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Generation and characterization of induced pluripotent stem cell derived from cynomolgus monkey (cmESF-iPS-C4). 食蟹猴诱导多能干细胞（cmESF-iPS-C4）的生成与鉴定。
IF 0.7 4区 医学
Stem cell research Pub Date : 2025-09-01 Epub Date: 2025-08-06 DOI: 10.1016/j.scr.2025.103799
Min-Tae Kim, Xing Zhen, Se-Hee Choe, Eunsu Jeon, Tae-Don Kim, Sang-Je Park, Jong-Hee Lee
{"title":"Generation and characterization of induced pluripotent stem cell derived from cynomolgus monkey (cmESF-iPS-C4).","authors":"Min-Tae Kim, Xing Zhen, Se-Hee Choe, Eunsu Jeon, Tae-Don Kim, Sang-Je Park, Jong-Hee Lee","doi":"10.1016/j.scr.2025.103799","DOIUrl":"10.1016/j.scr.2025.103799","url":null,"abstract":"<p><p>Cynomolgus monkey iPSCs were generated from ear fibroblasts, offering a non-invasive and accessible cell source for autologous therapies and preclinical research. These iPSCs demonstrated robust pluripotency and differentiation potential, successfully giving rise to functional macrophages. Validation confirmed chromosomal stability, transgene clearance, and mycoplasma-free status. While this study focuses on establishing a reliable iPSC source, these cells hold promise for generating functional cell types for potential autologous applications in primate models. This platform provides a valuable foundation for advancing regenerative medicine and precision immunotherapy, bridging the gap between in vitro research and future translational studies.</p>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"87 ","pages":"103799"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144822649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of an iPSC line (CHSUi001-A) from a patient with JAK3 gene mutations 从JAK3基因突变患者中产生iPSC系（CHSUi001-A）
IF 0.7 4区 医学
Stem cell research Pub Date : 2025-08-30 DOI: 10.1016/j.scr.2025.103822
Meng Gao , Na Li , Xingcui Wang
{"title":"Generation of an iPSC line (CHSUi001-A) from a patient with JAK3 gene mutations","authors":"Meng Gao ,&nbsp;Na Li ,&nbsp;Xingcui Wang","doi":"10.1016/j.scr.2025.103822","DOIUrl":"10.1016/j.scr.2025.103822","url":null,"abstract":"<div><div>This study describes the establishment of an induced pluripotent stem cell (iPSC) line derived from a patient harboring two heterozygous <em>JAK3</em> gene mutations: c.1914G &gt; T and c.1048C &gt; T. The iPSCs were generated via non-integrating episomal vector-mediated reprogramming of peripheral blood mononuclear cells (PBMCs), expressing OCT4, SOX2, KLF4, BCL-XL and c-MYC. The resulting iPSCs exhibited robust expression of pluripotency markers, demonstrated trilineage differentiation potential in vitro, and maintained a normal karyotype. This iPSC line serves as a valuable resource for elucidating the molecular mechanisms underlying JAK3-associated immunodeficiencies and for preclinical drug screening.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"88 ","pages":"Article 103822"},"PeriodicalIF":0.7,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation and characterization of three human induced pluripotent stem cell lines from patients with glycogen storage disease type II 糖原储存病II型患者三种人诱导多能干细胞系的生成和特性
IF 0.7 4区 医学
Stem cell research Pub Date : 2025-08-29 DOI: 10.1016/j.scr.2025.103823
Matthieu Lejars , Christelle Kabore , Benjamin Marande , Laura Brulle-Soumare , Nejette Lallouche , Karim Wahbi , Edoardo Malfatti , Teresinha Evangelista , Lina El Kassar , Pascal Fragner , Karine Giraud-Triboult , Lucile Hoch , Xavier Nissan , Quentin Miagoux
{"title":"Generation and characterization of three human induced pluripotent stem cell lines from patients with glycogen storage disease type II","authors":"Matthieu Lejars ,&nbsp;Christelle Kabore ,&nbsp;Benjamin Marande ,&nbsp;Laura Brulle-Soumare ,&nbsp;Nejette Lallouche ,&nbsp;Karim Wahbi ,&nbsp;Edoardo Malfatti ,&nbsp;Teresinha Evangelista ,&nbsp;Lina El Kassar ,&nbsp;Pascal Fragner ,&nbsp;Karine Giraud-Triboult ,&nbsp;Lucile Hoch ,&nbsp;Xavier Nissan ,&nbsp;Quentin Miagoux","doi":"10.1016/j.scr.2025.103823","DOIUrl":"10.1016/j.scr.2025.103823","url":null,"abstract":"<div><div>Glycogen storage disease type II (GSDII), or Pompe disease, is a rare autosomal recessive metabolic disorder characterized by the deficiency of the lysosomal enzyme acid alpha-glucosidase (GAA). GAA deficiency results in the progressive accumulation of glycogen in cardiac and skeletal muscle tissues, leading to cellular dysfunction and clinical manifestations, including muscle weakness, respiratory difficulties, and cardiomyopathy. In this study, we report the derivation of three induced pluripotent stem cell (iPSC) lines from peripheral blood mononuclear cells of GSDII patients. These patient-derived iPSC lines can be used to study pathological features of the disease and evaluate therapeutic strategies for Pompe disease.