Sleep medicine最新文献

{"title":"Combined impact of obstructive sleep apnea and periodic limb movements on sleep parameters","authors":"Moon Park ,&nbsp;Gulcin Benbir Senel ,&nbsp;Harshil Modi ,&nbsp;Viraj Jain ,&nbsp;Lourdes M. DelRosso","doi":"10.1016/j.sleep.2025.03.012","DOIUrl":"10.1016/j.sleep.2025.03.012","url":null,"abstract":"<div><h3>Study objectives</h3><div>This study examines the combined effects of Obstructive Sleep Apnea (OSA) and Periodic Limb Movements of Sleep (PLMS) on sleep parameters. Specifically, it aims to determine whether their co-occurrence exacerbates sleep fragmentation, reduces sleep efficiency, and alters restorative sleep stages compared to either condition alone.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed 581 adults undergoing polysomnography at UCSF Fresno. Subjects were categorized into three groups: OSA, PLMS, and OSA and PLMS. Sleep metrics, including Total Sleep Time (TST), Wake After Sleep Onset (WASO), and sleep stages (N1, N2, N3, REM), were compared across groups using Kruskal-Wallis tests and linear regression, adjusting for age.</div></div><div><h3>Results</h3><div>The coexistence of OSA and PLMS was associated with a significant reduction in TST and a synergistic effect on deep sleep stages (N3) and REM, indicating amplified sleep disruption beyond additive effects. OSA and PLMS led to a marked increase in WASO and awakenings, although the impact on WASO was additive rather than synergistic.</div></div><div><h3>Conclusions</h3><div>These findings underscore the need for tailored treatment approaches when OSA and PLMS co-occur. Standard OSA treatments like CPAP may be insufficient, as they don't address PLMS-induced sleep fragmentation. Effective management of both conditions could improve sleep quality and mitigate associated health risks.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 339-345"},"PeriodicalIF":3.8,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143631696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to “Letter to the Editor regarding ‘Parkinson's Disease: News on the Action of Melatonin’ by Scorza et al.”","authors":"Ramkumar Sugumaran ,&nbsp;Kadarla Shiva Sai Krishna ,&nbsp;Jayaram Saibaba ,&nbsp;Sunil K. Narayan ,&nbsp;Sandhiya S ,&nbsp;Rajeswari M","doi":"10.1016/j.sleep.2025.03.005","DOIUrl":"10.1016/j.sleep.2025.03.005","url":null,"abstract":"","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"130 ","pages":"Pages 13-14"},"PeriodicalIF":3.8,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of phenotypic characteristics between responders and non-responders to treatment for obstructive sleep apnea with maxillomandibular advancement in adults","authors":"Khang Huy Thai ,&nbsp;Ying-An Chen ,&nbsp;Chuan-Fong Yao ,&nbsp;Ning-Hung Chen ,&nbsp;Yu-Fang Liao ,&nbsp;Yu-Ray Chen","doi":"10.1016/j.sleep.2025.03.006","DOIUrl":"10.1016/j.sleep.2025.03.006","url":null,"abstract":"<div><h3>Background and objective</h3><div>3D cone-beam computed tomography (CBCT) images obtained presurgery and postsurgery can expand our knowledge of predictors of successful maxillomandibular advancement (MMA) for treatment of adult patients with obstructive sleep apnea (OSA). This prospective cohort study aimed to identify predictors of successful MMA surgery for adults with OSA using anatomical CBCT measurements.</div></div><div><h3>Methods</h3><div>Analysis of anatomical outcomes was conducted by comparing postoperative with preoperative measures from 3D CBCT images. Preoperative and postoperative variables of responders were compared with non-responders. A postoperative AHI &lt;10 and a reduction of &gt;50 % identified responders.</div></div><div><h3>Results</h3><div>A total of 50 patients met the inclusion criteria. The mean (SD) AHI was 32.3 (21.0). The mean (SD) age was 32.4 (9.2) years; 72 % were male; mean (SD) body mass index was 22.4 (3.2) kg/m². Mean (SD) time of follow-up was 2.0 (1.5) years. Thirty participants were identified as responders. Compared with preoperative characteristics of non-responders, AHI was significantly lower, the maxilla was shorter, the hyoid position was higher and more forward, tongue and soft palate were shorter, and oropharyngeal airway space was wider and larger (all <em>p</em> &lt; .05). Multivariate logistic regression revealed preoperative variables of maxillary and mandibular width, tongue length, airway length, oropharyngeal anteroposterior dimension, and the surgical variable for degree of mandibular advancement were predictors of successful treatment of OSA with MMA.