Frequency of obstructive sleep apnea in patients with asthma or allergic rhinitis: a systematic review and meta-analysis

IF 3.4 2区 医学 Q1 CLINICAL NEUROLOGY
Nuno Barros Ferreira , Alexandra Ponte , Ana Castelo Grande , Ana Cláudia Pimenta , Cláudia Sofia Pinto , Jean Bousquet , Marta Drummond , Bernardo Sousa-Pinto
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引用次数: 0

Abstract

Background

Asthma and allergic rhinitis (AR) are prevalent respiratory diseases that often coexist with obstructive sleep apnea (OSA). The objective of this study was to evaluate whether asthma or AR are associated with a higher frequency of OSA.

Methods

We performed a systematic review including cross-sectional and cohort studies that evaluated adult participants with and without asthma or AR and reported OSA diagnosed via polysomnography. We searched PubMed, Web of Science, and Scopus. Risk of bias was assessed using the ROBINS-E tool. Certainty of evidence was evaluated using the GRADE Framework. A random-effects meta-analysis of odds ratios (OR) to quantify the association between asthma or AR and OSA was performed.

Results

We included 12 studies (N = 19,203 participants). The meta-analysis indicated a higher frequency of OSA in AR patients (OR = 2.4; 95 %CI = 1.1; 5.3) compared to patients without the disease. In overall patients with asthma, the association with OSA (OR = 1.4; 95 %CI = 0.9; 2.2) was weaker than that observed in patients with moderate to severe asthma (OR = 10.1; 95 % CI = 1.3; 81.7). Patients with asthma exhibited slightly higher apnea-hypopnea index and oxygen desaturation index, along with lower mean oxygen saturation, compared to patients without asthma.

Conclusions

This meta-analysis identified an association between AR or asthma (particularly moderate to severe asthma) and OSA. Future research should address risk assessment of OSA for asthma and AR patients through prospective cohort studies, controlling for referral bias and asthma severity.

Abstract Image

哮喘或变应性鼻炎患者阻塞性睡眠呼吸暂停的频率:系统回顾和荟萃分析
背景哮喘和变应性鼻炎(AR)是常见的呼吸系统疾病,常与阻塞性睡眠呼吸暂停(OSA)共存。本研究的目的是评估哮喘或AR是否与OSA的高频率相关。方法:我们进行了一项系统综述,包括横断面和队列研究,评估有或无哮喘或AR的成年参与者,并报告通过多导睡眠图诊断为OSA。我们搜索了PubMed, Web of Science和Scopus。使用ROBINS-E工具评估偏倚风险。使用GRADE框架评估证据的确定性。对优势比(OR)进行随机效应荟萃分析,以量化哮喘或AR与OSA之间的关联。结果纳入12项研究(N = 19203名受试者)。meta分析显示,AR患者发生OSA的频率更高(OR = 2.4;95% ci = 1.1;5.3)。在所有哮喘患者中,与OSA的相关性(OR = 1.4;95% ci = 0.9;2.2)弱于中重度哮喘患者(OR = 10.1;95% ci = 1.3;81.7)。与非哮喘患者相比,哮喘患者的呼吸暂停低通气指数和氧去饱和指数略高,平均氧饱和度较低。本荟萃分析确定了AR或哮喘(特别是中度至重度哮喘)与OSA之间的关联。未来的研究应通过前瞻性队列研究解决哮喘和AR患者OSA的风险评估,控制转诊偏倚和哮喘严重程度。
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来源期刊
Sleep medicine
Sleep medicine 医学-临床神经学
CiteScore
8.40
自引率
6.20%
发文量
1060
审稿时长
49 days
期刊介绍: Sleep Medicine aims to be a journal no one involved in clinical sleep medicine can do without. A journal primarily focussing on the human aspects of sleep, integrating the various disciplines that are involved in sleep medicine: neurology, clinical neurophysiology, internal medicine (particularly pulmonology and cardiology), psychology, psychiatry, sleep technology, pediatrics, neurosurgery, otorhinolaryngology, and dentistry. The journal publishes the following types of articles: Reviews (also intended as a way to bridge the gap between basic sleep research and clinical relevance); Original Research Articles; Full-length articles; Brief communications; Controversies; Case reports; Letters to the Editor; Journal search and commentaries; Book reviews; Meeting announcements; Listing of relevant organisations plus web sites.
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