Spinal cord最新文献_第8页

Immunohistochemical labeling of ongoing axonal degeneration 10 days following cervical contusion spinal cord injury in the rat 大鼠颈挫伤脊髓损伤后10天持续轴突变性的免疫组织化学标记。

IF 2.1 4区医学

Spinal cord Pub Date : 2025-01-03 DOI: 10.1038/s41393-024-01053-x

Anna F. Fusco, Sabhya Rana, Marda Jorgensen, Victoria E. Bindi, Michael D. Sunshine, Gerry Shaw, David D. Fuller

{"title":"Immunohistochemical labeling of ongoing axonal degeneration 10 days following cervical contusion spinal cord injury in the rat","authors":"Anna F. Fusco, Sabhya Rana, Marda Jorgensen, Victoria E. Bindi, Michael D. Sunshine, Gerry Shaw, David D. Fuller","doi":"10.1038/s41393-024-01053-x","DOIUrl":"10.1038/s41393-024-01053-x","url":null,"abstract":"Experimental Animal Study. To continue validating an antibody which targets an epitope of neurofilament light chain (NF-L) only available during neurodegeneration and to utilize the antibody to describe the pattern of axonal degeneration 10 days post-unilateral C4 contusion in the rat. University of Florida laboratory in Gainesville, USA. Sprague Dawley rats received either a unilateral 150kdyne C4 contusion (n = 4 females, n = 5 males) or a laminectomy control surgery (n = 2 females, n = 3 males). Ten days following SCI or laminectomy, spinal cords and brainstems were processed for immunohistochemistry. Serial spinal cord and brainstem cross-sections were stained with the degeneration-specific NF-L antibody (MCA-6H63) and dual labeled with either an antibody against the C-terminus portion of NF-L (NF-L-Ct), to label healthy axons, or an antibody against amyloid precursor protein (APP), considered the current “gold standard” for identifying axonal injury. The pattern of ongoing axonal degeneration was assessed. Spinal cord and brainstem cross-sections from injured rats had punctate MCA-6H63 positive fibers with a pathological appearance, loss of anti-NF-L-Ct colabeling, and frequent colocalization with APP. Immunopositive fibers were abundant rostral and caudal to the lesion in white matter tracts that would be disrupted by the unilateral C4 contusion. This pattern of staining was not observed in control tissue. The MCA-6H63 antibody labels degenerating axons following SCI and offers a tool to quantify axonal degeneration.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"63 2","pages":"86-94"},"PeriodicalIF":2.1,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of prehospital care for neurotrauma in Iran 伊朗神经外伤院前护理评价

IF 2.1 4区医学

Spinal cord Pub Date : 2024-12-27 DOI: 10.1038/s41393-024-01054-w

Mohsen Hajiqasemi, Mahgol Sadat Hassan Zadeh Tabatabaei, Vafa Rahimi-Movaghar

{"title":"Evaluation of prehospital care for neurotrauma in Iran","authors":"Mohsen Hajiqasemi, Mahgol Sadat Hassan Zadeh Tabatabaei, Vafa Rahimi-Movaghar","doi":"10.1038/s41393-024-01054-w","DOIUrl":"10.1038/s41393-024-01054-w","url":null,"abstract":"Narrative review. Neurotrauma has a considerable impact on healthcare, the economy, and human resources worldwide. In Iran, young males are especially vulnerable, with road traffic accidents (RTAs) being the major cause. Evaluating prehospital care systems is critical for detecting shortcomings and implementing improvements. This study seeks to evaluate the prehospital neurotrauma care procedure in Iran, highlighting its strengths and flaws. We searched PubMed and Scopus databases for literature on the present condition of prehospital neurotrauma care in Iran. Consultations with an expert panel yielded additional material not previously available in the literature, particularly on Iran’s emergency medical system. Our findings indicate that the emergency dispatch system in Iran is relatively well-managed, regardless of the lack of a single emergency contact number. However, major obstacles still exist, particularly in terms of human resources, training, and equipment availability. Emergency medical technicians (EMTs) have intermediate to poor levels of knowledge and skills in dealing with neurotrauma, which might be considerably improved by ongoing training programs. Furthermore, Iranian hospitals lack specific trauma center designations and levels, resulting in overcrowded emergency rooms and delayed care delivery. National neurotrauma guidelines have been adopted in recent years, although their compliance is not consistently monitored. Compared to developed healthcare systems, Iran’s prehospital treatment system for individuals with neurotrauma has considerable limitations. Improving EMT education, recruiting more trained professionals, and simultaneous improvement of current medical facilities should be addressed as the first steps toward better care.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"63 2","pages":"51-57"},"PeriodicalIF":2.1,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does irisin mediate metabolic effects of androgen deficiency? A cross-sectional study in men with chronic spinal cord injury 鸢尾素是否介导雄激素缺乏的代谢作用？男性慢性脊髓损伤的横断面研究。

