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Generation of an anti-CD19 CAR knock-in human induced pluripotent stem cell line using CRISPR/Cas9 technology 利用CRISPR/Cas9技术生成抗cd19 CAR敲入的人诱导多能干细胞系
IF 0.8 4区 医学
Stem cell research Pub Date : 2025-04-26 DOI: 10.1016/j.scr.2025.103721
Shuoting Wang , Yashu Feng , Qi Xing , Tiancheng Zhou , Jiajun Liu
{"title":"Generation of an anti-CD19 CAR knock-in human induced pluripotent stem cell line using CRISPR/Cas9 technology","authors":"Shuoting Wang ,&nbsp;Yashu Feng ,&nbsp;Qi Xing ,&nbsp;Tiancheng Zhou ,&nbsp;Jiajun Liu","doi":"10.1016/j.scr.2025.103721","DOIUrl":"10.1016/j.scr.2025.103721","url":null,"abstract":"<div><div>Chimeric antigen receptor T cell (CAR-T) therapy represents a major breakthrough in the field of tumor immunotherapy. CD19-targeted CAR-T cells (CD19 CAR-T) have emerged as an important therapeutic approach for treating B-cell malignancies. We successfully constructed a human induced pluripotent stem cell (iPSC) line with an anti-CD19 CAR knock-in using CRISPR/Cas9-mediated gene targeting technology. This cell line can stably express the CAR gene while maintaining its typical stem cell morphology and normal karyotype. Furthermore, this cell line possesses multilineage differentiation potential and can be directionally differentiated into various chimeric antigen receptor-expressing immune cells for targeting CD19-positive tumors.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"86 ","pages":"Article 103721"},"PeriodicalIF":0.8,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of two human induced pluripotent stem cell lines from Allan-Herndon-Dudley syndrome (AHDS) patients with SLC16A2:G401R or SLC16A2: H192R mutation SLC16A2:G401R或SLC16A2: H192R突变的allen - hernton - dudley综合征（AHDS）患者的两种人类诱导多能干细胞系的生成
IF 0.8 4区 医学
Stem cell research Pub Date : 2025-04-25 DOI: 10.1016/j.scr.2025.103725
Katarzyna A. Ludwik , Judit Küchler , David Sebinger , Robert Opitz , Peter Kühnen , Harald Stachelscheid
{"title":"Generation of two human induced pluripotent stem cell lines from Allan-Herndon-Dudley syndrome (AHDS) patients with SLC16A2:G401R or SLC16A2: H192R mutation","authors":"Katarzyna A. Ludwik ,&nbsp;Judit Küchler ,&nbsp;David Sebinger ,&nbsp;Robert Opitz ,&nbsp;Peter Kühnen ,&nbsp;Harald Stachelscheid","doi":"10.1016/j.scr.2025.103725","DOIUrl":"10.1016/j.scr.2025.103725","url":null,"abstract":"<div><div>Allan-Herndon-Dudley syndrome (AHDS) is an X-linked disorder characterized by profound psychomotor impairment. It is caused by mutations in the <em>SLC16A2</em> gene, which encodes monocarboxylate transporter 8 (MCT8), a crucial thyroid hormone transporter. Here we report generation of two male patient-derived iPSC lines harboring either SLC16A2:G401R or SLC16A2:H192R.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"86 ","pages":"Article 103725"},"PeriodicalIF":0.8,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pig embryonic stem cells with porcine specific-MSGN1 upstream region-based reporter system for monitoring paraxial mesoderm differentiation 利用猪特异性msgn1上游区域报告系统监测猪胚胎干细胞近轴中胚层分化
IF 0.8 4区 医学
Stem cell research Pub Date : 2025-04-21 DOI: 10.1016/j.scr.2025.103724
Jinsol Jeong , Kwang-Hwan Choi , Dong-Kyung Lee , Yelim Ahn , Chang-Kyu Lee
{"title":"Pig embryonic stem cells with porcine specific-MSGN1 upstream region-based reporter system for monitoring paraxial mesoderm differentiation","authors":"Jinsol Jeong ,&nbsp;Kwang-Hwan Choi ,&nbsp;Dong-Kyung Lee ,&nbsp;Yelim Ahn ,&nbsp;Chang-Kyu Lee","doi":"10.1016/j.scr.2025.103724","DOIUrl":"10.1016/j.scr.2025.103724","url":null,"abstract":"<div><div>Pig embryonic stem cells were introduced with an <em>MSGN1</em> upstream region-based reporter system, composed of <em>EGFP</em> sequence under porcine-specific <em>MSGN1</em> promoter (p<em>MSGN1</em>), through electroporation. The engineered cell line maintained pluripotency similar to that of the parental cell line, and reporter activity was confirmed upon the induction of the paraxial mesoderm. The p<em>MSGN1-EGFP</em> reporter system is a valuable tool for monitoring the differentiation process of the paraxial mesoderm and analyzing induction efficiency, providing insight into developmental mechanisms.