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Generation of two induced pluripotent stem cell lines from Lynch syndrome patients carrying heterozygous MLH1 mutations 来自Lynch综合征患者携带杂合MLH1突变的两种诱导多能干细胞系的产生
IF 0.7 4区 医学
Stem cell research Pub Date : 2025-09-11 DOI: 10.1016/j.scr.2025.103832
Erin Hu , Arianne Caudal , Christopher D. Yan , Yanjun Zha , Uri Ladabaum , Joseph C. Wu
{"title":"Generation of two induced pluripotent stem cell lines from Lynch syndrome patients carrying heterozygous MLH1 mutations","authors":"Erin Hu ,&nbsp;Arianne Caudal ,&nbsp;Christopher D. Yan ,&nbsp;Yanjun Zha ,&nbsp;Uri Ladabaum ,&nbsp;Joseph C. Wu","doi":"10.1016/j.scr.2025.103832","DOIUrl":"10.1016/j.scr.2025.103832","url":null,"abstract":"<div><div>Lynch syndrome (LS), previously known as hereditary nonpolyposis colorectal cancer (HNPCC), is one of the most common hereditary cancer<!--> <!-->syndromes. LS is caused by a pathogenic mutation in one of the four DNA mismatch repair<!--> <!-->genes<!--> <em>MLH1</em>,<!--> <em>MSH2</em>,<!--> <em>MSH6</em>, or<!--> <em>PMS2</em>, or in<!--> <em>EPCAM</em>, which is upstream of<!--> <em>MSH2</em>. We generated two human induced pluripotent stem cell (iPSC) lines from LS patients carrying different single heterozygous missense mutations in the<!--> <em>MLH1</em> <!-->gene. Pluripotency, morphology, karyotype stability, and differentiation capacity of both lines were<!--> <!-->normal. These patient-specific iPSC lines are<!--> <!-->a valuable tool to investigate LS phenotypes and develop potential therapeutics.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"88 ","pages":"Article 103832"},"PeriodicalIF":0.7,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145060088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation and characterization of two pluripotent stem cell lines from Primary Lateral Sclerosis (PLS) patients 原发性侧索硬化症（PLS）患者两种多能干细胞系的产生和特性分析
IF 0.7 4区 医学
Stem cell research Pub Date : 2025-09-08 DOI: 10.1016/j.scr.2025.103828
Laverde-Paz Mayra Juliana , Maki Kassidy , Melo-Escobar Isabel , McCartan Robyn , Benatar Michael , Wuu Joanne , Zeier Zane
{"title":"Generation and characterization of two pluripotent stem cell lines from Primary Lateral Sclerosis (PLS) patients","authors":"Laverde-Paz Mayra Juliana ,&nbsp;Maki Kassidy ,&nbsp;Melo-Escobar Isabel ,&nbsp;McCartan Robyn ,&nbsp;Benatar Michael ,&nbsp;Wuu Joanne ,&nbsp;Zeier Zane","doi":"10.1016/j.scr.2025.103828","DOIUrl":"10.1016/j.scr.2025.103828","url":null,"abstract":"<div><div>Primary Lateral Sclerosis (PLS) is an ultra-rare disorder characterized by the selective degeneration of upper motor neurons. Here, we report the generation and validation of two human induced pluripotent stem cell (iPSC) lines derived from unrelated male and female donors without any known family history of PLS or identifiable genetic risk factors. Aside from a juvenile subtype, PLS is predominantly idiopathic, and existing animal models fail to replicate its clinical features. As such, these iPSC lines offer a valuable resource for studying sporadic, adult-onset PLS—the most prevalent form of the disease.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"88 ","pages":"Article 103828"},"PeriodicalIF":0.7,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145060091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of the human iPSC line (AHJNMUi001-A) from a patient with arrhythmogenic right ventricular cardiomyopathy (ARVC) carrying the LMNA c.821C>T pathogenic variant 从携带LMNA c.821C >t致病变异的心律失常性右室心肌病（ARVC）患者身上产生的人iPSC系(AHJNMUi001-A
IF 0.7 4区 医学
Stem cell research Pub Date : 2025-09-07 DOI: 10.1016/j.scr.2025.103830
Yuanyuan Han , Haiyan Wang , Hongsheng Zhang , Manman Wang , Lijun Gan , Fanhua Meng
