Sleep medicine最新文献

{"title":"Why NIV setting definitions may be tricky: Trigger sensitivity","authors":"Sonia Khirani ,&nbsp;Lucie Griffon ,&nbsp;Anais Le ,&nbsp;Domenico Paolo La Regina ,&nbsp;Marine Dosso ,&nbsp;Clément Poirault ,&nbsp;Brigitte Fauroux","doi":"10.1016/j.sleep.2024.11.015","DOIUrl":"10.1016/j.sleep.2024.11.015","url":null,"abstract":"<div><div>Noninvasive ventilation (NIV) is widely used in children. The spontaneous/timed (S/T) mode is the most common used mode for home NIV. Different devices are available, and the manufacturers are free to name the modes and define the settings, with no regulation. In particular, the definitions of the trigger sensitivities still differ between manufacturers and/or devices. The inspiratory trigger (TgI) sensitivity may be set according to a numerical or word-rating scale, while the expiratory trigger (TgE) sensitivity may be set as a percentage of the peak inspiratory flow, or using a numerical or word rating scale which correspond to specific predefined percentages of inspiratory flow. Moreover, the TgE sensitivity may be set according to the peak inspiratory flow or to the diminution of peak inspiratory flow, which may be very confusing. Patient-ventilator asynchrony (PVA) may be due to an inadequate comprehension of the settings by the user, which is challenging. We report here the cases of four children and adolescents with an incorrect setting of the TgI and/or TgE, leading to PVA. This pleads for a harmonization of the definitions of the settings, and in particular of the trigger sensitivities. In the meanwhile, NIV professionals should be aware of the different definitions to avoid setting errors leading to PVA.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"125 ","pages":"Pages 18-20"},"PeriodicalIF":3.8,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social support and isolation in narcolepsy and idiopathic hypersomnia: An international survey.","authors":"Julie Flygare, Lauren Oglesby, Sairam Parthasarathy, Michael J Thorpy, Emmanuel Mignot, Eileen B Leary, Anne Marie Morse","doi":"10.1016/j.sleep.2024.11.013","DOIUrl":"https://doi.org/10.1016/j.sleep.2024.11.013","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate factors associated with feeling supported in adjusting to life when diagnosed with narcolepsy or idiopathic hypersomnia.</p><p><strong>Methods: </strong>An online survey was disseminated by nonprofit organization Project Sleep via email and social networks. Intended recipients were adults (≥18 years old) diagnosed with narcolepsy or idiopathic hypersomnia. Multivariable regression was used to assess predictors of feeling supported in adjusting to life with these conditions.</p><p><strong>Results: </strong>The survey was completed by 1308 individuals (narcolepsy type 1, 48.4 %; narcolepsy type 2, 28.7 %; idiopathic hypersomnia, 22.9 %). Overall, 68.7 % of respondents were ≤40 years of age; 87.7 % were female; and 88.8 % were White. Respondents lived in 38 different countries (65.5 % in the United States). At time of diagnosis, most (91.1 %) did not know anyone with the same diagnosis. At time of the survey, 486 respondents (37.2 %) still did not know anyone with their diagnosis. Only 32.3 % of respondents felt supported in adjusting to life with narcolepsy or idiopathic hypersomnia. Knowing someone with the same diagnosis at the time of the survey was a significant predictor of perceived support. Younger age (18-30 years) and being married were also associated with greater perceived support, whereas a diagnosis of narcolepsy type 2 or idiopathic hypersomnia (versus narcolepsy type 1) and living outside the US were associated with less perceived support.</p><p><strong>Conclusions: </strong>People with narcolepsy or idiopathic hypersomnia often do not know others living with the same condition, even though this is associated with feeling supported. Clinicians should assess for social support and assist with resource identification.