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Generation of an induced pluripotent stem cell line (AHMUCNi004-A) from a 14-year-old male with Down syndrome 来自14岁唐氏综合症男性的诱导多能干细胞系（AHMUCNi004-A）的产生。
IF 0.7 4区 医学
Stem cell research Pub Date : 2026-03-01 Epub Date: 2026-01-31 DOI: 10.1016/j.scr.2026.103918
Li Sun , Juanjuan Li , Wenjie Hu , Chengwei Wang , Yin Xu
{"title":"Generation of an induced pluripotent stem cell line (AHMUCNi004-A) from a 14-year-old male with Down syndrome","authors":"Li Sun ,&nbsp;Juanjuan Li ,&nbsp;Wenjie Hu ,&nbsp;Chengwei Wang ,&nbsp;Yin Xu","doi":"10.1016/j.scr.2026.103918","DOIUrl":"10.1016/j.scr.2026.103918","url":null,"abstract":"<div><div>Down syndrome (DS), resulting from trisomy 21, is the most prevalent genetic cause of neurodevelopmental impairment and a significant risk factor for developing pathology of Alzheimer’s disease (AD). In this study, we generated an induced pluripotent stem cell (iPSC) line (AHMUCNi004-A) from peripheral blood mononuclear cells (PBMCs) of a 14-year-old male with DS using non-integrative episomal vectors. The AHMUCNi004-A line exhibits typical iPSCs’ morphology, expresses hallmark pluripotency markers, and maintains the constitutive trisomy 21 karyotype. Furthermore, the line demonstrates the capacity to differentiate into derivatives of all three embryonic germ layers.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"91 ","pages":"Article 103918"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146114098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The establishment of a GPD1L knockout human embryonic stem cell line (WAe009-A-80) using the CRISPR/Cas9 system 利用CRISPR/Cas9系统建立GPD1L基因敲除的人胚胎干细胞系（WAe009-A-80）
IF 0.7 4区 医学
Stem cell research Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1016/j.scr.2026.103910
Tao Dong , Yan Zhao , Hai-feng Jin , Hong-ming Pan , Li-ling Yue , Yan Lin , Lei Shen
{"title":"The establishment of a GPD1L knockout human embryonic stem cell line (WAe009-A-80) using the CRISPR/Cas9 system","authors":"Tao Dong ,&nbsp;Yan Zhao ,&nbsp;Hai-feng Jin ,&nbsp;Hong-ming Pan ,&nbsp;Li-ling Yue ,&nbsp;Yan Lin ,&nbsp;Lei Shen","doi":"10.1016/j.scr.2026.103910","DOIUrl":"10.1016/j.scr.2026.103910","url":null,"abstract":"<div><div>The <em>GPD1L</em> gene is located on 3p22.3. It encodes the glycerol phosphate dehydrogenase 1-like protein with homology to glycerol phosphate dehydrogenase (GPD1L), but the function of this enzyme is unclear. Mutations in <em>GPD1L</em> have been associated with BrS (Brugada syndrome) and SIDS (sudden infant death syndrome) and reduce Na<sup>+</sup> inward current through an unknown mechanism in human cardiomyocytes. Here, a <em>GPD1L</em> knockout human embryonic stem cell line was generated using CRISPR/Cas9 system. The <em>GPD1L</em> knockout human embryonic stem cell maintains the pluripotency, differentiation into three germ layers, forming normal EBs.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"91 ","pages":"Article 103910"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145980499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of eight human induced pluripotent stem cells lines from patients with Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS) 来自常染色体隐性痉挛性共济失调（ARSACS）患者的8个人诱导多能干细胞系的生成。
IF 0.7 4区 医学
Stem cell research Pub Date : 2026-03-01 Epub Date: 2025-12-24 DOI: 10.1016/j.scr.2025.103894
Laurie Martineau , Vincent Roy , Sabrina Bellenfant , Mathieu Blais , François Gros-Louis , Nicolas Dupré
{"title":"Generation of eight human induced pluripotent stem cells lines from patients with Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS)","authors":"Laurie Martineau ,&nbsp;Vincent Roy ,&nbsp;Sabrina Bellenfant ,&nbsp;Mathieu Blais ,&nbsp;François Gros-Louis ,&nbsp;Nicolas Dupré","doi":"10.1016/j.scr.2025.103894","DOIUrl":"10.1016/j.scr.2025.103894","url":null,"abstract":"<div><div>Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS) is a rare inherited neurodegenerative disorder causing progressive spasticity, ataxia and peripheral neuropathy, leading to significant motor and sensory impairments. To advance the study of ARSACS pathogenesis and therapeutic development, we generated eight induced pluripotent stem cell (iPSC) lines from patient-derived fibroblasts or peripheral blood mononuclear cells (PBMCs) using non-integrating Sendai virus-based reprogramming method and covering four different <em>SACS</em> gene mutations. These iPSC lines provide a powerful platform to investigate disease mechanisms, evaluate therapeutic candidates, and support the development of personalized medicine approaches for ARSACS.