Sleep medicine最新文献

{"title":"K- complex metrics predict psychomotor vigilance in young and middle-aged adults with obstructive sleep apnea: A severity-dependent neural biomarker study","authors":"Rongcui Sui ,&nbsp;Jie Li ,&nbsp;Yunhan Shi ,&nbsp;Shizhen Yuan ,&nbsp;Xingjun Wang ,&nbsp;Wen Xu ,&nbsp;Ming Xia ,&nbsp;Yanru Li ,&nbsp;Demin Han","doi":"10.1016/j.sleep.2025.106750","DOIUrl":"10.1016/j.sleep.2025.106750","url":null,"abstract":"<div><h3>Background</h3><div>K-complexes, electroencephalographic markers of sleep protective mechanisms, may reflect cognitive impairment in obstructive sleep apnea (OSA). We investigated whether K-complex metrics (frequency, density, duration, amplitude) independently predict psychomotor vigilance in patients with OSA.</div></div><div><h3>Methods</h3><div>In 140 young and middle-aged adults, K-complexes were automatically detected via a U-Net neural network analyzing F3-M2 electroencephalogram recording. K-complex metrics, including frequency (Hz), density (events/min), duration (sec) and amplitude (μV), were measured. Psychomotor vigilance was assessed via standardized Psychomotor Vigilance Test (PVT). Hierarchical regression models evaluated associations between K-complex metrics and psychomotor vigilance, adjusted for age, education, and apnea-hypopnea index (AHI).</div></div><div><h3>Results</h3><div>K-complex metrics showed severity-dependent associations with psychomotor vigilance in young and middle-aged adults with OSA, meaning the nature of these associations predictably changed based on OSA severity. In patients with mild/moderate OSA, lower K-complex frequency (p = 0.011) was associated with better psychomotor vigilance. In patients with severe OSA, higher K-complex density (p = 0.019) and amplitude (p = 0.030) were independently associated with better psychomotor vigilance. K-complex metrics explained 15.2 % and 23.5 % additional variance in PVT Lapses in patients with mild/moderate and severe OSA, respectively. Age, education, and AHI further modulated psychomotor vigilance, particularly in patients with mild/moderate OSA.</div></div><div><h3>Conclusions</h3><div>K-complex density, frequency, and amplitude serve as severity-dependent neural biomarkers of psychomotor vigilance in young and middle-aged adults with OSA. These findings suggest the role of sleep metrics in psychomotor vigilance and highlight potential electrophysiological targets for intervention.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"135 ","pages":"Article 106750"},"PeriodicalIF":3.4,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144890970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Listening to the sound of your own brain waves enhances sleep quality and quantity.","authors":"A Aloulou, M Chauvineau, A Destexhe, D Léger","doi":"10.1016/j.sleep.2025.106755","DOIUrl":"https://doi.org/10.1016/j.sleep.2025.106755","url":null,"abstract":"<p><p>This pilot study examined the effects of relaxing personalized sound sequences (PSS), derived from individual slow-wave brain activity on sleep in adults with subjective insomnia complaints. Thirteen participants underwent one-night polysomnography to record delta wave activity (0.5-4 Hz), which was then transformed into individualized sound sequences. A randomized, single-blind, crossover protocol was then conducted at home, including two conditions of 3-5 consecutive nights: listening to the PSS and a non-personalized placebo sound sequence (PLA) for 30 min at bedtime. Objective sleep was assessed using a dry-electroencephalographic (EEG) headband and subjective sleep with a digital sleep diary. Compared to PLA, the PSS condition significantly increased total sleep time (Δ = +21.4 min, p = 0.05) and REM sleep proportion (Δ = +2.6 %, p < 0.05), reduced REM latency (Δ = -15.6 min, p < 0.05) and improved overall sleep quality score (Δ = +1.5 A U., p < 0.05). Exploratory trends suggested that participants with the shorter sleep duration (<390 min, n = 5) and longer sleep onset latencies (>20 min, n = 4) in the PLA condition experienced greater improvements with PSS. These preliminary results suggest that listening to one's own slow brain waves converted into sound may improve both sleep quality and quantity in individuals with moderate insomnia, with potentially enhanced benefits for those with more severe sleep difficulties.