IF 2.1 4区医学

Spinal cord Pub Date : 2024-12-26 DOI: 10.1038/s41393-024-01056-8

Claudia Venditti, Veronica Carnicelli, Valentina Gizzi, Camilla Tonni, Daniele Tienforti, Luca Spagnolo, Giorgio Felzani, Mauro Maccarrone, Marco G. Baroni, Arcangelo Barbonetti

{"title":"Does irisin mediate metabolic effects of androgen deficiency? A cross-sectional study in men with chronic spinal cord injury","authors":"Claudia Venditti, Veronica Carnicelli, Valentina Gizzi, Camilla Tonni, Daniele Tienforti, Luca Spagnolo, Giorgio Felzani, Mauro Maccarrone, Marco G. Baroni, Arcangelo Barbonetti","doi":"10.1038/s41393-024-01056-8","DOIUrl":"10.1038/s41393-024-01056-8","url":null,"abstract":"Retrospective study. To check the hypothesis that irisin could mediate systemic metabolic effects of testosterone in men with chronic spinal cord injury (SCI). Spinal Unit of the San Raffaele Institute in Sulmona. Fifteen men with chronic SCI admitted to a rehabilitation program were involved. They underwent clinical and biochemical evaluations. Irisin levels were measured with a high-sensitivity ELISA kit. Free testosterone levels were calculated (cFT) from total testosterone, sex hormone binding globulin, and albumin concentrations using the Vermeulen formula. Androgen deficiency (total testosterone <3 ng/ml and cFT <64 pg/ml) was found in 53% of participants and was associated with significantly lower irisin levels, higher body mass index (BMI), and higher triglycerides. Participants were engaged in significantly poorer leisure time physical activity (LTPA). Circulating irisin correlated with cFT (r = 0.55; p = 0.03) and both were negatively correlated with triglycerides levels, homeostatic model assessment of insulin resistance (HOMA-IR) and systemic inflammation, as assessed by erythrocyte sedimentation rate (ESR). Correlations with irisin did not reach statistical significance for either BMI (r = −0.40; p = 0.13) or LTPA (r = 0.46; p = 0.08). In bivariate linear regression models, lower irisin levels were significantly associated with higher triglycerides (β = −0.46; 95% CI: −0.75 to −0.16), HOMA-IR (β = −0.32; 95% CI: −0.63 to −0.004) and ESR (β = −0.89; 95% CI: −1.69 to −0.10) independently of cFT. Conversely, the negative associations of cFT with the same variables were lost after adjustment for irisin levels. Spinal cord-injured men with androgen deficiency exhibit lower levels of irisin, which could mediate the systemic effects of testosterone.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"63 2","pages":"80-85"},"PeriodicalIF":2.1,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology and surgical outcomes of pediatric intradural spinal tumors: results from a retrospective series of patients operated in the first two decades of life 小儿硬膜内脊髓肿瘤的流行病学和手术结果：来自20岁前手术患者的回顾性分析。

IF 2.1 4区医学

Spinal cord Pub Date : 2024-12-13 DOI: 10.1038/s41393-024-01052-y

Narihito Nagoshi, Toshiki Okubo, Masahiro Ozaki, Satoshi Suzuki, Kazuki Takeda, Takahito Iga, Morio Matsumoto, Masaya Nakamura, Kota Watanabe

