Spinal cord最新文献_第3页

Surgical and clinical outcomes of ventral versus dorsal/lateral intradural extramedullary schwannomas: a retrospective comparative study 腹侧与背侧/外侧硬膜内髓外神经鞘瘤的手术和临床结果：一项回顾性比较研究。

IF 2.2 4区医学

Spinal cord Pub Date : 2025-07-09 DOI: 10.1038/s41393-025-01105-w

Toshiki Okubo, Narihito Nagoshi, Takahito Iga, Kazuki Takeda, Masahiro Ozaki, Satoshi Suzuki, Morio Matsumoto, Masaya Nakamura, Kota Watanabe

{"title":"Surgical and clinical outcomes of ventral versus dorsal/lateral intradural extramedullary schwannomas: a retrospective comparative study","authors":"Toshiki Okubo, Narihito Nagoshi, Takahito Iga, Kazuki Takeda, Masahiro Ozaki, Satoshi Suzuki, Morio Matsumoto, Masaya Nakamura, Kota Watanabe","doi":"10.1038/s41393-025-01105-w","DOIUrl":"10.1038/s41393-025-01105-w","url":null,"abstract":"Retrospective comparative study. To compare the surgical and clinical outcomes of ventral intradural extramedullary (IDEM) schwannomas to those of dorsal/lateral IDEM schwannomas. The single institution in Japan. This study included 94 patients with cervical or thoracic IDEM schwannomas who underwent tumor resection via a posterior approach between 2012 and 2022. Patients were categorized into Ventral (n = 12) and Dorsal/Lateral (n = 82) groups based on tumor localization. Demographic and surgical data, including surgical time and intraoperative motor evoked potential (MEP) changes, as well as clinical outcomes such as Japanese Orthopaedic Association (JOA) scores and gait function (modified McCormick scale, MMCS), were evaluated. The Ventral group had a significantly longer surgical time (p = 0.039) and was more likely to experience a temporary decrease in intraoperative MEP waveforms (p = 0.008) compared to the Dorsal/Lateral group. However, there were no significant differences between the groups in age at surgery, sex, level, tumor size, estimated blood loss, JOA score improvement, JOA recovery rate, or gait function at the final follow-up. Gross total resection (GTR) was achieved in all cases. Despite longer surgical times and more likely to experience a temporary decrease in intraoperative MEP waveforms, ventral IDEM schwannomas do not result in significantly worse surgical or clinical outcomes compared to dorsal/lateral IDEM schwannomas. These findings suggest that even if the surgical procedure requires longer, gross total resection of ventral schwannomas via a posterior approach is resulting in favorable treatment outcomes.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"63 8","pages":"410-417"},"PeriodicalIF":2.2,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Empowering lives of people with SCI: unlocking the transformative potential of the World Health Assembly’s resolution on rehabilitation – the 2024 ISCoS lecture 增强脊髓损伤患者的生活能力：释放世界卫生大会关于康复的决议的变革潜力- 2024年ISCoS讲座。

