Sleep medicine最新文献

{"title":"Melatonin on sleep in Parkinson’s disease: A randomized double blind placebo controlled trial","authors":"Ramkumar Sugumaran ,&nbsp;Kadarla Shiva Sai Krishna ,&nbsp;Jayaram Saibaba ,&nbsp;Sunil K. Narayan ,&nbsp;S. Sandhiya ,&nbsp;M. Rajeswari","doi":"10.1016/j.sleep.2024.10.020","DOIUrl":"10.1016/j.sleep.2024.10.020","url":null,"abstract":"<div><h3>Background</h3><div>Sleep disturbances are one of the most common non-motor symptoms in Idiopathic Parkinson's Disease (IPD) patients. However, the effect of melatonin on sleep problems in Parkinson's disease patients is unclear.</div></div><div><h3>Aims and objectives</h3><div>To study the effect of melatonin on sleep in IPD patients through subjective and objective assessment.</div></div><div><h3>Methods</h3><div>Between August 2023 to February 2024, we conducted a randomized, double-blind, placebo-controlled trial on IPD patients. We randomized eligible subjects to melatonin (3 mg) (n = 43) or placebo (n = 43) for 8 weeks. The primary endpoint was sleep quality assessed through the Pittsburgh sleep quality index and daytime sleepiness using Epworth sleepiness scale. Secondary endpoints were polysomnographic sleep parameters, quality of life, motor and non-motor symptoms. Assessments were done at baseline and at the end of 8 weeks.</div></div><div><h3>Results</h3><div>We screened 107 IPD patients and 86 patients were included in the study. Seventy three patients (melatonin, 35 and placebo, 38) completed the study. The mean change in Pittsburgh Sleep Quality Index (PSQI) score between the two groups was 1.87 (95 % CI: 1.5–2.1; p = 0.001) and Epworth Sleepiness Scale (ESS) score was 1.25 (95 % CI: 0.80–1.71; p = 0.001) favoring melatonin. The mean difference between the two groups for Non-Motor Symptoms Scale (NMSS) was 6.11 (95 % CI 5.27–6.92; p = 0.001), Parkinson's Disease Questionnaire (PDQ 39) 8.12 (95 % CI 6.97–9.50; p = 0.001) &amp; Polysomnography (PSG) parameters [sleep latency 8.36 (95 % CI 4.38–12.34; p = 0.001) and total sleep time 14.51 (95 % CI 5.00–24.41; p = 0.005)] favoring melatonin. Side effects attributable to melatonin were minimal.</div></div><div><h3>Conclusion</h3><div>Melatonin is an effective and safe treatment option for sleep problems in PD patients, and beneficial effects on sleep quality are associated with improved non-motor symptoms and quality of life. We need to emphasize the fact that though we had statistically significant changes in our outcomes, it is not clear whether such changes would have real-life impact (meaningfulness) that would be relevant to licensing authorities or management as patients in our study are young, have short disease duration, have high use of anticholinergics and on modest levodopa equivalent dose. So, we are doubtful if this could be generalized to the typical PD population who are older, have longer disease duration and are on potentially sedating medications or not.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 502-509"},"PeriodicalIF":3.8,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic polymorphisms and bruxism: A scoping review","authors":"Júlia Meller Dias de Oliveira ,&nbsp;Manuella Salm Coelho ,&nbsp;Renata Paz Leal Pereira ,&nbsp;Patrícia Pauletto ,&nbsp;Joyce Duarte ,&nbsp;João Armando Brancher ,&nbsp;Juliana Feltrin-Souza ,&nbsp;Eliete Neves Silva Guerra ,&nbsp;Carla Massignan ,&nbsp;Graziela De Luca Canto","doi":"10.1016/j.sleep.2024.10.024","DOIUrl":"10.1016/j.sleep.2024.10.024","url":null,"abstract":"<div><h3>Background</h3><div>Recent studies have highlighted the multifactorial nature of bruxism, with behavioral, psychosocial, and physiological factors, including genetic predisposition, contributing to its development. However, the role of genetic markers in determining susceptibility to bruxism remains poorly understood, with limited studies offering significant findings.</div></div><div><h3>Objectives</h3><div>To identify the current knowledge to investigate the susceptibility of genetic markers for sleep (SB) and/or awake bruxism (AB).</div></div><div><h3>Materials and methods</h3><div>Seven electronic databases and two grey literature platforms were searched up to January 2024. We included studies that related different types of genes and/or genetic polymorphisms with different types of bruxism, regardless of age or sex of the participants. To be included the study must have described the form of detection of bruxism.