儿童肥胖患者中DUSP21表达与阻塞性睡眠呼吸暂停有关

IF 3.4 2区医学 Q1 CLINICAL NEUROLOGY

Sleep medicine Pub Date : 2025-09-14 DOI:10.1016/j.sleep.2025.106809

Fabio Affaticati , Eline Vermeiren , Pieter Meysman , Esther Bartholomeus , Kim Van Hoorenbeeck , Benson Ogunjimi , Stijn Verhulst , Annelies Van Eyck

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引用次数: 0

摘要

背景：肥胖是儿童发生阻塞性睡眠呼吸暂停（OSA）的一个众所周知的危险因素。OSA和肥胖都与心血管和代谢合并症独立相关。这些合并症是由共同的病理生理途径驱动的，因此很难区分肥胖和OSA的个体贡献。本研究旨在通过全血mRNA测序探讨肥胖儿童OSA的分子机制。方法：在一家三级医院开始多学科减肥治疗时，纳入了8-18岁的肥胖儿童。采用多导睡眠图诊断OSA (oAHI≥2)，采集全血标本进行mRNA测序。结果：共纳入40例儿童（平均年龄12.4±2.3岁，女性占57.5%），其中10例诊断为OSA。差异表达分析确定了OSA患者和非OSA患者之间11个差异表达基因（DEGs）。7个基因表达上调（SLC43A3、KLRC3、DAAM2、USP9Y、KDM5D、TTTY15、DBCORP1）， 4个基因表达下调（DUSP21、XIST、MAP、POLR3D）。DUSP21变化最显著，Log2FoldChange为-7.88 （p = 0.0002）。结论：与单纯肥胖的儿童相比，肥胖和OSA患儿表现出不同的基因表达谱。值得注意的是，DUSP21可能在OSA的病理生理机制中发挥重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

DUSP21 expression is associated with obstructive sleep apnea in pediatric patients with obesity

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DUSP21 expression is associated with obstructive sleep apnea in pediatric patients with obesity

Background

Obesity is a well-known risk factor for developing obstructive sleep apnea (OSA) in children. Both OSA and obesity are independently associated with cardiovascular and metabolic comorbidities. These comorbidities are driven by shared pathophysiological pathways, making it difficult to distinguish the individual contributions of obesity and OSA. This study aimed to investigate the molecular mechanisms of OSA in children with obesity through whole blood mRNA sequencing.

Methodology

Children with obesity, aged 8–18 years, were enrolled at the start of a multidisciplinary weight loss treatment in a tertiary hospital. Polysomnography was used to diagnose OSA (oAHI ≥2), and whole blood samples were collected for mRNA sequencing.

Results

A total of 40 children (mean age 12.4 ± 2.3 years, 57.5 % female) were included, of which 10 patients were diagnosed with OSA. Differential expression analysis identified 11 differentially expressed genes (DEGs) between patients with and without OSA. Seven genes were upregulated (SLC43A3, KLRC3, DAAM2, USP9Y, KDM5D, TTTY15, DBCORP1), while 4 genes were downregulated (DUSP21, XIST, MAP, POLR3D). DUSP21 showed the most significant change, with a Log2FoldChange of −7.88 (p = 0.0002).

Conclusion

Children with both obesity and OSA exhibit distinct gene expression profiles compared to children with obesity alone. Notably, DUSP21 may play a significant role in the pathophysiological mechanisms of OSA.

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来源期刊

Sleep medicine 医学-临床神经学

CiteScore

8.40

自引率

6.20%

发文量

1060

审稿时长

49 days

期刊介绍： Sleep Medicine aims to be a journal no one involved in clinical sleep medicine can do without. A journal primarily focussing on the human aspects of sleep, integrating the various disciplines that are involved in sleep medicine: neurology, clinical neurophysiology, internal medicine (particularly pulmonology and cardiology), psychology, psychiatry, sleep technology, pediatrics, neurosurgery, otorhinolaryngology, and dentistry. The journal publishes the following types of articles: Reviews (also intended as a way to bridge the gap between basic sleep research and clinical relevance); Original Research Articles; Full-length articles; Brief communications; Controversies; Case reports; Letters to the Editor; Journal search and commentaries; Book reviews; Meeting announcements; Listing of relevant organisations plus web sites.