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"86 ","pages":"Article 103724"},"PeriodicalIF":0.8,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143864518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation and characterization of a human induced pluripotent stem cell (iPSC) line from a patient with BAG3 P209L myofibrillar myopathy-6 BAG3 P209L肌原纤维性肌病-6患者诱导多能干细胞（iPSC）系的生成和表征
IF 0.8 4区 医学
Stem cell research Pub Date : 2025-04-21 DOI: 10.1016/j.scr.2025.103718
Kerstin Filippi , Isabelle Riße , Luke M. Judge , Bruce R. Conklin , Bernd K. Fleischmann , Michael Hesse
{"title":"Generation and characterization of a human induced pluripotent stem cell (iPSC) line from a patient with BAG3 P209L myofibrillar myopathy-6","authors":"Kerstin Filippi ,&nbsp;Isabelle Riße ,&nbsp;Luke M. Judge ,&nbsp;Bruce R. Conklin ,&nbsp;Bernd K. Fleischmann ,&nbsp;Michael Hesse","doi":"10.1016/j.scr.2025.103718","DOIUrl":"10.1016/j.scr.2025.103718","url":null,"abstract":"<div><div>Bag3 is important for protein homeostasis in mechanically stressed muscle proteins as member of the chaperone-assisted selective autophagy (CASA) complex. Patients with <em>BAG3</em> <!-->P209L myofibrillar myopathy-6 (MFM6) carry a point mutation (p.P209L; c.626C&gt;T) in the <em>BAG3</em> gene and display clinical features such as restrictive cardiomyopathy, skeletal muscle dystrophy and polyneuropathy. To obtain a representative MFM6-model, biopsies from a female <em>BAG3</em> <!-->P209L-patient were used to generate a human induced pluripotent stem cell (iPSC) line. For quality control, germ layer differentiation and pluripotency analyses were conducted. This iPSC allows us to characterize the pathophysiology of MFM6 and develop innovative experimental therapeutic strategies.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"86 ","pages":"Article 103718"},"PeriodicalIF":0.8,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of a MYL3 knockout stem cell line (WAe009-A-1H) by episomal vector-based CRISPR/Cas9 system 基于episisal载体的CRISPR/Cas9系统生成MYL3敲除干细胞系(WAe009-A-1H
IF 0.8 4区 医学
Stem cell research Pub Date : 2025-04-20 DOI: 10.1016/j.scr.2025.103723
Rui Bai , Wei Fu , Xiaojie Hou , Juyi Wan
{"title":"Generation of a MYL3 knockout stem cell line (WAe009-A-1H) by episomal vector-based CRISPR/Cas9 system","authors":"Rui Bai ,&nbsp;Wei Fu ,&nbsp;Xiaojie Hou ,&nbsp;Juyi Wan","doi":"10.1016/j.scr.2025.103723","DOIUrl":"10.1016/j.scr.2025.103723","url":null,"abstract":"<div><div>The Myosin light chain 3 (MYL3) gene encodes the ventricular essential light chain isoform, which is an important modulator of sarcomeric myosin cross-bridge kinetics. Variants in MYL3 are a cause of hypertrophic cardiomyopathy and dilated cardiomyopathy with cardiac failure and sudden cardiac death (SCD). To further elucidate the involvement of MYL3 in the pathogenesis of cardiomyopathies, we have created a MYL3 knockout human embryonic stem cell line using the CRISPR/Cas9 system. Notably, this MYL3-knockout cell line retains normal morphology, pluripotency, and karyotype. This resource provides a valuable tool for investigating MYL3-related health and disease.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"86 ","pages":"Article 103723"},"PeriodicalIF":0.8,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143886026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of iPSC lines (ICHi001-A, ICHi002-A, ICHi003-A, ICHi004-A) from four patients carrying Titin truncating variants associated with dilated cardiomyopathy 从4名携带与扩张型心肌病相关的Titin截断变异的患者中产生iPSC系（ICHi001-A、ICHi002-A、ICHi003-A、ICHi004-A）
IF 0.8 4区 医学
Stem cell research Pub Date : 2025-04-20 DOI: 10.1016/j.scr.2025.103719
Cecilia Thairi , Rebecca Artioli , Marianna Paulis , Camilla Galli , Simon Cotič , Alessia Paldino , Ilenia Marino , Gianfranco Sinagra , Chiara Collesi , Matteo Dal Ferro , Elisa Di Pasquale
