Sleep medicine最新文献

{"title":"The role of objective sleep duration, continuity, and architecture for subjective sleep perception: Findings from an intensive longitudinal study using heart-rate variability to infer objective sleep indicators","authors":"Justin Hachenberger ,&nbsp;Sebastian Baron ,&nbsp;Manuel Schabus ,&nbsp;Sakari Lemola","doi":"10.1016/j.sleep.2025.02.040","DOIUrl":"10.1016/j.sleep.2025.02.040","url":null,"abstract":"<div><div>This study investigates the relationship between objective sleep indicators derived from heart rate variability (HRV) and sleep perception in young adults using an intensive longitudinal design over 14 consecutive nights. The sample included 178 participants aged 18–29 years from two separate studies, who provided data via daily sleep diaries. Using a multi-resolution convolutional neural network model, heart rate variability measured via ambulatory electrocardiography was used for sleep stage classification. Within-subject analyses revealed that longer total sleep time, higher sleep efficiency, more slow-wave sleep, and more rapid-eye-movement sleep were associated with better sleep perception, while longer wake after sleep onset was linked to poorer sleep perception. Notably, no significant associations were found on the between-subject level. The objective sleep indicators explained nearly five times as much variance in sleep perception at the within-subject level than at the between-subject level. Additionally, gender, as well as depressive symptoms and insomnia symptoms measured at baseline did not moderate the within-subject associations between objective sleep indicators and sleep perception. These findings underscore the importance of sufficient sleep duration, quality of sleep architecture, and sleep continuity for individuals' perceptions of their sleep on a nightly basis. The study's use of HRV-derived sleep staging over multiple nights represents a methodological strength, providing detailed and less intrusive assessment compared to traditional polysomnography. Furthermore, these results are particularly important for clinical applications, as they can be basis for individualized interventions to improve sleep perception.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 167-174"},"PeriodicalIF":3.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional cerebral blood perfusion impairment in type 1 narcolepsy patients: An arterial spin labeling study","authors":"Lin Xu ,&nbsp;Ruilin Zhang ,&nbsp;Rong Xue ,&nbsp;Linlin Wang ,&nbsp;Zhu Ai ,&nbsp;Lili Li ,&nbsp;Wei Wu ,&nbsp;Zuojun Wang","doi":"10.1016/j.sleep.2025.02.036","DOIUrl":"10.1016/j.sleep.2025.02.036","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the pathophysiological characteristics of cerebral blood flow (CBF) in patients with narcolepsy type 1 (NT1) via the arterial spin labeling (ASL) technique.</div></div><div><h3>Methods</h3><div>Thirty patients with diagnostic NT1 (PTs) and 34 age- and sex-matched healthy controls (HCs) were recruited for this study. Basic information was collected, and clinical evaluation and neuroimaging, including ASL and T1-3DBRAVO, was performed. The z-normalized CBF (zCBF) and spatial coefficient of variation (sCoV) were calculated, and the changes in NT1 were compared via analysis of covariate (ANCOVA). Furthermore, spearman's correlation analysis between impaired regional perfusion and clinical features was performed. Age, sex, and normalized grey matter volume were included as covariates.</div></div><div><h3>Results</h3><div>Compared with that of HCs, the zCBF of PTs significantly differed in regions of fronto-temporal-occipital cortex, right insula and posterior insula, and left rostral/dorsal anterior cingulate gyrus (ACG) (<em>P</em> &lt; 0.006). Moreover, the sCoV was significantly altered in the frontotemporal cortex, rostral ACG, right hippocampus, and posterior insula (<em>P</em> &lt; 0.003). In PTs, positive correlations were identified between the zCBF of the right superior/middle frontal gyrus (SFG/MFG) and mean sleep latency, and between the zCBF of the left SFG of the frontal pole and sleep hallucination severity. Moreover, the sCoV of the right MFG/hippocampus were positively associated with Rapid Eye Movement efficiency and negatively associated with Hamilton Anxiety Scale score, respectively.