in exaggerated nociceptive input during stretching. The inability of the applied clinical drugs to mitigate the detrimental effects of stretching highlights the complexity of the stretching phenomenon and emphasizes the need for further investigation.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"62 10","pages":"574-583"},"PeriodicalIF":2.1,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Remote limb ischemic preconditioning alleviated spinal cord injury through inhibiting proinflammatory immune response and promoting the survival of spinal neurons 远端肢体缺血预处理通过抑制促炎免疫反应和促进脊髓神经元的存活,减轻了脊髓损伤。
IF 2.1 4区 医学
Spinal cord Pub Date : 2024-08-17 DOI: 10.1038/s41393-024-01015-3
Yitong Yan, Zihan Li, Shuangyue Zhang, Fan Bai, Yingli Jing, Fubiao Huang, Yan Yu
{"title":"Remote limb ischemic preconditioning alleviated spinal cord injury through inhibiting proinflammatory immune response and promoting the survival of spinal neurons","authors":"Yitong Yan, Zihan Li, Shuangyue Zhang, Fan Bai, Yingli Jing, Fubiao Huang, Yan Yu","doi":"10.1038/s41393-024-01015-3","DOIUrl":"10.1038/s41393-024-01015-3","url":null,"abstract":"Experimental animal study. To investigate the protective effect of remote limb ischemia preconditioning (RLPreC) on traumatic spinal cord injury (SCI) and explore the underlying biological mechanisms using RNA sequencing. China Rehabilitation Science Institute; Beijing; China. spinal cord injury was induced in mice using a force of 0.7 N. RLPreC treatment was administered. Motor function, pain behavior, and gene expression were assessed. RLPreC treatment significantly improved motor function and reduced pain-like behavior in SCI mice. RNA-Seq analysis identified 5247 differentially expressed genes (DEGs). GO analysis revealed enrichment of immune response, inflammatory signaling, and synaptic transmission pathways among these DEGs. KEGG analysis indicated suppression of inflammation and promotion of synapse-related pathways. RLPreC is a promising therapeutic strategy for improving motor function and alleviating pain after traumatic SCI. RNA-Seq analysis provides insights into potential therapeutic targets and warrants further investigation.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"62 10","pages":"562-573"},"PeriodicalIF":2.1,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leisure-time physical activity motives and perceived gains for individuals with spinal cord injury 脊髓损伤者的闲暇体育锻炼动机和感知收益。
IF 2.1 4区 医学
Spinal cord Pub Date : 2024-07-30 DOI: 10.1038/s41393-024-01013-5
Paul K. Watson, Laura Stendell, Camila Quel de Oliveira, James W. Middleton, Mohit Arora, Glen M. Davis
{"title":"Leisure-time physical activity motives and perceived gains for individuals with spinal cord injury","authors":"Paul K. Watson, Laura Stendell, Camila Quel de Oliveira, James W. Middleton, Mohit Arora, Glen M. Davis","doi":"10.1038/s41393-024-01013-5","DOIUrl":"10.1038/s41393-024-01013-5","url":null,"abstract":"Longitudinal cross-sectional. To examine motives to, and perceived gains from, leisure-time physical activity (LTPA) in people with spinal cord injury (SCI). Community. One hundred and five physically active individuals with SCI undertook an online survey and a semi-structured interview. The Exercise Motives and Gains Inventory was used to examine the movies towards, and the gains from LTPA, and the Leisure-time Physical Activity Questionnaire was administered via interview to gather LTPA data. A cross-sectional analysis, which included descriptive, inferential, and regression statistics, was conducted on all participants, physical activity (PA) guideline adherers and PA guideline non-adherers. The most common motives for LTPA were improvements in health and fitness, management of appearance and weight, and avoidance of illness. The most common gains from LTPA included improved health, fitness, strength and endurance, increased nimbleness, and enjoyment and revitalisation. Whilst health enhancement appears to be a significant motivator for LTPA, other psychosocial aspects, such as affiliation and revitalisation, appear to influence engagement and volume of LTPA. Regular LTPA should be encouraged for its health benefits, and emphasis should be placed on promoting its ability to reduce illness, facilitate affiliation, and manage stress.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"62 9","pages":"546-552"},"PeriodicalIF":2.1,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41393-024-01013-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141856613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to “Knowledge, perceptions, and beliefs about urinary tract infections in persons with neurogenic bladder and impacts on interventions to promote person-centered care” 对 "关于神经源性膀胱患者尿路感染的知识、看法和信念以及对促进以人为本的护理的干预措施的影响 "的回应。
