Sleep medicine最新文献

{"title":"Sleep quality and sleep duration are associated with charitable donations: Evidence from two population-based surveys","authors":"Allison E. Nickel,&nbsp;Michael K. Scullin","doi":"10.1016/j.sleep.2024.10.007","DOIUrl":"10.1016/j.sleep.2024.10.007","url":null,"abstract":"<div><h3>Study objectives</h3><div>Insufficient sleep alters emotional processing, leading to mood disturbances, reduced gratitude, and potentially the withdrawal of compassionate helping. Using data from two national surveys, we investigated whether sleep quality and sleep duration were associated with willingness to donate to local charities and places of worship.</div></div><div><h3>Methods</h3><div>We conducted secondary analyses of two Gallup-administered studies that used random address-based sampling methodologies to approximate population-representative samples. BRS-5 included 1501 respondents and BRS-6 included 1336 respondents (independent samples). Each survey inquired about sleep quality and whether participants had donated in the last year to local organizations and places of worship. In addition, BRS-5 included questions about sleep duration.</div></div><div><h3>Results</h3><div>In both studies, participants who had better sleep quality and better sleep durations were more likely to donate charitably to local organizations and places of worship (ORs of 1.07–1.45). Most associations remained significant when accounting for age, gender, and income.</div></div><div><h3>Conclusion</h3><div>Better sleep was associated with a greater likelihood to donate charitably. Experimental work is needed to determine if the relationship between sleep health and prosocial behaviors is uni- or bi-directional.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 378-380"},"PeriodicalIF":3.8,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142401373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidimensional phenotyping to distinguish among central (CSA), obstructive (OSA) and co-existing central and obstructive sleep apnea (CSA-OSA) phenotypes in real-world data","authors":"Jean-Louis Pépin ,&nbsp;Alan R. Schwartz ,&nbsp;Rami Khayat ,&nbsp;Robin Germany ,&nbsp;Scott McKane ,&nbsp;Matthieu Warde ,&nbsp;Van Ngo ,&nbsp;Sebastien Baillieul ,&nbsp;Sebastien Bailly ,&nbsp;Renaud Tamisier","doi":"10.1016/j.sleep.2024.09.040","DOIUrl":"10.1016/j.sleep.2024.09.040","url":null,"abstract":"<div><h3>Purpose</h3><div>When navigating the landscape of obstructive sleep apnea (OSA), central sleep apnea (CSA) and intersection of the two diseases (co-existing CSA-OSA), there are significant knowledge gaps. Data are scarce regarding the respective prevalence and differences in clinical presentation of the three conditions. One major issue for characterization of the prevalence of the different sleep apnea entities is the scoring of central versus obstructive hypopneas which is not included in the routine practice of many sleep laboratories.</div></div><div><h3>Method</h3><div>We prospectively assessed multidomain symptoms and collected data on comorbidities, medications and treatment indications in a large monocentric real-life dataset (n &gt; 2400) of patients referred for suspicion of sleep apnea. We have systematically distinguished central versus obstructive hypopneas to define OSA, CSA and co-existing CSA-OSA.</div></div><div><h3>Results</h3><div>When CSA was defined by the proportion of central apneas (and hypopneas were considered obstructive by default), the prevalence of CSA was 4.59 % (co-existing CSA-OSA: 11.03 %, and OSA: 84.37 %). When the distinction between obstructive and central hypopneas was used to classify the sleep disordered breathing, the prevalence of CSA was fourfold higher at 19.69 % (co-existing: 19.16 %, OSA: 61.16 %). The burden of cardiovascular and metabolic comorbidities was the highest in the CSA and co-existing sleep apnea subgroups. The three sleep apnea groups exhibited different constellations of symptoms but most of the patients with CSA, co-existing and OSA were symptomatic after comprehensive evaluation. The CSA group exhibited the most severe disturbances in sleep architecture on polysomnography. Therapeutic indications differed depending on the subtype of respiratory events.