{"title":"Generation of iPSC lines (ICHi001-A, ICHi002-A, ICHi003-A, ICHi004-A) from four patients carrying Titin truncating variants associated with dilated cardiomyopathy","authors":"Cecilia Thairi ,&nbsp;Rebecca Artioli ,&nbsp;Marianna Paulis ,&nbsp;Camilla Galli ,&nbsp;Simon Cotič ,&nbsp;Alessia Paldino ,&nbsp;Ilenia Marino ,&nbsp;Gianfranco Sinagra ,&nbsp;Chiara Collesi ,&nbsp;Matteo Dal Ferro ,&nbsp;Elisa Di Pasquale","doi":"10.1016/j.scr.2025.103719","DOIUrl":"10.1016/j.scr.2025.103719","url":null,"abstract":"<div><div>Inherited dilated cardiomyopathy (iDCM) is a disease of the heart muscle, characterized by left ventricle enlargement, systolic dysfunction and arrhythmias. iDCM represents a common cause of heart failure and the most frequent cause of heart transplantation. Among the causative genes, <em>TTN</em>, encoding the sarcomeric protein Titin, represents the most prevalent (about 25 % of cases). The heterogeneous clinical manifestations and variable response to therapy represent a major challenge in patients’ clinical management. To deepen the knowledge of this disease, we generated and fully characterized induced Pluripotent Stem Cell lines from 4 iDCM patients carrying 4 different truncating variants of <em>TTN</em> gene.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"86 ","pages":"Article 103719"},"PeriodicalIF":0.8,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of two induced pluripotent stem cell lines from breast cancer patients carrying BRCA1 mutations 来自携带BRCA1突变的乳腺癌患者的两种诱导多能干细胞系的产生
IF 0.8 4区 医学
Stem cell research Pub Date : 2025-04-18 DOI: 10.1016/j.scr.2025.103716
Yi-Ing Chen , Arianne Caudal , Amira G. Flores-Banuelos , Christopher D. Yan , Walter G. Park , Mohan Viswanathan , Joseph C. Wu
{"title":"Generation of two induced pluripotent stem cell lines from breast cancer patients carrying BRCA1 mutations","authors":"Yi-Ing Chen ,&nbsp;Arianne Caudal ,&nbsp;Amira G. Flores-Banuelos ,&nbsp;Christopher D. Yan ,&nbsp;Walter G. Park ,&nbsp;Mohan Viswanathan ,&nbsp;Joseph C. Wu","doi":"10.1016/j.scr.2025.103716","DOIUrl":"10.1016/j.scr.2025.103716","url":null,"abstract":"<div><div>Haploinsufficiency of <em>BRCA1</em> increases the risk of various cancers due to its critical functions in cell cycle checkpoint regulation and DNA repair. This study generated and characterized two induced pluripotent stem cell (iPSC) lines derived from breast cancer patients with mutations in the <em>BRCA1</em> gene (c.676del and c.5096G&gt;A). Both lines exhibited typical iPSC morphology, karyotype, pluripotency marker expression, and trilineage differentiation capabilities. <em>BRCA1</em>-mutated iPSCs provide a valuable resource to investigate pathogenic mechanisms and develop personalized medicine.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"86 ","pages":"Article 103716"},"PeriodicalIF":0.8,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of hiPSC lines with fusion tagged thyroid hormone receptor α isoforms to study isoform-specific actions of TRα1 and TRα2 生成融合标记甲状腺激素受体α亚型的hiPSC细胞系，研究TRα1和TRα2的特异性作用
IF 0.8 4区 医学
Stem cell research Pub Date : 2025-04-17 DOI: 10.1016/j.scr.2025.103720
Nina Härting , Katarzyna A. Ludwik , Regina Jahn , Frank J. Kaiser , Harald Stachelscheid
{"title":"Generation of hiPSC lines with fusion tagged thyroid hormone receptor α isoforms to study isoform-specific actions of TRα1 and TRα2","authors":"Nina Härting ,&nbsp;Katarzyna A. Ludwik ,&nbsp;Regina Jahn ,&nbsp;Frank J. Kaiser ,&nbsp;Harald Stachelscheid","doi":"10.1016/j.scr.2025.103720","DOIUrl":"10.1016/j.scr.2025.103720","url":null,"abstract":"<div><div>The role of the nuclear thyroid hormone receptor TRα1 as a mediator of thyroid hormone action on target gene expression is well understood. However, the function of the TRα2 splicing isoform, which does not bind thyroid hormones, remains unexplored. As no reliable antibodies are available to investigate TRα1 and TRα2 specifically, we introduced small fusion tags into the <em>THRA</em> locus of the male healthy donor iPSC lines BIHi001-B and BIHi005-A by CRISPR/Cas9-mediated genome editing. Consequently, the modified lines express C-terminally tagged TRα1-2xHA or TRα2-3xFLAG. These genome-edited lines facilitate the investigation of isoform-specific actions of TRα in different cell types.