</p>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":" ","pages":"106755"},"PeriodicalIF":3.4,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respiratory changes in sleep bruxism: a message from central sleep apnea","authors":"Qian Ouyang ,&nbsp;Zhijun Zhong ,&nbsp;Qi Li ,&nbsp;Xueliang Zou ,&nbsp;Chunmei Gan ,&nbsp;Fang Yi ,&nbsp;Dongyuan Yao","doi":"10.1016/j.sleep.2025.106751","DOIUrl":"10.1016/j.sleep.2025.106751","url":null,"abstract":"","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"135 ","pages":"Article 106751"},"PeriodicalIF":3.4,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144896387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between insomnia, chronotype, and positive airway pressure adherence in children and adolescents","authors":"Lena Xiao ,&nbsp;Rianna Sarbajna ,&nbsp;Sarah Kuyntjes ,&nbsp;Nisha Cithiravel ,&nbsp;Reshma Amin ,&nbsp;Jackie Chiang ,&nbsp;Adele Baker ,&nbsp;Indra Narang","doi":"10.1016/j.sleep.2025.106745","DOIUrl":"10.1016/j.sleep.2025.106745","url":null,"abstract":"<div><h3>Study objectives</h3><div>Positive airway pressure (PAP) therapy is highly efficacious for the treatment of sleep-disordered breathing in children but is limited by poor adherence. We sought to evaluate the relationship between insomnia and chronotype on PAP adherence in children.</div></div><div><h3>Methods</h3><div>This is a cross-sectional study conducted at the Hospital for Sick Children (Toronto, Canada) of children aged 4–18 years old prescribed PAP for a minimum of six months. Self-reported and/or caregiver-reported questionnaires including the Pediatric Insomnia Severity Index and Children's Chronotype Questionnaire were completed. PAP therapy usage was measured using objective download data.</div></div><div><h3>Results</h3><div>There were 159 participants included (median age = 14.2 years, females = 38%). Median PAP usage was 436.0 min/night (IQR 147.0, 516.0) for the morning group, 417.0 min/night (IQR 189.2, 538.8) for the intermediate group, and 161.5 min/night (IQR 6.0, 405.2) for the evening group. Children with an evening chronotype used PAP therapy for a median of 264.4 min less per night than children with an intermediate chronotype (95% CI 65.8, 397.1; p = 0.0018). Children used PAP therapy for 37.0 min less per night for each 1-point increase in the sleep maintenance problems score (95% CI 10.0, 47.7; p &lt; 0.001) and 33.7 min less per night for each 1-point increase in the sleep onset problems score (95% CI 20.0, 39.5; p &lt; 0.001). Sleep onset and sleep maintenance problems significantly influenced the relationship between chronotype and PAP usage.</div></div><div><h3>Conclusion</h3><div>We found that insomnia and evening chronotype were associated with reduced PAP adherence in children. These may be modifiable factors to promote PAP adherence.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"135 ","pages":"Article 106745"},"PeriodicalIF":3.4,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144896745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a home-based videoconferencing exercise training program on circadian rhythms and sleep quality in healthy older adults","authors":"E. Milot ,&nbsp;A. Langeard ,&nbsp;S. Rehel ,&nbsp;L. Bigot ,&nbsp;A. Gauthier ,&nbsp;N. Bessot ,&nbsp;G. Quarck","doi":"10.1016/j.sleep.2025.106746","DOIUrl":"10.1016/j.sleep.2025.106746","url":null,"abstract":"<div><div>The aging process affects circadian rhythms and sleep quality, leading to various disruptions and health challenges. These changes, along with increased sedentary behavior, contribute to deteriorating sleep quality and overall health. Physical activity is crucial for entraining circadian rhythm and sleep improvement. Despite the well-explored benefits of face-to-face physical training, accessibility barriers for older adults necessitate innovative approaches like videoconferencing interventions. This study evaluated the effects of a home-based videoconferencing exercise training (ET) program on circadian rhythms and sleep quality in healthy older adults. Forty-three participants (61–79 years) were randomized to either remote physical ET or health education sessions (active control (AC) group). Pre- and post-intervention evaluations included circadian rhythm assessment using 7-day actigraphy and sleep quality via two polysomnography sessions. Significant differences between groups were observed in Z-score changes for mesor and amplitude values. Significant differences between groups in Z-score changes were also observed for sleep efficiency, the percentage of stage 1 sleep values, and insomnia severity index scores between. The study findings suggest that a home-based videoconferencing ET program positively impacts circadian rhythms and sleep quality in healthy older adults. This non-pharmaceutical approach offers an accessible and scalable solution to address age-related sleep disturbances and enhance overall well-being. However, findings on objective and subjective sleep parameters are preliminary and need confirmation in larger, standardized studies.