Sleep medicine最新文献

{"title":"Sleep related injury and its correlates in isolated rapid eye movement sleep behavior disorder","authors":"Yuhua Yang ,&nbsp;Jing Wang ,&nbsp;Li Zhou ,&nbsp;Yaping Liu ,&nbsp;Shi Tang ,&nbsp;Siyi Gong ,&nbsp;Ningning Li ,&nbsp;Zhixuan He ,&nbsp;Jianzhang Ni ,&nbsp;Joey W.Y. Chan ,&nbsp;Steven W.H. Chau ,&nbsp;Yun Kwok Wing ,&nbsp;Bei Huang","doi":"10.1016/j.sleep.2024.11.032","DOIUrl":"10.1016/j.sleep.2024.11.032","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate factors associated with sleep related injury (SRI) and persistent SRI (pSRI) in patients with isolated rapid eye movement sleep behavior disorder (iRBD).</div></div><div><h3>Methods</h3><div>This is a retrospective cohort study. A total of 388 patients with iRBD were involved for a comprehensive review of sleep related injuries. SRI is defined as a lifetime history of injurious behaviors to self and/or bed partner, and pSRI is considered if injurious symptoms continued to occur frequently (≥1/month). Correlations of SRI/pSRI with clinical, lifestyle and polysomnographic characteristics were analyzed.</div></div><div><h3>Results</h3><div>Lifetime SRI was reported in 322 (83 %) patients (66.3 ± 8.5 years old, male 77.0 %), with 19.3 % having severe injuries, including fractures (2.5 %) and subdural hemorrhage (1.2 %), while 7.5 % required medical attendance. SRI was related to more severe depressive features (P_adj = 0.017), current alcohol drinking (P_adj = 0.014) and higher mentalis phasic and tonic EMG activity (P_adj = 0.042 and 0.048). After a mean follow-up of 5.1 years, 18.2 % of SRI patients (38/209) had pSRI despite intense treatment. Frequent nightmare at baseline (OR [95 % CI] = 1.43 [1.01, 2.03]), restless leg syndrome (OR [95 % CI] = 5.68 [1.42, 22.64]) and adult-onset sleepwalking (OR [95 % CI] = 2.52 [1.10, 5.76]) were associated with an increased risk of pSRI.</div></div><div><h3>Conclusions</h3><div>SRI is common in patients with iRBD and 18 % had pSRI despite intensive treatment, emphasizing the importance of bedside safety. The identification of risk factors for SRI and pSRI underscores the need for systematic clinical screening and targeted interventions for at-risk patients.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"126 ","pages":"Pages 9-18"},"PeriodicalIF":3.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142745874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of insomnia on prefrontal activation during a verbal fluency task in patients with major depressive disorder: A preliminary fNIRS study","authors":"Shuai Yang ,&nbsp;Xiaoyi Kong ,&nbsp;Xiangxia Zhang ,&nbsp;Yueming Zhang ,&nbsp;Xueyan Li ,&nbsp;Yi-Jun Ge","doi":"10.1016/j.sleep.2024.11.030","DOIUrl":"10.1016/j.sleep.2024.11.030","url":null,"abstract":"<div><h3>Background</h3><div>Insomnia often co-occurs with major depressive disorder (MDD) and significantly affects patient recovery and prognosis. However, how insomnia affects prefrontal cortex activation in MDD patients and its association with both subjective and objective sleep quality remains unclear. This study combined functional near-infrared spectroscopy (fNIRS) with polysomnography (PSG) to investigate differences in prefrontal activation during a verbal fluency task (VFT) in patients with MDD, with and without insomnia.</div></div><div><h3>Methods</h3><div>Seventy-eight patients with MDD and 42 healthy controls underwent polysomnography and sleep and mood assessments including the Pittsburgh Sleep Quality Index (PSQI) and Self-Rating Depression Scale (SDS). Prefrontal activation was measured using fNIRS during the VFT.</div></div><div><h3>Results</h3><div>Patients with MDD and insomnia had higher PSQI scores than patients with MDD without insomnia. fNIRS revealed increased left prefrontal cortex activation in these patients, which was negatively correlated with the total sleep time and sleep efficiency and positively correlated with the PSQI score.</div></div><div><h3>Conclusion</h3><div>This study combined fNIRS and PSG to demonstrate that MDD patients with insomnia showed increased levels of prefrontal cortex activation, associated with both subjective and objective sleep quality.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"125 ","pages":"Pages 114-119"},"PeriodicalIF":3.