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A method for detecting stemness of glioblastoma: 3D-tumor spheroid assay 一种检测胶质母细胞瘤干性的方法：三维肿瘤球体法
IF 0.7 4区 医学
Stem cell research Pub Date : 2026-03-01 Epub Date: 2026-02-07 DOI: 10.1016/j.scr.2026.103925
Yan Chen , Hao Zeng , Kaixiang Ni , Jiantong Jiao , Songtao Qi
{"title":"A method for detecting stemness of glioblastoma: 3D-tumor spheroid assay","authors":"Yan Chen ,&nbsp;Hao Zeng ,&nbsp;Kaixiang Ni ,&nbsp;Jiantong Jiao ,&nbsp;Songtao Qi","doi":"10.1016/j.scr.2026.103925","DOIUrl":"10.1016/j.scr.2026.103925","url":null,"abstract":"<div><div>Glioblastoma is one of the most common primary malignant brain tumors, characterized by high aggressiveness and chemoresistance. Glioma stem like cells (GSCs) are recognized as critical drivers of tumor initiation, intratumoral heterogeneity, and treatment resistance. This protocol establishes a standardized 3D-tumor spheroid assay to functionally evaluate tumor cell stemness, providing a reproducible platform for investigating glioma malignant phenotypes and screening therapeutic strategies targeting GSCs. This streamlined 96 well assay reduces detection time and resource requirements compared to traditional multi round sphere forming workflows, thereby facilitating high throughput drug screening and detailed mechanistic studies of glioma biology in both research and preclinical settings.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"91 ","pages":"Article 103925"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146189607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation and characterization of iPSC lines (SPPHIi005-A, SPPHIi006-A, SPPHIi007-A) from a CRB1-mutation associated retinitis pigmentosa family crb1突变相关视网膜色素变性家族iPSC系（SPPHIi005-A, SPPHIi006-A, SPPHIi007-A）的产生和特性
IF 0.7 4区 医学
Stem cell research Pub Date : 2026-03-01 Epub Date: 2026-02-01 DOI: 10.1016/j.scr.2026.103914
Ning Xiao , Weijia Wu , Lingxue Gong , Ying Lv , Huan Li , Xiaoxin Guo , Yutong Wei , Lixin Zhang , Siyu Zhu , Xiangmei Li , Bo Gong , Bolin Deng , Xueming Ju
{"title":"Generation and characterization of iPSC lines (SPPHIi005-A, SPPHIi006-A, SPPHIi007-A) from a CRB1-mutation associated retinitis pigmentosa family","authors":"Ning Xiao ,&nbsp;Weijia Wu ,&nbsp;Lingxue Gong ,&nbsp;Ying Lv ,&nbsp;Huan Li ,&nbsp;Xiaoxin Guo ,&nbsp;Yutong Wei ,&nbsp;Lixin Zhang ,&nbsp;Siyu Zhu ,&nbsp;Xiangmei Li ,&nbsp;Bo Gong ,&nbsp;Bolin Deng ,&nbsp;Xueming Ju","doi":"10.1016/j.scr.2026.103914","DOIUrl":"10.1016/j.scr.2026.103914","url":null,"abstract":"<div><div>Mutations in the Crumbs homolog 1 (CRB1) gene are associated with autosomal recessive retinal pigmentosa (RP). We derived two human-induced pluripotent stem cell (hiPSC) lines, SPPHIi006-A and SPPHIi007-A, from a consanguineous family affected by RP. These lines carry either a homozygous or heterozygous CRB1 variant c.1997 T &gt; A (p.V666D). Additionally, we established a hiPSC line, SPPHIi005-A, from a healthy family member without the CRB1 mutation to serve as a normal control (HC). All three hiPSC lines demonstrated normal karyotypes, cell morphology, hiPSC markers, and differentiation into three germ layers. These hiPSC lines offer valuable models for exploring therapeutic strategies for CRB1-associated RP.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"91 ","pages":"Article 103914"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146182653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation and characterization of 5 induced pluripotent stem cell (iPSC) lines from Parkinson’s disease patients carrying GBA1 variants 5种携带GBA1变异的帕金森病患者诱导多能干细胞（iPSC）系的产生和特性
IF 0.7 4区 医学
Stem cell research Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1016/j.scr.2026.103909
Inigo Yoldi Bergua , Ibrahim Boussaad , Elizabet Petkovski , Zied Landoulsi , NCER-PD Consortium , DEEPEN-iRBD Consortium , Rejko Krüger , Giuseppe Arena
