Sleep medicine最新文献

{"title":"Adaptive servo ventilation in chronic heart failure: the best is yet to come","authors":"Johan Verbraecken","doi":"10.1016/j.sleep.2025.106660","DOIUrl":"10.1016/j.sleep.2025.106660","url":null,"abstract":"","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"133 ","pages":"Article 106660"},"PeriodicalIF":3.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144535490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonrestorative sleep mediates the influence of Adverse Childhood Experiences on psychological distress, physical health, mental health, and activity limitation: A longitudinal study for the general population in Japan","authors":"Megumi Hazumi ,&nbsp;Kentaro Matsui ,&nbsp;Takahiro Tabuchi ,&nbsp;Ryo Okubo ,&nbsp;Takuya Yoshiike ,&nbsp;Shingo Kitamura ,&nbsp;Aoi Kawamura ,&nbsp;Kentaro Nagao ,&nbsp;Tomohiro Utsumi ,&nbsp;Muneto Izuhara ,&nbsp;Jun Kizuki ,&nbsp;Momo Fushimi ,&nbsp;Daisuke Nishi ,&nbsp;Kenichi Kuriyama","doi":"10.1016/j.sleep.2025.106658","DOIUrl":"10.1016/j.sleep.2025.106658","url":null,"abstract":"<div><h3>Background</h3><div>Adverse childhood experiences (ACEs) refer to traumatic events faced by children and adolescents, such as abuse, violence, and neglect. The longitudinal mediation effects of ACEs on mental health, physical health, and activity, particularly using nonrestorative sleep (NRS), a subjective perception of unrefreshing sleep, remain unclear. Thus, this study aimed to investigate the mediating role of NRS in the relationships between ACEs and subsequent health problems and daytime inactivity in adulthood.</div></div><div><h3>Methods</h3><div>Using data from the Japan COVID-19 and Society Internet Survey, we conducted a longitudinal study with mediation analysis. Psychological distress (K6 ≥ 13), physical and mental health problems, and daytime inactivity (Health-Related Quality of Life-4; all defined as ≥14 days/month), NRS (≥16 days/month), and ACEs (≥4 items from a validated ACEs list) were assessed.</div></div><div><h3>Results</h3><div>Among the 17,042 participants, 52.8 % were male, with a mean age of 50.35 years (SD = 17.73). Significant mediational pathways via NRS were observed from ACEs to psychological distress (RR = 1.14, 95 % CI = 1.08–1.19, p &lt; 0.001), physical health problems (RR = 1.30, 95 % CI = 1.21–1.40, p &lt; 0.001), mental health problems (RR = 1.20, 95 % CI = 1.13–1.28, p &lt; 0.001), and daytime inactivity (RR = 1.27, 95 % CI = 1.17–1.37, p &lt; 0.001). <strong>Conclusions</strong>: Our findings demonstrated that NRS mediated the impact of ACEs on mental and physical health issues and daytime inactivity, suggesting sleep quality as a potential target for mitigating early life adversity.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"133 ","pages":"Article 106658"},"PeriodicalIF":3.8,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144523231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of media use behaviors by types and content with sleep problems in Chinese adolescents","authors":"Si-Rui Gao ,&nbsp;Ming-Yang Xue ,&nbsp;Lu Yang,&nbsp;Xiao-Hua Ji-Ke,&nbsp;Chen-Shuo Song,&nbsp;Xin-Hui Jia,&nbsp;Bao-Peng Liu","doi":"10.1016/j.sleep.2025.106653","DOIUrl":"10.1016/j.sleep.2025.106653","url":null,"abstract":"<div><h3>Background</h3><div>Electronic media has become integral to adolescents’ daily lives, yet sleep problems remain a critical public health concern. This cross-sectional study investigated the associations between media use behaviors (by types and content) and sleep problems among Chinese adolescents, with a focus on school days, non-school days and their difference respectively.</div></div><div><h3>Methods</h3><div>A sample of 5194 adolescents from Shandong Province completed a questionnaire contained the Pittsburgh Sleep Quality Index (PSQI) and a media use behaviors scale. Multivariate logistic regression and restricted cubic spline models were used to analyze the associations.</div></div><div><h3>Results</h3><div>Excessive use (&gt;120 min) of electronic media across all types and content on non-school days was significantly associated with sleep problems. Sex-specific associations emerged: online shopping was predominantly associated with females (school days &gt;120 min: OR = 2.486, 95 % CI = 1.343–4.604), whereas online communication (non-school days &gt;120 min: OR = 1.768, 95 % CI = 1.284–2.434) and leisure and entertainment (non-school days &gt;120 min: OR = 2.116, 95 % CI = 1.381–3.241) were associated with males. Adolescents living off campus exhibited stronger associations between school-day media use behaviors and sleep problems. Nonlinear dose-response associations were observed for time differences in media use between school and non-school days.