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of insomnia and feasibility of a nurse-administered digital cognitive behavioural therapy two years after corona virus disease hospitalisation","authors":"Thea Christine Thorshov ,&nbsp;Toril Dammen ,&nbsp;Anne Moen ,&nbsp;Gunnar Einvik ,&nbsp;Harald Hrubos-Strøm","doi":"10.1016/j.sleep.2024.11.028","DOIUrl":"10.1016/j.sleep.2024.11.028","url":null,"abstract":"<div><h3>Background</h3><div>Disturbed sleep is prevalent after corona virus disease (COVID-19). However, little is known of post infectious prevalence, course, predictors and treatment of chronic insomnia.</div></div><div><h3>Aim</h3><div>To estimate the prevalence of chronic insomnia three and twelve months after hospitalisation for COVID-19, to identify predictors of chronic insomnia, and to evaluate the feasibility of a nurse-administered digital cognitive behavioural therapy for insomnia (dCBTi) protocol.</div></div><div><h3>Method</h3><div>Patients hospitalised at Akershus University Hospital (Norway) for COVID-19 between February–June 2020 were eligible. The 94 patients that consented to participate were contacted by phone and interviewed with a modified DUKE structured interview three- and twelve months after discharge. Participants with chronic insomnia after twelve months were offered a nurse-administered dCBTi treatment protocol. Outcome measurements were sleep efficiency (SE) calculated by standard formulas (0-100 %) and the Bergen Insomnia Scale (BIS) (0-42).</div></div><div><h3>Results</h3><div>At three-month follow-up, 22 persons (23 %) fulfilled the diagnostic criteria for chronic insomnia. At twelve-month follow-up, 23 fulfilled the diagnostic criteria. The odds ratios for chronic insomnia after twelve months were 0.857 (0.742–0.989) for body mass index (BMI), and 0.239 (0.069–0.821) for male sex. Ten participated in the dCBTi feasibility study. Five completed the treatment protocol. SE improved, but not significantly. The BIS score improved significantly from 24 to 12 (p-value = 0.036).</div></div><div><h3>Conclusion</h3><div>Chronic insomnia remained stable three- and twelve months post COVID-19 hospitalisation. Female sex and low BMI were independent predictors of chronic insomnia twelve months post infection, but only 50 % of participants completed the protocol. Completers significantly reduced insomnia symptoms.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"125 ","pages":"Pages 108-113"},"PeriodicalIF":3.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional mean disease alleviation (3D-MDA): The next step in measuring sleep apnea treatment effectiveness","authors":"Thomas M. Kaffenberger ,&nbsp;Ryan J. Soose ,&nbsp;Patrick J. Strollo ,&nbsp;Olivier M. Vanderveken","doi":"10.1016/j.sleep.2024.11.027","DOIUrl":"10.1016/j.sleep.2024.11.027","url":null,"abstract":"<div><div>Mean disease alleviation measures the effectiveness of Obstructive Sleep Apnea (OSA) treatments. It combines a patient's adherence to treatment normalized to their total sleep time and the treatment's efficacy as determined by the change in the apnea-hypopnea index. This metric fails to capture the patient's OSA-related symptoms, which are a key component and, in some cases, the primary component, of determining response to treatment.</div><div>We propose an enhanced metric called three-dimensional mean disease alleviation (3D-MDA), which incorporates the symptom response to better reflect the true treatment impact.</div></div><div><h3>Results</h3><div>The proposed 3D-MDA metric aims to provide a more comprehensive assessment of OSA treatment effectiveness by integrating the subjective impact, therapy adherence, and objective efficacy. Further, 3D-MDA is adaptable over time as the optimal metrics for these categories continue to evolve.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"125 ","pages":"Pages 27-30"},"PeriodicalIF":3.8,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of simulated snoring sounds with artificial intelligence for the diagnosis of obstructive sleep apnea","authors":"Lucheng Fang ,&nbsp;Jie Cai ,&nbsp;Zilin Huang ,&nbsp;Aikebaier Tuohuti ,&nbsp;Xiong Chen","doi":"10.1016/j.sleep.2024.11.018","DOIUrl":"10.1016/j.sleep.2024.11.018","url":null,"abstract":"<div><h3>Background</h3><div>Performing simulated snoring (SS) is a commonly used method to evaluate the source of snoring in obstructive sleep apnea (OSA). SS sounds is considered as a potential biomarker for OSA. SS sounds can be easily recorded, which is a cost-effective method for prescreening purposes.</div></div><div><h3>Objective</h3><div>This study aimed to validate the performance of artificial intelligence (AI) models using SS sounds for OSA diagnosis.