Sleep medicine最新文献

{"title":"Sleep characteristics and brain structure: A systematic review with meta-analysis","authors":"Tergel Namsrai ,&nbsp;Joseph M. Northey ,&nbsp;Ananthan Ambikairajah ,&nbsp;Oli Ahmed ,&nbsp;Khawlah Alateeq ,&nbsp;Daniela Andrea Espinoza Oyarce ,&nbsp;Richard Burns ,&nbsp;Ben Rattray ,&nbsp;Nicolas Cherbuin","doi":"10.1016/j.sleep.2025.02.028","DOIUrl":"10.1016/j.sleep.2025.02.028","url":null,"abstract":"<div><h3>Background</h3><div>As the global population ages, the prevalence of associated conditions, including neurodegeneration and dementia, will increase. Thus, reducing risk factors is crucial to prevention. Sleep contributes to brain homeostasis and repair, which, if impaired, could lead to neurodegeneration. However, the relationship between sleep characteristics, disorders, and brain morphology is poorly understood in healthy adults. Therefore, we aimed to systematically analyse the literature and clarify how sleep characteristics are associated with brain structures.</div></div><div><h3>Methods</h3><div>We systematically searched PUBMED, MEDLINE, ProQuest, Web of Science, and Scopus for empirical studies of healthy adults examining the associations between sleep characteristics or disorders and brain structure, adjusting for age, gender, and head size. We conducted a meta-analysis with random effects models for volumetric studies and a seed-based spatial analysis for voxel-based morphometry (VBM) studies.</div></div><div><h3>Results</h3><div>One hundred and five articles (60 volumetric, 45 VBM) with 106 studies reporting 108,364 participants were included. Most studies (73.1%) found sleep characteristics and disorders to be associated with predominantly lower brain volumes (cross-sectional: 51.9% of all cross-sectional; longitudinal: 45.5% of longitudinal). In VBM studies, REM sleep behaviour disorder was linked to lower grey matter volume in the right frontal gyrus (z-score = −3.617, 68 voxels, p-value = &lt;0 0.001).</div></div><div><h3>Conclusion</h3><div>Sleep characteristics - poor quality, short or long sleep - and sleep disorders are predominantly associated with lower brain volumes, suggesting that inadequate sleep (short, long or poor quality) might contribute to neurodegeneration. This insight highlights the importance of monitoring, managing, and enforcing sleep health to prevent or mitigate potential neurodegenerative processes.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 316-329"},"PeriodicalIF":3.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Over-the-counter products for insomnia in adults: A scoping review of randomised controlled trials","authors":"Adriana Salame ,&nbsp;Silvy Mathew ,&nbsp;Cini Bhanu ,&nbsp;Juan Carlos Bazo-Alvarez ,&nbsp;Sukvinder Kaur Bhamra ,&nbsp;Michael Heinrich ,&nbsp;Kate Walters ,&nbsp;Rachael Frost","doi":"10.1016/j.sleep.2025.02.027","DOIUrl":"10.1016/j.sleep.2025.02.027","url":null,"abstract":"<div><h3>Background</h3><div>Insomnia is highly prevalent and poses significant personal and socio-economic challenges. While the National Institute for Health and Care Excellence (NICE) recommendations define possible medical approaches, over-the-counter products are commonly used to self-manage insomnia symptoms. This scoping review aims to determine the size and scope of the evidence-base regarding the effectiveness and safety of over-the-counter products for insomnia symptoms in adults.</div></div><div><h3>Methods</h3><div>The electronic databases of CENTRAL, MEDLINE, EMBASE, PsycINFO, and AMED were searched from inception to December 19th, 2022, for all randomised controlled trials evaluating over-the-counter products compared to placebo, in adults aged 18–65 with insomnia symptoms. Results were synthesised descriptively.</div></div><div><h3>Results</h3><div>51 randomised controlled trials were included, evaluating herbal products (n = 34), dietary supplements (n = 15), herbal-dietary combinations (n = 4), and over-the-counter medicines (n = 2). Sample sizes ranged between 10 and 405 participants. Eleven studies were conducted in participants with co-morbidities. Interventions were most frequently given as monotherapy and compared against placebo. Most studies (n = 41) demonstrated interventions’ positive effects on insomnia symptoms. Among the most studied products, valerian and melatonin have substantial evidence to demonstrate their effectiveness and safety. Promising products demonstrating benefits compared with prescription medication alone included: valerian; lemon balm and fennel; and valerian, hops, and passionflower. Intervention-related side effects were mostly mild and transient. No serious adverse events were reported across all studies.