Sleep medicine最新文献

Corrigendum to “Patterns of sleep problems and internalizing and externalizing problems among Chinese adolescents: A latent class analysis” [Sleep Med. 95 (2022) 47–54] “中国青少年睡眠问题与内化和外化问题的模式：一个潜在的类分析”的勘误表[睡眠医学，95 (2022)47-54]

IF 3.8 2区医学

Sleep medicine Pub Date : 2025-04-25 DOI: 10.1016/j.sleep.2025.106525

Lei Yue , Naixue Cui , Zhenzhen Liu , Cunxian Jia , Xianchen Liu

引用次数: 0

IF 3.8 2区医学

Sleep medicine Pub Date : 2025-04-24 DOI: 10.1016/j.sleep.2025.106536

Pınar Yavuz , Erhan Özel , İzzet Erdal , İbrahim Öncel , Banu Anlar

{"title":"Sleep-related problems and sleep disorders in ataxia telangiectasia","authors":"Pınar Yavuz , Erhan Özel , İzzet Erdal , İbrahim Öncel , Banu Anlar","doi":"10.1016/j.sleep.2025.106536","DOIUrl":"10.1016/j.sleep.2025.106536","url":null,"abstract":"<div><h3>Objective</h3><div>Ataxia telangiectasia (AT) is a rare neurodegenerative disorder and sleep-related problems may be expected. We investigated sleep-related problems in children with AT in relation to their clinical status.</div></div><div><h3>Methods</h3><div>We administered Children's Sleep Habits Questionnaire and Sleep Disturbance Scale for Children to patients with AT (n = 46) and a matched healthy control (HC) (n = 92). We defined clinical subgroups of AT as mild (n = 10) and moderate/severe (n = 36) according to patients' clinical scores. We compared the results between the groups.</div></div><div><h3>Results</h3><div>The median age was 130.5 (104.8–175.0) months in AT patients and 125.5 (85.0–177.0) months in HC. The frequency (6.5 % in AT, 0 % in HC), risk of sleep disturbance (60 % in AT, 25 % in HC), and sleep problems (80 % in AT, 50 % in HC) were higher in AT than in HC. As the male/female ratio differed between AT and HC in our study, we applied further analyses adjusting for gender and age; AT patients were almost 4.5 times more likely to develop sleep disturbances and 6 times more likely to have sleep problems than HC. Sleep-related problems decreased with increasing age in HC; sleep problems partially decreased in AT, but sleep disturbances did not decrease in AT.</div></div><div><h3>Conclusion</h3><div>Sleep architecture, behavior, and habits may be disturbed in AT, justifying the inclusion of sleep screening tools in the clinical follow-up of these patients even if no symptoms are reported in the medical history. Further clinical studies in large cohorts are needed to develop sleep screening tools specific to AT and similar neurodegenerative diseases.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"131 ","pages":"Article 106536"},"PeriodicalIF":3.8,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep architecture correlates with neurological and neurobehavioral short- and mid-term outcome in a sample of very preterm infants. A pilot study 在一个极早产儿样本中，睡眠结构与神经和神经行为的短期和中期结果相关。一项初步研究

IF 3.8 2区医学

Sleep medicine Pub Date : 2025-04-23 DOI: 10.1016/j.sleep.2025.106538

Sara Uccella , Valentina Marazzotta , Deborah Preiti , Marcella Battaglini , Gaia Burlando , Monica Roascio , Andrea Rossi , Gabriele Arnulfo , Luca Antonio Ramenghi , Lino Nobili

