Potential marker of brain impairment secondary to obstructive sleep apnea: The brain asymmetry

IF 3.4 2区 医学 Q1 CLINICAL NEUROLOGY
Jianhong Liao , Yunhan Shi , Xiaotian Zhu , Yanru Li , Demin Han
{"title":"Potential marker of brain impairment secondary to obstructive sleep apnea: The brain asymmetry","authors":"Jianhong Liao ,&nbsp;Yunhan Shi ,&nbsp;Xiaotian Zhu ,&nbsp;Yanru Li ,&nbsp;Demin Han","doi":"10.1016/j.sleep.2025.106701","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Obstructive sleep apnea (OSA) is one of the leading causes of sleep disorders and often exhibits psychological impairments. Brain asymmetry (BA), a recognized marker of psychological traits, has been found to be significantly elevated in OSA and associated with anxiety and personality traits. However, evidence for a causal relationship between BA and respiratory events remains lacking.</div></div><div><h3>Methods</h3><div>Patients undergoing polysomnography at the Sleep Medicine Center were enrolled in this study. Subsequently, sleep apnea or hypopnea with a duration of &gt;15 s and intervals of &gt;20 s were extracted and analyzed for BA changes during peri-respiratory events periods. Differences in power spectrum density in bilateral EEG activity were calculated for the frontal, central, and occipital regions.</div></div><div><h3>Results</h3><div>A total of 71 subjects were included in the study and 6445 respiratory events were extracted. We obtained 1265 respiratory events in N1, 3655 in N2, 62 in N3, and 1463 in REM. In frontal, BA was elevated during the event and recovered at the end of the event (<em>P&lt; 0.0001</em>), with a uniform pattern across bands. In central, respiratory events similarly induced BA (<em>P&lt; 0.0001</em>). In the occipital region, a decrease in BA was observed during respiratory events and a sudden rise at the end of the event (<em>P&lt;0.001</em>). Non-severe and severe OSA exhibit similar trends. In addition, subgroup analyses indicated alpha, beta and gamma as the main contributors to BA fluctuations.</div></div><div><h3>Conclusions</h3><div>Our findings suggest respiratory events trigger BA across brain regions. These findings, combined with previous studies, suggest BA may be a marker and characteristic phenotype of neurological dysfunction in OSA.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"134 ","pages":"Article 106701"},"PeriodicalIF":3.4000,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sleep medicine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1389945725003764","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background

Obstructive sleep apnea (OSA) is one of the leading causes of sleep disorders and often exhibits psychological impairments. Brain asymmetry (BA), a recognized marker of psychological traits, has been found to be significantly elevated in OSA and associated with anxiety and personality traits. However, evidence for a causal relationship between BA and respiratory events remains lacking.

Methods

Patients undergoing polysomnography at the Sleep Medicine Center were enrolled in this study. Subsequently, sleep apnea or hypopnea with a duration of >15 s and intervals of >20 s were extracted and analyzed for BA changes during peri-respiratory events periods. Differences in power spectrum density in bilateral EEG activity were calculated for the frontal, central, and occipital regions.

Results

A total of 71 subjects were included in the study and 6445 respiratory events were extracted. We obtained 1265 respiratory events in N1, 3655 in N2, 62 in N3, and 1463 in REM. In frontal, BA was elevated during the event and recovered at the end of the event (P< 0.0001), with a uniform pattern across bands. In central, respiratory events similarly induced BA (P< 0.0001). In the occipital region, a decrease in BA was observed during respiratory events and a sudden rise at the end of the event (P<0.001). Non-severe and severe OSA exhibit similar trends. In addition, subgroup analyses indicated alpha, beta and gamma as the main contributors to BA fluctuations.

Conclusions

Our findings suggest respiratory events trigger BA across brain regions. These findings, combined with previous studies, suggest BA may be a marker and characteristic phenotype of neurological dysfunction in OSA.
继发于阻塞性睡眠呼吸暂停的脑损伤的潜在标志:大脑不对称
背景:阻塞性睡眠呼吸暂停(OSA)是导致睡眠障碍的主要原因之一,通常表现为心理障碍。脑不对称(BA)是一种公认的心理特征标志,在OSA患者中显著升高,并与焦虑和人格特征相关。然而,BA与呼吸事件之间因果关系的证据仍然缺乏。方法在睡眠医学中心接受多导睡眠图检查的患者加入本研究。随后,提取持续时间为15秒、间隔时间为20秒的睡眠呼吸暂停或低通气,分析呼吸期事件期间BA的变化。计算双侧脑电活动的功率谱密度在额叶、中央和枕叶区域的差异。结果共纳入71例受试者,提取呼吸事件6445例。我们在N1期获得1265例呼吸事件,在N2期获得3655例,在N3期获得62例,在REM期获得1463例。在额叶,BA在事件期间升高,并在事件结束时恢复(P<;0.0001),带间的图案均匀。在中央,呼吸事件类似地诱发BA (P<;0.0001)。在枕区,呼吸事件期间BA下降,事件结束时BA突然上升(P<0.001)。非重度和重度OSA表现出相似的趋势。此外,亚组分析表明,α、β和γ是BA波动的主要因素。结论:我们的研究结果表明,呼吸事件触发BA跨脑区。这些发现,结合以往的研究,提示BA可能是OSA患者神经功能障碍的标志和特征性表型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Sleep medicine
Sleep medicine 医学-临床神经学
CiteScore
8.40
自引率
6.20%
发文量
1060
审稿时长
49 days
期刊介绍: Sleep Medicine aims to be a journal no one involved in clinical sleep medicine can do without. A journal primarily focussing on the human aspects of sleep, integrating the various disciplines that are involved in sleep medicine: neurology, clinical neurophysiology, internal medicine (particularly pulmonology and cardiology), psychology, psychiatry, sleep technology, pediatrics, neurosurgery, otorhinolaryngology, and dentistry. The journal publishes the following types of articles: Reviews (also intended as a way to bridge the gap between basic sleep research and clinical relevance); Original Research Articles; Full-length articles; Brief communications; Controversies; Case reports; Letters to the Editor; Journal search and commentaries; Book reviews; Meeting announcements; Listing of relevant organisations plus web sites.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信