</div></div><div><h3>Conclusions</h3><div>Over-the-counter products show promising, but inconclusive findings in alleviating insomnia symptoms in adults. Future research should focus on investigating products currently used in real life, consider economic evaluations, and be evaluated in populations with co-morbidities and ethnic minorities, to better guide clinical advice.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 219-237"},"PeriodicalIF":3.8,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of high-intensity interval training exercise on sleep quality in women with probable post-traumatic stress disorder: A pilot randomized controlled trial","authors":"Melissa J. McGranahan,&nbsp;Patrick J. O'Connor","doi":"10.1016/j.sleep.2025.02.029","DOIUrl":"10.1016/j.sleep.2025.02.029","url":null,"abstract":"<div><div>Poor sleep quality is a major problem for women with post-traumatic stress disorder (PTSD). Potential causes of poor sleep quality include elevated symptoms of anxiety, hyperarousal, and decreased high frequency-heart rate variability (HF-HRV). Exercise training both decreases anxiety symptoms and increases HF-HRV among samples without PTSD. The effect of exercise training on sleep quality, HF-HRV and PTSD-related symptoms has not been tested in a sample of women exposed to trauma. This study aimed to evaluate the impact of High-Intensity Interval Training (HIIT) on sleep quality in a sample of women with probable PTSD and test if reductions in anxiety or hyperarousal symptoms and/or increased HF-HRV mediate improved sleep quality. Thirty women with poor sleep quality and a Post-Traumatic Diagnostic Scale (PDS-5) score indicative of PTSD (≥ 28) were randomly assigned to either six-weeks of HIIT or a waitlist control (WL). Sleep quality, PTSD and anxiety symptoms were assessed at baseline (BL), weeks 2, 4, 6, and post-intervention (POST). HF-HRV was measured at BL and POST. A mixed model ANOVA 2 group × 5 time interaction for sleep quality was significant (p &lt; 0.001; HIIT BL: 11.27 ± 2.55; POST: 5.60 ± 2.03 versus WL BL: 9.47 ± 2.83; POST: 8.23 ± 2.39; Hedges’ d = −1.57). Anxiety and hyperarousal symptom reductions significantly mediated sleep quality changes. HF-HRV mediation models were non-significant. HIIT-based cycle exercise training in a sample of women with probable PTSD improves sleep quality, and reductions in trait anxiety and hyperarousal symptoms mediated these improvements.</div></div><div><h3>Clinical trial registration</h3><div>(Clinical Trials. gov) Identifier: NCT05097352.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 245-256"},"PeriodicalIF":3.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143563848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does therapeutic CPAP pressure correlate with OSA severity in children?","authors":"Sonia Khirani ,&nbsp;Lucie Griffon ,&nbsp;Marine Dosso ,&nbsp;Domenico Paolo La Regina ,&nbsp;Meryl Vedrenne-Cloquet ,&nbsp;Clément Poirault ,&nbsp;Brigitte Fauroux","doi":"10.1016/j.sleep.2025.02.033","DOIUrl":"10.1016/j.sleep.2025.02.033","url":null,"abstract":"<div><h3>Objective/background</h3><div>Continuous positive airway pressure (CPAP) is widely used to treat severe obstructive sleep apnea (OSA) in children. We observed that non polysomnography (PSG)-titrated CPAP pressures ranged close to 8 cmH₂O in children with OSA. The aim of this study was to determine if there was a relationship between OSA severity, the age of the children and CPAP pressure.</div></div><div><h3>Methods</h3><div>Children with OSA, comprising mainly children with complex OSA, who were started on constant CPAP, with no attended PSG according to our clinical practice, were included. CPAP pressure, baseline polygraphic and anthropometrics data were retrospectively collected.</div></div><div><h3>Results</h3><div>Mean therapeutic CPAP pressure was 8 ± 1 (range 6–12) cmH₂O in 153 children treated with CPAP at a mean age of 3.7 ± 3.4 (0.1–15.9) years. CPAP pressure slightly correlated with age at CPAP initiation (r = 0.226, p = 0.005), baseline mixed and obstructive apnea-hypopnea index (MOAHI; r = 0.185, p = 0.025), oxygen desaturation index (ODI; r = 0.300, p &lt; 0.001), mean (r = −0.230, p = 0.005) and minimal pulse oximetry (SpO₂; r = −0.318, p &lt; 0.001). BMI z-score did not correlate with CPAP pressure, apnea-hypopnea index (AHI), MOAHI, nor ODI. CPAP pressure, AHI, MOAHI and ODI did not vary between age categories.