{"title":"Generation of the human iPSC line (AHJNMUi001-A) from a patient with arrhythmogenic right ventricular cardiomyopathy (ARVC) carrying the LMNA c.821C>T pathogenic variant","authors":"Yuanyuan Han ,&nbsp;Haiyan Wang ,&nbsp;Hongsheng Zhang ,&nbsp;Manman Wang ,&nbsp;Lijun Gan ,&nbsp;Fanhua Meng","doi":"10.1016/j.scr.2025.103830","DOIUrl":"10.1016/j.scr.2025.103830","url":null,"abstract":"<div><div>Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a hereditary infiltrative cardiomyopathy characterized by fibrofatty replacement of the right ventricular myocardium, which may extend to the left ventricle in the advanced stages. Clinically, the condition is commonly associated with right ventricular dilation, malignant arrhythmias, and an increased risk of sudden cardiac death. In this study, we successfully established induced pluripotent stem cell (iPSC) lines from peripheral blood mononuclear cells of ARVC patients carrying a heterozygous <em>LMNA</em> gene mutation (c.821C&gt;T, p.A274D), using a non-integrating Sendai virus-based reprogramming method. The resulting cell lines displayed typical pluripotent stem cell morphology, a normal karyotype, and trilineage differentiation potential. Furthermore, they stably expressed key pluripotency markers, making them a valuable model for investigating the pathophysiological mechanisms of ARVC and for drug screening. This model holds significant translational potential for precision medicine.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"88 ","pages":"Article 103830"},"PeriodicalIF":0.7,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145019961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of a biallelic NRAP-knockout mutant from a human iPSC line 从人类iPSC系中产生双等位基因nrap敲除突变体
IF 0.7 4区 医学
Stem cell research Pub Date : 2025-09-04 DOI: 10.1016/j.scr.2025.103829
Janice Raabe , Vanessa Lewandowski , Sigrid Fuchs , Alexandra Hammerschmidt , Angelika Piasecki , Ellen Orthey , Elisabeth Krämer , Elisabeth Ehler , Friederike Cuello
{"title":"Generation of a biallelic NRAP-knockout mutant from a human iPSC line","authors":"Janice Raabe ,&nbsp;Vanessa Lewandowski ,&nbsp;Sigrid Fuchs ,&nbsp;Alexandra Hammerschmidt ,&nbsp;Angelika Piasecki ,&nbsp;Ellen Orthey ,&nbsp;Elisabeth Krämer ,&nbsp;Elisabeth Ehler ,&nbsp;Friederike Cuello","doi":"10.1016/j.scr.2025.103829","DOIUrl":"10.1016/j.scr.2025.103829","url":null,"abstract":"<div><div>Cardiomyopathies, a leading cause of mortality, are associated with dysfunctional intercalated discs, which connect neighbouring cardiomyocytes and ensure proper contractility. In human cardiac diseases, loss-of-function mutations of the intercalated disc-associated protein Nebulin-Related Anchoring Protein (NRAP) have been reported. NRAP plays a crucial role in myofibril assembly and mechanotransduction, however, its regulatory functions remain unclear. To investigate the effects of NRAP loss-of-function in cardiac disease, a human induced pluripotent stem cell (hiPSC) line was generated carrying a biallelic <em>NRAP</em>–knockout (KO) using the CRISPR-Cas9 technology. Control and mutant cell lines were assessed for karyotype integrity, pluripotency, off-target effects, mycoplasma contamination, and differentiation into ectoderm, mesoderm, and endoderm. This hiPSC line provides a valuable tool to study how NRAP modulates cardiac function and contributes to disease progression.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"88 ","pages":"Article 103829"},"PeriodicalIF":0.7,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145010146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An iPSC line (FINi102-A) carrying a heterozygous R950Q variant in KCNT1 from a boy with early-onset epilepsy 一个携带KCNT1杂合R950Q变体的iPSC系（FINi102-A）来自一名早发性癫痫男孩
IF 0.7 4区 医学
Stem cell research Pub Date : 2025-09-03 DOI: 10.1016/j.scr.2025.103826
Dmitry A. Ovchinnikov , Sharon Jong , Saul Mullen , Justin West , Snezana Maljevic , Steve Petrou
{"title":"An iPSC line (FINi102-A) carrying a heterozygous R950Q variant in KCNT1 from a boy with early-onset epilepsy","authors":"Dmitry A. Ovchinnikov ,&nbsp;Sharon Jong ,&nbsp;Saul Mullen ,&nbsp;Justin West ,&nbsp;Snezana Maljevic ,&nbsp;Steve Petrou","doi":"10.1016/j.scr.2025.103826","DOIUrl":"10.1016/j.scr.2025.103826","url":null,"abstract":"<div><div>The <em>KCNT1</em> gene, affected in early-onset epilepsies, encodes a T-type sodium-activated potassium channel, K<sub>Na</sub>1.1, involved in membrane post-firing re-hyperpolarisation in various neuronal cell types. Fibroblasts from a boy with early-onset epilepsy carrying a heterozygous missense (R950Q) KCNT1 variant were reprogrammed using Sendai virus. This iPSC line displayed normal hiPSC morphology, expression of pluripotency markers, ability to differentiate into all three embryonic germ layers, and no high-density SNP array-detectable aneuploidies. This line can be used for modelling of, and the development of precision therapies for, debilitating early-onset epilepsies and other conditions caused by the variants in <em>KCNT1</em>.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"88 ","pages":"Article 103826"},"PeriodicalIF":0.7,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of three induced pluripotent stem cell lines from a long QT syndrome type 2 family harboring the pathogenic KCNH2 c.209A > G (p.His70Arg) variant 来自长QT综合征2型家族的三种诱导多能干细胞系携带致病性KCNH2 c.209A > G （p.His70Arg）变异