</p>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"125 ","pages":"65-73"},"PeriodicalIF":3.8,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of exercise on sleep quality in general population: Meta-analysis and systematic review","authors":"Xiaojie Zhou ,&nbsp;Yan Kong ,&nbsp;Beibei Yu ,&nbsp;Shengnan Shi ,&nbsp;Hui He","doi":"10.1016/j.sleep.2024.10.036","DOIUrl":"10.1016/j.sleep.2024.10.036","url":null,"abstract":"<div><h3>Purpose</h3><div>Sleep is the foundation of human physiological health and psychological health, as well as one of the basic needs for human survival. Sleep quality problems are prevalent in the population, and poor sleep quality is often closely related to the occurrence of many diseases, which seriously affects the quality of life and may even result in a shortened lifespan, so that improving sleep health has become a real problem that needs to be solved urgently. Exercise, as an important non-pharmacological tool, has been widely used for sleep quality enhancement, while the efficacy of exercise on subjective and objective sleep with respect to individual sleep quality remains controversial. Therefore, the aim of this meta-analysis was to compare the effects of exercise on subjective sleep quality and objective sleep efficiency in a non-athlete population, and to further rank the effectiveness of exercise types to provide appropriate means of exercise to improve sleep.</div></div><div><h3>Methods</h3><div>This study was evaluated by literature search in five databases, PubMed, Embase, Web of Science, Cochrane, and EBSCO, and paired meta-analysis and network meta-analysis were performed using Review Manager 5.3 and stata16.0.</div></div><div><h3>Results</h3><div>A total of 7494 studies were retrieved, and 81 eligible randomized controlled trials involving 6193 subjects were finally included. The primary outcome metrics included subjective sleep quality (PSQI), and the secondary outcome was objective sleep efficiency (SE), of which 65 reported PSQI and 23 reported SE. The results of paired meta-analysis showed that exercise significantly decreased PSQI [MD = −1.77, (95 % CI = −2.28,-1.25),P &lt; 0.05] and increased SE [MD = 4.81, (95 % CI = 2.89,6.73),P &lt; 0.05]. The results of the network meta-analysis showed that body and mind exercise [MD = −2.28, (95 % CI = −3.19,-1.36),P &lt; 0.05, SUCRA = 85.6] may be the best exercise to improve PSQI, and aerobic exercise [MD = 5.02, (95 % CI = 2.52,7.52),P &lt; 0.05, SUCRA = 75.1] is most likely to be the best type of exercise to improve SE. In regression analyses, there was a moderating effect of exercise cycle (β = −0.25 [0.40, 0.46], SE = 0.10 [P = 0.015, R² = 0.24]) and age (β = −0.20 [-0.04, −0.01, SE = −2.06 [P = 0.039,R² = 0.16]) as moderators of objective sleep efficiency.</div></div><div><h3>Conclusion</h3><div>Exercise is effective in improving both subjective and objective sleep quality. Body and mind exercise, aerobic exercise, and aerobic combined with resistance exercise may be the preferred way to improve sleep, and the longer the exercise cycle, the more obvious the improvement in sleep effect, the improvement effect will gradually decrease with age.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"125 ","pages":"Pages 1-13"},"PeriodicalIF":3.8,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep risk factors modify the association between c-reactive protein and type 2 diabetes: A prospective cohort study","authors":"Mengying Wang ,&nbsp;Huangda Guo ,&nbsp;Hexiang Peng ,&nbsp;Siyue Wang ,&nbsp;Xueheng Wang ,&nbsp;Meng Fan ,&nbsp;Jin Jiang ,&nbsp;Tianjiao Hou ,&nbsp;Chenghua Gao ,&nbsp;Wenyan Xian ,&nbsp;Jie Huang ,&nbsp;Tao Wu","doi":"10.1016/j.sleep.2024.11.001","DOIUrl":"10.1016/j.sleep.2024.11.001","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the prospective association between serum CRP levels and T2D incidence and explore whether such association was modified by sleep risk factors.</div></div><div><h3>Methods</h3><div>The study included 366 746 participants without diabetes and exhibited CRP measures at baseline from the UK Biobank. Sleep risk factors included sleep duration, insomnia, snoring, chronotype, and daytime sleepiness. Cox proportional hazards model was used to estimate the hazard ratio (HR), and 95 % confidence interval (CI) of T2D associated with CRP levels. Interactions between CRP and sleep risk factors were also tested.</div></div><div><h3>Results</h3><div>During a median follow-up of 10.4 years, 14 200 T2D cases were identified. The HRs (95 % CIs) of T2D were 1.31 (1.21–1.43), 1.62 (1.50–1.75), 1.98 (1.83–2.13), and 2.38 (2.21–2.57), respectively, in higher quintile groups of CRP levels compared with the lowest group (p-value for trend &lt;0.001). There were interactions of CRP levels with self-reported sleep duration, snoring, and daytime sleepiness (p-value for interaction = 0.002, 0.0002, and 0.0001). The associated risks between T2D and the elevation in CRP were more evident among participants with high-risk sleep factors.</div></div><div><h3>Conclusions</h3><div>Our study indicates that the elevation in serum CRP levels is associated with a higher T2D incidence; and such relation is modified by sleep risk factors including sleep duration, snoring, and daytime sleepiness.