</div></div><div><h3>Conclusions</h3><div>A weak correlation was observed between therapeutic CPAP pressure and MOAHI in our cohort of children, with no correlation with BMI, highlighting the potential role of other factors, such as anatomical features. Future studies should confirm these findings with PSG-titrated CPAP pressures, and determine predictive factors for therapeutic CPAP. Predicting the level of CPAP may be relevant in clinical practice, as PSG-titrated CPAP procedure becomes more challenging.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 89-93"},"PeriodicalIF":3.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Putamen dopaminergic dysfunction is associated with sleep disturbance in drug-naïve patients with Parkinson's disease","authors":"Masakazu Ozawa ,&nbsp;Hidetomo Murakami ,&nbsp;Yuichiro Muraoka ,&nbsp;Momoyo Ibukuro ,&nbsp;Tomotaka Shiraishi ,&nbsp;Asako Onda ,&nbsp;Hiromasa Matsuno ,&nbsp;Keiko Bono ,&nbsp;Tadashi Umehara ,&nbsp;Shusaku Omoto ,&nbsp;Hirotaka James Okano ,&nbsp;Yasuyuki Iguchi","doi":"10.1016/j.sleep.2025.02.031","DOIUrl":"10.1016/j.sleep.2025.02.031","url":null,"abstract":"<div><h3>Background</h3><div>Sleep disturbance (SD) is common in Parkinson's disease (PD) and adversely affect the quality of life (QOL). Although dopamine dysfunction has been implicated, the specific role of dopaminergic activity in SD among patients with PD remains unclear. Given that dopamine-related medications can affect sleep, it is essential to assess SD in drug-naïve patients. This study investigated the association between SD and uptake of striatal dopamine transporters using Dopamine Transporter Single-Photon Emission Computed Tomography with ¹²³I-Ioflupane (DAT-SPECT).</div></div><div><h3>Methods</h3><div>We retrospectively analyzed 112 drug-naïve patients through the PD Sleep Scale-version-2 (PDSS-2) and DAT-SPECT. Patients were divided into SD and non-SD groups using a PDSS-2 cut-off score of 15. The Mann-Whitney <em>U</em> test and binomial regression were used to compare the groups.</div></div><div><h3>Results</h3><div>SD was identified in 47.3 % of participants, correlating significantly with increased age, more severe motor symptoms, cognitive decline, depressive symptoms, and reduced QOL scores. Binomial regression analyses—adjusted for sex, age, motor dysfunction, cognitive function, and nocturnal autonomic cardiovascular dysfunction—showed that reduced DAT-SPECT uptake in the left anterior and posterior putamen significantly contributed to higher PDSS-2 scores.</div></div><div><h3>Conclusion</h3><div>This study demonstrated a link between SD and putamen DAT-SPECT uptake in drug-naïve patients with PD, indicating the role of dopamine in sleep regulation. These findings underscore the importance of managing SD in patients with PD to improve QOL and suggest the need for further investigation of the impact of dopaminergic dysfunction on sleep.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 82-88"},"PeriodicalIF":3.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awakening to sleep: Sixteen years of World Sleep Day global initiatives and future directions","authors":"Lourdes M. DelRosso ,&nbsp;Fang Han ,&nbsp;Richard P. Allen ,&nbsp;Antonio Culebras ,&nbsp;Christian Guilleminault ,&nbsp;Liborio Parrino ,&nbsp;Sophia Hendrickson ,&nbsp;Tyler Ringstad ,&nbsp;Allan O'Bryan","doi":"10.1016/j.sleep.2025.02.022","DOIUrl":"10.1016/j.sleep.2025.02.022","url":null,"abstract":"<div><div>World Sleep Day is an international campaign to raise public awareness of sleep health. Since 2008, the WSD campaign has grown from a small group of advocates to include hundreds of volunteer organizers in over 70 countries. A historical database of 2047 World Sleep Day (WSD) awareness activities recorded over 16 years was examined to characterize the growth of WSD and to delineate areas for further development. Between 2014 and 2024, WSD activity grew in Europe from 24 to 132 activities and in Asia from 10 to 94; however, WSD activity grew in Africa from one to 20 activities and Oceania from five to 18. Growth has been considerable, yet organizing and outreach work needs to accelerate in Africa and Asia to further advance the purpose of WSD.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 118-121"},"PeriodicalIF":3.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143511296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors and prognosis of acute ischemic stroke related restless legs syndrome","authors":"Xi-Xi Wang ,&nbsp;Ye Liu ,&nbsp;Jia-Min Song ,&nbsp;Yu-Lei Zhang ,&nbsp;Yu Wang ,&nbsp;Ondo G. William ,&nbsp;Ya Feng ,&nbsp;Yun-Cheng Wu","doi":"10.1016/j.sleep.2025.02.030","DOIUrl":"10.1016/j.sleep.2025.02.030","url":null,"abstract":"<div><h3>Background</h3><div>Recent studies suggest that stroke may be associated with an increased prevalence of restless legs syndrome (RLS) as a comorbidity or a risk factor. We aimed to explore the association between acute ischemic stroke (AIS) and RLS, and the possible pathogenesis of acute ischemic stroke related restless legs syndrome (AIS-RLS), for guiding its diagnosis and treatment.