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"88 ","pages":"Article 103823"},"PeriodicalIF":0.7,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144933496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of human induced pluripotent stem cell lines from healthy Korean donors (IPBi101-A, IPBi102-A, IPBi103-A, IPBi105-A, IPBi107-A, IPBi108-A, IPBi110-A, IPBi111-A, IPBi113-A, and IPBi114-A) 韩国健康供体人诱导多能干细胞系（IPBi101-A、IPBi102-A、IPBi103-A、IPBi105-A、IPBi107-A、IPBi108-A、IPBi110-A、IPBi111-A、IPBi113-A和IPBi114-A）的生成
IF 0.7 4区 医学
Stem cell research Pub Date : 2025-08-27 DOI: 10.1016/j.scr.2025.103821
Miju Lee , Jaecheol Park , Yoon-Eun Kim , Songeun Nah , Mira Han , Chan Yeong Heo , Mahito Nakanishi , Jihwan Song
{"title":"Generation of human induced pluripotent stem cell lines from healthy Korean donors (IPBi101-A, IPBi102-A, IPBi103-A, IPBi105-A, IPBi107-A, IPBi108-A, IPBi110-A, IPBi111-A, IPBi113-A, and IPBi114-A)","authors":"Miju Lee ,&nbsp;Jaecheol Park ,&nbsp;Yoon-Eun Kim ,&nbsp;Songeun Nah ,&nbsp;Mira Han ,&nbsp;Chan Yeong Heo ,&nbsp;Mahito Nakanishi ,&nbsp;Jihwan Song","doi":"10.1016/j.scr.2025.103821","DOIUrl":"10.1016/j.scr.2025.103821","url":null,"abstract":"<div><div>Human induced pluripotent stem cell (iPSC) lines were derived from peripheral blood mononuclear cells (PBMCs) obtained from ten healthy Korean donors of diverse ages and genders using a Sendai virus-based reprogramming method. These iPSC lines expressed markers of undifferentiated state and demonstrated trilineage differentiation potential <em>in vitro</em>. Characterization confirmed normal karyotypes, clearance of the Sendai virus, and short tandem repeat (STR) profiles identical to the parental PBMCs. These cell lines can serve as a valuable resource for disease modeling, drug screening, and as a human-based alternative to animal experiments.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"88 ","pages":"Article 103821"},"PeriodicalIF":0.7,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144911876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of CHOPi014-A from healthy adult peripheral blood mononuclear cells 健康成人外周血单个核细胞生成CHOPi014-A
IF 0.7 4区 医学
Stem cell research Pub Date : 2025-08-24 DOI: 10.1016/j.scr.2025.103820
Alyssa L. Gagne , Jean Ann Maguire , Lea Dungan , Paul Gadue , Deborah L. French , Giulia Pavani
{"title":"Generation of CHOPi014-A from healthy adult peripheral blood mononuclear cells","authors":"Alyssa L. Gagne ,&nbsp;Jean Ann Maguire ,&nbsp;Lea Dungan ,&nbsp;Paul Gadue ,&nbsp;Deborah L. French ,&nbsp;Giulia Pavani","doi":"10.1016/j.scr.2025.103820","DOIUrl":"10.1016/j.scr.2025.103820","url":null,"abstract":"<div><div>CHOPWT15<!--> <!-->is a control male induced pluripotent stem cell (iPSC) line that can be used to model genetic variants by creating an allelic series of isogenic lines using genome editing technologies (<span><span>Hockemeyer and Jaenisch, 2016</span></span>, <span><span>Maguire et al., 2022</span></span>, <span><span>Pavani et al., 2022</span></span>). An allelic series of iPSC lines provides the means to perform genotype and phenotype analyses of pathological variants without the confounding effects of genetic background. Peripheral blood mononuclear cells (PBMCs), obtained from a healthy adult male, were reprogrammed using Sendai virus creating an iPSC line that has undetectable copy number variations (CNVs, resolution &gt;= 100 kb) and differentiates to all three germlayers.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"88 ","pages":"Article 103820"},"PeriodicalIF":0.7,"publicationDate":"2025-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144902637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of an induced pluripotent stem cell line, JHUi008-A, from a healthy female donor 诱导多能干细胞系JHUi008-A的生成，来自健康女性供体
