Sleep medicine最新文献

{"title":"Posterior airway compromise following orthognathic surgery in skeletal class III patient - A systematic review and meta-analysis","authors":"Nadav Grinberg ,&nbsp;Sara Whitefield ,&nbsp;Shlomi Kleinman ,&nbsp;Clariel Ianculovici ,&nbsp;Svetlana Feldman ,&nbsp;Oren Peleg","doi":"10.1016/j.sleep.2025.03.001","DOIUrl":"10.1016/j.sleep.2025.03.001","url":null,"abstract":"<div><div>Obstructive Sleep Apnea (OSA) has been proven to have short- and long-term adverse effects on patients. OSA is associated with severe co-morbidities. Clinical studies have evaluated the volumetric changes in the posterior airway space following Orthognathic surgeries. The following study aims to assess the long-term airway compromise following different procedures for correcting skeletal Cl-III relationships. The research followed the PRISMA protocol guidelines and included a comprehensive electronic search of the National Institutes of Health (NIH), PubMed, and Embase databases, utilizing specific inclusion and exclusion criteria. All studies included airway measurements taken at three different time points, ensuring long-term follow-up of at least six months. Two authors evaluated quality blindly. We compared the types of surgical procedures alongside the volumetric airway measurements taken before and after the operation. Meta-analysis was performed using a random effect model if heterogeneity was detected. Otherwise, a common effect model was conducted under a 95 % confidence level. Sixteen publications met the inclusion criteria for qualitative assessment, and nine were eligible for quantitative evaluation. All included studies were rated within low to moderate risk of bias. Posterior airway volume changes in class III patients between the mandible-only and bimaxillary procedures immediately after the surgery were significantly different; p &lt; 0.05. However, this difference between those groups was not found in long-term follow-up, and airway volumes were comparable. In conclusion, the meta-analysis results confirm that bimaxillary and mandible-only surgery similarly decrease the posterior airway space volumes in long-term follow-up.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 192-199"},"PeriodicalIF":3.8,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143534851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomised pilot trial for bedtime procrastination: Examining the efficacy and feasibility of the Reducing Evening Screen Time online intervention (REST-O)","authors":"Vanessa M. Hill ,&nbsp;Sally A. Ferguson ,&nbsp;Amanda L. Rebar ,&nbsp;Hailey Meaklim ,&nbsp;Grace E. Vincent","doi":"10.1016/j.sleep.2025.02.043","DOIUrl":"10.1016/j.sleep.2025.02.043","url":null,"abstract":"<div><div>Bedtime procrastination is associated with inadequate sleep and is a novel intervention target to improve sleep health. Formative work indicates that pre-sleep electronic device use, a ubiquitous bedtime procrastination behaviour, may be targeted using a behaviour change approach. This pilot study aimed to examine (1) the acceptability and feasibility of the Reducing Evening Screen Time online program (REST-O) in new career starters, and (2) the preliminary effect of the program on daily pre-sleep electronic device use and sleep duration, as well as weekly measures of bedtime procrastination, excessive device use, and sleep quality and duration. Participants (<em>N</em> = 55) were randomised into three arms; an active Control (<em>n</em> = 19), Prevent (<em>n</em> = 18) and Substitute (<em>n</em> = 18), who used behavioural substitution at different times of day. Daily assessments were conducted for two weeks, and weekly measures at baseline, pre-intervention, post-intervention, and follow-up (end of Week Three). All groups experienced a reduction in daily pre-sleep device use (<em>M</em> = 23.4 min per day) and an increase in daily sleep duration (<em>M</em> = 12.7 min per day) post-intervention. Continued reductions in bedtime procrastination, excessive device use, and improvements in sleep quality and duration were observed at follow-up. The program appears feasible and acceptable to participants with a high daily completion rate (<em>M</em> = 84.7 %). Reductions in habit strength and hedonic motivation suggest potential mechanisms of change. Findings provide preliminary evidence for behaviour change interventions in targeting pre-sleep electronic device use and bedtime procrastination, with broader implications for sleep health.