IF 2.2 4区医学

Spinal cord Pub Date : 2025-07-08 DOI: 10.1038/s41393-025-01100-1

Carlotte Kiekens

{"title":"Empowering lives of people with SCI: unlocking the transformative potential of the World Health Assembly’s resolution on rehabilitation – the 2024 ISCoS lecture","authors":"Carlotte Kiekens","doi":"10.1038/s41393-025-01100-1","DOIUrl":"10.1038/s41393-025-01100-1","url":null,"abstract":"Narrative review. To summarize the key messages presented during the ISCoS lecture at the 63rd ISCoS Annual Meeting, focusing on the global rehabilitation landscape, particularly regarding spinal cord injury. Not applicable. The review starts by providing an overview of the World Health Organization (WHO) Rehabilitation 2030 initiative. It then describes how to bridge evidence with rehabilitation practice and the role of CochraneRehab. Rehabilitation is contextualized within Rehabilitation 2030 and the World Health Assembly resolution on strengthening rehabilitation in health systems, highlighting significant policy shifts and technical tools developed by the WHO. The increase in global rehabilitation needs is outlined, citing estimates that nearly one-third of the global population could benefit from rehabilitation services. The role of CochraneRehab is discussed as a catalyst for enhancing primary research quality, evidence synthesis, and knowledge dissemination in rehabilitation. The review advocates for alternative study designs and innovative methodologies, including big data and artificial intelligence, to address persistent evidence gaps in spinal cord injury. In this pivotal moment for global rehabilitation, all stakeholders must unite to implement the WHA resolution and advocate for quality rehabilitation services in health systems and high-quality, innovative research methods to address evidence gaps like those in spinal cord injury care. This requires generating and disseminating evidence-based interventions and overcoming the inherent challenges of implementing these changes in everyday clinical practice.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"63 9","pages":"477-481"},"PeriodicalIF":2.2,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microglial landscape and signaling in spinal cord injury 脊髓损伤中的小胶质细胞景观和信号传导。

IF 2.2 4区医学

Spinal cord Pub Date : 2025-07-07 DOI: 10.1038/s41393-025-01103-y

Qingsheng Zhou, Jianchao Liu, Qiongxuan Fang, Chunming Zhang, Wei Liu, Yifeng Sun

{"title":"Microglial landscape and signaling in spinal cord injury","authors":"Qingsheng Zhou, Jianchao Liu, Qiongxuan Fang, Chunming Zhang, Wei Liu, Yifeng Sun","doi":"10.1038/s41393-025-01103-y","DOIUrl":"10.1038/s41393-025-01103-y","url":null,"abstract":"An integrated bioinformatics data study. This study uses bioinformatics analysis to map the microglial landscape, investigate key signaling pathways, and reveal the molecular mechanisms that facilitate SCI recovery. Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University. In this study, we performed an integrative bioinformatics analysis of single-cell RNA sequencing (scRNA-seq), spatial transcriptomic (ST), and bulk RNA-seq datasets from the Gene Expression Omnibus (GEO), utilizing R packages (Seurat, DESeq2, limma, GSVA) and the Enrichr platform. Single-cell and spatial transcriptomic profiling uncovered dynamic shifts in the microglial landscape post-SCI, characterized by the suppression of innate microglial populations alongside the expansion of reactive microglial subsets. Mechanistically, the TGFβ signaling pathway was identified as a critical regulator of innate microglial migration, promoting functional recovery after SCI. Conversely, reactive microglia exhibiting heightened Trem2 expression were found to exacerbate neuroinflammatory responses and drive neural cell death. These findings collectively indicate that targeting the dual regulatory axis of Trem2-mediated neuroinflammation and TGFβ-driven repair mechanisms may offer a synergistic therapeutic strategy to enhance functional recovery following spinal cord injury.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"63 8","pages":"418-425"},"PeriodicalIF":2.2,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protocol for developing the nutrition dataset for the international spinal cord society: an international eDelphi approach 为国际脊髓学会开发营养数据集的协议：国际eDelphi方法。

IF 2.2 4区医学

Spinal cord Pub Date : 2025-07-04 DOI: 10.1038/s41393-025-01102-z

Priya Iyer, Gary J. Farkas, Sherri L. LaVela, Shashivadan P. Hirani, Samford Wong

引用次数: 0

Features of registered clinical trials and associated papers on physical activity involving people with spinal cord injury 脊髓损伤患者体力活动的注册临床试验及相关论文的特点。

IF 2.2 4区医学

Spinal cord Pub Date : 2025-07-02 DOI: 10.1038/s41393-025-01101-0

Cameron M. Gee, Kendra R. Todd

引用次数: 0

A qualitative study of experiencing cauda equina syndrome and its aftercare in the UK 在英国经历马尾综合征及其后护理的定性研究。