IF 0.7 4区 医学
Stem cell research Pub Date : 2025-08-24 DOI: 10.1016/j.scr.2025.103819
Christianne J. Chua , Deborah DiSilvestre , Rosy Joshi-Mukherjee , Leslie Tung , Gordon F. Tomaselli , Kenneth R. Boheler
{"title":"Generation of an induced pluripotent stem cell line, JHUi008-A, from a healthy female donor","authors":"Christianne J. Chua ,&nbsp;Deborah DiSilvestre ,&nbsp;Rosy Joshi-Mukherjee ,&nbsp;Leslie Tung ,&nbsp;Gordon F. Tomaselli ,&nbsp;Kenneth R. Boheler","doi":"10.1016/j.scr.2025.103819","DOIUrl":"10.1016/j.scr.2025.103819","url":null,"abstract":"<div><div>The use of well characterized human induced pluripotent stem cells (hiPSCs) is essential for developmental studies and disease modeling. Here, we report the generation of a normal, female line of hiPSCs following reprogramming of peripheral blood mononuclear cells (PBMCs) derived from a healthy female donor using Sendai virus technology. This line, which has been extensively employed for the <em>in vitro</em> study of mesoderm-derived cardiomyocytes, is available and registered in the Human Pluripotent Stem Cell Registry (hPSCreg). It exhibits a normal karyotype, expresses stemness markers, and demonstrates robust trilineage differentiation potential.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"88 ","pages":"Article 103819"},"PeriodicalIF":0.7,"publicationDate":"2025-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation and characterization of a patient-derived iPSC line, CSSi022-A (15666), with a pathogenic MFN2 mutation causing Charcot-Marie-Tooth disease type 2A 患者来源的iPSC系CSSi022-A（15666）的产生和特性，该系具有致病性MFN2突变，可导致2A型沙科-玛丽-图斯病
IF 0.7 4区 医学
Stem cell research Pub Date : 2025-08-23 DOI: 10.1016/j.scr.2025.103817
Angela Maria Giada Giovenale , Ilaria Ferrone , Silvia Tomaselli , Martina Mazzoni , Giorgia Ruotolo , Elisa Maria Turco , Barbara Torres , Alessandro De Luca , Paola Zanfardino , Edvige Vulcano , Daniela Ferrari , Devid Damiani , Filippo M. Santorelli , Maria Pennuto , Angelo Luigi Vescovi , Vittoria Petruzzella , Jessica Rosati
{"title":"Generation and characterization of a patient-derived iPSC line, CSSi022-A (15666), with a pathogenic MFN2 mutation causing Charcot-Marie-Tooth disease type 2A","authors":"Angela Maria Giada Giovenale ,&nbsp;Ilaria Ferrone ,&nbsp;Silvia Tomaselli ,&nbsp;Martina Mazzoni ,&nbsp;Giorgia Ruotolo ,&nbsp;Elisa Maria Turco ,&nbsp;Barbara Torres ,&nbsp;Alessandro De Luca ,&nbsp;Paola Zanfardino ,&nbsp;Edvige Vulcano ,&nbsp;Daniela Ferrari ,&nbsp;Devid Damiani ,&nbsp;Filippo M. Santorelli ,&nbsp;Maria Pennuto ,&nbsp;Angelo Luigi Vescovi ,&nbsp;Vittoria Petruzzella ,&nbsp;Jessica Rosati","doi":"10.1016/j.scr.2025.103817","DOIUrl":"10.1016/j.scr.2025.103817","url":null,"abstract":"<div><div>Charcot-Marie-Tooth disease type 2A (CMT2A; OMIM 609260) is a rare sensorimotor neuropathy caused by mutations in the MFN2 gene (1p36.22). We successfully reprogrammed fibroblasts from an 8-year-old girl carrying a de novo MFN2 mutation into induced pluripotent stem cells using non-integrative vectors. The line shows normal karyotype, pluripotency, and trilineage differentiation, providing a valuable in vitro model to study disease mechanisms.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"88 ","pages":"Article 103817"},"PeriodicalIF":0.7,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144917603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Derivation of clinical-grade HLA-homozygous induced pluripotent stem cell line UNIONi001-A from umbilical cord blood of a Han Chinese male neonate 从汉族男性新生儿脐带血中提取临床级hla纯合诱导多能干细胞UNIONi001-A
IF 0.7 4区 医学
Stem cell research Pub Date : 2025-08-23 DOI: 10.1016/j.scr.2025.103818
Xiaohui Shi , Qianping Zhang , Lijuan Cui , Ying Jia , Jinmei Zhang , Li Zhang , Ruizhen Hou , Wenling Yang , Wei Du , Yu Zhang