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"134 ","pages":"Article 106746"},"PeriodicalIF":3.4,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144879455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-sleep electroencephalographic slowing correlates with the severity of obstructive sleep apnea and daytime sleepiness","authors":"Xiaoli Li ,&nbsp;Yuhan Xu ,&nbsp;Hui Xu ,&nbsp;Jianing Yang ,&nbsp;Yijing Guo","doi":"10.1016/j.sleep.2025.106753","DOIUrl":"10.1016/j.sleep.2025.106753","url":null,"abstract":"","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"135 ","pages":"Article 106753"},"PeriodicalIF":3.4,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144890969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biphasic sleep and human health: A theoretical paradigm for personalized sleep","authors":"João Sena-Ribeiros ,&nbsp;Cátia Reis","doi":"10.1016/j.sleep.2025.106743","DOIUrl":"10.1016/j.sleep.2025.106743","url":null,"abstract":"<div><div>As our understanding of sleep evolves, a recurring recommendation remains that adults should sleep in a single, uninterrupted nocturnal bout – commonly referred to as monophasic sleep. However, the scientific foundation for this standard may be less canonical than previously assumed, particularly when considering individual variability in sleep needs and organization. Historical texts and recent research suggest an alternative view: that sleep can be naturally segmented into two periods across the 24h cycle – a pattern known as biphasic sleep. This review explores the physiological implications of biphasic sleep, examining its potential benefits and limitations under healthy conditions and in particular contexts, such as shift working. With this available data, an original hypothesis is proposed, consisting of a novel framework of sleep distribution according to sleeping types. This aims to stimulate new research about biphasic schedules and how sleep architecture might adapt to them over time. The strengths and weaknesses of existing research will be critically assessed, culminating in recommendations for future investigations and methodological approaches. These insights may ultimately inform more personalized and flexible sleep guidelines better aligned with individual and societal needs.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"134 ","pages":"Article 106743"},"PeriodicalIF":3.4,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal investigation of sleep and circadian rest-activity rhythms in non-small cell lung cancer patients during immunotherapy and associations with fatigue, depression, and perceived stress","authors":"Louise Strøm ,&nbsp;Robert Zachariae ,&nbsp;Lisa M. Wu ,&nbsp;Peter Meldgaard ,&nbsp;Sonia Ancoli-Israel ,&nbsp;Mats Lekander ,&nbsp;Daniel Mroczek ,&nbsp;Ali Amidi","doi":"10.1016/j.sleep.2025.106740","DOIUrl":"10.1016/j.sleep.2025.106740","url":null,"abstract":"<div><h3>Background</h3><div>Patients with advanced non-small cell lung cancer (NSCLC) face poor prognosis. However, new therapies like immune checkpoint inhibitors (ICIs) have improved survival. Nevertheless, ICIs act through immune activation – a proposed underlying mechanism of frequently reported symptoms such as sleep and circadian disturbances. The objective of this study was to longitudinally investigate sleep and circadian rest-activity rhythms and associations with psychological symptoms in NSCLC during ICI treatment.</div></div><div><h3>Methods</h3><div>Newly diagnosed NSCLC patients were included in this prospective study, assessing insomnia severity, total sleep time, circadian rest-activity rhythms, and psychological symptoms (fatigue, depression, and stress) during the first five months of ICI treatment, using validated questionnaires, sleep diaries and actigraphy.</div></div><div><h3>Results</h3><div>Forty-nine patients were included. Prior to treatment, patients slept on average 5.8 hours/night and 49 % reported clinical levels of insomnia. Spontaneous improvements in insomnia severity and total sleep time were observed, along with marginal but non-significant improvements in circadian rest-activity rhythm robustness. Insomnia severity was significantly associated with higher levels of fatigue (p = .004), depression (p = .007), and perceived stress (p = .033). Moreover, lower circadian rest-activity robustness was associated with more fatigue (p = .021). At baseline, mean levels of fatigue, depression, and perceived stress were below clinical levels and declined further over time.</div></div><div><h3>Conclusion</h3><div>Sleep disturbances, circadian disruption, and psychological symptom burden in NSCLC patients were greatest prior to and shortly after initiation of ICI treatment, with gradual improvement over the first five months. However, inter-individual differences in sleep and circadian disturbances were evident and linked to psychological symptoms.