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 306-315"},"PeriodicalIF":3.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural brain network metrics as novel predictors of treatment response in restless legs syndrome","authors":"Kang Min Park ,&nbsp;Keun Tae Kim ,&nbsp;Dong Ah Lee ,&nbsp;Yong Won Cho","doi":"10.1016/j.sleep.2025.02.045","DOIUrl":"10.1016/j.sleep.2025.02.045","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate morphometric similarity networks in patients with newly diagnosed restless legs syndrome (RLS) compared with healthy controls and to examine their relationship with treatment response.</div></div><div><h3>Methods</h3><div>A total of 49 patients with newly diagnosed RLS and 58 healthy controls were prospectively enrolled. Brain magnetic resonance imaging was performed using a 3-T scanner, and morphometric similarity network analysis was conducted on T1-weighted images. The severity of RLS was assessed using the International RLS Scale at baseline and at three months post-treatment initiation. Patients were classified as good or poor responders based on a decrease of ≥5 points in RLS severity scores following treatment with either pramipexole or pregabalin.</div></div><div><h3>Results</h3><div>Although no significant differences were observed in morphometric similarity networks between patients with RLS and controls, both modularity and small-worldness indices were lower in the RLS group (0.218 vs. 0.258, <em>p</em> = 0.023; 0.841 vs. 0.861, <em>p</em> = 0.042). Among the 40 patients who completed follow-up evaluation, 27 were good responders and 13 were poor responders. Network diameter was significantly higher in good responders than in poor responders (7.061 vs. 6.552, <em>p</em> = 0.002). Similarly, eccentricity was elevated in good responders (5.875 vs. 5.385, <em>p</em> = 0.008). Receiver operating characteristic curve analysis revealed high predictive values for both diameter and eccentricity (AUC = 0.838, <em>p</em> &lt; 0.001; AUC = 0.751, <em>p</em> = 0.002, respectively).</div></div><div><h3>Conclusion</h3><div>Network metrics, particularly diameter and eccentricity, demonstrate potential utility as biomarkers for predicting treatment response in patients with RLS.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 212-218"},"PeriodicalIF":3.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of odds ratio product with respiratory and arousal measures in post-stroke patients","authors":"Reeman Marzouqah ,&nbsp;Sean Jairam ,&nbsp;Ivan Ntale ,&nbsp;Kathleen S.J. Preston ,&nbsp;Sandra E. Black ,&nbsp;Richard H. Swartz ,&nbsp;Brian J. Murray ,&nbsp;Magdy Younes ,&nbsp;Mark I. Boulos","doi":"10.1016/j.sleep.2025.02.048","DOIUrl":"10.1016/j.sleep.2025.02.048","url":null,"abstract":"<div><h3>Study objectives</h3><div>Obstructive Sleep Apnea (OSA) affects up to 70 % of post-stroke patients, complicating recovery and rehabilitation. This study aimed to evaluate the utility of the Odds Ratio Product (ORP), a continuous EEG-derived metric of sleep depth, in predicting conventional respiratory and arousal measures in stroke patients. We hypothesized that ORP metrics will predict conventional measures in patients with a history of stroke or Transient ischemic attack (TIA).</div></div><div><h3>Methods</h3><div>A retrospective analysis was conducted on 113 stroke/TIA individuals who underwent in-laboratory polysomnography (PSG). ORP metrics, including ORP_nrem, ORP_rem, ORP₉, and Wake Intrusion Indices (WIIs), were analyzed using multivariate linear regression models. Models were stratified by OSA status. Standardized coefficients were used to assess associations with the apnea-hypopnea index (AHI), respiratory disturbance index (RDI), and arousal indices.