</div></div><div><h3>Conclusion</h3><div>PTs exhibited abnormal regional perfusion in the frontal-temporal-occipital cortex and limbic system regions, which may serve as patient-specific imaging markers. Alterations in perfusion may lead to the clinical manifestations of underlying psychological and sleep disorders in PTs.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 122-130"},"PeriodicalIF":3.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143511295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential respiratory function response in paediatric spinal muscular atrophy types 2 and 3 treated with nusinersen over 3 years","authors":"Archana Chacko ,&nbsp;Peter D. Sly ,&nbsp;Robert S. Ware ,&nbsp;Brett Dyer ,&nbsp;Sean Deegan ,&nbsp;Nicole Thomas ,&nbsp;Leanne M. Gauld","doi":"10.1016/j.sleep.2025.02.034","DOIUrl":"10.1016/j.sleep.2025.02.034","url":null,"abstract":"<div><h3>Aim</h3><div>To establish whether the initial positive effect of nusinersen (NUS) on respiratory outcomes in the first year of treatment was maintained in children with Spinal Muscular Atrophy (SMA) type 2 and to further define the effect on children with type 3 treated over 3 years.</div></div><div><h3>Methods</h3><div>A prospective observational study of children with type 2 and 3 beginning NUS in Queensland, Australia between June 2018–December 2020 was undertaken. Investigations conducted included age-appropriate lung function and polysomnography. Lung function data for two-years preceding NUS initiation was retrospectively collected. Change in lung function/polysomnography was assessed using mixed effects linear regression.</div></div><div><h3>Results</h3><div>24 of 30 children with type 2 and 3 SMA (14 males; 2.6–15.8) were included (type 2 n = 12; type 3 n = 12). No child had respiratory-related admissions during the period of study. For type 2, annual decline in FVC z-score pre-treatment was −0.75 (95 % CI: 1.14, −0.39, p &lt; 0.001), and for the first 3 years on NUS was −0.20 ([95 % CI: 0.33, −0.06, p = 0.01] difference p = 0.008). For type 3 minimal change was seen: pre-NUS and post FVC z-scores −0.20 (95 % CI: 1.00, 0.61 p = 0.05) and −0.46 (95 % CI: 0.88, −0.04 p = 0.40) respectively (difference p = 0.46). Mean change in total apnoea-hypopnoea indices (total AHI) in type 2 tended to reduce −1.75 (95 % CI: 4.95–0.9, p = 0.24); type 3 appeared to remain stable (−0.39 [95 % CI: 1.1–0.33, p = 0.28). One child with type 2 ceased NIV due to normalisation of total AHI and gas exchange.</div></div><div><h3>Conclusion</h3><div>Nusinersen lung function (FVC-z-scores) stability seen in the first year was maintained over 3 years and the total AHI tended to improve in type 2, but the long-term effects in type 3 are less clear.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 354-362"},"PeriodicalIF":3.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep characteristics and brain structure: A systematic review with meta-analysis","authors":"Tergel Namsrai ,&nbsp;Joseph M. Northey ,&nbsp;Ananthan Ambikairajah ,&nbsp;Oli Ahmed ,&nbsp;Khawlah Alateeq ,&nbsp;Daniela Andrea Espinoza Oyarce ,&nbsp;Richard Burns ,&nbsp;Ben Rattray ,&nbsp;Nicolas Cherbuin","doi":"10.1016/j.sleep.2025.02.028","DOIUrl":"10.1016/j.sleep.2025.02.028","url":null,"abstract":"<div><h3>Background</h3><div>As the global population ages, the prevalence of associated conditions, including neurodegeneration and dementia, will increase. Thus, reducing risk factors is crucial to prevention. Sleep contributes to brain homeostasis and repair, which, if impaired, could lead to neurodegeneration. However, the relationship between sleep characteristics, disorders, and brain morphology is poorly understood in healthy adults. Therefore, we aimed to systematically analyse the literature and clarify how sleep characteristics are associated with brain structures.