</div></div><div><h3>Conclusions</h3><div>The associations between media use behaviors and sleep problems differ by types and content. Based on these patterns, tailored interventions limiting specific media exposures and promoting balanced schedules may be considered to address sleep concerns in Chinese adolescents.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"133 ","pages":"Article 106653"},"PeriodicalIF":3.8,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144535491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Local efficiency analysis of the emotion regulation network in younger and older adults experiencing sleep deprivation: A task-based fMRI study","authors":"Sanaz Nasiri ,&nbsp;Rassoul Amirfattahi ,&nbsp;Meysam Siyah Mansoory ,&nbsp;Mehdi Khodamoradi","doi":"10.1016/j.sleep.2025.106655","DOIUrl":"10.1016/j.sleep.2025.106655","url":null,"abstract":"<div><div>Previous neuroimaging studies have examined how sleep deprivation affects emotional processing. However, graph theory has not yet been utilized to analyze functional magnetic resonance imaging (fMRI) data in relation to the brain regions and networks involved in emotions and feelings among sleep-deprived individuals. This study involved a dataset comprising 46 younger participants (ages 20–30) and 39 older participants (ages 65–75) who underwent an emotional task-based fMRI investigation. We identified graph edges within the brain's emotional networks and utilized recurrence plots to evaluate local efficiency (LE). In both age groups experiencing sleep deprivation, most brain regions associated with emotion regulation exhibited a decrease in LE across all three types of emotional tasks, with only a few regions showing an increase in LE. Notably, younger adults demonstrated greater LE across most regions following sleep deprivation compared to older adults, particularly in the prefrontal cortex (PFC) components of the emotion regulation network. Conversely, older adults displayed greater LE in certain areas post-sleep deprivation than younger adults, especially in lower-order cortical and some subcortical structures within the emotion regulation network. Our findings indicate that sleep deprivation produces distinct patterns of LE in the emotion regulation network for younger and older adults. This could deepen our understanding of novel mechanisms and potentially inform therapeutic strategies for sleep-related emotional disorders in the future.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"133 ","pages":"Article 106655"},"PeriodicalIF":3.8,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144523232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extreme pediatric obstructive sleep Apnea: Clinical Features, management, long-term outcomes and mortality","authors":"Kantisa Sirianansopa ,&nbsp;Colin Massicotte ,&nbsp;Sundeep Bola ,&nbsp;Jackie Chiang ,&nbsp;Indra Narang ,&nbsp;Nikolaus E. Wolter ,&nbsp;Evan J. Propst ,&nbsp;Reshma Amin","doi":"10.1016/j.sleep.2025.106652","DOIUrl":"10.1016/j.sleep.2025.106652","url":null,"abstract":"<div><h3>Objectives</h3><div>Extreme obstructive sleep apnea (OSA), defined by an obstructive apnea-hypopnea index (OAHI) ≥100 events/hr, presents management challenges in pediatric patients due to its severity and associated comorbidities. This study aims to review the clinical characteristics, management strategies, and outcomes in this population.</div></div><div><h3>Methods</h3><div>Retrospective reviewed patients aged ≤18 years with extreme OSA who underwent level 1 polysomnography (PSG) from 2010 to 2024. Logistic regression was performed to identify factor associated with surgical management, residual OSA, and revision surgery. Kaplan-Meier analysis was used to estimate 5-year mortality.</div></div><div><h3>Results</h3><div>Fifty patients were reviewed, with a median (IQR) age: 4.9 (1.9, 12.8) years and 32 (64 %) were male. Median (IQR) OAHI was 123.2 (112, 143.1) events/hour, with median (IQR) nadir SpO₂ of 65.5 % (52.3, 74.3). The residual OSA was noted 77.8 % on follow-up PSG after initial surgery. A BMI Z-score &lt; −2 was significantly associated with surgical management [OR 19.8, 95 % CI 1.9–21.7, <em>p</em> = 0.013]. A nadir SpO₂ ≤ 60 % was associated with residual OSA [OR 12.5, 95 % CI 1.2–13.6, <em>p</em> = 0.03]. Additionally, spending more than 10 % of total sleep time with SpO₂ &lt; 90 % was associated with the need for revision surgery [OR 7.6, 95 % CI 1.1–12.4, <em>p</em> = 0.04]. The 5-year respiratory illness-related mortality rate was 8 % (n = 4), with higher mortality observed in children age ≤2 years (<em>p</em> = 0.003) and those with craniofacial anomalies or symptomatic laryngomalacia (<em>p</em> = 0.004).