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 674-680"},"PeriodicalIF":3.8,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"mCLAS adaptively rescues disease-specific sleep and wake phenotypes in neurodegeneration","authors":"Inês Dias ,&nbsp;Christian R. Baumann ,&nbsp;Daniela Noain","doi":"10.1016/j.sleep.2024.11.009","DOIUrl":"10.1016/j.sleep.2024.11.009","url":null,"abstract":"<div><div>Sleep alterations are hallmarks of prodromal Alzheimer's (AD) and Parkinson's disease (PD), with fundamental neuropathological processes of both diseases showing susceptibility of change upon deep sleep modulation. However, promising pharmacological deep sleep enhancement results are hindered by specificity and scalability issues, thus advocating for noninvasive slow-wave activity (SWA) boosting methods to investigate the links between deep sleep and neurodegeneration. Accordingly, we have recently introduced mouse closed-loop auditory stimulation (mCLAS), which is able to successfully boost SWA during deep sleep in neurodegeneration models. Here, we aim at further exploring mCLAS’ acute effect onto disease-specific sleep and wake alterations in AD (Tg2576) and PD (M83) mice. We found that mCLAS adaptively rescues pathological sleep and wake traits depending on the disease-specific impairments observed at baseline in each model. Notably, in AD mice mCLAS significantly increases NREM long/short bout ratio, decreases vigilance state distances by decreasing transition velocities and increases the percentage of cumulative time spent in NREM sleep in the last 3h of the dark period. Contrastingly, in PD mice mCLAS significantly decreases NREM sleep consolidation, by potentiating faster and more frequent transitions between vigilance states, decreases average EMG muscle tone during REM sleep and increases alpha power in WAKE and NREM sleep. Overall, our results indicate that mCLAS selectively prompts an acute alleviation of neurodegeneration-associated sleep and wake phenotypes, by either potentiating sleep consolidation and vigilance state stability in AD or by rescuing bradysomnia and decreasing cortical hyperexcitability in PD. Further experiments assessing the electrophysiological, neuropathological and behavioural long-term effects of mCLAS in neurodegeneration may majorly impact the clinical establishment of sleep-based therapies.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 704-716"},"PeriodicalIF":3.8,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insomnia disorder is associated with 24-hour cortical hyperarousal","authors":"Yanyuan Dai ,&nbsp;Jingwen Ma ,&nbsp;Alexandros N. Vgontzas ,&nbsp;Baixin Chen ,&nbsp;Le Chen ,&nbsp;Jun Wu ,&nbsp;Dandan Zheng ,&nbsp;Jiansheng Zhang ,&nbsp;Maria Karataraki ,&nbsp;Yun Li","doi":"10.1016/j.sleep.2024.11.002","DOIUrl":"10.1016/j.sleep.2024.11.002","url":null,"abstract":"<div><h3>Objective</h3><div>Cortical hyperarousal has been proposed as a primary underlying mechanism for insomnia disorder. However, most evidence comes from nighttime sleep and whether patients with insomnia disorder have cortical hyperarousal through the 24-h sleep/wake cycle is not resolved.</div></div><div><h3>Methods</h3><div>We included 49 patients with insomnia disorder and 49 age-and sex-matched normal sleepers. All participants underwent an over-night polysomnography followed by a Multiple Sleep Latency Test during daytime. Nighttime and daytime delta, theta, alpha, sigma and beta relative power at central electroencephalogram derivations during wakefulness and non-rapid eye movement (NREM) sleep were calculated. Insomnia disorder was defined based on the International Classification of Sleep Disorders Third Edition criteria. Insomnia with objective short sleep duration was defined as patients with insomnia who slept &lt;7 h based on nighttime polysomnography recording.</div></div><div><h3>Results</h3><div>Compared to normal sleepers, patients with insomnia disorder had significantly higher nighttime (<em>P</em> = 0.040) and daytime (<em>P</em> = 0.021) relative electroencephalogram power in beta during NREM sleep and marginally significantly lower relative electroencephalogram power in theta (<em>P</em> = 0.060) during nighttime wakefulness. Furthermore, linear trend association was observed across normal sleepers, and patients with insomnia who slept ≥7 h and insomnia who slept &lt;7 h in relative electroencephalogram power in beta during nighttime and daytime NREM sleep, and relative electroencephalogram power in theta during nighttime wakefulness (all <em>P</em> for trend &lt;0.05).