{"title":"Sleep architecture correlates with neurological and neurobehavioral short- and mid-term outcome in a sample of very preterm infants. A pilot study","authors":"Sara Uccella , Valentina Marazzotta , Deborah Preiti , Marcella Battaglini , Gaia Burlando , Monica Roascio , Andrea Rossi , Gabriele Arnulfo , Luca Antonio Ramenghi , Lino Nobili","doi":"10.1016/j.sleep.2025.106538","DOIUrl":"10.1016/j.sleep.2025.106538","url":null,"abstract":"<div><div>Newborns spend most of their time sleeping. This activity fosters neurodevelopment. Prematurity, defined by birth occurring prior the 37th week of gestation, disrupts normal brain <em>in-utero</em> programming, with long-lasting consequences that carry a high social burden. Sleep alterations may contribute to these sequelae. In this pilot study we aimed to describe the 24-h distribution of sleep states among very preterm infants (VPI), and to correlate it with neurobehavioral assessment up to 6 months of corrected age (CA). Secondly, we aimed to assess if the presence of a brain lesion detected at MRI could affect sleep duration, architecture, and quality.</div><div>Ten VPI were assessed at 32 weeks postmenstrual age (PMA) with a 24-h video-polysomnography and received a neurobehavioral examination at the time of the recording, at term equivalent age (TEA), and at 6 months CA. Analysis of sleep stages distribution and transitions, and power spectra were conducted.</div><div>Total sleep time and amount of quiet sleep positively correlated with neurological, and neurobehavioral assessment at 32 weeks PMA, at TEA, and at 6 months CA, while Sleep Onset Active Sleep (SOAS) had a negative association. Infants carrying brain lesions showed lower QS time accompanied by a higher prevalence of AS + SOAS and showed a gradient for higher power of posterior slow activity (slow δ and δ) during SOAS in the left hemisphere posterior regions.</div><div>Understanding sleep dynamics among preterm infants might provide future therapeutic/management strategies, which need to encompass sleep care.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"131 ","pages":"Article 106538"},"PeriodicalIF":3.8,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of melatonin on sleep quality and daytime sleepiness in Parkinson's disease: A systematic review and meta-analysis of randomized placebo-controlled trials 褪黑素对帕金森病患者睡眠质量和白天嗜睡的影响：随机安慰剂对照试验的系统回顾和荟萃分析

IF 3.8 2区医学

Sleep medicine Pub Date : 2025-04-23 DOI: 10.1016/j.sleep.2025.106540

Azzam Zrineh , Rami Akwan , Muhammad M. Elsharkawy , Bashar Douden , Wadi Sleibi , Mohamed Eldesouki

{"title":"The effect of melatonin on sleep quality and daytime sleepiness in Parkinson's disease: A systematic review and meta-analysis of randomized placebo-controlled trials","authors":"Azzam Zrineh , Rami Akwan , Muhammad M. Elsharkawy , Bashar Douden , Wadi Sleibi , Mohamed Eldesouki","doi":"10.1016/j.sleep.2025.106540","DOIUrl":"10.1016/j.sleep.2025.106540","url":null,"abstract":"<div><h3>Background</h3><div>Sleep disturbances are common in Parkinson's disease (PD), significantly impacting quality of life. Melatonin may help, but evidence regarding dosage, formulation, and treatment duration remains inconclusive.</div></div><div><h3>Objective</h3><div>To quantitatively analyze the effect of melatonin on sleep quality and daytime sleepiness in patients with PD.</div></div><div><h3>Methods</h3><div>We comprehensively searched multiple databases up to February 2025, selecting relevant randomized controlled trials (RCTs). RevMan software was used for analysis. Subgroup analyses included treatment duration (4 weeks vs. 8–12 weeks), dose (≤4 mg vs. >4 mg), and formulation (immediate-release vs. prolonged-release).</div></div><div><h3>Results</h3><div>Five RCTs (206 patients) were included. Doses ≤4 mg showed no significant improvement in total Pittsburgh Sleep Quality Index (PSQI) scores (MD = −1.26, 95 % CI: −2.72 to 0.20). Doses >4 mg demonstrated a stronger effect (MD = −2.90, 95 % CI: −4.02 to −1.78). Short-term use (4 weeks) significantly improved PSQI scores (MD = −2.43, 95 % CI: −3.98 to −0.88), whereas longer treatment (8–12 weeks) showed a non-significant effect (MD = −1.24, 95 % CI: −3.15 to 0.67). Immediate-release formulations significantly improved PSQI scores (MD = −2.20, 95 % CI: −3.32 to −1.08), while prolonged-release formulations showed no significant effect (MD = −0.61, 95 % CI: −4.15 to 2.93). Melatonin modestly reduced excessive daytime sleepiness measured by the Epworth Sleepiness Scale (ESS) (MD: −0.97, 95 % CI: −1.81, −0.14).</div></div><div><h3>Conclusion</h3><div>Melatonin may improve sleep quality and reduce daytime sleepiness in PD patients, particularly with short-term use of immediate-release formulations.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"131 ","pages":"Article 106540"},"PeriodicalIF":3.8,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of one-night partial sleep deprivation on perivascular space volume fraction: Findings from the Stockholm Sleepy Brain Study 一晚部分睡眠剥夺对血管周围空间体积分数的影响：来自斯德哥尔摩嗜睡脑研究的发现