</div></div><div><h3>Conclusions and relevance</h3><div>Our findings suggest preoperative anatomical characteristics, as well as required surgical advancement should be evaluated when considering MMA for treatment of adults with OSA. The application of 3D CBCT provided detailed information on anatomical characteristics that should be an essential tool when evaluating adult patients with OSA who will benefit from treatment with MMA.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 346-353"},"PeriodicalIF":3.8,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143631728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoupling of global signal and cerebrospinal fluid inflow is associated with cognitive decline in patients with obstructive sleep apnoea","authors":"Ying Li ,&nbsp;Shiwei Lin ,&nbsp;Zheng Guo ,&nbsp;Qunjun Liang ,&nbsp;Yanyu Zhang ,&nbsp;Xiaoshan Lin ,&nbsp;Shengli Chen ,&nbsp;Fajian Wei ,&nbsp;Li Zhu ,&nbsp;Shuo Li ,&nbsp;Yingwei Qiu","doi":"10.1016/j.sleep.2025.03.009","DOIUrl":"10.1016/j.sleep.2025.03.009","url":null,"abstract":"<div><h3>Objectives</h3><div>The role of cortical glymphatic dysfunction in the cognitive impairment of the obstructive sleep apnea (OSA) requires further study. To compare the coupling between the resting-state blood-oxygen-level-dependent (BOLD) signals and cerebrospinal fluid (CSF) signals (BOLD-CSF coupling), a proxy for the cortical glymphatic function, across patients with differing severities of OSA and relate them with disease characteristics and treatment.</div></div><div><h3>Methods</h3><div>A total of 153 participants (89 OSA patients and 64 matched controls) were prospectively included. OSA patients were classified into three groups (mild, moderate, and severe OSA) according to the apnea-hypopnea index (AHI). All participants underwent neuropsychological assessment and BOLD functional magnetic resonance imaging. BOLD-CSF coupling was assessed at global and regional levels and correlated with the cognitive impairment. Alterations in BOLD-CSF coupling and cognitive performance after treatment were assessed in OSA patients.</div></div><div><h3>Result</h3><div>Severe OSA patients exhibited weaker global and anterior BOLD-CSF coupling than mild OSA patients, moderate OSA patients, and healthy controls (HCs). Furthermore, the weaker global and anterior BOLD-CSF coupling was associated with poor cognitive performance in all OSA patients. Notably, cognitive performance and cortical glymphatic function improved significantly in patients with OSA after treatment.</div></div><div><h3>Conclusion</h3><div>Our findings demonstrated cortical glymphatic dysfunction in severe OSA patients, especially in the anterior region of the brain. Cortical glymphatic dysfunction may underlie the cognitive impairment in OSA patients, both of which would improve in OSA patients after treatment.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 330-338"},"PeriodicalIF":3.8,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143628409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotypic clusters of narcolepsy type 1: Insights from age of onset, weight gain, sleep patterns, and impulsivity","authors":"Wang Mengmeng ,&nbsp;Wu Lanbo ,&nbsp;Wang Weihan ,&nbsp;Dong Xiaosong ,&nbsp;Han Fang ,&nbsp;Karen Spruyt ,&nbsp;Xiao Fulong","doi":"10.1016/j.sleep.2025.02.047","DOIUrl":"10.1016/j.sleep.2025.02.047","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to discern the underlying relationships between clinical manifestations and neuroimaging phenotypes among patients with narcolepsy type 1 (NT1).</div></div><div><h3>Methods</h3><div>Demographic characteristics, clinical manifestations, polysomnography parameters, and comorbidities were collected in 158 NT1 patients. Using R software, we applied k-medoid cluster analysis to create homogenous NT1 patient clusters. Subsequently, we identified clinical and neuroimaging features within each cluster and examined associations between neuroimaging and clinical phenotypes across different subgroups.</div></div><div><h3>Results</h3><div>Four clusters were found: patients with the youngest onset-age exhibit more severe objective sleepiness. However, it is easily ignored or not reported due to mild subjective sleepiness, which may be responsible for the long delay between disease onset and diagnosis in this group of patients. Patients with teenage onset and greater weight gain showed shorter sleep latency, more obvious disturbed nocturnal sleep (DNS), the highest proportion of hallucination and sleep paralysis, as well as the highest motor impulsivity score, but minimum volumes in the left para-hippocampal gyrus (PHG) and right precuneus. Patients with teenage onset and less weight gain showed the longest sleep latency and maximum volumes in the right frontal region and left posterior cingulate cortex (PCC). Adult-onset patients reported the highest Epworth Sleepiness Scale (ESS) scores, more obvious impulsivity behavior and more sleep apnea comorbidity. Volumes in left PHG and left PCC were associated with mean sleep latency, respectively.