</div></div><div><h3>Results</h3><div>ORP metrics demonstrated statistically significant associations with conventional respiratory and arousal measures, with varying predictive strength across models. Specifically, ORP_nrem and WIIs exhibited strong predictive effects across all models. ORP₉ significantly predicted respiratory and arousal measures in the overall sample and the OSA subgroup, but its predictive value diminished in the non-OSA subgroup. ORP_rem was statistically significantly associated with respiratory and arousal measures; however, its associations with arousal measures were weaker in participants with OSA compared to those without OSA.</div></div><div><h3>Conclusion</h3><div>ORP metrics have the potential to refine OSA diagnoses and improve therapeutic strategies in post-stroke/TIA populations. Their integration into sleep assessments could facilitate early intervention and potentially optimize stroke recovery outcomes, addressing gaps in current evaluation methods.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 257-263"},"PeriodicalIF":3.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143563849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “The effects of sleep duration on the risk of dementia incidence in short and long follow-up studies: A systematic review and meta-analysis” [Sleep Med 124 (2024) 522-530]","authors":"Connie Howard ,&nbsp;Naaheed Mukadam ,&nbsp;Esther K. Hui ,&nbsp;Gill Livingston","doi":"10.1016/j.sleep.2025.02.039","DOIUrl":"10.1016/j.sleep.2025.02.039","url":null,"abstract":"","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Page 131"},"PeriodicalIF":3.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143511297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Negative effects of cognitive behavioral therapy for insomnia: Psychometric evaluation of an insomnia-specific extension for the Negative Effect Questionnaire","authors":"Laura Simon ,&nbsp;Yannik Terhorst ,&nbsp;Ann-Marie Küchler ,&nbsp;Dieter Riemann ,&nbsp;David Daniel Ebert ,&nbsp;Alexander Rozental ,&nbsp;Kai Spiegelhalder ,&nbsp;Harald Baumeister","doi":"10.1016/j.sleep.2025.02.044","DOIUrl":"10.1016/j.sleep.2025.02.044","url":null,"abstract":"<div><h3>Introduction</h3><div>Negative effects of psychotherapy encompass unwanted events caused by the treatment. Evidence exists that cognitive behavioral therapy for insomnia (CBT-I) can lead to negative effects (e.g., exhaustion, reduced motivation). Psychometrically validated instruments are needed to enable systematic investigation of negative effects and their consequences. This study aimed to develop an insomnia-specific extension for the Negative Effect Questionnaire (NEQ) and to evaluate its psychometric properties.</div></div><div><h3>Method</h3><div>Based on a literature review, an item pool was developed as an extension to the NEQ. This item pool was iteratively refined. Both the NEQ and the developed item pool were administered to participants enrolled in a stepped-care model for insomnia that includes an internet-delivered CBT-I. The psychometric properties of the item pool were evaluated using confirmatory factor analyses (CFAs). Additionally, responses to open-ended questions were categorized and analyzed.</div></div><div><h3>Results</h3><div>Data from 210 participants were available. In the newly developed item pool, participants reported a mean of 4.7 negative effects (range: 0 to 22). CFA indicated a good fit (RSMEA = 0.05; SRMR = 0.07) of a model with five latent factors (somatic symptoms, cognitive symptoms, safety, emotional symptoms, daytime functioning). The correlation analyses between the model's latent factors and the NEQ subscales indicated adequate discriminant validity.</div></div><div><h3>Discussion</h3><div>The observed prevalence rates of insomnia-specific negative effects highlight the need to assess the negative effects of CBT-I with an insomnia-specific instrument. The CFA suggests that the 24-item NEQ-Insomnia is a valid instrument, suitable for standalone use or as an extension to the NEQ for assessing the negative effects of CBT-I.