IF 3.8 2区医学

Sleep medicine Pub Date : 2025-04-23 DOI: 10.1016/j.sleep.2025.106537

Rachel M. Custer , Kirsten M. Lynch , Giuseppe Barisano , Megan M. Herting , Torbjörn Åkerstedt , Gustav Nilsonne , Hedyeh Ahmadi , Jeiran Choupan

{"title":"Effects of one-night partial sleep deprivation on perivascular space volume fraction: Findings from the Stockholm Sleepy Brain Study","authors":"Rachel M. Custer , Kirsten M. Lynch , Giuseppe Barisano , Megan M. Herting , Torbjörn Åkerstedt , Gustav Nilsonne , Hedyeh Ahmadi , Jeiran Choupan","doi":"10.1016/j.sleep.2025.106537","DOIUrl":"10.1016/j.sleep.2025.106537","url":null,"abstract":"<div><div>Increased waste clearance in the brain is thought to occur most readily during deep sleep (stage N3). Sleep deprivation disrupts time spent in deeper sleep stages, fragmenting the clearance process. Here, we have utilized the publicly available Stockholm Sleepy Brain Study to investigate whether various sleep-related measures are associated with changes in perivascular space (PVS) volume fraction following a late-night short-sleep experiment. The study sample consisted of 60 participants divided into old (65–75 years) and young (20–30 years) age groups. We found that partial sleep deprivation was not significantly associated with major PVS changes. In our centrum semiovale models, we observed an interaction between percentage of total sleep time spent in N3 and sleep deprivation status on PVS volume fraction. In our basal ganglia models, we saw an interaction between N2 (both percentage of total sleep time and absolute time in minutes) and sleep deprivation status. However, the significance of these findings did not survive multiple comparisons corrections. This work highlights the need for future longitudinal studies of PVS and sleep, allowing for quantification of within-subject morphological changes occurring in PVS due to patterns of poor sleep. Our findings here provide insight on the impact that a single night of late-night short-sleep has on the perivascular waste clearance system.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"131 ","pages":"Article 106537"},"PeriodicalIF":3.8,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143879101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trigger issues with a life support device in children 触发儿童生命维持设备的问题

IF 3.8 2区医学

Sleep medicine Pub Date : 2025-04-23 DOI: 10.1016/j.sleep.2025.106534

Sonia Khirani , Florian Stehling , Benjamin Dudoignon , Alessandro Amaddeo , Marine Dosso , Clément Poirault , Lucie Griffon , Brigitte Fauroux

引用次数: 0

Unique associations of ADHD and cognitive disengagement syndrome symptoms with sleep problems and circadian preference in adults 成人多动症和认知脱离综合征症状与睡眠问题和昼夜节律偏好的独特关联

IF 3.8 2区医学

Sleep medicine Pub Date : 2025-04-21 DOI: 10.1016/j.sleep.2025.106531

Laura E. Knouse , Stephen P. Becker

{"title":"Unique associations of ADHD and cognitive disengagement syndrome symptoms with sleep problems and circadian preference in adults","authors":"Laura E. Knouse , Stephen P. Becker","doi":"10.1016/j.sleep.2025.106531","DOIUrl":"10.1016/j.sleep.2025.106531","url":null,"abstract":"<div><div>People with attention-deficit/hyperactivity disorder (ADHD) experience higher rates of sleep difficulties coupled with greater circadian preference for eveningness. Emerging evidence suggests that symptoms of cognitive disengagement syndrome (CDS) may be associated with sleep difficulties and eveningness preference independently of ADHD symptoms. However, most studies have been conducted with children, adolescents, or college students. This study examined unique associations between ADHD and CDS symptom dimensions and sleep problems and circadian preference in a non-referred sample of adults. 106 adults (ages 18–75 years; <em>M</em>age = 38.69 years) completed self-report assessments of ADHD and CDS symptoms, sleep quality and functioning, and circadian preference. ADHD inattentive (ADHD-IN), ADHD hyperactive-impulsive (ADHD-HI), and CDS symptoms evinced differential unique associations in regression analyses. Only ADHD-IN symptoms were uniquely associated with more frequent sleep medication use. Only ADHD-HI symptoms were uniquely associated with shorter sleep duration and greater nighttime sleep disturbance. Only CDS symptoms were uniquely associated with poorer sleep quality, longer sleep onset latency, greater daytime dysfunction, greater global sleep impairment, and greater eveningness preference. Findings support the importance of considering the role of CDS in sleep disturbance and circadian preference in adults with ADHD and point to the need for careful assessment of these dimensions in research and clinical care.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"131 ","pages":"Article 106531"},"PeriodicalIF":3.8,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143864769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glymphatic pathway dysfunction in severe obstructive sleep apnea: A meta-analysis 严重阻塞性睡眠呼吸暂停的淋巴通路功能障碍：荟萃分析