</div></div><div><h3>Conclusion</h3><div>Our findings imply that <em>not</em> differentiating between central and obstructive hypopneas will underestimate the severity of central sleep disordered breathing abnormalities that mislead therapeutic decisions and might limit improvements in quality of life and sleepiness that are expected in appropriately treated patients with CSA.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 426-433"},"PeriodicalIF":3.8,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between temporomandibular and sleep disorders in adults: An overview of systematic reviews","authors":"Marcelo Rigon ,&nbsp;Karen Obara ,&nbsp;Luana Paixão ,&nbsp;Jefferson Rosa Cardoso ,&nbsp;Almiro José Machado Junior","doi":"10.1016/j.sleep.2024.10.002","DOIUrl":"10.1016/j.sleep.2024.10.002","url":null,"abstract":"<div><h3>Objective</h3><div>This study emphasizes the general relevance of sleep disorders (SD) and temporomandibular disorders (TMD), explores their bidirectional relationship, and describes the importance of systematic reviews in the critical analysis of the literature. This review aimed to comprehensively summarize the relationship between SD and TMD in adults while ensuring a reliable and objective analysis of data from the existing literature.</div></div><div><h3>Methods</h3><div>Systematic reviews were evaluated to investigate this association between two conditions in adults. The study was registered with Prospero and followed the PECOT structure in identifying the research question. Searches in multiple databases were conducted until February 2024 using relevant keywords. The risk of bias was assessed using the Risk of Bias in Systematic Reviews tool, involving two independent reviewers.</div></div><div><h3>Results</h3><div>Data were extracted using different evaluation instruments, and results were analyzed and presented through the synthesis of information collected in selected systematic reviews. The selection included seven systematic reviews of observational studies, with exclusion criteria defined to ensure methodological quality. The results showed that reviewed studies presented clarity and relevance in defining the eligibility criteria, but that the identification and selection of studies, data collection, and synthesis of results varied. Most studies considered the potential risks, but some require greater transparency and methodological rigor.</div></div><div><h3>Conclusions</h3><div>This review points out the association between SD and TMD in adults, with most studies presenting a low risk of bias, although some uncertainties were observed.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 404-415"},"PeriodicalIF":3.8,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142422951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptive sleep behaviours and shift work tolerance during the transition to shift work","authors":"Rachael Harris ,&nbsp;Sean P.A. Drummond ,&nbsp;Ben Meadley ,&nbsp;Shantha M.W. Rajaratnam ,&nbsp;Brett Williams ,&nbsp;Karen Smith ,&nbsp;Kelly-Ann Bowles ,&nbsp;Elle Nguyen ,&nbsp;Megan L. Dobbie ,&nbsp;Alexander P. Wolkow","doi":"10.1016/j.sleep.2024.10.003","DOIUrl":"10.1016/j.sleep.2024.10.003","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate whether recruit paramedics adapt their sleep behaviour during the first 12-months of shift work and to identify sleep behaviours that are associated with better shift work tolerance (SWT) after 12-months of shift work.</div></div><div><h3>Methods</h3><div>Recruit paramedics (n = 105; M_age = 25.81 years; 51.38% female) were evaluated before (baseline), and after six- and 12-months of shift work. At each timepoint, participants completed questionnaires evaluating their mental health and sleep. Participants also underwent 14 days of sleep and shift monitoring (sleep/work diaries and actigraphy) at each timepoint to examine sleep behaviours, including sleep opportunity (SO), sleep regularity and number of sleep episodes.