</div></div><div><h3>Methods</h3><div>In this single-center, prospective study, we identified consecutive AIS patients and segregated into AIS-RLS group and non-AIS-RLS group based on the diagnostic criteria of RLS. The differences in baseline data, clinical features, examination results, stroke etiology, stroke location, and clinical prognosis (functional disability, cognitive and mood disorders) of the two groups were analyzed. Logistic regression analysis was used to evaluate the risk factors for RLS.</div></div><div><h3>Results</h3><div>A total of 201 AIS patients were included in our study, and 21 (10.45 %) demonstrated RLS. Compared with non-AIS-RLS group, AIS-RLS group patients had higher systolic blood pressure (SBP) at admission (<em>P</em> &lt; 0.05), higher mean 24-h SBP (<em>P</em> &lt; 0.01), higher mean 24-h diastolic blood pressure (DBP) (<em>P</em> &lt; 0.01), higher mean daytime SBP (<em>P</em> &lt; 0.01), higher mean daytime DBP (<em>P</em> &lt; 0.01), higher mean nocturnal SBP (<em>P</em> &lt; 0.01), higher mean nocturnal DBP (<em>P</em> &lt; 0.05), smaller variation coefficient of 24-h SBP (<em>P</em> &lt; 0.05). The distribution of AIS-RLS and non-AIS-RLS was not different for each subtype according to the cortical and subcortical classification of lesion sites. The NIHSS score, GAD-7 score and PHQ-9 score were higher at 7 days (<em>P</em> &lt; 0.05), and the modified Rankin scale (mRS) was higher at 3 months follow-up (<em>P</em> &lt; 0.05) in the AIS-RLS group. In the logistic regression, the higher SBP at admission had a statistically significant effect on AIS-RLS(OR = 1.030,<em>P</em> = 0.016)even after adjusting for age and gender(OR = 1.030,<em>P</em> = 0.014).</div></div><div><h3>Conclusion</h3><div>Stroke anatomy did not differ between AIS-RLS and non-AIS-RLS groups. AIS-RLS group patients tend to experience higher blood pressure. Moreover, AIS-RLS patients had worse clinical prognosis (functional disability and mood disorders) compared with non-AIS-RLS patients.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 75-81"},"PeriodicalIF":3.8,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143474585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic beds for the treatment of positional obstructive sleep apnea – A randomized cross-over pilot trial","authors":"Martina Meszaros ,&nbsp;Alexander Breuss ,&nbsp;Elisabeth Wilhelm ,&nbsp;Robert Riener ,&nbsp;Malcolm Kohler ,&nbsp;Esther I. Schwarz","doi":"10.1016/j.sleep.2025.02.025","DOIUrl":"10.1016/j.sleep.2025.02.025","url":null,"abstract":"<div><h3>Background</h3><div>Interventions leading to avoidance of supine position and thus reducing the likelihood of upper airway collapse during sleep are a treatment approach for positional obstructive sleep apnea (POSA). The aim of this randomized cross-over trial was to assess the effect of two actuated beds (trunk-elevation and sideward-tilting) on OSA severity and sleep fragmentation in POSA.</div></div><div><h3>Methods</h3><div>After baseline polysomnography, adult patients with POSA were randomly assigned to two nights of intervention in the intelligent sleep apnea bed ISABel1 and ISABel2. In the case of obstructive apnea or hypopnea, ISABel1 elevated the upper body by 50° and ISABel2 induced a unilateral bed tilt of 40°, with both interventions lasting 10 min. Sustained trunk elevations without sliding down (ISABel1) and position change from supine to non-supine (ISABel2) were defined as successful interventions.</div></div><div><h3>Results</h3><div>Six adult men (57 ± 11 years, BMI 28 ± 4 kg/m2, AHI 39 ± 15/h) with POSA were included. Neither trunk elevation (ISABel1) nor side tilt (ISABel2) – approximately 10 interventions per night – significantly reduced apnea-hypopnea index (AHI), whereas trunk elevation showed a tendency to reduce supine AHI. Actuated beds had no effect on sleep efficiency and arousals. Only 13 % of side tilts in ISABel2 resulted in a successful shift to a non-supine position. The time to the next respiratory event after bed movement was longer in the trunk elevating bed than in the side-tilting bed.</div></div><div><h3>Conclusion</h3><div>Trunk elevating beds decrease supine AHI and both side-tilting and trunk elevating beds increase the time to the next obstructive apnea or hypopnea.