IF 3.8 2区医学

Sleep medicine Pub Date : 2025-04-21 DOI: 10.1016/j.sleep.2025.106528

Sadegh Ghaderi , Sana Mohammadi , Farzad Fatehi

{"title":"Glymphatic pathway dysfunction in severe obstructive sleep apnea: A meta-analysis","authors":"Sadegh Ghaderi , Sana Mohammadi , Farzad Fatehi","doi":"10.1016/j.sleep.2025.106528","DOIUrl":"10.1016/j.sleep.2025.106528","url":null,"abstract":"<div><h3>Background</h3><div>Obstructive sleep apnea (OSA), a sleep disorder, is associated with cognitive decline and is potentially linked to glymphatic system dysfunction. This meta-analysis investigates glymphatic function in severe OSA (apnea-hypopnea index ≥30) using the Diffusion Tensor Imaging Analysis along the Perivascular Space (DTI-ALPS) index.</div></div><div><h3>Methods</h3><div>This study followed PRISMA guidelines for systematic reviews and meta-analyses. A comprehensive search of PubMed, Web of Science, Scopus, and Embase was conducted from inception to January 20, 2024. Studies investigating the ALPS index in OSA using DTI were included. Analyses included a random-effects meta-analysis, sensitivity analysis, meta-regression, publication bias evaluation (funnel plot, Egger's test, and Begg's test), and risk of bias assessment.</div></div><div><h3>Results</h3><div>Systematic review identified four studies (137 patients with severe OSA and 170 healthy controls (HCs)). Pooled analysis revealed a significant reduction in the DTI-ALPS index in severe OSA patients compared to HCs (standardized mean difference: −0.95, 95 % CI: −1.46 to −0.44, p < 0.001), indicating impaired glymphatic function. Heterogeneity was moderate to high (I<sup>2</sup> = 76.07 %), but sensitivity analyses confirmed robustness. Meta-regression analyses identified the sources of heterogeneity as the apnea-hypopnea index (β = −0.039, p = 0.009) and the Epworth Sleepiness Scale (β = −0.150, p = 0.032), with no effects observed for age or male ratio. Qualitative (funnel plot) and quantitative publication bias assessments (Egger's and Begg's tests) showed no significant bias, and risk of bias evaluations using the Newcastle-Ottawa Scale indicated high methodological quality across studies.</div></div><div><h3>Conclusions</h3><div>These findings suggest that severe OSA disrupts glymphatic activity. The DTI-ALPS index emerges as a promising tool for assessing glymphatic dysfunction in OSA.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"131 ","pages":"Article 106528"},"PeriodicalIF":3.8,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subjective sleep quality in healthy young adults moderates associations of sensitivity to punishment and reward with functional connectivity of regions relevant for insomnia disorder 健康青壮年主观睡眠质量调节奖惩敏感性与失眠症相关区域功能连接的关联

IF 3.8 2区医学

Sleep medicine Pub Date : 2025-04-18 DOI: 10.1016/j.sleep.2025.106527

Michal Rafal Zareba , Tatiana Davydova , María-Ángeles Palomar-García , Jesús Adrián-Ventura , Victor Costumero , Maya Visser