</div></div><div><h3>Results</h3><div>Linear mixed models found SO increased (on day shifts and rest days), and sleep regularity decreased between baseline and follow-up timepoints. There were no changes in SO (on day shifts, nightshifts, and rest days) or sleep regularity between six- and 12-months of shift work. Latent profile analysis at 12-months follow-up identified high (n = 52), medium (n = 27), and low (n = 9) SWT levels (measured via depression, anxiety, insomnia, sleep quality and sleep efficiency) in paramedics. Reduced sleep regularity (i.e., more irregular sleep) between six- and 12-months of work and prioritising major sleep (rather than naps) at six-months predicted high SWT.</div></div><div><h3>Conclusions</h3><div>These findings suggest clear SWT levels exist early in paramedics' careers whereby symptoms of depression, anxiety, and insomnia were the strongest contributors to SWT. New paramedics’ sleep behaviours, including sleep regularity and prioritisation of longer sleep between nightshifts, may play an important role in influencing how paramedics tolerate shift work.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 483-493"},"PeriodicalIF":3.8,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Signal detection of drugs associated with obstructive and central sleep apnoea","authors":"C. Jambon-Barbara ,&nbsp;B. Revol ,&nbsp;A. Hlavaty ,&nbsp;M. Joyeux-Faure ,&nbsp;J.C. Borel ,&nbsp;J.L. Cracowski ,&nbsp;J.L. Pepin ,&nbsp;C. Khouri","doi":"10.1016/j.sleep.2024.09.045","DOIUrl":"10.1016/j.sleep.2024.09.045","url":null,"abstract":"<div><div>We aim to discover new safety signals of drug-induced sleep apnoea (SA), a global health problem affecting approximately 1 billion people worldwide.</div><div>We first conducted a series of sequence symmetry analyses (SSA) in a cohort composed from all patients who received a first SA diagnosis or treatment between 2006 and 2018 in the Echantillon Généraliste des Bénéficaires (EGB), a random sample of the French healthcare database. We used two primary outcomes to estimate the sequence ratio (SR) for all drug classes available in France: a sensitive one (diagnosis or treatment of SA) and a specific one (Positive Airway Pressure (PAP) therapy). We then performed disproportionality analyses using the “Bayesian neural network method” on all cases of sleep apnoea (MedDRA high level term) reported up to November 2023 in the World Health Organisation (WHO) pharmacovigilance database.</div><div>Among the 728,167 individuals, 46,193 had an incident diagnosis or treatment for SA and 17,080 had started an incident treatment by PAP therapy. Fifty-eight drug classes had a significant SR, with 7 considered highly plausible: opium alkaloids and derivatives, benzodiazepine derivatives, other centrally acting agents, other anxiolytics, carbamic acid esters, quinine and derivatives and antivertigo preparations; with consistent signals found for the first 3 drug classes in the disproportionality analysis.</div><div>In this signal detection study, we found that opioids, benzodiazepines (but not Z-drugs) and myorelaxing agents are associated with the onset or aggravation of SA. Moreover, a new safety signal for antivertigo preparations such as betahistine emerged and needs to be further explored.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 315-322"},"PeriodicalIF":3.8,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142376042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond bedwetting: How successful treatment is observed in sleep macrostructure","authors":"Leticia Azevedo Soster ,&nbsp;Simone Nascimento Fagundes ,&nbsp;Adrienne Lebl ,&nbsp;Rosana Cardoso Alves ,&nbsp;Vera H. Koch ,&nbsp;Karen Spruyt","doi":"10.1016/j.sleep.2024.09.035","DOIUrl":"10.1016/j.sleep.2024.09.035","url":null,"abstract":"<div><h3>Introduction</h3><div>Sleep enuresis (SE), commonly known as bedwetting, refers to involuntary urination during sleep. It is a prevalent condition affecting approximately 15 % of children at age 5, 10 % by age 7, and 5 % by age 10. This condition can significantly impact both children and their families. The pathophysiology of SE is complex and not yet fully understood. There are several established treatment methods, but limited information on their sleep dynamics.