</div></div><div><h3>Conclusion</h3><div>Narcolepsy patients with teenage onset and greater weight gain exhibit severe sleepiness, severe DNS and high motor impulsivity. Results from this research will provide a new reference for the pathogenesis, diagnosis and management of narcolepsy.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"130 ","pages":"Pages 3-12"},"PeriodicalIF":3.8,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A high arousal threshold is associated with nocturnal gastroesophageal reflux in obstructive sleep apnea","authors":"Zhaoyan Feng ,&nbsp;Shuai Wu ,&nbsp;Mengmeng Wang ,&nbsp;Huanhuan Wang ,&nbsp;Yanyan Hou ,&nbsp;Huijie Yi ,&nbsp;Fulong Xiao ,&nbsp;Liyue Xu ,&nbsp;Xiaosong Dong ,&nbsp;Fang Han","doi":"10.1016/j.sleep.2025.03.004","DOIUrl":"10.1016/j.sleep.2025.03.004","url":null,"abstract":"<div><h3>Objective</h3><div>Nocturnal gastroesophageal reflux (nGER) was reported to be associated with obstructive sleep apnea (OSA). However, pathophysiological traits in OSA patients with nGER were poorly understood, and arousal threshold (ArTH) might play an important role in this relationship. This study aimed to identify the clinical characteristics of patients with OSA comorbid with nGER, and investigate the association between ArTH and nGER in patients with OSA.</div></div><div><h3>Methods</h3><div>482 adult patients with OSA diagnosed by polysomnography (PSG) at Peking University People's Hospital were recruited in this cross-sectional study. nGER presence was defined as typical nGER symptoms (heartburn or acid regurgitation occurring at night which affects sleep, with or without medication treatment) at least once a week in the past four weeks. A low ArTH was predicted based on the following PSG features: a total score of 2 or more, with one point assigned for each of the following criteria: apnea-hypopnea index (AHI) &lt; 30/h, nadir oxygen saturation &gt; 82.5 %, the proportion of hypopneas &gt; 58.3 %, otherwise the ArTH was classified as high. Demographic and anthropometric characteristics, PSG parameters, and questionnaires related to clinical symptoms and comorbidities were obtained. The associations between nGER and clinical features were examined by multivariate logistic regressions.</div></div><div><h3>Results</h3><div>The prevalence of typical nGER symptoms in patients with OSA was 17.8 %. High ArTH (<em>P</em> = 0.006), BMI ≥28 kg/m² (<em>P</em> = 0.023), the Epworth Sleepiness Scale (ESS) Scores &gt;16 (<em>P</em> = 0.006), and age over 60 years old (<em>P</em> = 0.002) were associated with a markedly increased risk of nGER in patients with OSA. Notably, in non-obese patients with OSA, a high ArTH not only significantly added to the presence of nGER (OR = 2.905, 95 % CI: 1.352–6.241, <em>P</em> &lt; 0.01) after controlling for age, sex, ESS scores, comorbidities (including hypertension, diabetes mellitus, hyperlipidemia, coronary artery disease, and stroke) and total arousal index, but also associated with nGER symptom frequencies (OR = 2.856, 95 % CI = 1.118–7.294, <em>P</em> = <em>0.028)</em> after adjusting for age, ESS scores, and medication use.</div></div><div><h3>Conclusions</h3><div>A high ArTH is independently associated with nGER in patients with OSA. For non-obese patients with OSA, a high ArTH is not only associated with the presence of nGER but also correlated with nGER symptom frequencies.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 297-305"},"PeriodicalIF":3.8,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143601271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melatonin for Huntington's Disease (HD) gene carriers with HD-related sleep disturbance - A pilot study","authors":"Shayan A. Zadegan,&nbsp;Nicholas Karagas,&nbsp;Will Tanigaki,&nbsp;Brittany Duncan,&nbsp;Deepa Dongarwar,&nbsp;Jorge Patino,&nbsp;Natalia P. Rocha,&nbsp;Erin Furr Stimming","doi":"10.1016/j.sleep.2025.02.032","DOIUrl":"10.1016/j.sleep.2025.02.032","url":null,"abstract":"<div><h3>Background</h3><div>Sleep disorders are common in people with Huntington's Disease (HD). Possible causes include disruptions to the body's internal clock and changes in melatonin levels. Although melatonin is known to treat sleep disruptions related to circadian rhythm disorders, its effects on HD patients have not been thoroughly explored.