{"title":"Epidemiology and surgical outcomes of pediatric intradural spinal tumors: results from a retrospective series of patients operated in the first two decades of life","authors":"Narihito Nagoshi, Toshiki Okubo, Masahiro Ozaki, Satoshi Suzuki, Kazuki Takeda, Takahito Iga, Morio Matsumoto, Masaya Nakamura, Kota Watanabe","doi":"10.1038/s41393-024-01052-y","DOIUrl":"10.1038/s41393-024-01052-y","url":null,"abstract":"Retrospective cohort study. Due to the rarity of intradural spinal tumors (ISTs) in individuals under 20, comprehensive studies are lacking. This study aims to compare the clinical data of intramedullary and extramedullary IST cases in patients under 20 years of age with those of adult cases and to identify functional predictors that affect surgical outcomes. The single institution in Japan. This retrospective study included 1367 patients diagnosed with extramedullary or intramedullary ISTs who underwent surgery at our institution from 2001 to 2021. Patients were divided into two groups: under 20 years old (Under-20) and 20 years and older. Collected data included demographics, magnetic resonance imaging (MRI) results, and surgical and clinical information. Neurological status was evaluated using the modified McCormick Scale (mMS). Among 1367 cases, 55 patients (4.0%) were under 20 years old. The most frequent tumors in the Under-20 group were astrocytoma (18.2%), followed by myxopapillary ependymoma (16.4%). Seven patients in the Under-20 group died during follow-up. Among the surviving patients, unstable gait post-surgery was associated with malignant tumors and worse preoperative mMS scores. This study highlights significant differences in IST epidemiology and pathology between minors and adults, emphasizing the need for early MRI to prevent paralysis progression and improve outcomes. Understanding these differences is crucial for effective diagnosis and treatment during the first two decades of life.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"63 2","pages":"75-79"},"PeriodicalIF":2.1,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a clinical practice guideline on pressure ulcers in people with spinal cord injuries inspired by the ADAPTE method 受ADAPTE方法启发的脊髓损伤患者压疮临床实践指南的制定。

IF 2.1 4区医学

Spinal cord Pub Date : 2024-12-09 DOI: 10.1038/s41393-024-01051-z

Knaerke Soegaard, Dimitri Beeckman, Sofie Verhaeghe, Fin Biering-Sørensen, Jens Ahm Sørensen

{"title":"Development of a clinical practice guideline on pressure ulcers in people with spinal cord injuries inspired by the ADAPTE method","authors":"Knaerke Soegaard, Dimitri Beeckman, Sofie Verhaeghe, Fin Biering-Sørensen, Jens Ahm Sørensen","doi":"10.1038/s41393-024-01051-z","DOIUrl":"10.1038/s41393-024-01051-z","url":null,"abstract":"Guideline adaptation study using the ADAPTE method. The aim of this study was the development and validation of a Danish clinical practice guideline for PU/PI prevention and treatment for people with SCI through adaptation of existing guidelines. The ADAPTE method is a systematic framework used to adapt existing clinical practice guidelines to a new context, such as a different healthcare setting or population. This method ensures that the adapted guidelines are relevant, evidence-based, and practical for the specific context in which they will be implemented. Relevant stakeholders and treatment units within the Danish healthcare system involved in the rehabilitation, treatment, and care of people with SCI. The adaptation yielded 22 topics and 121 recommendations, which underwent external review. Stakeholders gave positive feedback and qualified the recommendations. However, they also highlighted challenges in implementation due to the complexity of PU/PI prevention and treatment and organizational issues within the Danish healthcare system. This study has resulted in the development of a comprehensive Danish clinical practice guideline tailored specifically for the prevention and treatment of PU/PI among people with SCI within the Danish healthcare system. The external review emphasizes the imperative for continuous research aimed at strengthening evidence-based approaches to both prevention and treatment. Furthermore, it highlights the necessity for systematic dissemination strategies to facilitate the integration of the guideline into clinical practice.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"63 2","pages":"1-9"},"PeriodicalIF":2.1,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41393-024-01051-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: The influencing factors for tracheostomy decannulation after traumatic cervical spinal cord injury: a retrospective study 修正：外伤性颈脊髓损伤后气管造口脱管的影响因素：回顾性研究。

IF 2.1 4区医学

Spinal cord Pub Date : 2024-12-09 DOI: 10.1038/s41393-024-01050-0

Yongqi Xie, Weichao Zhao, Run Peng, Liang Zhang, Yunxiao Jia, Mingliang Yang, Lianjun Gao

引用次数: 0

The influencing factors for tracheostomy decannulation after traumatic cervical spinal cord injury: a retrospective study 外伤性颈脊髓损伤后气管造口拔管的影响因素：一项回顾性研究。

IF 2.1 4区医学

Spinal cord Pub Date : 2024-11-19 DOI: 10.1038/s41393-024-01048-8

Yongqi Xie, Weichao Zhao, Run Peng, Liang Zhang, Yunxiao Jia, Mingliang Yang, Lianjun Gao