</div></div><div><h3>Objective</h3><div>This study aimed to evaluate differences in sleep structure before and after treatment in patients with monosymptomatic SE (MSE), focusing on alarm therapy, desmopressin, and a combination of both. The analysis compared pre- and post-treatment differences within each treatment arm. The analysis was conducted for both successful and unsuccessful treatment outcomes.</div></div><div><h3>Methods/results</h3><div>This was a prospective study with MSE patients, aged 6–16 years, diagnosed by multidisciplinary assessment. Of the 140 initial applicants 75 were initially included in the study and randomized for therapeutic intervention in three treatment arms, namely: alarm, desmopressin and alarm + desmopressin. Therapeutic response was evaluated 12 months after treatment discontinuation. Polysomnographic evaluation pre and post treatment was carried out. 51/75 completed the entire protocol. 42/51 were successfully treated and had a median age of 10 [8–12] and the non-success, 8 [7–10]. Among the successful patients, the percentage of N2 sleep decreased from a median of 55.7 %–48.5 % (p = 0.0004) in the alarm arm, from 58.8 % to 50 % (p = 0.002) in the desmopressin arm, and from 54.7 % to 50.9 % (p = 0.044) in the combined arm. The percentage of N3 sleep increased from 25.7 % to 30.1 % (p = 0.004) in the alarm arm, from 21.6 % to 26 % (p = 0.032) in the desmopressin arm, and from 23.7 % to 28.3 % (p = 0.014) in the combined arm. The arousal index significantly increased from pre-to post-treatment in all arms: in the alarm arm, from 1.25 to 2.8 (p = 0.002); in the desmopressin arm, from 1.3 to 2.7 (p = 0.019); and in the combined treatment arm, from 1 to 4 (p = 0.003). No significant differences were observed in the non-successful arm or among those who experienced complete resolution of the enuresis without treatment.</div></div><div><h3>Conclusion</h3><div>The observed increase in N3 sleep and arousal and decrease in N2 sleep following successful treatment, regardless of the specific interventions, underscores the role of sleep in the pathophysiology of enuresis. Conversely, the lack of sleep differences in the non-successful arm further highlights the importance of sleep, beyond developmental factors, in influencing the clinical outcomes of enuresis, especially since all children were assessed 12 months after the start of treatment.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 331-337"},"PeriodicalIF":3.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are scoring respiratory effort-related arousals worth the effort? --A study comparing outcomes between 4 % vs 3 % hypopnea scoring rules","authors":"Xinhang Tu ,&nbsp;Timothy I. Morgenthaler ,&nbsp;Julie Baughn ,&nbsp;Daniel L. Herold ,&nbsp;Melissa C. Lipford","doi":"10.1016/j.sleep.2024.09.037","DOIUrl":"10.1016/j.sleep.2024.09.037","url":null,"abstract":"<div><h3>Study objectives</h3><div>The respiratory effort-related arousal (RERA) has been combined with apneas and hypopneas into the respiratory disturbance index (RDI). RERAs are characterized by ≥ 10 s of increasing upper airway effort terminating in arousal without meeting hypopnea criteria. The recent change to hypopnea definitions now includes a ≥30 % reduction in airflow for 10 s with EITHER a 3 % oxygen desaturation OR an arousal. Consequently, many events previously categorized as RERAs will now be included in the 3 % hypopneas, likely reducing the number of events scored as RERAs. We hypothesized that the 3 % apnea-hypopnea index (3%AHI) would approximate the 4%RDI, with the number of 3 % RERAs being negligible.</div></div><div><h3>Research question</h3><div>How does the transition from the 4 % to the 3 % hypopnea rules impact the significance of RERAs in clinical practice, and how we should relate the AHI and RDI using the different hypopnea rules?