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 94-100"},"PeriodicalIF":3.8,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of reproductive factors and circadian syndrome in middle-aged and elderly women: A nationwide cross-sectional study from China, the United Kingdom and the United States","authors":"Linli Liu ,&nbsp;Pengming Sun ,&nbsp;Jun Lin ,&nbsp;Sanshan Wu","doi":"10.1016/j.sleep.2025.02.026","DOIUrl":"10.1016/j.sleep.2025.02.026","url":null,"abstract":"<div><div>Circadian Syndrome (CircS) was recently recognized as a novel predictor of cardiovascular disease (CVD) risk, with reproductive factors playing an important role in CVD risk. Yet, studies linking reproductive factors to CircS remain sparse. Data on middle-aged and elderly women were extracted from three nationally representative surveys: the China Health and Retirement Longitudinal Study (CHARLS) and the English Longitudinal Study on Ageing (ELSA) provided the training set, and the National Health and Nutrition Examination Survey (NHANES) constituted the validation set. We employed logistic regression to evaluate the association between self-reported reproductive factors and CircS risk, with inverse probability of treatment weighting (IPTW) and subgroup analyses conducted to verify the stability. A total of 11,721 participants were analyzed. CircS prevalence differed significantly across countries, with 51.40 % in China and 20.19 % in the United Kingdom. Early menarche (age &lt;12 years) correlated with increased CircS risk in CHARLS (OR 1.38 [95 % CI 0.99–1.92]; <em>p</em> = 0.061), ELSA (OR 1.64 [95 % CI 1.36–1.98]; <em>p</em> &lt; 0.001), and NHANES (OR1.52 [95 % CI: 1.21–1.89]; <em>p</em> &lt; 0.001). Premature menopause (age &lt;40 years) was associated with a roughly 30 % higher CircS risk. A shorter reproductive lifespan was significantly linked to CircS, with this relationship emerging at a reproductive lifespan of ≥40 years in CHARLS (OR1.39 [95 % CI: 1.04–1.84]; <em>p</em> = 0.024). The aforementioned correlations retained significance following IPTW and subgroup analyses. Early menarche, premature menopause, and abbreviated reproductive lifespans may negatively affect CircS. Public health strategies should incorporate menstrual cycle-related reproductive health into primary CircS prevention.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 283-291"},"PeriodicalIF":3.8,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are sleep and awake bruxism associated with sleep quality and duration in adults? A systematic review and meta-analysis","authors":"Guilherme Azario de Holanda,&nbsp;Thiago Azario de Holanda,&nbsp;Maísa Casarin","doi":"10.1016/j.sleep.2025.02.023","DOIUrl":"10.1016/j.sleep.2025.02.023","url":null,"abstract":"<div><div>The objective of this systematic review was to investigate the association between sleep quality with awake bruxism or sleep bruxism in adult individuals. Inclusion criteria comprised observational studies conducted in adults related to the research question, assessing bruxism by instrumental or non-instrumental approaches, and sleep quality by subjective or objective measures, or sleep duration. Sleep disorders, syndromes, neurological and psychiatric disorders, or psychotropic medications were excluded. PubMed, Embase, Web of Science, Scopus, Cochrane Library, and Google Scholar databases were searched until August 2024. Risk of bias was assessed by the JBI Critical Appraisal Checklist tool for cross-sectional studies, and the Newcastle-Ottawa scale for case-control studies. Independent meta-analyses comparing awake or sleep bruxism individuals with control individuals were performed when there were at least two studies for each sleep outcome. Thirty-two studies assessing a total of 4706 individuals were included. Meta-analyses showed no differences between sleep bruxism and control individuals regarding polysomnography parameters (sleep efficiency, sleep latency, awakenings, wake after sleep onset, and sleep duration). Pittsburgh Sleep Quality Index showed higher scores for sleep bruxism individuals compared to control individuals (MD = 1.98; 95 % CI = 0.96–3.00) and for awake bruxism individuals compared to control individuals (MD = 1.99; 95 % CI = 0.42–3.57). In total, 12 studies were rated as low risk of bias, 15 as moderate risk of bias, and 5 as high risk of bias. The certainty of evidence was rated as very low. Objective sleep quality was not associated with sleep bruxism, while subjective sleep quality was associated with both sleep and awake bruxism.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 175-186"},"PeriodicalIF":3.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143534850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}