</div></div><div><h3>Results</h3><div>A total of 21 reports were included. Of these, 16 were primary research reports. The remaining five articles consisted of four systematic reviews and a literature review incorporating a systematic mapping process, and network visualization. Within the pool of 16 primary study reports, seven focused on the association of genetic polymorphisms with both SB and AB, while seven concentrated solely on the association with SB. One primary study reported results related to probable AB and one article did not specify the bruxism type. Regarding all the studied genes and polymorphisms, significant association results were obtained for 15 polymorphisms from 11 different genes. Self-reported SB was associated with genes from the serotonergic (<em>5HTR2A</em>) and dopaminergic pathways (<em>DRD2</em>, <em>DRD3</em>, and <em>ANKK1</em>), as well as genes encoding enzymes (<em>COMT</em> and <em>MMP9</em>) and proteins (<em>ACTN</em>3 and <em>ANKK1</em>). Instrumentally reported SB was linked only to the reverse telomerase gene (<em>TERT</em>). Self-reported AB was associated with the <em>ACTN3</em> and <em>ANKK1</em> genes.</div></div><div><h3>Conclusion</h3><div>This review identified 30 genes and 56 polymorphisms variations potentially associated with either SB or AB. However, few presented significant results regarding positive associations, mostly acting at neurotransmitter pathways. The authors recommend further studies to determine the susceptibility of genetic markers as a risk factor for bruxism.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 554-575"},"PeriodicalIF":3.8,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142535009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleeping on the edge: Adolescents living at moderate altitude report greater sleep need","authors":"Alexandria Montenegro,&nbsp;Giovanni Alvarado,&nbsp;Ashleigh Hilton,&nbsp;Cara A. Palmer","doi":"10.1016/j.sleep.2024.10.017","DOIUrl":"10.1016/j.sleep.2024.10.017","url":null,"abstract":"<div><h3>Purpose</h3><div>Research in adults suggests that altitude impacts the restorative properties of sleep and increases risk for mental health concerns. The aim of this study was to extend this research to an adolescent sample to examine how living at altitude may be associated with greater sleep need and mental health symptoms during a period of the life-span when risk for insufficient sleep and mental health difficulties is high.</div></div><div><h3>Methods</h3><div>Data were collected from 105 adolescents aged 10–17 years residing at moderate-high altitudes. Parents reported on sociodemographics and adolescent depressive and anxiety symptoms, and adolescents reported on their subjective sleep need and sleep duration. Altitude was calculated using U.S. Geological Survey data.</div></div><div><h3>Results</h3><div>Adjusting for age, sex, socioeconomic status, rurality, and sleep duration, living at higher altitude was associated with reports of greater sleep need. Altitude was unrelated to mental health symptoms.</div></div><div><h3>Discussion</h3><div>The majority of adolescents do not obtain the recommended amount of sleep. These findings suggest that adolescents living at moderate-high altitudes may be at further risk due increased sleep need at higher elevations.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 551-553"},"PeriodicalIF":3.8,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acetazolamide as a therapeutic alternative for central sleep apnea in pediatric patient with FBXO28 gene mutation: A case report and review of literature","authors":"Kantisa Sirianansopa ,&nbsp;Reshma Amin","doi":"10.1016/j.sleep.2024.10.023","DOIUrl":"10.1016/j.sleep.2024.10.023","url":null,"abstract":"<div><div>Central sleep apnea (CSA) is a significant concern in children with neurodevelopmental disorders and genetic syndromes, where conventional treatments such as bilevel positive airway pressure (BiLevelPAP) therapy may be poorly tolerated. Acetazolamide, a carbonic anhydrase inhibitor, is an alternative treatment that induces a metabolic acidosis, which may help stabilize respiratory disturbances by enhancing ventilatory drive. However, evidence regarding its use in pediatric populations remains limited. We report the case of a 12-year-old male with an FBXO28 gene-related disorders with significant CSA. Due to intolerance to BiLevelPAP therapy, a trial of acetazolamide was initiated. The dose was adjusted to maintain a mild metabolic acidosis, with regular blood work and clinical monitoring to assess for potential side effects. Follow-up polysomnography (PSG) demonstrated significant improvements in the central apnea-hypopnea index (CAHI) and periodic breathing. No significant adverse effects were reported, and the family noted a substantial improvement in quality of life.