</div></div><div><h3>Methods</h3><div>We systematically searched PUBMED, MEDLINE, ProQuest, Web of Science, and Scopus for empirical studies of healthy adults examining the associations between sleep characteristics or disorders and brain structure, adjusting for age, gender, and head size. We conducted a meta-analysis with random effects models for volumetric studies and a seed-based spatial analysis for voxel-based morphometry (VBM) studies.</div></div><div><h3>Results</h3><div>One hundred and five articles (60 volumetric, 45 VBM) with 106 studies reporting 108,364 participants were included. Most studies (73.1%) found sleep characteristics and disorders to be associated with predominantly lower brain volumes (cross-sectional: 51.9% of all cross-sectional; longitudinal: 45.5% of longitudinal). In VBM studies, REM sleep behaviour disorder was linked to lower grey matter volume in the right frontal gyrus (z-score = −3.617, 68 voxels, p-value = &lt;0 0.001).</div></div><div><h3>Conclusion</h3><div>Sleep characteristics - poor quality, short or long sleep - and sleep disorders are predominantly associated with lower brain volumes, suggesting that inadequate sleep (short, long or poor quality) might contribute to neurodegeneration. This insight highlights the importance of monitoring, managing, and enforcing sleep health to prevent or mitigate potential neurodegenerative processes.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 316-329"},"PeriodicalIF":3.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Over-the-counter products for insomnia in adults: A scoping review of randomised controlled trials","authors":"Adriana Salame ,&nbsp;Silvy Mathew ,&nbsp;Cini Bhanu ,&nbsp;Juan Carlos Bazo-Alvarez ,&nbsp;Sukvinder Kaur Bhamra ,&nbsp;Michael Heinrich ,&nbsp;Kate Walters ,&nbsp;Rachael Frost","doi":"10.1016/j.sleep.2025.02.027","DOIUrl":"10.1016/j.sleep.2025.02.027","url":null,"abstract":"<div><h3>Background</h3><div>Insomnia is highly prevalent and poses significant personal and socio-economic challenges. While the National Institute for Health and Care Excellence (NICE) recommendations define possible medical approaches, over-the-counter products are commonly used to self-manage insomnia symptoms. This scoping review aims to determine the size and scope of the evidence-base regarding the effectiveness and safety of over-the-counter products for insomnia symptoms in adults.</div></div><div><h3>Methods</h3><div>The electronic databases of CENTRAL, MEDLINE, EMBASE, PsycINFO, and AMED were searched from inception to December 19th, 2022, for all randomised controlled trials evaluating over-the-counter products compared to placebo, in adults aged 18–65 with insomnia symptoms. Results were synthesised descriptively.</div></div><div><h3>Results</h3><div>51 randomised controlled trials were included, evaluating herbal products (n = 34), dietary supplements (n = 15), herbal-dietary combinations (n = 4), and over-the-counter medicines (n = 2). Sample sizes ranged between 10 and 405 participants. Eleven studies were conducted in participants with co-morbidities. Interventions were most frequently given as monotherapy and compared against placebo. Most studies (n = 41) demonstrated interventions’ positive effects on insomnia symptoms. Among the most studied products, valerian and melatonin have substantial evidence to demonstrate their effectiveness and safety. Promising products demonstrating benefits compared with prescription medication alone included: valerian; lemon balm and fennel; and valerian, hops, and passionflower. Intervention-related side effects were mostly mild and transient. No serious adverse events were reported across all studies.