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 200-211"},"PeriodicalIF":3.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum levels of 1,3-β-D-glucan is correlated with NLRP3 inflammasome activation and insomnia severity in people with chronic insomnia disorder","authors":"Yasaman Afsari ,&nbsp;Fereshteh Atabi ,&nbsp;Zahra Aghelan ,&nbsp;Habibolah Khazaie ,&nbsp;Zahra Vakili ,&nbsp;Seyed Hosein Abtahi ,&nbsp;Mahan Rezaie Pouya","doi":"10.1016/j.sleep.2025.02.046","DOIUrl":"10.1016/j.sleep.2025.02.046","url":null,"abstract":"<div><div>This study aimed to explore the correlation between serum levels 1,3-β-D-glucan as a biomarker for gut microbiome imbalance and NLRP3 inflammasome/IL-1β axis activation and insomnia severity in humans with chronic insomnia disorder (CID). Blood samples were collected from 20 people diagnosed with CID based on the Pittsburgh Sleep Quality Index (PSQI) and video-polysomnography and 20 healthy individuals based on PSQI. 1,3-β-D-glucan, IL-1β, and NLRP3 protein serum levels were assayed using enzyme-linked immunosorbent assay (ELISA). 1,3-β-D-glucan, IL-1β, and NLRP3 protein serum concentrations in the CID group were significantly higher than in the control group. Also, we observed a significant positive correlation between the serum levels of these three factors in the CID group and a significant positive correlation between 1,3-β-D-glucan and insomnia severity index. Our findings suggest that 1,3-β-D-glucan may indicate gut microbiome imbalance in people with CID and may play an important role in the pathogenesis of chronic insomnia by activating the NLRP3/IL-1β inflammasome pathway. These results highlight the potential for dual therapeutic strategies targeting gut microbiota modulation and NLRP3 inflammasome inhibition to disrupt the neuroinflammatory cascade driving chronic insomnia.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 187-191"},"PeriodicalIF":3.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parkinson’s disease: News on the action of melatonin","authors":"Fulvio A. Scorza ,&nbsp;Raphael Wuo-Silva ,&nbsp;Josef Finsterer ,&nbsp;Feres Chaddad-Neto","doi":"10.1016/j.sleep.2025.02.038","DOIUrl":"10.1016/j.sleep.2025.02.038","url":null,"abstract":"<div><div>Melatonin has been shown to improve sleep quality in Parkinson's disease (PD) patients with good safety and tolerability. Beyond its neurological benefits, emerging evidence suggests that melatonin may exert cardioprotective effects, which could be relevant in the context of sudden unexpected death in PD (SUDPAR). PD is associated with high mortality rates, and autonomic dysfunction and cardiac abnormalities may play a role in SUDPAR. Translational studies suggest that melatonin concentrations could serve as potential biomarkers for cardiac dysfunction in PD. Melatonin supplementation has demonstrated neuroprotective properties by modulating apoptosis, autophagy, oxidative stress, inflammation, α-synuclein aggregation, and dopamine loss. Additionally, clinical data indicate that melatonin levels are altered in patients with coronary heart disease, heart failure, and stroke. Reduced melatonin production is associated with increased risk of cardiac events and sudden cardiac death. Given its anti-inflammatory, antioxidant, immunomodulatory, and vasomotor properties, melatonin may represent a promising adjunctive therapy for PD, potentially mitigating both neurological and cardiovascular risks.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"130 ","pages":"Pages 1-2"},"PeriodicalIF":3.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary findings of DNA hypermethylation of MDGA1 in idiopathic restless legs syndrome","authors":"Xiao-Ying Zhu ,&nbsp;Xin-Rong He ,&nbsp;Yu Wang ,&nbsp;Chun-Ni Guo ,&nbsp;Hong-Ming Wang ,&nbsp;Xuan Li ,&nbsp;Xi-Xi Wang ,&nbsp;Jing Zhang ,&nbsp;Ya Feng ,&nbsp;Jing-Tao Feng ,&nbsp;Jia-Peng Zhao ,&nbsp;Shu-Qin Chen ,&nbsp;Yue Zhang ,&nbsp;Te Liu ,&nbsp;Yun-Cheng Wu","doi":"10.1016/j.sleep.2025.02.042","DOIUrl":"10.1016/j.sleep.2025.02.042","url":null,"abstract":"<div><h3>Background</h3><div>Both genetic and environmental factors contribute to the development of restless legs syndrome (RLS). Epigenetic mechanisms might play a vital role in RLS but remain underexplored. MDGA1, involved in synaptic inhibition, has been identified by genome-wide association studies as a potential risk gene for RLS. However, its role and underlying mechanisms in RLS are largely unknown.