</div></div><div><h3>Methods</h3><div>We prospectively collected 76 consecutive polysomnography results in 4 adult age groups. We re-scored the respiratory events utilizing both the 3 % and the 4 % hypopnea rules and compared the outcomes.</div></div><div><h3>Results</h3><div>Among 76 diagnostic studies (mean age 47.5 years, males 47.4 %), the 3 % RERA index [0.8 (0.0, 3.1)] [median (Q1, Q3)] was significantly lower than the 4 % RERA index [3.5 (1.0, 7.3)]. The 3%AHI was 3.07 ± 9.23 (mean ± SD) higher than the 4%RDI (p = 0.005). The 3%AHI was 8.63 ± 8.86 higher than the 4%AHI in all age groups (p &lt; 0.001). This was mainly due to an increased hypopnea index (+8.51 ± 9.03, p &lt; 0.001). In patients with obstructive sleep apnea (OSA), the 3%RERA contributes 4.3 % to the 3%RDI, while the 4%RERA contributes 27.7 % to the 4%RDI.</div></div><div><h3>Interpretations</h3><div>Both 3%RDI and 3%AHI are higher than the 4%RDI, primarily due to identification of more hypopnea events, resulting in more patients being classified as having OSA. This change in criteria complicates the comparison of hypopnea and RERA contributions between sleep studies scored using the different hypopnea rules.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 396-403"},"PeriodicalIF":3.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of insomnia and use of sleep aids among adults in Canada","authors":"Charles M. Morin ,&nbsp;Lydi-Anne Vézina-Im ,&nbsp;Si-Jing Chen ,&nbsp;Hans Ivers ,&nbsp;Colleen E. Carney ,&nbsp;Jean-Philippe Chaput ,&nbsp;Thien Thanh Dang-Vu ,&nbsp;Judith R. Davidson ,&nbsp;Geneviève Belleville ,&nbsp;Dominique Lorrain ,&nbsp;Ojistoh Horn ,&nbsp;Rébecca Robillard ,&nbsp;the Canadian Sleep Research Consortium","doi":"10.1016/j.sleep.2024.09.044","DOIUrl":"10.1016/j.sleep.2024.09.044","url":null,"abstract":"<div><h3>Objectives</h3><div>To estimate the prevalence of insomnia and the use of sleep aids among Canadian adults.</div></div><div><h3>Methods</h3><div>Data were derived from a phone interview conducted (April to October 2023) with a stratified, population-based sample of 4037 adults (57.6 % females; mean age 50.6 ± 18.4; range 18–102 years old) living in Canada. Post-stratified survey weights were included in the analysis to ensure the representativity of the adult Canadian population.</div></div><div><h3>Results</h3><div>The prevalence estimate of insomnia disorder was 16.3 % (95 % CI 15.1–17.6), with higher rates in females (risk ratio [RR] 1.24, 95 % CI 1.06–1.45), Indigenous peoples (RR 1.77, 95 % CI 1.27–2.47), and individuals with poorer mental or physical health. Overall, 14.7 % of respondents reported having used prescribed sleep medications in the previous 12 months, 28.7 % used natural products or over-the-counter (OTC) sleep aids, 15.6 % used cannabis-derived products and 9.7 % used alcohol for sleep in the last 12 months. Higher proportions of females used prescribed medication (RR 1.79, 95 % CI 1.31–2.43) and natural products or OTC medication (RR 1.41, 95 % CI 1.16–1.71), while more males used cannabis (RR 1.33, 95 % CI 1.03–1.72) and alcohol (RR 1.67, 95 % CI 1.16–2.33) for sleep. Higher proportions of older adults (≥65 years) were taking prescribed medications, while more young adults (18–35 years) used natural products or OTC medications, cannabis, and alcohol as sleep aids.</div></div><div><h3>Conclusions</h3><div>Insomnia is a highly prevalent condition in Canada and there is widespread and increasing use of various medications and substances to cope with this health issue. These findings highlight the need for public health interventions to promote healthy sleep and for wider dissemination of evidence-based treatments for insomnia, such as cognitive behavioral therapy which is the first-line treatment for insomnia in practice guidelines, to reduce sleep health disparities.