{"title":"Subjective sleep quality in healthy young adults moderates associations of sensitivity to punishment and reward with functional connectivity of regions relevant for insomnia disorder","authors":"Michal Rafal Zareba , Tatiana Davydova , María-Ángeles Palomar-García , Jesús Adrián-Ventura , Victor Costumero , Maya Visser","doi":"10.1016/j.sleep.2025.106527","DOIUrl":"10.1016/j.sleep.2025.106527","url":null,"abstract":"<div><div>Chronic unhealthy sleeping behaviours are a major risk factor for the emergence of mood and anxiety disorders. Nevertheless, we are still lacking understanding why some individuals are more prone than others to affective dysregulation caused by sleep disruption. With preliminary evidence suggesting that brain activity during positive and negative emotional processing might play an important modulating role, we conducted whole-brain resting-state functional connectivity analyses in a large cohort of healthy young adults (N = 155). Using regions consistently affected in insomnia disorder as seeds, we investigated sleep quality-related neural connectivity patterns that were both insensitive and sensitive to the interactions with individual measures of reward and punishment processing, additionally assessing the links with indices of emotional health. The majority of the findings reflected interactions between sleep quality and reinforcement sensitivity, with the opposite associations reported in the good and poor sleepers. One of such connections, the coupling between precentral gyrus and posterior insula, was additionally negatively linked to trait anxiety, with the lowest connectivity values observed in poor sleepers with higher sensitivity to punishment. In turn, the only finding associated solely with sleep quality, i.e. coupling between subgenual anterior cingulate cortex and thalamus, was also related to the habitual use of emotion suppression strategies. As such, the present study provides evidence that reinforcement sensitivity plays an essential role in understanding the associations of poor sleep quality with brain connectivity and emotional health, hinting at a potential link that may help explain individual differences in susceptibility to sleep-related affective dysregulation.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"131 ","pages":"Article 106527"},"PeriodicalIF":3.8,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143864768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and clinical significance of comorbid insomnia and sleep apnea (COMISA) in three population-based cohorts from Benin, Switzerland and India 来自贝宁、瑞士和印度的三个人群队列中共病性失眠和睡眠呼吸暂停（COMISA）的患病率及临床意义

IF 3.8 2区医学

Sleep medicine Pub Date : 2025-04-18 DOI: 10.1016/j.sleep.2025.106526

Geoffroy Solelhac , Ablo Prudence Wachinou , Abhishek Goyal , Théo Imler , Abhijit Pakhare , Amit Kumar Sen , Jose Haba-Rubio , Gregory Heiniger , Adrien Waeber , Peter Vollenweider , Pedro Marques-Vidal , Sandra Van Den Broecke , Roch Christian Johnson , Pierre-Marie Preux , Nicola Andrea Marchi , Raphaël Heinzer

{"title":"Prevalence and clinical significance of comorbid insomnia and sleep apnea (COMISA) in three population-based cohorts from Benin, Switzerland and India","authors":"Geoffroy Solelhac , Ablo Prudence Wachinou , Abhishek Goyal , Théo Imler , Abhijit Pakhare , Amit Kumar Sen , Jose Haba-Rubio , Gregory Heiniger , Adrien Waeber , Peter Vollenweider , Pedro Marques-Vidal , Sandra Van Den Broecke , Roch Christian Johnson , Pierre-Marie Preux , Nicola Andrea Marchi , Raphaël Heinzer","doi":"10.1016/j.sleep.2025.106526","DOIUrl":"10.1016/j.sleep.2025.106526","url":null,"abstract":"<div><h3>Introduction</h3><div>COMISA is defined as a comorbid condition comprising insomnia and obstructive sleep apnea (OSA). This study aims to assess the prevalence of COMISA and its association with cardiovascular risk factors within three population-based cohorts from Benin (BeSAS, n = 1733), Switzerland (HypnoLaus, n = 1999), and India (BLESS, n = 958).</div></div><div><h3>Methods</h3><div>OSA was assessed by nocturnal recordings, while the presence of insomnia symptoms was assessed by questionnaires in the three cohorts. Adjusted logistic regression models were employed to assess the associations of COMISA with hypertension, diabetes and metabolic syndrome. These associations were also examined using different COMISA definitions based on insomnia subtypes (initiation difficulties and early morning awakenings/maintenance difficulties).</div></div><div><h3>Results</h3><div>The crude prevalence of COMISA was 11.4 % in HypnoLaus, 9.1 % in BLESS and 1.7 % in BeSAS. In HypnoLaus, COMISA showed a trend towards an association with hypertension (OR: 1.34, p = 0.09) and metabolic syndrome (OR: 1.37, p = 0.09), which was statistically significant when insomnia was defined by sleep initiation difficulties. In BLESS, COMISA was significantly associated with both hypertension (OR: 3.30, p < 0.001) and metabolic syndrome (OR: 1.1.71, p = 0.008). No significant associations were observed in BeSAS.</div></div><div><h3>Conclusion</h3><div>COMISA has a high prevalence worldwide and may be associated with hypertension and metabolic syndrome.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"131 ","pages":"Article 106526"},"PeriodicalIF":3.8,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0