</div></div><div><h3>Conclusions</h3><div>Over-the-counter products show promising, but inconclusive findings in alleviating insomnia symptoms in adults. Future research should focus on investigating products currently used in real life, consider economic evaluations, and be evaluated in populations with co-morbidities and ethnic minorities, to better guide clinical advice.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 219-237"},"PeriodicalIF":3.8,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of high-intensity interval training exercise on sleep quality in women with probable post-traumatic stress disorder: A pilot randomized controlled trial","authors":"Melissa J. McGranahan,&nbsp;Patrick J. O'Connor","doi":"10.1016/j.sleep.2025.02.029","DOIUrl":"10.1016/j.sleep.2025.02.029","url":null,"abstract":"<div><div>Poor sleep quality is a major problem for women with post-traumatic stress disorder (PTSD). Potential causes of poor sleep quality include elevated symptoms of anxiety, hyperarousal, and decreased high frequency-heart rate variability (HF-HRV). Exercise training both decreases anxiety symptoms and increases HF-HRV among samples without PTSD. The effect of exercise training on sleep quality, HF-HRV and PTSD-related symptoms has not been tested in a sample of women exposed to trauma. This study aimed to evaluate the impact of High-Intensity Interval Training (HIIT) on sleep quality in a sample of women with probable PTSD and test if reductions in anxiety or hyperarousal symptoms and/or increased HF-HRV mediate improved sleep quality. Thirty women with poor sleep quality and a Post-Traumatic Diagnostic Scale (PDS-5) score indicative of PTSD (≥ 28) were randomly assigned to either six-weeks of HIIT or a waitlist control (WL). Sleep quality, PTSD and anxiety symptoms were assessed at baseline (BL), weeks 2, 4, 6, and post-intervention (POST). HF-HRV was measured at BL and POST. A mixed model ANOVA 2 group × 5 time interaction for sleep quality was significant (p &lt; 0.001; HIIT BL: 11.27 ± 2.55; POST: 5.60 ± 2.03 versus WL BL: 9.47 ± 2.83; POST: 8.23 ± 2.39; Hedges’ d = −1.57). Anxiety and hyperarousal symptom reductions significantly mediated sleep quality changes. HF-HRV mediation models were non-significant. HIIT-based cycle exercise training in a sample of women with probable PTSD improves sleep quality, and reductions in trait anxiety and hyperarousal symptoms mediated these improvements.</div></div><div><h3>Clinical trial registration</h3><div>(Clinical Trials. gov) Identifier: NCT05097352.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 245-256"},"PeriodicalIF":3.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143563848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does therapeutic CPAP pressure correlate with OSA severity in children?","authors":"Sonia Khirani ,&nbsp;Lucie Griffon ,&nbsp;Marine Dosso ,&nbsp;Domenico Paolo La Regina ,&nbsp;Meryl Vedrenne-Cloquet ,&nbsp;Clément Poirault ,&nbsp;Brigitte Fauroux","doi":"10.1016/j.sleep.2025.02.033","DOIUrl":"10.1016/j.sleep.2025.02.033","url":null,"abstract":"<div><h3>Objective/background</h3><div>Continuous positive airway pressure (CPAP) is widely used to treat severe obstructive sleep apnea (OSA) in children. We observed that non polysomnography (PSG)-titrated CPAP pressures ranged close to 8 cmH₂O in children with OSA. The aim of this study was to determine if there was a relationship between OSA severity, the age of the children and CPAP pressure.</div></div><div><h3>Methods</h3><div>Children with OSA, comprising mainly children with complex OSA, who were started on constant CPAP, with no attended PSG according to our clinical practice, were included. CPAP pressure, baseline polygraphic and anthropometrics data were retrospectively collected.