</div></div><div><h3>Conclusion</h3><div>Early identification of high-risk patients, vigilant care, and multidisciplinary follow-up are essential for optimizing outcomes in extreme OSA.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"133 ","pages":"Article 106652"},"PeriodicalIF":3.8,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144513885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective association of weekend catch-up sleep with metabolic syndrome in Chinese children and adolescents with sleep insufficiency","authors":"Haiyuan Zhu ,&nbsp;Qiqi Wu ,&nbsp;Runquan Zhang ,&nbsp;Zebang Zhang ,&nbsp;Yumei Feng ,&nbsp;Tao Liu ,&nbsp;Dan Liu ,&nbsp;Xiongfei Chen ,&nbsp;Xiaomei Dong","doi":"10.1016/j.sleep.2025.106654","DOIUrl":"10.1016/j.sleep.2025.106654","url":null,"abstract":"<div><h3>Background</h3><div>Short sleep has been associated with metabolic syndrome (MetS). Weekend catch-up sleep (WCS) serves as a compensatory strategy for sleep deficits, yet its association with MetS in children and adolescents remains unclear. This study aimed to investigate whether WCS is related to a decreased risk for MetS in sleep-deprived individuals of this population.</div></div><div><h3>Methods</h3><div>A total of 8930 participants aged 7–17 years with weekday sleep insufficiency were selected from the China Nutrition and Health Surveillance of Children and Lactating Women (2017). Sleeping hours on weekdays/weekends and WCS duration were calculated based on self-reported weekday/weekend sleep schedules. MetS was defined using Cook's criteria. Logistic regression and restricted cubic spline (RCS) regression models adjusting for covariates were used to assess the relationships between WCS and MetS.</div></div><div><h3>Results</h3><div>WCS had a significantly protective association with the prevalence of MetS (<em>p</em> &lt; 0.05). RCS analysis revealed an L-shaped relationship (<em>p</em> for non-linear = 0.029), with 1 h of WCS emerging as a potentially optimal duration.</div></div><div><h3>Conclusions</h3><div>Our findings support WCS as a potential modifiable strategy to mitigate MetS risk in sleep-deficient pediatric populations.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"133 ","pages":"Article 106654"},"PeriodicalIF":3.8,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meditation as a non-pharmacological treatment for narcolepsy: A literature review","authors":"Fan Feng ,&nbsp;Hui Guo ,&nbsp;Grace A. Ding ,&nbsp;Albert Yeung","doi":"10.1016/j.sleep.2025.106651","DOIUrl":"10.1016/j.sleep.2025.106651","url":null,"abstract":"<div><div>Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness (EDS), cataplexy, sleep paralysis, and hallucinations, and is often associated with other psychological and physiological disturbances. These symptoms lead to decreased social functioning and lower quality of life for individuals with narcolepsy. While current pharmacological treatment for narcolepsy can be effective in improving symptoms, there are also significant side effects (e.g., headaches, dizziness, insomnia). Meditation, a non-pharmacological intervention focusing on regulation of attention and emotion, could be a viable alternative. We introduce the conceptualization and applications of meditation, and review the potential mechanisms and existing evidence of meditation as an intervention for reducing narcolepsy symptoms (i.e., EDS, cataplexy, sleep paralysis, and overweight).</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"133 ","pages":"Article 106651"},"PeriodicalIF":3.8,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144491387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence and sleep: an opportunity for a new, broader view of sleep health data. Introduction to the special issue “Artificial Intelligence and Sleep”","authors":"Damien Léger,&nbsp;Alexandre Rouen","doi":"10.1016/j.sleep.2025.106650","DOIUrl":"10.1016/j.sleep.2025.106650","url":null,"abstract":"","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"133 ","pages":"Article 106650"},"PeriodicalIF":3.8,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144491389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma IL-22 and Claudin-4 in obstructive sleep apnea: A pilot observational study linking mucosal barrier biomarkers to disease severity","authors":"Dan Liu ,&nbsp;Yan Wang ,&nbsp;Zhiding Wang ,&nbsp;Jing Feng","doi":"10.1016/j.sleep.2025.106641","DOIUrl":"10.1016/j.sleep.2025.106641","url":null,"abstract":"<div><h3>Background</h3><div>Obstructive sleep apnea (OSA) is characterized as a low-grade inflammatory condition resulting from injury induced by intermittent hypoxia (IH). Interleukin-22 (IL-22), a mucosa-targeting cytokine, regulates tight junction proteins like Claudin-4 (CLDN4) to enhance barrier function, yet its role in OSA remains underexplored.