</div></div><div><h3>Methods</h3><div>All participants underwent full-night polysomnography (PSG) monitoring at the sleep center. SS sounds of the participants were recorded during the laryngoscopy procedure. The audio data were processed via Python, and relevant features were extracted. OSA diagnostic models were developed using three machine learning (ML) algorithms and one deep learning (DL) algorithm. The diagnostic performance was evaluated by multiple indicators.</div></div><div><h3>Results</h3><div>A total of 465 participants were included. For the support vector machine algorithm, the accuracy values at apnea-hypopnea index (AHI) levels of 5, 15, and 30 per hour were 0.914, 0.887, and 0.807, respectively. For the K-nearest neighbor algorithm, the accuracy values at AHI levels of 5, 15, and 30 per hour were 0.896, 0.872, and 0.756, respectively. For the random forest algorithm, the accuracy values at AHI levels of 5, 15, and 30 per hour were 0.905, 0.881, and 0.804, respectively. For the audio spectrogram transformer algorithm, the accuracy values at AHI levels of 5, 15, and 30 per hour were 0.926, 0.887, and 0.830, respectively.</div></div><div><h3>Conclusions</h3><div>Our study demonstrates that DL models can effectively screen and identify OSA with commendable performance. In addition, the identification ability of the DL models was better than that of any of the ML models.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"125 ","pages":"Pages 100-107"},"PeriodicalIF":3.8,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Different regulative effects of high- and low-frequency external trigeminal nerve stimulation (eTNS) on sleep activity: Preliminary study","authors":"Chen Cheng ,&nbsp;Mengnan Jia ,&nbsp;Xiangmiao Peng ,&nbsp;Yuchen Sun ,&nbsp;Yunyun Jiao ,&nbsp;Mengkai Zhang ,&nbsp;Xiaoyu Song ,&nbsp;Zhaoyang Chu ,&nbsp;Xiao Zeng ,&nbsp;Jin-Bo Sun ,&nbsp;Xue-Juan Yang ,&nbsp;Wei Qin","doi":"10.1016/j.sleep.2024.11.007","DOIUrl":"10.1016/j.sleep.2024.11.007","url":null,"abstract":"<div><h3>Study objective</h3><div>With the growing prominence of peripheral nerve stimulation technology, the clinical applications and potential neurophysiological mechanisms of external trigeminal nerve stimulation (eTNS) have garnered increasing attention. Despite its status as the sole neuromodulation method commonly employed in sleep, no studies have explored the effects of eTNS at varying frequencies on sleep activities. This study aims to investigate the regulatory effects of high-frequency and low-frequency eTNS on sleep activities using polysomnography.</div></div><div><h3>Methods</h3><div>In this within-subjects experiment, 20 participants underwent a night of adaptation sleep, followed by 8-h sessions of sham, 120Hz-, and 2Hz-eTNS interventions in a randomized order in the sleep laboratory, with polysomnographic signals collected throughout.</div></div><div><h3>Results</h3><div>The results indicated that 120Hz-eTNS significantly improved sleep efficiency, increased N2 sleep proportion, and reduced sleep latency, without significantly affecting sleep stage transition probabilities, sleep duration, or sleep-specific wave activities. Conversely, while 2Hz-eTNS did not impact sleep efficiency or latency, it increased the proportion of N3 sleep, stabilizes N3 sleep, and enhanced the survival probability of N3 and REM sleep duration. Additionally, it increases the density of slow oscillations (SOs), improved the coupling ratio of SO-spindles, and enhanced coupling timing accuracy.</div></div><div><h3>Conclusions</h3><div>These findings suggest that eTNS during sleep can indeed modulate sleep activities, with different frequencies exerting distinct regulatory effects. This may hold significant value for advancing the clinical application and efficacy of eTNS.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"125 ","pages":"Pages 136-145"},"PeriodicalIF":3.8,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in nighttime insomnia symptoms in Canada from 2007 to 2021","authors":"Jean-Philippe Chaput ,&nbsp;Charles M. Morin ,&nbsp;Rebecca Robillard ,&nbsp;Colleen E. Carney ,&nbsp;Thien Thanh Dang-Vu ,&nbsp;Judith R. Davidson ,&nbsp;Grant R. Tomkinson ,&nbsp;Justin J. Lang ,&nbsp;Canadian Sleep Research Consortium","doi":"10.1016/j.sleep.2024.11.025","DOIUrl":"10.1016/j.sleep.2024.11.025","url":null,"abstract":"<div><h3>Objective</h3><div>National estimates and trends in insomnia symptoms in Canada are outdated. Updates are needed to inform the development of targeted prevention and intervention strategies. This study aimed to examine the prevalence and trends in nighttime insomnia symptoms among Canadians aged 12 years and older between 2007 and 2021.