</div></div><div><h3>Objective</h3><div>to assess the effectiveness of melatonin in improving the sleep quality of individuals with HD.</div></div><div><h3>Methods</h3><div>double-blind, randomized, placebo-controlled, crossover trial with individuals with HD experiencing sleep disturbances, defined as Pittsburgh Sleep Quality Index (PSQI) &gt; 5. Participants received 4-week treatments with 5 mg immediate-release melatonin/placebo, separated by a one-week wash-out (NCT04421339). Clinical assessments were conducted at baseline, week 5 (crossover visit), and week 9 (final visit) and included the PSQI, HD Sleep Questionnaire (HD-SQ), Epworth Sleepiness Scale (ESS), Montreal Cognitive Assessment (MoCA), Neuro-QoL™ v2.0 Cognitive Function, Neuropsychiatric Inventory Questionnaire (NPI-Q), Hospital Anxiety and Depression Scale (HADS), Unified Huntington Disease Rating Scale (UHDRS), and Clinical Global Impression (CGI).</div></div><div><h3>Results</h3><div>Fifteen patients (46.53 ± 13.92 years old, seven females) completed the study procedures. We found no significant differences between melatonin and placebo treatments in the primary outcome (PSQI), other sleep measures (ESS and HD-SQ), neuropsychiatric symptoms (NPI-Q, HADS, Neuro-QoL, MoCA), and motor/functional measures.</div></div><div><h3>Conclusions</h3><div>We found that melatonin did not significantly differ from placebo in improving sleep quality in individuals with HD. Given the conflicting findings from previous research, it may be beneficial to explore alternative dosages of melatonin, increase the sample size, and consider different stages of HD in future studies.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 238-244"},"PeriodicalIF":3.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143563847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of an action commercial video game on adult non-gamers psychological well-being, cognitive functioning, and sleep","authors":"Oreste De Rosa ,&nbsp;Paolo D'Onofrio ,&nbsp;Francesca Conte ,&nbsp;Paola De Luca ,&nbsp;Claudia Schiavone ,&nbsp;Alessio Lustro ,&nbsp;Serena Malloggi ,&nbsp;Fiorenza Giganti ,&nbsp;Torbjörn Åkerstedt ,&nbsp;Gianluca Ficca","doi":"10.1016/j.sleep.2025.03.002","DOIUrl":"10.1016/j.sleep.2025.03.002","url":null,"abstract":"<div><h3>Introduction</h3><div>The ever-growing diffusion of video games (VG) prompts to investigate their effects on health. While different studies exist on the topic, their results are difficult to interpret, probably because modulating factors have been mostly neglected. Here, we explore VG type and gamers’ experience levels by assessing the impact of a violent VG on sleep, cognitive functioning, and psychological well-being in a sample of non-gamers.</div></div><div><h3>Methods</h3><div>In a within-subjects design, 18 adult non-gamers (M^age = 24.4 ± 3.68 years, 12 F) underwent a baseline assessment including sleep logs and actigraphy for one week, one night of home polysomnography (PSG), administration of a cognitive testing battery, and questionnaires on psychological health. The baseline assessment was followed by an experimental condition and an active control condition, in balanced order between participants, each lasting four days: a) three nights of pre-sleep activity manipulation, in which participants either played an action VG or watched a familiar action TV series for an hour before bedtime, with PSG on the last night; b) administration of the cognitive battery and questionnaires on the 4th day.</div></div><div><h3>Results</h3><div>After video gaming, participants reported better visuospatial working memory and reduced stress levels compared with the baseline and the active-control condition. Except for reduced efficiency in TVW, no between-condition difference emerged for sleep measures.</div></div><div><h3>Conclusions</h3><div>In contrast to the common assumption that VGs are detrimental to several health-related variables, our data show that controlled, time-constrained video gaming may positively affect next-day cognitive functioning and stress, while not compromising objective sleep quality.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 274-282"},"PeriodicalIF":3.