{"title":"Generation and characterization of 5 induced pluripotent stem cell (iPSC) lines from Parkinson’s disease patients carrying GBA1 variants","authors":"Inigo Yoldi Bergua ,&nbsp;Ibrahim Boussaad ,&nbsp;Elizabet Petkovski ,&nbsp;Zied Landoulsi ,&nbsp;NCER-PD Consortium ,&nbsp;DEEPEN-iRBD Consortium ,&nbsp;Rejko Krüger ,&nbsp;Giuseppe Arena","doi":"10.1016/j.scr.2026.103909","DOIUrl":"10.1016/j.scr.2026.103909","url":null,"abstract":"<div><div>Parkinson’s disease (PD) patients carrying variants in <em>GBA1</em> exhibit distinct phenotypic characteristics of disease, including earlier age at onset, faster motor decline and higher frequency of cognitive decline. As carriers of <em>GBA1</em> define a relevant PD subgroup and in order to prepare for future precision medicine approaches to treat <em>GBA1</em>-mediated PD, we generated 5 induced pluripotent stem cell (iPSC) lines from primary skin fibroblasts of PD patients, each carrying a heterozygous variant in <em>GBA1</em> (p.L483P; p.L483P; p.G241R; p.N409S; p.N409S). iPSCs pluripotency was confirmed by qPCR and immunocytochemistry, and their ability to differentiate into the 3 germ layers was validated.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"91 ","pages":"Article 103909"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145941353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of a male isogenic pair and a female isogenic pair(R83C) for studying NAA10-related syndrome as part of a large Ogden syndrome biobank 作为大型奥格登综合征生物库的一部分，用于研究naa10相关综合征的雄性等基因对和雌性等基因对（R83C）的生成
IF 0.7 4区 医学
Stem cell research Pub Date : 2026-03-01 Epub Date: 2026-01-06 DOI: 10.1016/j.scr.2025.103901
Soha Patil , Naresh Patel , Rikhil Makwana , Manali Nikte , Dorota Moroziewicz , NYSCF Global Stem Cell Array® Team , Matt Zimmer , Christopher Hunter , Frederick J. Monsma Jr. , Daniel Paull , Josephine Wesely , Gholson J. Lyon
{"title":"Generation of a male isogenic pair and a female isogenic pair(R83C) for studying NAA10-related syndrome as part of a large Ogden syndrome biobank","authors":"Soha Patil ,&nbsp;Naresh Patel ,&nbsp;Rikhil Makwana ,&nbsp;Manali Nikte ,&nbsp;Dorota Moroziewicz ,&nbsp;NYSCF Global Stem Cell Array® Team ,&nbsp;Matt Zimmer ,&nbsp;Christopher Hunter ,&nbsp;Frederick J. Monsma Jr. ,&nbsp;Daniel Paull ,&nbsp;Josephine Wesely ,&nbsp;Gholson J. Lyon","doi":"10.1016/j.scr.2025.103901","DOIUrl":"10.1016/j.scr.2025.103901","url":null,"abstract":"<div><div>Ogden Syndrome, also known as <em>NAA10</em>-related neurodevelopmental disorder, is an X-linked disease caused by pathologic variants in <em>NAA10</em>, the catalytic sub-unit of the NatA N-α-terminal acetyltransferase, and characterized by variable neurologic, behavioral, and cardiovascular deficits. We present the generation of 2 isogenic pairs of patient-derived iPSCs having a R83C mutation in NAA10. A male hemizygous NAA10 line which was corrected to WT, and a female heterozygous which was edited to be WT/WT as well as R83C/R83C. Combined with the published cohort of &gt;30 NAA10-related syndrome patient iPSC lines and isogenic pairs it represents a powerful cohort to investigate NAA10-related syndrome (<span><span>Wesely et al., 2024</span></span>).</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"91 ","pages":"Article 103901"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145980564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of a SV2A knockout human embryonic stem cell line by CRISPR/Cas9 system 利用CRISPR/Cas9系统产生SV2A基因敲除的人胚胎干细胞系。
IF 0.7 4区 医学
Stem cell research Pub Date : 2026-03-01 Epub Date: 2026-02-07 DOI: 10.1016/j.scr.2026.103924
Feng Yao , Xing Qi , Shan Yongli , Zhong Xiaofen
{"title":"Generation of a SV2A knockout human embryonic stem cell line by CRISPR/Cas9 system","authors":"Feng Yao ,&nbsp;Xing Qi ,&nbsp;Shan Yongli ,&nbsp;Zhong Xiaofen","doi":"10.1016/j.scr.2026.103924","DOIUrl":"10.1016/j.scr.2026.103924","url":null,"abstract":"<div><div>Synaptic Vesicle Glycoprotein 2A (SV2A) is a ubiquitously expressed brain glycoprotein, localized to synaptic terminals. It regulates vesicle exocytosis, maintains neurotransmitter release, and serves as a receptor for both botulinum neurotoxins (e.g., BoNT/A) and tetanus neurotoxin (TeNT). It is a target for antiseizure drugs and implicated in epilepsy, Alzheimer’s, and Parkinson’s diseases. We generated a homozygous <em>SV2A</em>-knockout human embryonic stem cell (hESC) line WAe001-A-3F (H1-<em>SV2A<sup>−/−</sup></em>), using CRISPR/Cas9 genome editing technology. The <em>SV2A</em>-knockout embryonic stem cell lines provide a precise in vitro model to dissect its roles in synaptic function and disease mechanisms.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"91 ","pages":"Article 103924"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146182636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of an induced pluripotent stem cell (iPSC) line (IPSCi001-A), from a 40-year-old female patient with occult macular dystrophy carrying the c.133C > T mutation in the RP1L1 gene 诱导多能干细胞（iPSC）系（IPSCi001-A）的产生，来自一名40岁的女性隐匿性黄斑营养不良患者，该患者携带RP1L1基因的c.133C > T突变