</div></div><div><h3>Methods</h3><div>This pilot observational study included consecutive patients who underwent polysomnography. Plasma IL-22 and CLDN4 levels were measured using an enzyme-linked immunosorbent assay. Rat models of IH-exposed colon tissues were used for histology and immunohistochemical analysis. All statistical analyses were performed using SPSS 20.0.</div></div><div><h3>Results</h3><div>The expression of plasma IL-22 and CLDN4 was found to be positively correlated in OSA patients (r = 0.512, <em>p</em> &lt; 0.001). Plasma IL-22 and CLDN4 levels exhibited a significant positive correlation with the apnea–hypopnea index (both <em>p</em> &lt; 0.001), arousal index (<em>p</em> = 0.001 and <em>p</em> = 0.014), oxygen desaturation index (<em>p</em> &lt; 0.001 and <em>p</em> = 0.001), and T90 (r = 0.379, <em>p</em> &lt; 0.001 and <em>p</em> = 0.002). They also exhibited significant negative correlations with sleep efficiency (0.029; <em>p</em> = 0.004), REM sleep phases (<em>p</em> = 0.037 and <em>p</em> = 0.015), and mean oxygen saturation (SpO₂) (<em>p</em> = 0.044 and <em>p</em> = 0.006). Plasma IL-22 and CLDN4 were significantly increased in the OSA group (<em>p</em> &lt; 0.001), especially in severe OSA. The diagnostic value of plasma IL-22 combined with CLDN4 was superior to that of other indicators, with an AUC of 0.849 (0.783–0.915) for diagnosing OSA and an AUC of 0.909 (0.856–0.961) for diagnosing severe OSA. Pathological staining of the rat colon confirmed the damage of intermittent hypoxia (IH) to the intestine. The rat IH group had more IL-22 in the intestinal lymph node and more CLDN4 in the intestinal epithelium than the normal control (NC) group. The expression trends of IL-22 and CLDN4 in rat plasma were consistent with those observed in tissue samples.</div></div><div><h3>Conclusion</h3><div>Plasma IL-22 and CLDN4 were associated with OSA severity and mucosal barrier alterations. Their co-regulation aligns with preclinical models of IH-driven barrier adaptation, supporting further mechanistic investigation. The diagnostic potential of the IL-22 +CLDN4 panel warrants validation in larger patient cohorts.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"133 ","pages":"Article 106641"},"PeriodicalIF":3.8,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High obstructive sleep apnea severity and lack of treatment access in MassHealth Limited patients, a predominantly Latinx population","authors":"Christopher A. Cano ,&nbsp;Sogol Javaheri","doi":"10.1016/j.sleep.2025.106648","DOIUrl":"10.1016/j.sleep.2025.106648","url":null,"abstract":"<div><h3>Objectives</h3><div>MassHealth Limited (MHL), a subset of Massachusetts’ Medicaid program, covers sleep studies but not obstructive sleep apnea (OSA) treatment, including positive airway pressure (PAP) therapy. This study characterizes the demographics and OSA severity of patients receiving MHL and compares them to those with full MassHealth (MH) benefits to assess inequities in treatment access.</div></div><div><h3>Participants and methods</h3><div>We conducted a retrospective cohort study of 134 MHL and 402 MH patients who underwent a sleep study for OSA evaluation at the Brigham and Women’s Faulkner Hospital (2019–2024). We analyzed age, BMI, OSA severity, SpO₂ % nadir, and comorbidity burden across four patient groups based on insurance and self-reported ethnicity: MHL-Latinx, MH-Latinx, MH-Black, and MH-White, with men and women assessed separately.</div></div><div><h3>Results</h3><div>The MHL population was predominantly Latinx (90 %), with 82 % preferring Spanish, Haitian Creole, or Brazilian Portuguese as their primary language. Moderate-to-severe OSA was most prevalent in MHL-Latinx men (77.5 %) and MHL-Latinx women (53.0 %). On follow-up, about one-third of MHL-Latinx patients with moderate-to-severe OSA obtained PAP therapy through self-pay or insurance change.</div></div><div><h3>Conclusions</h3><div>In this sample of MHL beneficiaries, a predominantly Latinx population, patients experience a high burden of moderate-to-severe OSA yet lack access to PAP therapy due to insurance limitations. Expanding MHL coverage to include OSA treatment is critical to addressing sleep health inequities.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"133 ","pages":"Article 106648"},"PeriodicalIF":3.8,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144364956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}