{"title":"The influencing factors for tracheostomy decannulation after traumatic cervical spinal cord injury: a retrospective study","authors":"Yongqi Xie, Weichao Zhao, Run Peng, Liang Zhang, Yunxiao Jia, Mingliang Yang, Lianjun Gao","doi":"10.1038/s41393-024-01048-8","DOIUrl":"10.1038/s41393-024-01048-8","url":null,"abstract":"Retrospective study. To investigate the outcomes and influencing factors of tracheostomy decannulation (TD) in persons with traumatic cervical spinal cord injury (SCI). China Rehabilitation Research Center (CRRC) in Beijing, China. From January 2017 to December 2021, 365 persons with traumatic cervical SCI were admitted to the China Rehabilitation Research Center. During hospitalization, tracheostomy patients were enrolled and divided into the TD group and non-TD group. Demographic and clinical data, as well as functional assessments, were collected and recorded for all persons. The factors influencing TD were analyzed using both univariate and multivariate logistic regression. A total of 78 persons with traumatic cervical SCI from CRRC were enrolled in this study. Of these, 48 persons (61.5%) underwent successful decannulation, with a median time of 93.5 days (IQR: 62.0–143.8 days). Multivariate logistic regression revealed that AIS A (P = 0.021, OR: 5.378, 95% CI, 1.287–22.474) and Charlson comorbidity index (CCI) (P = 0.003, OR: 1.836, 95% CI, 1.230–2.740) were significant risk factors of reduced success in TD. PEF in the TD group was 145.44 ± 50.56 L/min. Middle-aged and young persons with traumatic cervical SCI at C3 to C5 neurological level did not satisfy the criterion of PEF (over 160 L/min), but they can still attempt tracheostomy decannulation. AIS A and a high CCI will reduce the success rate of tracheostomy decannulation in persons suffering from traumatic cervical SCI.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"63 1","pages":"43-48"},"PeriodicalIF":2.1,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

“What should a rehabilitation hospital be like?” Priorities and expectations of people with spinal cord injury in Türkiye "康复医院应该是什么样的？土耳其脊髓损伤患者的优先事项和期望。

IF 2.1 4区医学

Spinal cord Pub Date : 2024-11-15 DOI: 10.1038/s41393-024-01049-7

Mucahit Atasoy, Eser Kalaoglu, Omer Faruk Bucak, Evrim Coskun

{"title":"“What should a rehabilitation hospital be like?” Priorities and expectations of people with spinal cord injury in Türkiye","authors":"Mucahit Atasoy, Eser Kalaoglu, Omer Faruk Bucak, Evrim Coskun","doi":"10.1038/s41393-024-01049-7","DOIUrl":"10.1038/s41393-024-01049-7","url":null,"abstract":"Survey study To understand the priorities and expectations of individuals with disabilities caused by spinal cord injuries(SCI) who require long-term inpatient rehabilitation at a rehabilitation hospital. Başakşehir Çam and Sakura City Hospital, İstanbul, Türkiye This cross-sectional clinical study included individuals over the age of 18 with SCI who had previously been hospitalized in a rehabilitation hospital. The 18-question survey, titled “What should a rehabilitation hospital be like according to persons with spinal cord injuries?” was administered to individuals hospitalized in the inpatient service of Çam Sakura City Hospital. It was also disseminated to people with SCI through social media. The participants’ demographic data was recorded. The survey was completed by 120 participants, comprising 70 males and 50 females. The mean age was 37.47 ± 11.63 years. The time since the SCI was less than one year for 20 individuals and more than one year for 100 individuals. The results showed that robotic rehabilitation and psychological support were the most requested rehabilitation domains, while interest in sexual rehabilitation was less than that in other rehabilitation domains. Furthermore, in the correlation analysis, elderly participants indicated that there should be more specialized services and outpatient clinics exclusive to the SCI. The study revealed a striking trend – participants expressed a strong desire for SCI-specific rehabilitation units and robotic rehabilitation. Additionally, the significance and necessity of sexual rehabilitation should be conveyed to people with SCI.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"63 1","pages":"38-42"},"PeriodicalIF":2.1,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of abdominal functional electrical stimulation on blood pressure in people with high level spinal cord injury 腹部功能性电刺激对高位脊髓损伤患者血压的影响。