</div></div><div><h3>Methods</h3><div>The Canadian Community Health Survey (CCHS), a nationally representative, repeated cross-sectional survey was used. Nighttime insomnia symptoms were self-reported and defined as trouble going to sleep or staying asleep most or all of the time.</div></div><div><h3>Results</h3><div>This study included data from 197,469 participants. Nighttime insomnia symptoms in Canadians have remained relatively stable from 2007 to 2021, with higher prevalence in adults (18–20 %), particularly women (19–24 %), and those with a medium level of education defined as secondary school graduation (16–21 %). However, nighttime insomnia symptoms became 1.24-fold more prevalent from 2007 to 2021 among women aged 18–64 years (19.3 % vs. 24.0 %) and 1.33-fold more prevalent among those with a medium level of education (15.9 % vs. 21.2 %). Nighttime insomnia symptoms were roughly two times more prevalent in individuals with poorer self-perceived general health, mental health, and life satisfaction compared to those with better self-perception. The prevalence of nighttime insomnia symptoms among those with poor general health increased 1.18-fold from 23.8 % in 2007 to 28.1 % in 2021.</div></div><div><h3>Conclusions</h3><div>Over this 14-year period, nighttime insomnia symptoms have remained consistently high in Canada, but have increasingly affected certain subgroups. Targeted efforts are needed to address this issue in the most affected segments of the population.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"125 ","pages":"Pages 21-26"},"PeriodicalIF":3.8,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of sleep quality, excessive daytime sleepiness, circadian features and motor subtypes on depressive symptoms in Parkinson's disease","authors":"Anastasiia D. Shkodina ,&nbsp;Kateryna A. Tarianyk ,&nbsp;Mykhaylo Yu Delva ,&nbsp;Azmat Ali Khan ,&nbsp;Abdul Malik ,&nbsp;Sabiha Fatima ,&nbsp;Athanasios Alexiou ,&nbsp;Md. Habibur Rahman ,&nbsp;Marios Papadakis","doi":"10.1016/j.sleep.2024.11.024","DOIUrl":"10.1016/j.sleep.2024.11.024","url":null,"abstract":"<div><h3>Objectives</h3><div>The diagnosis of Parkinson's disease (PD) is mainly based on the assessment of motor symptoms, although the influence of non-motor symptoms sometimes may be more significant on the patient's disability than the cardinal clinical signs of the disease. The predominant subtype of postural instability and gait disturbance is known to be associated with more severe non-motor symptoms of Parkinson's disease. Yet, the association between motor subtypes and specific mood symptoms remains understudied. The study aimed to analyze an association between sleep and chronotype signs, motor subtypes, with the severity of depressive symptoms in PD patients.</div></div><div><h3>Methods</h3><div>We have included 64 patients in the clinical study. The studied population was divided into the following groups: PIGD group – patients with PD and dominance of postural instability and gait disorders; non-PIGD group – patients with PD and dominance of tremor or intermediate motor subtype. We used the Unified Parkinson's Disease Rating Scale, Beck Depression Inventory, Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale, and Munich Chronotype Questionnaire.</div></div><div><h3>Results</h3><div>Patients with the PIGD subtype have higher levels of depressive symptoms and excessive daytime sleepiness, poorer sleep quality, later sleep onset and mid-sleep, longer sleep latency, and sleep inertia. PIGD motor subtype (p &lt; 0.001), poor sleep quality (p &lt; 0.001), mid-sleep (p = 0.016), and sleep latency (p = 0.025) had a significant impact on the level of depression in univariate regression analysis. Still, only mid-sleep (p = 0.019) and poor sleep quality (p = 0.003) increased the probability of higher severity of depression in the multivariate model.</div></div><div><h3>Conclusion</h3><div>Poor sleep quality and later mid-sleep may be predictors of more severe depressive symptoms in PD.