</div></div><div><h3>Brief summary</h3><div>This case highlights that maintaining a mild metabolic acidosis with acetazolamide is sufficient to stimulate respiratory drive and stabilize breathing in pediatric CSA, while minimizing risks of electrolyte imbalances and long-term renal consequences. Our findings align with existing literature, which indicates that acetazolamide may be effective for CSA without hypoventilation in children, particularly those with genetic syndromes. Further research is necessary to establish standardized treatment protocols, optimal dosing, and long-term safety.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 479-482"},"PeriodicalIF":3.8,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between insomnia and cognitive decline: A scoping review","authors":"Xiaotu Zhang,&nbsp;Jiawei Yin,&nbsp;Xuefeng Sun,&nbsp;Zihan Qu,&nbsp;Jindan Zhang,&nbsp;Hongshi Zhang","doi":"10.1016/j.sleep.2024.10.021","DOIUrl":"10.1016/j.sleep.2024.10.021","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the association between insomnia and cognitive decline to provide insights for clinical interventions and future research.</div></div><div><h3>Methods</h3><div>The PubMed, Embase, Web of Science, Scopus, Cochrane Library, and ProQuest databases were systematically searched to identify studies on the association between insomnia and cognitive decline published within the last decade. The quality of the included studies was evaluated, followed by data extraction and summary analysis.</div></div><div><h3>Results</h3><div>A total of 36 studies were included in the review. Both subjective and objective measures were utilized across 12 indices to assess sleep status, while cognitive function was evaluated using 5 scales and 34 tests. The results revealed a significantly increased risk of cognitive decline or Alzheimer's disease among patients with insomnia, alongside notable impairments in attention, memory, visuospatial abilities, executive function, and verbal memory. Comprehensive assessments of cognitive domains were more sensitive in detecting group differences compared to assessments of specific cognitive sub-functions. Furthermore, MRI analyses showed reduced gray matter volumes in regions such as the prefrontal cortex, cingulate gyrus, temporal lobe, and hippocampus, together with reduced integrity of the white matter in patients with insomnia.</div></div><div><h3>Conclusions</h3><div>The findings indicate a potentially bidirectional relationship between insomnia and cognitive decline, suggesting that each may influence and exacerbate the other. Insomnia may increase the risk of cognitive decline and appears to be associated with reduced gray matter volume and compromised white matter integrity in the brain, which could potentially lead to declines in attention, memory, visuospatial abilities, executive function, and verbal memory. Conversely, cognitive decline may contribute to the onset of insomnia, further deteriorating sleep quality. However, further research is necessary to fully comprehend this intricate relationship.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 540-550"},"PeriodicalIF":3.8,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep apnoea phenotypes in women: A cluster analysis from the ESADA cohort","authors":"A. Pataka ,&nbsp;J.L. Pepin ,&nbsp;M.R. Bonsignore ,&nbsp;S. Schiza ,&nbsp;T. Saaresranta ,&nbsp;I. Bouloukaki ,&nbsp;P. Steiropoulos ,&nbsp;G. Trakada ,&nbsp;R. Riha ,&nbsp;Z. Dogas ,&nbsp;D. Testelmans ,&nbsp;O.K. Basoglu ,&nbsp;S. Mihaicuta ,&nbsp;F. Fanfulla ,&nbsp;L. Grote ,&nbsp;S. Bailly","doi":"10.1016/j.sleep.2024.10.015","DOIUrl":"10.1016/j.sleep.2024.10.015","url":null,"abstract":"<div><h3>Introduction</h3><div>and Objectives: The clinical presentation of Obstructive Sleep Apnoea (OSA) differs between genders. This study aimed to identify the specific OSA phenotypes of women in the European Sleep Apnoea Database (ESADA) cohort.</div></div><div><h3>Materials and methods</h3><div>Latent class cluster analysis was applied to data from 9710 female OSA patients. Variables used included age, Body Mass Index (BMI), Epworth Sleepiness Scale (ESS), comorbidities (cardiovascular, pulmonary, psychiatric, metabolic, other) and the Apnoea Hypopnea Index (AHI).