IF 0.7 4区 医学
Stem cell research Pub Date : 2025-09-03 DOI: 10.1016/j.scr.2025.103827
Evan Scislowicz , Dingqian Ding , Anna G Griggs , Adriana Harbuzariu , Ilanit Itzhaki
{"title":"Generation of three induced pluripotent stem cell lines from a long QT syndrome type 2 family harboring the pathogenic KCNH2 c.209A > G (p.His70Arg) variant","authors":"Evan Scislowicz ,&nbsp;Dingqian Ding ,&nbsp;Anna G Griggs ,&nbsp;Adriana Harbuzariu ,&nbsp;Ilanit Itzhaki","doi":"10.1016/j.scr.2025.103827","DOIUrl":"10.1016/j.scr.2025.103827","url":null,"abstract":"<div><div>Long QT Syndrome Type 2 (LQT2) is a heart rhythm disorder caused by a loss-of-function mutation in the KCNH2 gene, characterized by a prolonged QT interval on an electrocardiogram (ECG) and symptoms such as syncope and potentially life-threatening Torsades de Pointes arrhythmia. We derived three induced pluripotent stem cell (iPSC) lines from a LQT2 family: two individuals with LQT2 who carry the pathogenic variant c.209A &gt; G (p.His70Arg), and one healthy individual. These iPSC lines exhibit normal karyotype, differentiation capability, stem cell pluripotency, and stem cell morphology, providing a model that can contribute to the fields of translational research and precision medicine.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"88 ","pages":"Article 103827"},"PeriodicalIF":0.7,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145045147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of a PHF19 knockout human embryonic stem cell line by CRISPR/Cas9 system 利用CRISPR/Cas9系统产生PHF19基因敲除的人胚胎干细胞系
IF 0.7 4区 医学
Stem cell research Pub Date : 2025-09-01 DOI: 10.1016/j.scr.2025.103824
Yuqing Ran , Jinghua Ruan , Yijia Wang , Xing Feng , Pingping Tan , Yuting Guan , Xiaoling Guo
{"title":"Generation of a PHF19 knockout human embryonic stem cell line by CRISPR/Cas9 system","authors":"Yuqing Ran ,&nbsp;Jinghua Ruan ,&nbsp;Yijia Wang ,&nbsp;Xing Feng ,&nbsp;Pingping Tan ,&nbsp;Yuting Guan ,&nbsp;Xiaoling Guo","doi":"10.1016/j.scr.2025.103824","DOIUrl":"10.1016/j.scr.2025.103824","url":null,"abstract":"<div><div>PHD finger protein 19 (PHF19) is a polycomb protein that promoted cardiac hypertrophy via epigenetic targeting SIRT2. To determine the role of PHF19 in myocardial hypertrophy, we established a large fragment knockout model of <em>PHF19</em> gene in human embryonic stem cells (hESCs-H7) using the CRISPR/Cas9 system based on a vector. This <em>PHF19</em>-KO cell line has a normal karyotype, classical human pluripotent stem cell morphology, strong pluripotency, and significantly reduced <em>PHF19</em> gene expression, which will become a useful tool for further in-depth research on the pathogenesis of <em>PHF19</em> gene deficiency induced myocardial hypertrophy.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"88 ","pages":"Article 103824"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144933497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of two B2M knockout induced pluripotent stem cell lines (DHMi005-A-8 and DHMi005-A-9) using CRISPR/Cas9 technology. 利用CRISPR/Cas9技术生成两个B2M敲除诱导的多能干细胞系（DHMi005-A-8和DHMi005-A-9）。
IF 0.7 4区 医学
Stem cell research Pub Date : 2025-09-01 Epub Date: 2025-08-06 DOI: 10.1016/j.scr.2025.103785
Katharina Abdel-Malek, Franziska von Eisenhart-Rothe, Santiago Stiegmann, Irina Gottmann, Stefanie A Doppler, Stephanie Schneider, Heike Preisler, Harald Lahm, Martina Dreßen