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143578763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posterior airway compromise following orthognathic surgery in skeletal class III patient - A systematic review and meta-analysis","authors":"Nadav Grinberg ,&nbsp;Sara Whitefield ,&nbsp;Shlomi Kleinman ,&nbsp;Clariel Ianculovici ,&nbsp;Svetlana Feldman ,&nbsp;Oren Peleg","doi":"10.1016/j.sleep.2025.03.001","DOIUrl":"10.1016/j.sleep.2025.03.001","url":null,"abstract":"<div><div>Obstructive Sleep Apnea (OSA) has been proven to have short- and long-term adverse effects on patients. OSA is associated with severe co-morbidities. Clinical studies have evaluated the volumetric changes in the posterior airway space following Orthognathic surgeries. The following study aims to assess the long-term airway compromise following different procedures for correcting skeletal Cl-III relationships. The research followed the PRISMA protocol guidelines and included a comprehensive electronic search of the National Institutes of Health (NIH), PubMed, and Embase databases, utilizing specific inclusion and exclusion criteria. All studies included airway measurements taken at three different time points, ensuring long-term follow-up of at least six months. Two authors evaluated quality blindly. We compared the types of surgical procedures alongside the volumetric airway measurements taken before and after the operation. Meta-analysis was performed using a random effect model if heterogeneity was detected. Otherwise, a common effect model was conducted under a 95 % confidence level. Sixteen publications met the inclusion criteria for qualitative assessment, and nine were eligible for quantitative evaluation. All included studies were rated within low to moderate risk of bias. Posterior airway volume changes in class III patients between the mandible-only and bimaxillary procedures immediately after the surgery were significantly different; p &lt; 0.05. However, this difference between those groups was not found in long-term follow-up, and airway volumes were comparable. In conclusion, the meta-analysis results confirm that bimaxillary and mandible-only surgery similarly decrease the posterior airway space volumes in long-term follow-up.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 192-199"},"PeriodicalIF":3.8,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143534851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural brain network metrics as novel predictors of treatment response in restless legs syndrome","authors":"Kang Min Park ,&nbsp;Keun Tae Kim ,&nbsp;Dong Ah Lee ,&nbsp;Yong Won Cho","doi":"10.1016/j.sleep.2025.02.045","DOIUrl":"10.1016/j.sleep.2025.02.045","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate morphometric similarity networks in patients with newly diagnosed restless legs syndrome (RLS) compared with healthy controls and to examine their relationship with treatment response.</div></div><div><h3>Methods</h3><div>A total of 49 patients with newly diagnosed RLS and 58 healthy controls were prospectively enrolled. Brain magnetic resonance imaging was performed using a 3-T scanner, and morphometric similarity network analysis was conducted on T1-weighted images. The severity of RLS was assessed using the International RLS Scale at baseline and at three months post-treatment initiation. Patients were classified as good or poor responders based on a decrease of ≥5 points in RLS severity scores following treatment with either pramipexole or pregabalin.</div></div><div><h3>Results</h3><div>Although no significant differences were observed in morphometric similarity networks between patients with RLS and controls, both modularity and small-worldness indices were lower in the RLS group (0.218 vs. 0.258, <em>p</em> = 0.023; 0.841 vs. 0.861, <em>p</em> = 0.042). Among the 40 patients who completed follow-up evaluation, 27 were good responders and 13 were poor responders. Network diameter was significantly higher in good responders than in poor responders (7.061 vs. 6.552, <em>p</em> = 0.002). Similarly, eccentricity was elevated in good responders (5.875 vs. 5.385, <em>p</em> = 0.008). Receiver operating characteristic curve analysis revealed high predictive values for both diameter and eccentricity (AUC = 0.838, <em>p</em> &lt; 0.001; AUC = 0.751, <em>p</em> = 0.002, respectively).</div></div><div><h3>Conclusion</h3><div>Network metrics, particularly diameter and eccentricity, demonstrate potential utility as biomarkers for predicting treatment response in patients with RLS.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 212-218"},"PeriodicalIF":3.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}