{"title":"Derivation of clinical-grade HLA-homozygous induced pluripotent stem cell line UNIONi001-A from umbilical cord blood of a Han Chinese male neonate","authors":"Xiaohui Shi ,&nbsp;Qianping Zhang ,&nbsp;Lijuan Cui ,&nbsp;Ying Jia ,&nbsp;Jinmei Zhang ,&nbsp;Li Zhang ,&nbsp;Ruizhen Hou ,&nbsp;Wenling Yang ,&nbsp;Wei Du ,&nbsp;Yu Zhang","doi":"10.1016/j.scr.2025.103818","DOIUrl":"10.1016/j.scr.2025.103818","url":null,"abstract":"<div><div>The clinical-grade iPSC line UNIONi001-A is derived from HLA-homozygous (HLAh) umbilical cord blood mononuclear cells (CBMCs) of a healthy Han Chinese male neonate. Cells were reprogrammed using episomal plasmids with OCT3/4, SOX2, KLF4, c-MYC and BCL-XL. The iPSCs exhibited typical pluripotent stem cell morphology, expressed pluripotency markers, maintained a normal karyotype, and could differentiate into three germ layers, making them suitable for cell therapy research and clinical use.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"88 ","pages":"Article 103818"},"PeriodicalIF":0.7,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144896037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of human induced pluripotent stem cell line from an obesity patient with POMC deficiency due to POMC:W84X mutation 由POMC:W84X突变引起的POMC缺乏症肥胖患者的人诱导多能干细胞系的生成
IF 0.7 4区 医学
Stem cell research Pub Date : 2025-08-22 DOI: 10.1016/j.scr.2025.103814
Katarzyna A. Ludwik , Regina Jahn , Sabine Jyrch , Lara Lechner , Valeria Fernandez Valone , Peter Kühnen , Harald Stachelscheid
{"title":"Generation of human induced pluripotent stem cell line from an obesity patient with POMC deficiency due to POMC:W84X mutation","authors":"Katarzyna A. Ludwik ,&nbsp;Regina Jahn ,&nbsp;Sabine Jyrch ,&nbsp;Lara Lechner ,&nbsp;Valeria Fernandez Valone ,&nbsp;Peter Kühnen ,&nbsp;Harald Stachelscheid","doi":"10.1016/j.scr.2025.103814","DOIUrl":"10.1016/j.scr.2025.103814","url":null,"abstract":"<div><div>We generated the human induced pluripotent stem cell (iPSC) line BIHi261-A from dermal fibroblasts of a patient with severe early-onset obesity caused by a homozygous truncating mutation in the POMC gene (W84X). Reprogramming was performed using a non-integrating, RNA-based vector expressing key pluripotency factors. The resulting iPSC line exhibited typical morphology, expressed markers of undifferentiated cells, maintained a normal karyotype, and demonstrated the capacity to differentiate into cell types of all three germ layers. BIHi261-A provides a valuable tool for studying the molecular mechanisms of POMC-related obesity and for developing potential therapeutic strategies.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"88 ","pages":"Article 103814"},"PeriodicalIF":0.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of a human PBMC induced pluripotent stem cell line JXEYi001-A-iPSC from a pediatric patient with ventricular arrhythmias 小儿室性心律失常患者PBMC诱导多能干细胞系JXEYi001-A-iPSC的生成
IF 0.7 4区 医学
Stem cell research Pub Date : 2025-08-22 DOI: 10.1016/j.scr.2025.103815
Yunguo Zhou , Yang Shen , Keyu Jiang , Fei Xu , Junkai Duan , Jinzhu Hu
{"title":"Generation of a human PBMC induced pluripotent stem cell line JXEYi001-A-iPSC from a pediatric patient with ventricular arrhythmias","authors":"Yunguo Zhou ,&nbsp;Yang Shen ,&nbsp;Keyu Jiang ,&nbsp;Fei Xu ,&nbsp;Junkai Duan ,&nbsp;Jinzhu Hu","doi":"10.1016/j.scr.2025.103815","DOIUrl":"10.1016/j.scr.2025.103815","url":null,"abstract":"<div><div>This study established an iPSC line, JXEYi001-A, from a 7-year-old male with a KCNJ2 mutation linked to ventricular arrhythmias (VA). KCNJ2 encodes Kir2.1, essential for cardiac repolarization; its mutations can cause short QT syndrome, increasing VA risk. Derived from PBMCs using Sendai virus, the line expresses pluripotency markers (OCT4, SOX2, NANOG, SSEA4) and has a normal male karyotype. Sanger sequencing confirmed the heterozygous c.431G &gt; A (p.Gly144Asp) mutation. This iPSC line aids in studying KCNJ2-related cardiac diseases, personalized medicine, and drug screening, advancing targeted therapies for VA.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"88 ","pages":"Article 103815"},"PeriodicalIF":0.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144896036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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