IF 2.1 4区医学

Spinal cord Pub Date : 2024-11-01 DOI: 10.1038/s41393-024-01046-w

Teodora Bojanic, Euan J. McCaughey, Harrison T. Finn, Peter Humburg, Rachel A. McBain, Bonsan B. Lee, Simon C. Gandevia, Claire L. Boswell-Ruys, Jane E. Butler

{"title":"The effect of abdominal functional electrical stimulation on blood pressure in people with high level spinal cord injury","authors":"Teodora Bojanic, Euan J. McCaughey, Harrison T. Finn, Peter Humburg, Rachel A. McBain, Bonsan B. Lee, Simon C. Gandevia, Claire L. Boswell-Ruys, Jane E. Butler","doi":"10.1038/s41393-024-01046-w","DOIUrl":"10.1038/s41393-024-01046-w","url":null,"abstract":"Single centre training study. To investigate, in a group of people with spinal cord injury (SCI), the effect of transcutaneous functional electrical stimulation of the abdominal muscles (abdominal FES) during cough training on blood pressure (BP), and how it is affected by injury characteristics and alters over time. Laboratory and community. Sixteen participants with SCI (C4-T5) underwent 25 of abdominal FES cough training (5 sets of 10 stimulated coughs) over 6 weeks as part of a previously published study on the effect of abdominal FES training on cough. Systolic BP (SBP), diastolic BP (DBP) and calculated mean arterial pressure (MAP) were measured at the completion of each set. Abdominal FES coughing resulted in an average ~30% acute increase in BP from initial resting BP across all sessions in almost all participants (p < 0.001). However, the increase in BP during abdominal FES coughs from rest reduced over the 25 sessions of training by ~35% for SBP, MAP and DBP (p = 0.024, p = 0.013 and p = 0.042, respectively). There was no meaningful change in resting BP over time (p = 0.935, p = 0.705 and p = 0.988, respectively). Overall, increases in BP during abdominal FES coughs were greatest for those with chronic injuries and cervical injuries. Transcutaneous abdominal FES during cough training acutely increases BP. However, the magnitude of the increase is reduced after 25 sessions of training. Abdominal FES may offer a solution to combat orthostatic hypotension, but its effectiveness may diminish over time.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"63 1","pages":"31-37"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41393-024-01046-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mortality and causes of death of traumatic spinal cord injury in Finland 芬兰外伤性脊髓损伤的死亡率和死亡原因。

IF 2.1 4区医学

Spinal cord Pub Date : 2024-10-30 DOI: 10.1038/s41393-024-01047-9

Elina Johansson, Eerika Koskinen, Mika Helminen, Aki Vainionpää, Teemu M. Luoto

{"title":"Mortality and causes of death of traumatic spinal cord injury in Finland","authors":"Elina Johansson, Eerika Koskinen, Mika Helminen, Aki Vainionpää, Teemu M. Luoto","doi":"10.1038/s41393-024-01047-9","DOIUrl":"10.1038/s41393-024-01047-9","url":null,"abstract":"Prospective cohort study. To study the mortality rates of TSCI patients compared to matched controls and to examine possible TSCI-related mortality risk factors and causes of death. Oulu and Tampere University Hospital, Finland. All consecutive patients with a new TSCI were included in a prospective study (n = 344, 2012-16). All patients were followed until death or the end of 2019. Patients were compared to a control group formed by randomly choosing gender, age, municipality, and calendar time-matched controls (5 controls/TSCI patient). Standardized mortality ratios (SMR) were calculated using general population mortality rates. Mortality information was extracted from the Statistics of Finland (Helsinki, Finland). TSCI patients had an increased mortality (SMR = 2.9) compared with the Finnish population. During the observation period, 26% of TSCI patients and 12% of the matched controls died. Of the TSCI patient deaths, 51% occurred within the first two years postinjury. Increased age, severity of TSCI (as per International SCI Core Data Set) and fall were related to mortality (p < 0.05). The two most common etiologies of death were: circulatory (30%), and pulmonary diseases (28%). Pneumonia was the single most frequent disease leading to death among TSCI patients. During the first years after injury, the mortality of the patients with TSCI is double compared to the controls. Most deaths occur within two years postinjury. Elderly patients with more severe fall-related injury have the highest mortality risk. Circulatory diseases and pulmonary diseases, especially pneumonia, are the foremost causes of death after TSCI.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"63 1","pages":"24-30"},"PeriodicalIF":2.1,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41393-024-01047-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0