IF 2.2 4区医学

Spinal cord Pub Date : 2025-06-28 DOI: 10.1038/s41393-025-01097-7

Nisaharan Srikandarajah, Simon Clark, Martin Wilby, Tony Marson, Adam Noble

{"title":"A qualitative study of experiencing cauda equina syndrome and its aftercare in the UK","authors":"Nisaharan Srikandarajah, Simon Clark, Martin Wilby, Tony Marson, Adam Noble","doi":"10.1038/s41393-025-01097-7","DOIUrl":"10.1038/s41393-025-01097-7","url":null,"abstract":"Qualitative, semi structured interviews. Cauda Equina Syndrome (CES) is a neurological emergency that can cause permanent disability to the lower limbs, including pain, weakness, and bladder, bowel and sexual dysfunction. There is little evidence on the lived experience of patients with different severities of CES. This study sought to address this. The interviews were conducted with persons who had experienced CES and been operated on for this condition in the UK. A sampling frame was used on a pre-existing database to select a maximum variation sample. Interviews were audio recorded and transcribed for thematic analysis supported by NVivo. Data saturation was achieved with 22 patients (12 female, 10 male) of whom 10 had CES-incomplete and 12 had CES-complete. Average age was 46 years and time since the operation was 62 months. Most interviews took place at the patients’ home or workplace. Data analysis identified 4 main data themes: (1) Varying priorities of physical health; (2) A fragmented healthcare service; (3) The process of adjustment; and 4) Anticipatory anxiety and diminished sense of self-worth. The identified themes confirm that CES can be a chronic condition, which requires holistic support to address the long-term outcomes. This highlights the importance of using the Cauda Equina Syndrome Core Outcome Set (CESCOS) in CES research studies to record these outcomes.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"63 8","pages":"426-431"},"PeriodicalIF":2.2,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Racial differences in serological markers across the first year of injury in spinal cord injury: responses to the letter to editor 脊髓损伤第一年血清学标志物的种族差异：致编辑信的回复。

IF 2.2 4区医学

Spinal cord Pub Date : 2025-06-24 DOI: 10.1038/s41393-025-01096-8

Jia Li, Matthew Farrow, Kerollos Ibrahim, Dana M. McTigue, John Kramer, Bobo Tong, Catherine Jutzeler, Linda Jones, Ceren Yarar-Fisher

引用次数: 0

Letter to the editor: Racial differences in serological markers across the first year of injury in spinal cord injury: a retrospective analysis of a multicenter interventional study by Jia Li et al. 致编辑：脊髓损伤第一年血清学标志物的种族差异：Jia Li等人多中心介入研究的回顾性分析。

IF 2.2 4区医学

Spinal cord Pub Date : 2025-06-17 DOI: 10.1038/s41393-025-01095-9

Vishal Kumar, Sharath Raj

引用次数: 0

Challenges and strategies for spinal cord injury research recruitment in rehabilitation hospitals: a single center perspective 康复医院脊髓损伤研究人员招聘的挑战与策略：单中心视角