</div></div><div><h3>Results</h3><div>Mean therapeutic CPAP pressure was 8 ± 1 (range 6–12) cmH₂O in 153 children treated with CPAP at a mean age of 3.7 ± 3.4 (0.1–15.9) years. CPAP pressure slightly correlated with age at CPAP initiation (r = 0.226, p = 0.005), baseline mixed and obstructive apnea-hypopnea index (MOAHI; r = 0.185, p = 0.025), oxygen desaturation index (ODI; r = 0.300, p &lt; 0.001), mean (r = −0.230, p = 0.005) and minimal pulse oximetry (SpO₂; r = −0.318, p &lt; 0.001). BMI z-score did not correlate with CPAP pressure, apnea-hypopnea index (AHI), MOAHI, nor ODI. CPAP pressure, AHI, MOAHI and ODI did not vary between age categories.</div></div><div><h3>Conclusions</h3><div>A weak correlation was observed between therapeutic CPAP pressure and MOAHI in our cohort of children, with no correlation with BMI, highlighting the potential role of other factors, such as anatomical features. Future studies should confirm these findings with PSG-titrated CPAP pressures, and determine predictive factors for therapeutic CPAP. Predicting the level of CPAP may be relevant in clinical practice, as PSG-titrated CPAP procedure becomes more challenging.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 89-93"},"PeriodicalIF":3.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Putamen dopaminergic dysfunction is associated with sleep disturbance in drug-naïve patients with Parkinson's disease","authors":"Masakazu Ozawa ,&nbsp;Hidetomo Murakami ,&nbsp;Yuichiro Muraoka ,&nbsp;Momoyo Ibukuro ,&nbsp;Tomotaka Shiraishi ,&nbsp;Asako Onda ,&nbsp;Hiromasa Matsuno ,&nbsp;Keiko Bono ,&nbsp;Tadashi Umehara ,&nbsp;Shusaku Omoto ,&nbsp;Hirotaka James Okano ,&nbsp;Yasuyuki Iguchi","doi":"10.1016/j.sleep.2025.02.031","DOIUrl":"10.1016/j.sleep.2025.02.031","url":null,"abstract":"<div><h3>Background</h3><div>Sleep disturbance (SD) is common in Parkinson's disease (PD) and adversely affect the quality of life (QOL). Although dopamine dysfunction has been implicated, the specific role of dopaminergic activity in SD among patients with PD remains unclear. Given that dopamine-related medications can affect sleep, it is essential to assess SD in drug-naïve patients. This study investigated the association between SD and uptake of striatal dopamine transporters using Dopamine Transporter Single-Photon Emission Computed Tomography with ¹²³I-Ioflupane (DAT-SPECT).</div></div><div><h3>Methods</h3><div>We retrospectively analyzed 112 drug-naïve patients through the PD Sleep Scale-version-2 (PDSS-2) and DAT-SPECT. Patients were divided into SD and non-SD groups using a PDSS-2 cut-off score of 15. The Mann-Whitney <em>U</em> test and binomial regression were used to compare the groups.</div></div><div><h3>Results</h3><div>SD was identified in 47.3 % of participants, correlating significantly with increased age, more severe motor symptoms, cognitive decline, depressive symptoms, and reduced QOL scores. Binomial regression analyses—adjusted for sex, age, motor dysfunction, cognitive function, and nocturnal autonomic cardiovascular dysfunction—showed that reduced DAT-SPECT uptake in the left anterior and posterior putamen significantly contributed to higher PDSS-2 scores.</div></div><div><h3>Conclusion</h3><div>This study demonstrated a link between SD and putamen DAT-SPECT uptake in drug-naïve patients with PD, indicating the role of dopamine in sleep regulation. These findings underscore the importance of managing SD in patients with PD to improve QOL and suggest the need for further investigation of the impact of dopaminergic dysfunction on sleep.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 82-88"},"PeriodicalIF":3.