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 338-345"},"PeriodicalIF":3.8,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"History of symptoms consistent with REM sleep behavior disorder in a population with Parkinson's Disease","authors":"Viviane Akemi Kakazu ,&nbsp;Dalva Poyares ,&nbsp;Sergio Tufik ,&nbsp;Henrique Ballalai Ferraz ,&nbsp;Gabriel Natan Pires","doi":"10.1016/j.sleep.2024.09.042","DOIUrl":"10.1016/j.sleep.2024.09.042","url":null,"abstract":"<div><div>REM Sleep Behavioral Disorder (RBD) is a parasomnia marked by the maintenance of muscle tone during REM sleep. Evidence has placed RBD as one of the possible prodromal stages of Parkinson's Disease (PD), but data on the proportion of people with PD who have had symptoms of RBD are limited. This study aimed to investigate the history of symptoms compatible with RBD in a population with PD. The sample was composed by 73 patients with clinically diagnosed PD being followed up at a reference outpatient setting, compared to 73 age- and sex-matched individuals with no PD. The evaluation of symptoms compatible with RBD was performed using the Brazilian version of the RBD Screening Questionnaire (RBDSQ). The prevalence of symptoms compatible with RBD was 65 % for PD and 10.09 % for controls. The RBDSQ score was significantly higher in the PD group (6.03 ± 0.35) in comparison to the control group (2.38 ± 0.23). The odds ratio for presenting previous RBD-compatible symptoms was 12.09 in favor of positive PD cases. PD diagnosis has the following diagnostic properties in relation to presenting RBD symptoms: sensitivity of 0.65, specificity of 0.86, positive predictive value of 0.82 and negative predictive value of 0.71. In conclusion, the proportion of PD patients showing RBD symptoms is high, corroborating the expected neuroprogression of the disease on a case-control design comprising outpatient PD cases. Clinical practitioners should include evaluations of RBD-compatible symptoms during the PD assessment and, if positive, forward to a sleep specialist.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 308-314"},"PeriodicalIF":3.8,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142376043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latent profiles of multi-dimensional sleep characteristics and association with overweight/obesity in Chinese preschool children","authors":"Jia-Yin Chen ,&nbsp;Xiao-Yi Che ,&nbsp;Xiang-Yu Zhao ,&nbsp;Yu-Jie Liao ,&nbsp;Peng-Jun Zhao ,&nbsp;Fei Yan ,&nbsp;Jue Fang ,&nbsp;Ying Liu ,&nbsp;Xiao-Dan Yu ,&nbsp;Guang-Hai Wang","doi":"10.1016/j.sleep.2024.09.033","DOIUrl":"10.1016/j.sleep.2024.09.033","url":null,"abstract":"<div><h3>Objectives</h3><div>To examine the association between latent profiles of multi-dimensional sleep characteristics and overweight/obesity (OWO) in Chinese preschool children.</div></div><div><h3>Study design</h3><div>The cross-sectional analysis included 3204 preschool children recruited from 24 kindergartens in Shanghai. Parents reported children's demographics and sleep characteristics, including sleep duration, timing and disturbances. Latent profile analysis (LPA) was used to identify sleep subtypes. Logistic regression models were used to evaluate the associations between sleep characteristics/subtypes and OWO.</div></div><div><h3>Results</h3><div>Short sleep duration, late bedtime, long social jetlag and sleep disturbances were significantly associated with increased OWO. However, when considering the interplay of sleep duration and timing, there was no significant association between sleep duration and OWO for children sleeping later than 22:00. Three sleep subtypes were identified based on children's sleep duration, timing and disturbances: \"Average Sleepers\" (n = 2107, 65.8 %), \"Good Sleepers\" (n = 481, 15.0 %), and \"Poor Sleepers\" (n = 616, 19.2 %). \"Good Sleepers\" had reduced odds of being OWO (AOR, 0.72; 95 % CI, 0.56–0.93) compared to \"Average Sleepers\", while \"Poor Sleepers\" showed an increased risk of OWO (AOR, 1.36; 95 % CI, 1.11–1.67).</div></div><div><h3>Conclusions</h3><div>These findings highlight that improving multiple sleep characteristics simultaneously is a promising option to prevent and intervene childhood obesity.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"124 ","pages":"Pages 346-353"},"PeriodicalIF":3.8,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}