</div></div><div><h3>Objective</h3><div>To investigate the relationship between DNA methylation levels in the promotor region of MDGA1 and RLS susceptibility and phenotypes.</div></div><div><h3>Methods</h3><div>Two independent RLS cohorts (including three large RLS families) and healthy controls (HCs) were recruited. Clinical characteristics were recorded, and DNA methylation levels of CpG islands in the MDGA1 gene from peripheral blood mononuclear cells were measured. Associations between MDGA1 methylation (MDGA1m) and RLS phenotypes (age, sex, and family history) were also analyzed.</div></div><div><h3>Results</h3><div>A total of 62 idiopathic RLS (iRLS) patients (29 from Cohort 1 and 33 from Cohort 2) and 45 healthy controls (24 from Cohort 1 and 21 from Cohort 2) were included. MDGA1 methylation levels were significantly higher in iRLS patients compared to HCs. Among RLS families, both RLS patients and non-RLS family members showed hypermethylation compared to HCs. Moreover, a positive family history of RLS was associated with an increased risk of MDGA1 hypermethylation.</div></div><div><h3>Conclusion</h3><div>Our study identified hypermethylation of the MDGA1 gene in the peripheral blood of RLS cases, which may be linked to family history.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 264-273"},"PeriodicalIF":3.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143578762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insomnia features and patient-reported daytime sleepiness in patients with obstructive sleep apnea","authors":"Gouveris H. ,&nbsp;Deiß A. ,&nbsp;Hackenberg B. ,&nbsp;Bahr-Hamm K. ,&nbsp;Huppertz T. ,&nbsp;Ludwig K. ,&nbsp;Matthias C. ,&nbsp;Simon P.","doi":"10.1016/j.sleep.2025.02.035","DOIUrl":"10.1016/j.sleep.2025.02.035","url":null,"abstract":"<div><div>Previous preliminary evidence suggests insomnia features playing a major causative or confounding role in daytime sleepiness in obstructive sleep apnea (OSA) patients. We investigated further this hypothesis in a larger OSA patient cohort. In a cross-sectional study in a tertiary medical center, consecutive patients presenting with suspected OSA, but without other sleepiness-promoting comorbidities, and tested by in-lab polysomnography (PSG) were evaluated prospectively for excessive daytime sleepiness (EDS) using the Epworth Sleepiness Scale (ESS) and for insomnia using the Insomnia Severity Index (ISI) respectively. Two hundred and thirty patients (63 female; average age: 54,1 y) were included in this OSA treatment-naïve cohort. ISI values correlated best (Spearman's rho = 0,29, p &lt; .001) with the total ESS score than any PSG -associated metric did. Especially ISI item 7- (interference of sleep problems with daily functions, r = 0,33, p &lt; .001) and item 2 - (difficulty staying asleep, r = 0,28, p &lt; .001) and to a lesser degree item 4 - (satisfaction with own current sleep patterns, r = 0,23, p = 0,025) scores showed significant correlations. Notably, no single significant correlation was found between ESS score and any PSG-metric at all. In a multiple regression analysis, the ISI item 7 score emerged as the sole significant independent predictor of the ESS score. We conclude that insomnia may significantly impact patient-reported daytime sleepiness in OSA patients. We suggest that assessment of insomnia symptoms and features (e.g. by means of ISI) should always be performed in OSA patients reporting daytime sleepiness. We propose that these preliminary findings should be validated in larger and diverse cohorts of OSA patients.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 292-296"},"PeriodicalIF":3.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}