</div></div><div><h3>Results</h3><div>Four different clusters were found: <u>Cluster 1</u>“Women with ischemic heart disease” (38.3 %):middle aged (59 years [53–65]),overweight to obese (BMI 30.1 kg/m² [26.9–33.5]), AHI 22.9 events/h[17.4–30], ESS 9 [5,12] with the highest prevalence of ischemic heart disease (56 %). <u>Cluster 2</u>“Elderly women with comorbidities” (23 %): oldest (66 years[60–71]), obese (BMI 36 kg/m² [31.6–40.4]),AHI 46 events/h [30–60.1]),ESS 9 [6-13] with the highest prevalence of comorbidities. <u>Cluster 3</u>“Sleepy obese women” (16.2 %): the youngest (49 years [42–55]), sleepiest (ESS 12 [8-16]), most obese(BMI 43 kg/m²[37.6–48.9]) females with severe OSA (AHI 53.3 events/h [32–80.5]). <u>Cluster 4</u> “Women with mild OSA and low comorbidities\" (22.5 %): middle aged (53.5 years [46–60]) with BMI 29 kg/m²[25–34.1],ESS9 [5,13]),AHI 8.6events/h[6.9–10.4])and low prevalence of comorbidities. The distribution of the clusters differed across Europe. PAP administration was higher in Clusters 2 and 3 but low in Cluster 4.</div></div><div><h3>Conclusion</h3><div>Four distinct female phenotypes were identified with different clinical presentation and comorbidities. Sex-based phenotyping may provide improved risk stratification and personalized treatment.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 494-501"},"PeriodicalIF":3.8,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations in the DTI-ALPS index and choroid plexus volume are associated with clinical symptoms in participants with narcolepsy type 1","authors":"Pengxin Hu ,&nbsp;Yuqing Yuan ,&nbsp;Yu Zou ,&nbsp;Ruifang Xiong ,&nbsp;Jiankun Dai ,&nbsp;Xihai Zhao ,&nbsp;Liang Xie ,&nbsp;Xiaoping Tang","doi":"10.1016/j.sleep.2024.10.019","DOIUrl":"10.1016/j.sleep.2024.10.019","url":null,"abstract":"<div><h3>Background</h3><div>Narcolepsy type 1 (NT1) is a sleep disorder characterized by excessive daytime sleepiness accompanied by cataplexy. Sleep disorders have been shown to affect the glymphatic system. This study aimed to evaluate changes in the diffusion tensor imaging along the perivascular space (DTI-ALPS) index and choroid plexus (CP) volume in NT1 participants, and to further explore their clinical significance.</div></div><div><h3>Methods</h3><div>We prospectively enrolled participants diagnosed with NT1 based on cerebrospinal fluid hypocretin-1 concentration and multiple sleep latency tests at our hospital. All participants underwent MRI to allow analysis of the DTI-ALPS index and CP volume. We subsequently performed correlation analyses between the DTI-ALPS index, CP volume, and important clinical parameters, including the Epworth Sleepiness Scale (ESS) score, Narcolepsy Severity Scale (NSS) score, stage rapid eye movement sleep (REM) ratio, stage 1 non-REM (N1) ratio, stage 2 non-REM (N2) ratio, and stage 3 non-REM (N3) ratio, among the NT1 participants. Inter-group and correlation analyses of DTI-ALPS index and CP volume were performed using age, sex, body mass index, and lateral ventricle volume as covariates.</div></div><div><h3>Results</h3><div>This study enrolled 41 NT1 participants and 42 healthy controls (HC). The DTI-ALPS index of NT1 participants was significantly lower than HC (1.444 ± 0.119 vs.1.661 ± 0.135, <em>P</em> &lt; 0.001), while the CP volume of NT1 participants was significantly larger than those of HC (0.831 ± 0.146 vs. 0.645 ± 0.137, <em>P</em> &lt; 0.001). The DTI-ALPS index was negatively correlated with both the ESS (<em>P</em>_{FDR-corrected}&lt;0.001) and NSS scores (<em>P</em>_{FDR-corrected} = 0.010), but positively correlated with the Stage N3 ratio (<em>P</em>_{FDR-corrected} = 0.033). The CP volume of NT1 participants was positively correlated with ESS (<em>P</em>_{FDR-corrected} = 0.047) and NSS scores (<em>P</em>_{FDR-corrected} = 0.047), but negatively correlated with the stage N3 ratio (<em>P</em>_{FDR-corrected} = 0.047).</div></div><div><h3>Conclusion</h3><div>Our study suggests that the DTI-ALPS index was lower and CP volume was larger in NT1 participants. The DTI-ALPS index and CP volume in the NT1 participants were related to disease severity and sleep structure. These findings may provide new insights into the mechanisms underlying NT1.