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"86 ","pages":"Article 103720"},"PeriodicalIF":0.8,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of an induced pluripotent stem cell line (PNUYHi003-A) from peripheral blood mononuclear cells of a patient with neuronal intranuclear inclusion disease 从神经性核内包涵性疾病患者外周血单个核细胞中产生诱导多能干细胞系(PNUYHi003-A
IF 0.8 4区 医学
Stem cell research Pub Date : 2025-04-16 DOI: 10.1016/j.scr.2025.103717
Tae-Yun Kim , Mi Kyoung Kim , Takeshi Mizuguchi , Naomichi Matsumoto , Jae-Hyeok Lee , Eun-Joo Kim , Na-Yeon Jung
{"title":"Generation of an induced pluripotent stem cell line (PNUYHi003-A) from peripheral blood mononuclear cells of a patient with neuronal intranuclear inclusion disease","authors":"Tae-Yun Kim ,&nbsp;Mi Kyoung Kim ,&nbsp;Takeshi Mizuguchi ,&nbsp;Naomichi Matsumoto ,&nbsp;Jae-Hyeok Lee ,&nbsp;Eun-Joo Kim ,&nbsp;Na-Yeon Jung","doi":"10.1016/j.scr.2025.103717","DOIUrl":"10.1016/j.scr.2025.103717","url":null,"abstract":"<div><div>Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder<!--> <!-->characterized by eosinophilic hyaline intranuclear inclusions in the nervous system. NIID is associated with GGC repeat expansions in the 5′ untranslated<!--> <!-->region of the <em>NOTCH2NLC</em> gene. The induced pluripotent stem cells (iPSC), generated from peripheral blood mononuclear cells of a 75-year-old male patient with NIID, exhibited stem cell marker expression, normal karyotype, absence of viral factors, successful differentiation into the three germ layers, and were analyzed for GGC repeat expansion. These patient-derived iPSCs have promising potential for exploring the genetic mechanisms underlying NIID.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"86 ","pages":"Article 103717"},"PeriodicalIF":0.8,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143859111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi0010-A) from a patient with Anti-MDA5 antibody-positive dermatomyositis 抗mda5抗体阳性皮肌炎患者诱导多能干细胞（iPSC）系（inndsu0010 - a）的生成
IF 0.8 4区 医学
Stem cell research Pub Date : 2025-04-15 DOI: 10.1016/j.scr.2025.103714
Chen Zhang , Shaoshuai Liang , Bing Zhao , Qingsong Fu , Fengyi Zhang , Xiaotian Ma , Didi Shan , Hongxu Wang , Jianing Li , Ping Sun , Yu Wang , Guoyong Zhang , Ying Hou , Tingjun Dai , Fuchen Liu , Chuanzhu Yan , Kai Shao
{"title":"Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi0010-A) from a patient with Anti-MDA5 antibody-positive dermatomyositis","authors":"Chen Zhang ,&nbsp;Shaoshuai Liang ,&nbsp;Bing Zhao ,&nbsp;Qingsong Fu ,&nbsp;Fengyi Zhang ,&nbsp;Xiaotian Ma ,&nbsp;Didi Shan ,&nbsp;Hongxu Wang ,&nbsp;Jianing Li ,&nbsp;Ping Sun ,&nbsp;Yu Wang ,&nbsp;Guoyong Zhang ,&nbsp;Ying Hou ,&nbsp;Tingjun Dai ,&nbsp;Fuchen Liu ,&nbsp;Chuanzhu Yan ,&nbsp;Kai Shao","doi":"10.1016/j.scr.2025.103714","DOIUrl":"10.1016/j.scr.2025.103714","url":null,"abstract":"<div><div>Anti-melanoma differentiation-associated protein 5 (MDA5) antibody-positive dermatomyositis (MDA5-DM) is a subtype of dermatomyositis, potentially triggered by viral infection (Lu et al., 2024). We generated and characterized a human induced pluripotent stem cell (hiPSC) line from skin fibroblasts of a patient with MDA5-DM. Their pluripotency was demonstrated by the expression of multiple pluripotency markers on the RNA and protein levels, as well as their ability to differentiate into all three germ layers.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"86 ","pages":"Article 103714"},"PeriodicalIF":0.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143839149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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