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"125 ","pages":"Pages 57-64"},"PeriodicalIF":3.8,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of age on hypnotics’ efficacy and safety in insomnia: A systematic review and meta-analysis","authors":"Nguyen Patrick Viet-Quoc ,&nbsp;Dang-Vu Thien Thanh ,&nbsp;Leduc Philippe (candidate) ,&nbsp;Champagne Sebastien ,&nbsp;Saidi Lidia (student) ,&nbsp;Desmarais Philippe","doi":"10.1016/j.sleep.2024.11.023","DOIUrl":"10.1016/j.sleep.2024.11.023","url":null,"abstract":"<div><h3>Objective</h3><div>This systematic review and meta-analysis evaluates the efficacy in improving sleep quality and safety of hypnotics in individuals aged 65 years or older compared to those under 65 years.</div></div><div><h3>Methods</h3><div>MEDLINE, EMBASE, Web of Science, and EBM Reviews were searched for randomized clinical trials comparing hypnotics to the placebo in adults with chronic insomnia between Jan 2000 and Dec 2022. The efficacy outcome included all participant self-assessments sleep quality questionnaires. The safety outcome included acceptability and tolerance. Standardized mean differences (SMD) was estimated using a random effect model.</div></div><div><h3>Results</h3><div>We included 17 and 53 clinical trials with 3688 and 14,720 participants in the ≥65 years and &lt;65 years group respectively. The SMD for the sleep quality outcome was −0.36 [Confidence interval (CI) 95 %: 0.45;-0.26] in the ≥65 years group compared to −0.51 [95%CI: 0.61; −0.41] in the &lt;65 years group (p = 0.02). Differences in efficacy were observed between pharmacological classes. The overall SMD for the tolerance outcome was - 0.25 [95%CI: 0.34; −0.16] favoring the placebo group (p &lt; 0.001). In the ≥65 years group the SMD was −0.07 [95%CI: 0.21; 0.08] compared to −0.31 [95%CI: 0.41; −0.21] in the &lt;65 years group (p = 0.01). There were no differences for acceptability.</div></div><div><h3>Conclusion</h3><div>We found that some hypnotics classes could be less effective in older individuals. We encourage authors to include details on multimorbidity and polypharmacy in their publications.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"125 ","pages":"Pages 120-127"},"PeriodicalIF":3.8,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A longitudinal study on the effects of oxygenation on sleep in Tibetan plateau residents","authors":"Chao Guo ,&nbsp;Yan Yan ,&nbsp;Yishu Zhu ,&nbsp;Pixin Gong ,&nbsp;Yige Liu ,&nbsp;Xi Lin ,&nbsp;Li Lan","doi":"10.1016/j.sleep.2024.11.017","DOIUrl":"10.1016/j.sleep.2024.11.017","url":null,"abstract":"<div><h3>Objective</h3><div>The decline in sleep quality induced by hypoxia is the main environmental exposure risk affecting the physiological health of high-altitude residents. The long-term effects of oxygen therapy on the sleep quality and health of highlanders remain unclear. This study aims to evaluate the impact of chronic oxygen therapy on sleep and health, providing a scientific basis for the establishment of regional centralized oxygen supply and the implementation of health regulations to improve sleep quality and health in plateau areas.</div></div><div><h3>Methods</h3><div>Conducted over a span of three years at an altitude of 3255 m in the Tibetan Plateau, this study included 317 participants and meticulously recorded sleep data for 1398 nights. The generalized estimation equation was used to analyze the impact of oxygen supply on sleep quality, physiological parameters, and indoor environment.</div></div><div><h3>Results</h3><div>The research found that long-term oxygen therapy significantly reduced the pulse rate of highland residents, increased their blood oxygen saturation, and consequently decreased their risk of cardiovascular disease. Oxygen-enriched environments improved the sleep quality of highland dwellers, significantly increasing their sleep efficiency, duration of rapid eye movement sleep and deep sleep, and subjective sleep quality evaluation, while also significantly reducing central sleep apnea-induced nighttime awakening events.</div></div><div><h3>Conclusions</h3><div>Long-term chronic oxygen therapy is beneficial to highland residents in terms of sleep respiratory rhythm, sleep quality, and cardiovascular function. It is imperative for both the local inhabitants of high-altitude areas and the local health authorities to be aware of the risks of hypoxia and the health benefits of oxygen therapy.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"125 ","pages":"Pages 74-86"},"PeriodicalIF":3.8,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}