IF 0.7 4区 医学
Stem cell research Pub Date : 2026-03-01 Epub Date: 2026-01-10 DOI: 10.1016/j.scr.2025.103902
An-Guor Wang , Chun-Ying Huang , Hui-Chen Cheng , Wei-Che Hung , Yen-Fu Cheng
{"title":"Generation of an induced pluripotent stem cell (iPSC) line (IPSCi001-A), from a 40-year-old female patient with occult macular dystrophy carrying the c.133C > T mutation in the RP1L1 gene","authors":"An-Guor Wang ,&nbsp;Chun-Ying Huang ,&nbsp;Hui-Chen Cheng ,&nbsp;Wei-Che Hung ,&nbsp;Yen-Fu Cheng","doi":"10.1016/j.scr.2025.103902","DOIUrl":"10.1016/j.scr.2025.103902","url":null,"abstract":"<div><div>Occult macular dystrophy (OMD) is a hereditary macular disease characterized by no visible macular abnormalities. It is an autosomal dominant disease associated with retinitis pigmentosa 1 like 1 (RP1L1) gene mutation. c.133C &gt; T mutation in the RP1L1 gene is the primary cause of severe visual impairment in OMD patients. The induced pluripotent stem cell (iPSC) line was generated using the integration-free Sendai virus method from peripheral blood mononuclear cells (PBMCs) of a vision-impaired patient harboring heterozygous RP1L1 c.133C &gt; T mutation. This cell line may serve as a cellular model for studying the pathogenic mechanisms of OMD caused by RP1L1 mutation.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"91 ","pages":"Article 103902"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145980563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of an induced pluripotent stem cell line (AHMUCNi004-A) from a 14-year-old male with Down syndrome 来自14岁唐氏综合症男性的诱导多能干细胞系（AHMUCNi004-A）的产生。
IF 0.7 4区 医学
Stem cell research Pub Date : 2026-03-01 Epub Date: 2026-01-31 DOI: 10.1016/j.scr.2026.103918
Li Sun , Juanjuan Li , Wenjie Hu , Chengwei Wang , Yin Xu
{"title":"Generation of an induced pluripotent stem cell line (AHMUCNi004-A) from a 14-year-old male with Down syndrome","authors":"Li Sun ,&nbsp;Juanjuan Li ,&nbsp;Wenjie Hu ,&nbsp;Chengwei Wang ,&nbsp;Yin Xu","doi":"10.1016/j.scr.2026.103918","DOIUrl":"10.1016/j.scr.2026.103918","url":null,"abstract":"<div><div>Down syndrome (DS), resulting from trisomy 21, is the most prevalent genetic cause of neurodevelopmental impairment and a significant risk factor for developing pathology of Alzheimer’s disease (AD). In this study, we generated an induced pluripotent stem cell (iPSC) line (AHMUCNi004-A) from peripheral blood mononuclear cells (PBMCs) of a 14-year-old male with DS using non-integrative episomal vectors. The AHMUCNi004-A line exhibits typical iPSCs’ morphology, expresses hallmark pluripotency markers, and maintains the constitutive trisomy 21 karyotype. Furthermore, the line demonstrates the capacity to differentiate into derivatives of all three embryonic germ layers.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"91 ","pages":"Article 103918"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146114098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The establishment of a GPD1L knockout human embryonic stem cell line (WAe009-A-80) using the CRISPR/Cas9 system 利用CRISPR/Cas9系统建立GPD1L基因敲除的人胚胎干细胞系（WAe009-A-80）
IF 0.7 4区 医学
Stem cell research Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1016/j.scr.2026.103910
Tao Dong , Yan Zhao , Hai-feng Jin , Hong-ming Pan , Li-ling Yue , Yan Lin , Lei Shen