IF 2.2 4区医学

Spinal cord Pub Date : 2025-06-10 DOI: 10.1038/s41393-025-01094-w

Steven Kirshblum, Brittany Snider, Einat Engel-Haber

{"title":"Challenges and strategies for spinal cord injury research recruitment in rehabilitation hospitals: a single center perspective","authors":"Steven Kirshblum, Brittany Snider, Einat Engel-Haber","doi":"10.1038/s41393-025-01094-w","DOIUrl":"10.1038/s41393-025-01094-w","url":null,"abstract":"A narrative review and perspective based on the experience of a single site in the U.S recruiting participants for clinical trials during the subacute phase (2 weeks to 3 months) following a traumatic spinal cord injury (SCI). To discuss challenges and propose strategies for enrolling individuals with SCI in research during the subacute phase within a comprehensive inpatient rehabilitation program. Acute rehabilitation hospitals where patients with SCI typically spend part of the subacute post-injury period. This review draws on the authors’ experience in research recruitment and retention. Key barriers and potential solutions are explored from both a practical and conceptual standpoint. Challenges identified include heterogeneous impairments, older age, higher incidence of incomplete injuries, placement issues, competition among studies, limited patient volume, tight rehabilitation schedules, logistical and medical concerns, and misalignment of research measures with clinical practices. Based on experience and literature review, strategic planning including integration of individuals with lived experience into the study design team, patient education, simplified consent processes, flexible research protocols, collaboration between clinical and research teams, and patient-centered approaches can enhance recruitment efforts. Research recruitment during the subacute phase of SCI presents numerous medical, injury-specific, and systems-based challenges. However, this period remains critical for advancing research influencing long-term outcomes for individuals with SCI. We recommend a collaborative, patient-centered approach that integrates research within clinical care, guided by practical experience and informed by existing literature, which can improve recruitment efforts and ultimately support meaningful advancements in SCI rehabilitation research.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"63 7","pages":"385-391"},"PeriodicalIF":2.2,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The incidence and trends of diving-related spine injuries in the United States and risk factors associated with spinal cord injury 美国潜水相关脊柱损伤的发生率和趋势以及与脊髓损伤相关的危险因素。

IF 2.2 4区医学

Spinal cord Pub Date : 2025-06-09 DOI: 10.1038/s41393-025-01098-6

Anthony E. Seddio, Sahir S. Jabbouri, Rajiv S. Vasudevan, Michael J. Gouzoulis, Wesley Day, Gwyneth C. Maloy, Arya G. Varthi, Daniel R. Rubio, Jonathan N. Grauer

{"title":"The incidence and trends of diving-related spine injuries in the United States and risk factors associated with spinal cord injury","authors":"Anthony E. Seddio, Sahir S. Jabbouri, Rajiv S. Vasudevan, Michael J. Gouzoulis, Wesley Day, Gwyneth C. Maloy, Arya G. Varthi, Daniel R. Rubio, Jonathan N. Grauer","doi":"10.1038/s41393-025-01098-6","DOIUrl":"10.1038/s41393-025-01098-6","url":null,"abstract":"Retrospective longitudinal cohort study. To characterize: (1) incidence and trends of diving-related spine injuries (DRSI) and diving-related spinal cord injury (DRSCI) in the United States and (2) risk-factors associated with DRSCI. Using a large, national, multi-insurance administrative dataset of over 161 million patients, those who suffered a DRSIs were identified and characterized. Persons who suffered a DRSIs were analyzed from 2010–2021. Estimated annual percentage change (EAPC) was calculated by log-linear regression. For those with DRSCI, risk-factors were assessed by multivariable logistic regression. Of 3829 persons who suffered DRSIs, the cervical spine was most frequently involved (53.0%). EAPCs of DRSIs at the cervical, thoracic, and lumbar spine significantly decreased over the studied years (−4.69, −6.81, and −4.88%, respectively; p < 0.05 for all), while DRSCI demonstrated a nonsignificant trend (p = 0.081). Among the 629 (16.4%) with DRSCI, risk-factors included: prior cervical spine surgery (OR 13.31, p < 0.001), history of cervical spondylolisthesis (OR 5.36, p < 0.001), male sex (OR 2.69, p < 0.001), history of cervical stenosis (OR 2.26, p < 0.001), coastal states (OR 1.38, p = 0.012), higher Elixhauser Comorbidity Index (OR 1.15, p < 0.001), and older age (OR 1.01, p = 0.029). The rate of DRSIs of the cervical, thoracic, and lumbar spine has significantly decreased in recent years in the United States. However, the nonsignificant trend in DRSCI highlights the importance of continued public health initiatives. Among those with DRSCI, several unique risk-factors were identified, laying the foundation for the refinement of current diving injury prevention programs.","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":"63 7","pages":"352-358"},"PeriodicalIF":2.2,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0