{"title":"Generation of two B2M knockout induced pluripotent stem cell lines (DHMi005-A-8 and DHMi005-A-9) using CRISPR/Cas9 technology.","authors":"Katharina Abdel-Malek, Franziska von Eisenhart-Rothe, Santiago Stiegmann, Irina Gottmann, Stefanie A Doppler, Stephanie Schneider, Heike Preisler, Harald Lahm, Martina Dreßen","doi":"10.1016/j.scr.2025.103785","DOIUrl":"10.1016/j.scr.2025.103785","url":null,"abstract":"<p><p>The transplantation of cells into a recipient organism has many hurdles to overcome, including the problem of T-cell-triggered cellular immune defense. Cellular rejection is based on antigen presentation by the MHC-I-complex, which is recognized by cytotoxic T lymphocytes. Elimination of the MHC-I-complex by knocking out the B2M (Beta-2-microglobulin) subunit may be one way of reducing or even completely preventing the initial cellular immune response during transplantation. Using CRISPR/Cas9 we established one heterozygous and one homozygous B2M knockout induced pluripotent stem cell (iPSC) line as a first step towards more effective cell transplantation.</p>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"87 ","pages":"103785"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CRISPR/Cas9-mediated editing of COQ4 in induced pluripotent stem cells: A model for investigating COQ4-associated human coenzyme Q10 deficiency 诱导多能干细胞中CRISPR/ cas9介导的辅酶q4编辑：研究辅酶q4相关的人类辅酶Q10缺陷的模型
IF 0.7 4区 医学
Stem cell research Pub Date : 2025-09-01 DOI: 10.1016/j.scr.2025.103825
Sonja Herbrich , Haribaskar Ramachandran , Annette Seibt , Isabella Tolle , Annika Zink , Alessandro Prigione , Andrea Rossi , Felix Distelmaier
{"title":"CRISPR/Cas9-mediated editing of COQ4 in induced pluripotent stem cells: A model for investigating COQ4-associated human coenzyme Q10 deficiency","authors":"Sonja Herbrich ,&nbsp;Haribaskar Ramachandran ,&nbsp;Annette Seibt ,&nbsp;Isabella Tolle ,&nbsp;Annika Zink ,&nbsp;Alessandro Prigione ,&nbsp;Andrea Rossi ,&nbsp;Felix Distelmaier","doi":"10.1016/j.scr.2025.103825","DOIUrl":"10.1016/j.scr.2025.103825","url":null,"abstract":"<div><div>Pathogenic variants in the gene <em>COQ4</em> cause primary coenzyme Q<sub>10</sub> deficiency, which is associated with symptoms ranging from early epileptic encephalopathy up to adult-onset ataxia-spasticity spectrum disease. We genetically modified commercially available wild-type iPS cells by using a CRISPR/Cas9 approach to create heterozygous and homozygous isogenic cell lines carrying the disease-causing <em>COQ4</em> variants c.458C &gt; T, p.Ala153Val and c.437T &gt; G, p.Phe146Cys, respectively. All iPSCs lines exhibited a normal cell morphology, expression of pluripotency markers, and the ability to differentiate into the three primary germ layers. The COQ4-deficient cell lines will provide a helpful tool to investigate the disease mechanism and to develop therapeutic strategies.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"88 ","pages":"Article 103825"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145019962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of two induced pluripotent stem cell lines from patients with Facioscapulohumeral muscular dystrophy. 面部肩胛骨-肱骨肌萎缩症患者两种诱导多能干细胞系的生成。
IF 0.7 4区 医学
Stem cell research Pub Date : 2025-09-01 Epub Date: 2025-07-29 DOI: 10.1016/j.scr.2025.103794
Ravichandra Venkateshappa, Francesca Vacante, Lingyun Xu, Gabriela Canel-Rivero, John W Day, Joseph C Wu
{"title":"Generation of two induced pluripotent stem cell lines from patients with Facioscapulohumeral muscular dystrophy.","authors":"Ravichandra Venkateshappa, Francesca Vacante, Lingyun Xu, Gabriela Canel-Rivero, John W Day, Joseph C Wu","doi":"10.1016/j.scr.2025.103794","DOIUrl":"10.1016/j.scr.2025.103794","url":null,"abstract":"<p><p>Facioscapulohumeral muscular dystrophy (FSHD) is a genetically complex condition marked by progressive skeletal muscle weakness, primarily affecting the face, shoulders, and upper arms. Here, we generated human induced pluripotent stem cell (iPSC) lines from two clinically diagnosed FSHD patients and characterized their pluripotency and germline markers. Both lines exhibited pluripotency markers, maintained normal karyotypes, and were capable of differentiating into all three germ layers. These iPSC lines are valuable resources for studying FSHD mechanisms and potential drug discovery applications.</p>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"87 ","pages":"103794"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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