{"title":"The establishment of a GPD1L knockout human embryonic stem cell line (WAe009-A-80) using the CRISPR/Cas9 system","authors":"Tao Dong ,&nbsp;Yan Zhao ,&nbsp;Hai-feng Jin ,&nbsp;Hong-ming Pan ,&nbsp;Li-ling Yue ,&nbsp;Yan Lin ,&nbsp;Lei Shen","doi":"10.1016/j.scr.2026.103910","DOIUrl":"10.1016/j.scr.2026.103910","url":null,"abstract":"<div><div>The <em>GPD1L</em> gene is located on 3p22.3. It encodes the glycerol phosphate dehydrogenase 1-like protein with homology to glycerol phosphate dehydrogenase (GPD1L), but the function of this enzyme is unclear. Mutations in <em>GPD1L</em> have been associated with BrS (Brugada syndrome) and SIDS (sudden infant death syndrome) and reduce Na<sup>+</sup> inward current through an unknown mechanism in human cardiomyocytes. Here, a <em>GPD1L</em> knockout human embryonic stem cell line was generated using CRISPR/Cas9 system. The <em>GPD1L</em> knockout human embryonic stem cell maintains the pluripotency, differentiation into three germ layers, forming normal EBs.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"91 ","pages":"Article 103910"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145980499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of eight human induced pluripotent stem cells lines from patients with Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS) 来自常染色体隐性痉挛性共济失调（ARSACS）患者的8个人诱导多能干细胞系的生成。
IF 0.7 4区 医学
Stem cell research Pub Date : 2026-03-01 Epub Date: 2025-12-24 DOI: 10.1016/j.scr.2025.103894
Laurie Martineau , Vincent Roy , Sabrina Bellenfant , Mathieu Blais , François Gros-Louis , Nicolas Dupré
{"title":"Generation of eight human induced pluripotent stem cells lines from patients with Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS)","authors":"Laurie Martineau ,&nbsp;Vincent Roy ,&nbsp;Sabrina Bellenfant ,&nbsp;Mathieu Blais ,&nbsp;François Gros-Louis ,&nbsp;Nicolas Dupré","doi":"10.1016/j.scr.2025.103894","DOIUrl":"10.1016/j.scr.2025.103894","url":null,"abstract":"<div><div>Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS) is a rare inherited neurodegenerative disorder causing progressive spasticity, ataxia and peripheral neuropathy, leading to significant motor and sensory impairments. To advance the study of ARSACS pathogenesis and therapeutic development, we generated eight induced pluripotent stem cell (iPSC) lines from patient-derived fibroblasts or peripheral blood mononuclear cells (PBMCs) using non-integrating Sendai virus-based reprogramming method and covering four different <em>SACS</em> gene mutations. These iPSC lines provide a powerful platform to investigate disease mechanisms, evaluate therapeutic candidates, and support the development of personalized medicine approaches for ARSACS.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"91 ","pages":"Article 103894"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of an induced pluripotent stem cell line CGOi001-A from a patient with hereditary thrombocytopenia and a germline ANKRD26 mutation 遗传性血小板减少症和种系ANKRD26突变患者诱导多能干细胞系CGOi001-A的产生
IF 0.7 4区 医学
Stem cell research Pub Date : 2026-03-01 Epub Date: 2026-01-31 DOI: 10.1016/j.scr.2026.103919
Aubrianna S. Ramsland , Karolina Dudek , Kelsey E. McNeely , Joseph M. Cannova , Zahra Khosravi , Jonathan Burnett , Yoav Gilad , Lucy A. Godley , Elizabeth A. Griffiths , Michael W. Drazer
{"title":"Generation of an induced pluripotent stem cell line CGOi001-A from a patient with hereditary thrombocytopenia and a germline ANKRD26 mutation","authors":"Aubrianna S. Ramsland ,&nbsp;Karolina Dudek ,&nbsp;Kelsey E. McNeely ,&nbsp;Joseph M. Cannova ,&nbsp;Zahra Khosravi ,&nbsp;Jonathan Burnett ,&nbsp;Yoav Gilad ,&nbsp;Lucy A. Godley ,&nbsp;Elizabeth A. Griffiths ,&nbsp;Michael W. Drazer","doi":"10.1016/j.scr.2026.103919","DOIUrl":"10.1016/j.scr.2026.103919","url":null,"abstract":"<div><div>Thrombocytopenia 2 (OMIM <span><span>610855</span><svg><path></path></svg></span>) is a hereditary thrombocytopenia and blood cancer syndrome caused by germline mutations in the 5′ untranslated region of <em>ANKRD26.</em> We generated an induced pluripotent stem cell (iPSC) line (CGOi001-A) from a donor with a germline <em>ANKRD26</em> mutation and hereditary thrombocytopenia. This line is a valuable resource for studying the <em>ANKRD26-</em>mutant cellular phenotype.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"91 ","pages":"Article 103919"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146126596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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