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awakening to sleep: Sixteen years of World Sleep Day global initiatives and future directions","authors":"Lourdes M. DelRosso ,&nbsp;Fang Han ,&nbsp;Richard P. Allen ,&nbsp;Antonio Culebras ,&nbsp;Christian Guilleminault ,&nbsp;Liborio Parrino ,&nbsp;Sophia Hendrickson ,&nbsp;Tyler Ringstad ,&nbsp;Allan O'Bryan","doi":"10.1016/j.sleep.2025.02.022","DOIUrl":"10.1016/j.sleep.2025.02.022","url":null,"abstract":"<div><div>World Sleep Day is an international campaign to raise public awareness of sleep health. Since 2008, the WSD campaign has grown from a small group of advocates to include hundreds of volunteer organizers in over 70 countries. A historical database of 2047 World Sleep Day (WSD) awareness activities recorded over 16 years was examined to characterize the growth of WSD and to delineate areas for further development. Between 2014 and 2024, WSD activity grew in Europe from 24 to 132 activities and in Asia from 10 to 94; however, WSD activity grew in Africa from one to 20 activities and Oceania from five to 18. Growth has been considerable, yet organizing and outreach work needs to accelerate in Africa and Asia to further advance the purpose of WSD.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 118-121"},"PeriodicalIF":3.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143511296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors and prognosis of acute ischemic stroke related restless legs syndrome","authors":"Xi-Xi Wang ,&nbsp;Ye Liu ,&nbsp;Jia-Min Song ,&nbsp;Yu-Lei Zhang ,&nbsp;Yu Wang ,&nbsp;Ondo G. William ,&nbsp;Ya Feng ,&nbsp;Yun-Cheng Wu","doi":"10.1016/j.sleep.2025.02.030","DOIUrl":"10.1016/j.sleep.2025.02.030","url":null,"abstract":"<div><h3>Background</h3><div>Recent studies suggest that stroke may be associated with an increased prevalence of restless legs syndrome (RLS) as a comorbidity or a risk factor. We aimed to explore the association between acute ischemic stroke (AIS) and RLS, and the possible pathogenesis of acute ischemic stroke related restless legs syndrome (AIS-RLS), for guiding its diagnosis and treatment.</div></div><div><h3>Methods</h3><div>In this single-center, prospective study, we identified consecutive AIS patients and segregated into AIS-RLS group and non-AIS-RLS group based on the diagnostic criteria of RLS. The differences in baseline data, clinical features, examination results, stroke etiology, stroke location, and clinical prognosis (functional disability, cognitive and mood disorders) of the two groups were analyzed. Logistic regression analysis was used to evaluate the risk factors for RLS.</div></div><div><h3>Results</h3><div>A total of 201 AIS patients were included in our study, and 21 (10.45 %) demonstrated RLS. Compared with non-AIS-RLS group, AIS-RLS group patients had higher systolic blood pressure (SBP) at admission (<em>P</em> &lt; 0.05), higher mean 24-h SBP (<em>P</em> &lt; 0.01), higher mean 24-h diastolic blood pressure (DBP) (<em>P</em> &lt; 0.01), higher mean daytime SBP (<em>P</em> &lt; 0.01), higher mean daytime DBP (<em>P</em> &lt; 0.01), higher mean nocturnal SBP (<em>P</em> &lt; 0.01), higher mean nocturnal DBP (<em>P</em> &lt; 0.05), smaller variation coefficient of 24-h SBP (<em>P</em> &lt; 0.05). The distribution of AIS-RLS and non-AIS-RLS was not different for each subtype according to the cortical and subcortical classification of lesion sites. The NIHSS score, GAD-7 score and PHQ-9 score were higher at 7 days (<em>P</em> &lt; 0.05), and the modified Rankin scale (mRS) was higher at 3 months follow-up (<em>P</em> &lt; 0.05) in the AIS-RLS group. In the logistic regression, the higher SBP at admission had a statistically significant effect on AIS-RLS(OR = 1.030,<em>P</em> = 0.016)even after adjusting for age and gender(OR = 1.030,<em>P</em> = 0.014).</div></div><div><h3>Conclusion</h3><div>Stroke anatomy did not differ between AIS-RLS and non-AIS-RLS groups. AIS-RLS group patients tend to experience higher blood pressure. Moreover, AIS-RLS patients had worse clinical prognosis (functional disability and mood disorders) compared with non-AIS-RLS patients.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 75-81"},"PeriodicalIF":3.8,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143474585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}