</div></div><div><h3>Conclusion</h3><div>Increased high-frequency electroencephalogram power during nighttime and daytime sleep suggests that insomnia is a disorder of 24-h cortical hyperarousal. Decreasing both nighttime and daytime cortical arousal levels should be our therapeutic target for insomnia.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 681-687"},"PeriodicalIF":3.8,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Daytime napping and depressive symptoms in bipolar disorder: A cross-sectional analysis of the APPLE cohort","authors":"Yuichi Esaki ,&nbsp;Kenji Obayashi ,&nbsp;Keigo Saeki ,&nbsp;Kiyoshi Fujita ,&nbsp;Nakao Iwata ,&nbsp;Tsuyoshi Kitajima","doi":"10.1016/j.sleep.2024.11.006","DOIUrl":"10.1016/j.sleep.2024.11.006","url":null,"abstract":"<div><h3>Background</h3><div>The relationship between daytime napping and depression remains debatable. Thus, we investigated whether daytime napping is associated with depressive symptoms in patients with bipolar disorder.</div></div><div><h3>Methods</h3><div>In a cross-sectional study, we enrolled 204 outpatients with bipolar disorder who were participants in the Association between Pathology of Bipolar Disorder and Light Exposure in Daily Life (APPLE) cohort study. Each participant's daytime napping was measured using an actigraph over 7 consecutive days. Depressive symptoms were evaluated using the Montgomery–Åsberg Depression Rating Scale, and scores of ≥8 points were considered indicative of a depressed state.</div></div><div><h3>Results</h3><div>One-hundred and ten (53.9 %) participants were depressed. In multivariable logistic regression analysis, as the number of nap days, number of naps per day, and nap duration increased, the odds ratio (OR) for depressed state significantly increased. Additionally, compared to the participants who did not nap, the participants who napped on five or more days a week or who had an average nap duration over 60 min had more than three times higher ORs in the depressed state (number of nap days: OR, 3.66; 95 % confidence interval [CI], 1.32–10.17; nap duration: OR, 3.14; 95 % CI, 1.12–8.81).</div></div><div><h3>Conclusions</h3><div>We found a significant and independent association between daytime napping and depressive symptoms in patients with bipolar disorder. Further studies are warranted to identify the effect of short napping on depressive symptoms in patients with bipolar disorder.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 688-694"},"PeriodicalIF":3.8,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of sleep restriction on cerebrovascular reactivity and cognitive outcomes in healthy adolescents: A pilot crossover trial","authors":"Amy Chan ,&nbsp;Chun Ting Au ,&nbsp;Myrtha E. Reyna ,&nbsp;Amanda Robertson ,&nbsp;Kirstin Walker ,&nbsp;Robyn Westmacott ,&nbsp;Manohar Shroff ,&nbsp;Luc Mertens ,&nbsp;Nomazulu Dlamini ,&nbsp;Indra Narang","doi":"10.1016/j.sleep.2024.11.005","DOIUrl":"10.1016/j.sleep.2024.11.005","url":null,"abstract":"<div><h3>Background</h3><div>The underlying mechanism for the association between sleep restriction (SR) and unfavorable cognitive outcomes in children and adolescents remains unclear. This study aimed to understand the effect of 5-night experimental SR on magnetic resonance imaging (MRI) measurements of cerebrovascular reactivity (CVR) and cognitive function in adolescents.</div></div><div><h3>Methods</h3><div>This randomized crossover study compared two sleep conditions, SR and Control Sleep (CS) in a home setting. Healthy adolescents aged 15–18 years were recruited. The protocol began with two nights of baseline sleep to record participants’ habitual sleep duration, followed by the two sleep conditions in the randomly allocated sequence, either SR (6 h in bed for 5 nights) followed by CS (9 h in bed for 5 nights), or the reverse sequence. Their sleep-wake pattern was monitored by an accelerometer and a sleep diary throughout the study period. Cerebral hemodynamics were assessed by hypercapnic challenge blood oxygen level-dependent (BOLD) MRI of CVR. Cognitive function was evaluated by NIH Toolbox Cognitive Battery on the day immediately after each sleep condition.</div></div><div><h3>Results</h3><div>A total of 27 participants (8 males; mean age: 16.8 ± 0.7 years, range 15–18 years) were included in the study. The average sleep duration was significantly reduced in the SR condition compared to the CS condition (320 ± 34 min vs. 426 ± 45 min, p &lt; 0.001). The CVR in the temporal occipital fusiform cortex [adjusted <em>β</em>(95 % CI) = −0.091(-0.010 to −0.172), p = 0.032] and occipital lobe [adjusted <em>β</em>(95 % CI) = −0.087 (−0.002 to −0.172), p = 0.045] was significantly lower following the SR condition when compared to the CS condition. Participants also had lower performance scores in the inhibitory control [adjusted <em>β</em>(95 % CI) = −6.0(−0.9 to −11.0), p = 0.019] and cognitive flexibility [adjusted <em>β</em>(95 % CI) = −6.6 (−1.7 to −11.6), p = 0.008] domains after the SR condition when compared to the CS condition.