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 471-478"},"PeriodicalIF":3.8,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep quality in secure psychiatric healthcare: Inpatient & staff perspectives","authors":"Poppy May Gardiner ,&nbsp;Iuliana Hartescu ,&nbsp;Kieran C. Breen ,&nbsp;Florence Emilie Kinnafick","doi":"10.1016/j.sleep.2024.10.005","DOIUrl":"10.1016/j.sleep.2024.10.005","url":null,"abstract":"<div><div>The lived experiences of psychiatric inpatients are not well represented in the literature, especially when these experiences pertain to health. Reports regarding sleep health are particularly sparse, despite the increasing prevalence of sleep disorders in this population. The current study aimed to explore inpatient and staff perspectives of inpatient sleep quality to aid the future development of a sleep quality intervention. Fourteen inpatients (average age 43 years, 36 % female) were recruited for individual interviews and eleven staff members were recruited for three focus groups, from a secure psychiatric hospital (England). A semi-structured interview guide facilitated discussions regarding the prevalence and type of inpatient sleep problems, existing support for inpatient sleep problems including medication, and the bidirectional relationships between nighttime sleep and daytime behaviours, such as napping and physical activity. Using reflexive thematic analysis, four themes were developed: Irregular Sleep Schedules, Nighttime Disruptions, The Patient's Bedroom, and Keeping a Routine &amp; Staying Physically Active. Study results can be utilised when developing inpatient sleep interventions, which were identified within the study as being sorely needed. Such interventions could focus on managing daytime sleeping, sedentary behaviour, and physical activity, in order to support good sleep hygiene, foster regular sleep/wake cycles, and improve overall health.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 453-461"},"PeriodicalIF":3.8,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regular sleep habits in toddlers are associated with social development and brain coherence","authors":"Yoshiko Iwatani ,&nbsp;Kuriko Kagitani-Shimono ,&nbsp;Azusa Ono ,&nbsp;Tomoka Yamamoto ,&nbsp;Ikuko Mohri ,&nbsp;Arika Yoshizaki ,&nbsp;Masako Taniike","doi":"10.1016/j.sleep.2024.10.018","DOIUrl":"10.1016/j.sleep.2024.10.018","url":null,"abstract":"<div><h3>Objective</h3><div>Although sleep habits are associated with the development of toddlers, factors affecting social development and brain function remain unclear. We aimed to elucidate the relationship between sleep habits and social development as well as brain coherence in toddlers.</div></div><div><h3>Methods</h3><div>We used the data set at 1.5–2 years old, in the longitudinal study until 6 years old. We evaluated sleep parameters, such as average wake-up time, bedtime, nighttime sleep duration, total sleep duration, and the standard deviation (SD) of sleep habits. We also examined the development, including the social stimuli fixation percentage using Gazefinder® and electroencephalography (EEG) coherence between brain regions.</div></div><div><h3>Results</h3><div>Seventy-two children (37 boys and 35 girls) were included. The fixation percentage for the human face was negatively correlated with the SD of the total sleep duration, nighttime sleep duration, nap duration, and bedtime (r = −0.516, <em>p</em> = 0.000; r = −0.331, <em>p</em> = 0.005; r = −0.330, <em>p</em> = 0.005; and r = −0.324, <em>p</em> = 0.005, respectively). The EEG analysis indicated that α-band coherence in the right centro-parietal area was negatively correlated with the total sleep duration (r = −0.283, <em>p</em> = 0.016). The path diagram demonstrated a direct significant effect of sleep duration irregularity on development including social communication and fixation percentage for human faces. Additionally, total sleep duration exhibited a direct effect on α cortical coherence in the right centro-parietal area.</div></div><div><h3>Conclusions</h3><div>In this study, we found an association between sleep irregularity and the development of social communication, preference for humans, and brain coherence in toddlers. We suggest that regular sleep plays an important role in promoting the development of social communication.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 531-539"},"PeriodicalIF":3.8,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-ventilator asynchrony: Heartbeat autotrigger","authors":"Cristina Embid,&nbsp;Mireia Dalmases,&nbsp;Lidia Lopez-Escuredo","doi":"10.1016/j.sleep.2024.10.016","DOIUrl":"10.1016/j.sleep.2024.10.016","url":null,"abstract":"","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 424-425"},"PeriodicalIF":3.8,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}