IF 2.1 4区 医学
Spinal cord Pub Date : 2024-07-29 DOI: 10.1038/s41393-024-01020-6
Matthias Walter
{"title":"Response to “Knowledge, perceptions, and beliefs about urinary tract infections in persons with neurogenic bladder and impacts on interventions to promote person-centered care”","authors":"Matthias Walter","doi":"10.1038/s41393-024-01020-6","DOIUrl":"10.1038/s41393-024-01020-6","url":null,"abstract":"","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"62 10","pages":"605-606"},"PeriodicalIF":2.1,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141793517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to ‘Knowledge, perceptions, and beliefs about urinary tract infections in persons with neurogenic bladder and impacts on interventions to promote person-centered care’ 对 "关于神经源性膀胱患者尿路感染的知识、看法和信念以及对促进以人为本的护理干预措施的影响 "的回应。
IF 2.1 4区 医学
Spinal cord Pub Date : 2024-07-29 DOI: 10.1038/s41393-024-01021-5
Margaret A. Fitzpatrick, Marissa Wirth, Stephen P. Burns, Charlesnika T. Evans
{"title":"Response to ‘Knowledge, perceptions, and beliefs about urinary tract infections in persons with neurogenic bladder and impacts on interventions to promote person-centered care’","authors":"Margaret A. Fitzpatrick, Marissa Wirth, Stephen P. Burns, Charlesnika T. Evans","doi":"10.1038/s41393-024-01021-5","DOIUrl":"10.1038/s41393-024-01021-5","url":null,"abstract":"","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"62 10","pages":"607-607"},"PeriodicalIF":2.1,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141793518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bodyweight influences the relationship between serum testosterone and bone mineral density in men with spinal cord injury 体重影响脊髓损伤男性血清睾酮与骨矿物质密度之间的关系。
IF 2.1 4区 医学
Spinal cord Pub Date : 2024-07-29 DOI: 10.1038/s41393-024-01022-4
Jakob N. Deitrich, Ashraf S. Gorgey
{"title":"Bodyweight influences the relationship between serum testosterone and bone mineral density in men with spinal cord injury","authors":"Jakob N. Deitrich, Ashraf S. Gorgey","doi":"10.1038/s41393-024-01022-4","DOIUrl":"10.1038/s41393-024-01022-4","url":null,"abstract":"Cross-sectional study. To examine the association between serum testosterone levels (T levels) and bone mineral density after spinal cord injury (SCI). Medical research center. Body composition assessments were measured in 53 men with chronic SCI. Serum T levels were measured after an overnight fast. Total and regional bone mineral density (BMD) and bone mineral content (BMC) were measured using dual-energy X-ray absorptiometry. Participants were classified into three groups based on their body weight [<65 kg, 65–80 kg, >80 kg] or serum T levels into low (400 ng/dl), mid-normal (401–544 ng/dl) and normal (>545 ng/dl) ranges. Serum T level was negatively related to body weight (r = −0.33, P = 0.016), fat mass (r = −0.46, P < 0.001) and percentage fat mass (r = −0.48, P < 0.001). There were no significant relationships between serum T levels and any of the bone health measurements. Body weight was related to total, regional (P < 0.01 for both) and knee BMD (P < 0.05). T level was only related to total and regional BMD in the group with body weight of 65–80 kg. Testosterone has no direct relationship with BMD except within a specific weight group. However, body weight or fat mass negatively influences circulating T levels in men with SCI. The relationship between serum T levels and BMD is mediated by body weight in men with SCI.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"62 10","pages":"555-561"},"PeriodicalIF":2.1,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141856612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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