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"134 ","pages":"Article 106740"},"PeriodicalIF":3.4,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144830129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissecting circadian and homeostatic processes in adolescents: An actigraphic study","authors":"Vincenzo Natale,&nbsp;Alice Andreose,&nbsp;Valeria Bacaro,&nbsp;Sara Giovagnoli,&nbsp;Federica Giudetti,&nbsp;Martina Grimaldi,&nbsp;Lorenzo Tonetti,&nbsp;Elisabetta Crocetti","doi":"10.1016/j.sleep.2025.106738","DOIUrl":"10.1016/j.sleep.2025.106738","url":null,"abstract":"<div><div>The present work used actigraphy to ecologically analyze the roles of circadian and homeostatic processes during the wake-sleep and sleep-wake transitions in adolescents. Four hundred and forty-three adolescents (15.6 ± 1.2 mean age; 45.1 % females) were enrolled in the research and wore an actigraph on the non-dominant wrist for at least three nights. We extracted the minute-by-minute motor activity counts across the wake-sleep transition to depict the motor wake inertia as modulated by the total of the previous wake hour (homeostatic process) or by the time of day of the bedtime (circadian process). The same was done for the sleep-wake transition to analyze whether motor sleep inertia is modulated primarily by the previous total sleep time or by the time of awakening. We performed the Functional Linear Modelling statistical framework in addition to the usual parametric statistics. Overall, results indicate a more substantial role of the homeostatic process in comparison to the circadian process during the wake-sleep transition, while results are less clear for the sleep-wake transition. The findings underscore the importance of ecologically studying the transition phases between wakefulness and sleep, as well as sleep and wakefulness, through actigraphy. To formulate new guidelines aimed at enhancing sleep quality during adolescence, further research is essential. For instance, it would be beneficial to explore how this pattern of outcomes may differ across the lifespan.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"134 ","pages":"Article 106738"},"PeriodicalIF":3.4,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144809878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Home video clips compared to polygraphy for obstructive sleep apnea diagnosis in children with autism spectrum disorder: A pilot study","authors":"Gianna Cox ,&nbsp;Sherri Lynne Katz ,&nbsp;Vid Bijelić ,&nbsp;Nicholas Barrowman ,&nbsp;Taylor Barwell ,&nbsp;Roya Shamsi ,&nbsp;Henrietta Blinder ,&nbsp;Melissa Cleroux ,&nbsp;Martine Brunet ,&nbsp;Jessica Remedios ,&nbsp;Taylor Johansen ,&nbsp;Naomi Dussah ,&nbsp;Refika Ersu","doi":"10.1016/j.sleep.2025.106737","DOIUrl":"10.1016/j.sleep.2025.106737","url":null,"abstract":"<div><h3>Introduction</h3><div>Children with autism spectrum disorder (ASD) have higher prevalence of obstructive sleep apnea (OSA) than typically developing children. Polysomnography (PSG), the gold standard test is challenging for children with ASD. Polygraphy (PG) may be better tolerated, but more accessible screening tools are needed. We evaluated diagnostic characteristics of video clips for OSA in this pilot study.</div></div><div><h3>Methods</h3><div>Children 4–18 years with ASD referred for PSG for suspected OSA were recruited. Parents recorded 3 2-min home videos, scored for OSA presence using Monash score (MS, positive if ≥ 3). Participants completed the Pediatric Sleep Questionnaire (PSQ; positive if ≥ 0.33) and underwent home PG, scored by obstructive apnea hypopnea index (oAHI), oxygen desaturation index 3 % (ODI3; ≥4.3 and &gt; 7 thresholds) and McGill Oximetry Score (MOS; positive if ≥ 2). Receiver-operator curves were used to compare diagnostic performance across tools for moderate-severe OSA (oAHI ≥5 events/hour).</div></div><div><h3>Results</h3><div>26 children participated; 15 (median age 7.1) provided video clips. Median oAHI was 2.4/hr; 26.7 % had moderate-severe OSA. Fourteen (93.3 %) had PSQ ≥0.33, three had MOS ≥2. ODI3 was ≥4.3 in 7 and &gt; 7 in 6 children. Median MS was 3.0. MS had 100 % sensitivity, 63.6 % specificity and AUC 78.4 for detecting moderate-severe OSA; average AUC increased when MS was combined with oximetry metrics.</div></div><div><h3>Conclusion</h3><div>MS showed high sensitivity but low specificity in detecting moderate-severe OSA. MS outperformed PSQ and MOS, but not ODI3. MS may be a viable alternative screening tool to identify OSA in children with ASD but requires further validation.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"134 ","pages":"Article 106737"},"PeriodicalIF":3.4,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144852793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}