</div></div><div><h3>Conclusions</h3><div>Short-term SR is associated with poorer cognitive function possibly through reduced cerebral vasodilatory capacity in specific cognitive regions.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 717-726"},"PeriodicalIF":3.8,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between age and comorbid insomnia and sleep apnea","authors":"Meina Wu ,&nbsp;Pei Xue ,&nbsp;Jinzhu Yan ,&nbsp;Christian Benedict","doi":"10.1016/j.sleep.2024.11.011","DOIUrl":"10.1016/j.sleep.2024.11.011","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate the age-related prevalence of comorbid insomnia and sleep apnea (COMISA).</div></div><div><h3>Methods</h3><div>A single-night polysomnography with video monitoring was conducted on 2176 Chinese adults (ages 18–102) to screen for obstructive sleep apnea (OSA). Insomnia was defined as difficulty initiating or maintaining sleep, or early morning awakening at least three times per week for more than three months, accompanied by daytime symptoms such as irritability, fatigue, or anxiety.</div></div><div><h3>Results</h3><div>Of the participants, 981 met the criteria for COMISA, defined by an apnea-hypopnea index (AHI) of ≥5 and the presence of insomnia. Compared to patients with OSA only (n = 433), COMISA patients were more often female (48 % vs. 24 %), had longer sleep onset latency (5.8 min), shorter total sleep time (14.0 min), lower AHI (14.4 points), and higher mean peripheral oxygen saturation (0.6 %; all p &lt; 0.05). The prevalence of COMISA versus OSA only was 51.9 % vs. 48.1 % in participants under 50 years, compared to 78.1 % vs. 21.9 % in those aged 70 or older. Logistic regression analysis adjusted for sex showed a 3 % increase in the odds of COMISA (95 % CI: 1.02–1.04) with each additional year of age.</div></div><div><h3>Conclusions</h3><div>Our findings reveal a significant association between increasing age and the development of COMISA, underscoring the need for heightened clinical awareness of this condition in elderly patients.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 659-661"},"PeriodicalIF":3.8,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"REM sleep behavior disorder: Relation between aggressiveness and emotions expressed in dream enactment and cognitive and anxiety/depression status","authors":"Paulo Bugalho ,&nbsp;Marta Magriço ,&nbsp;Vítor Mendes Ferreira","doi":"10.1016/j.sleep.2024.11.008","DOIUrl":"10.1016/j.sleep.2024.11.008","url":null,"abstract":"<div><div>Aggressiveness and negative emotions in dreams reports of patients with alfa-synucleinopathies have been associated with cognitive dysfunction. Observation of dream enactment episodes could be a more precise method to capture dream content in patients with REM sleep behavior disorder (RBD). Our objective was to assess the relation between aggressive and emotional dream enactment episodes in patients with RBD and cognition and depression/anxiety.</div><div>Motor events (ME) during REM sleep were classified by visual inspection of video-PSG files. Cognition and anxiety/depression were assessed with MoCA and the Hospital Anxiety and Depression Scale (HADS), respectively. Multivariate regression analysis was performed, with MoCA or HADS scores as predictors, age and DED as co-variates and aggressive, negative and positive ME frequency (raw values, per total and per complex indexes) as the dependent variable.</div><div>We included 15 patients with isolated RBD and 12 and 4 with RBD associated with Parkinson's disease and Dementia with Lewy Bodies, respectively. They presented a total of 873 ME. There was a significant positive association between HADS score and violent/complex and negative emotion/complex indexes. There was a significant positive association between MoCA score and violent/complex index.</div><div>A significant correlation between depression/anxiety severity and negative emotion and aggression ME frequency agrees with the dream continuity hypothesis and suggests that REM sleep acts as a regulator of emotional experience. Patients with a higher prevalence of aggressive ME had higher scores in cognitive testing, suggesting that the elaboration of these complex movements could depend on the integrity of cognitive functions.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 669-673"},"PeriodicalIF":3.8,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}