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"91 ","pages":"Article 103894"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of an induced pluripotent stem cell line CGOi001-A from a patient with hereditary thrombocytopenia and a germline ANKRD26 mutation 遗传性血小板减少症和种系ANKRD26突变患者诱导多能干细胞系CGOi001-A的产生
IF 0.7 4区 医学
Stem cell research Pub Date : 2026-03-01 Epub Date: 2026-01-31 DOI: 10.1016/j.scr.2026.103919
Aubrianna S. Ramsland , Karolina Dudek , Kelsey E. McNeely , Joseph M. Cannova , Zahra Khosravi , Jonathan Burnett , Yoav Gilad , Lucy A. Godley , Elizabeth A. Griffiths , Michael W. Drazer
{"title":"Generation of an induced pluripotent stem cell line CGOi001-A from a patient with hereditary thrombocytopenia and a germline ANKRD26 mutation","authors":"Aubrianna S. Ramsland ,&nbsp;Karolina Dudek ,&nbsp;Kelsey E. McNeely ,&nbsp;Joseph M. Cannova ,&nbsp;Zahra Khosravi ,&nbsp;Jonathan Burnett ,&nbsp;Yoav Gilad ,&nbsp;Lucy A. Godley ,&nbsp;Elizabeth A. Griffiths ,&nbsp;Michael W. Drazer","doi":"10.1016/j.scr.2026.103919","DOIUrl":"10.1016/j.scr.2026.103919","url":null,"abstract":"<div><div>Thrombocytopenia 2 (OMIM <span><span>610855</span><svg><path></path></svg></span>) is a hereditary thrombocytopenia and blood cancer syndrome caused by germline mutations in the 5′ untranslated region of <em>ANKRD26.</em> We generated an induced pluripotent stem cell (iPSC) line (CGOi001-A) from a donor with a germline <em>ANKRD26</em> mutation and hereditary thrombocytopenia. This line is a valuable resource for studying the <em>ANKRD26-</em>mutant cellular phenotype.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"91 ","pages":"Article 103919"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146126596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of two induced pluripotent stem cell (iPSC) lines (HZSMHCI001-A and HZSMHCI004-A) from a mother–child dyad with major depressive disorder and bipolar disorder 两种诱导多能干细胞（iPSC）系（HZSMHCI001-A和HZSMHCI004-A）从患有重度抑郁症和双相情感障碍的母子二代中产生。
IF 0.7 4区 医学
Stem cell research Pub Date : 2026-03-01 Epub Date: 2026-02-02 DOI: 10.1016/j.scr.2026.103920
Jun Zhao , Xiaoying Zhang , Chuqing Zhou , Youhui Jiang , Xiaoyi Tian , Xinyi Ren , Peiyan Ni , Jiangyong Qu
{"title":"Generation of two induced pluripotent stem cell (iPSC) lines (HZSMHCI001-A and HZSMHCI004-A) from a mother–child dyad with major depressive disorder and bipolar disorder","authors":"Jun Zhao ,&nbsp;Xiaoying Zhang ,&nbsp;Chuqing Zhou ,&nbsp;Youhui Jiang ,&nbsp;Xiaoyi Tian ,&nbsp;Xinyi Ren ,&nbsp;Peiyan Ni ,&nbsp;Jiangyong Qu","doi":"10.1016/j.scr.2026.103920","DOIUrl":"10.1016/j.scr.2026.103920","url":null,"abstract":"<div><div>Bipolar disorder (BD) and major depressive disorder (MDD) are severe, heritable psychiatric illnesses. Here, we report the generation of two induced pluripotent stem cell (iPSC) lines from peripheral blood mononuclear cells of a female with MDD (HZSMHCI004-A) and her son with BD (HZSMHCI001-A). Reprogramming was achieved using non-integrating episomal vectors. Both iPSC lines exhibit normal karyotypes, express key pluripotency markers, and demonstrate the capacity to differentiate into derivatives of all three germ layers <em>in vivo</em> via teratoma formation assays. These cell lines represent a valuable resource for investigating the distinct and shared pathophysiology of MDD and BD on a controlled genetic background.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"91 ","pages":"Article 103920"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146126598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of two tetracycline-inducible NGN2 iN iPSC lines carrying a heterozygous floating-Harbor syndrome SRCAP truncating mutation 携带杂合浮动港综合征SRCAP截断突变的两个四环素诱导的NGN2在iPSC系的产生。
IF 0.7 4区 医学
Stem cell research Pub Date : 2026-03-01 Epub Date: 2026-02-03 DOI: 10.1016/j.scr.2026.103922
Inbal Kantor , Jordan L. Wright , David J. Amor , Paul J. Lockhart
{"title":"Generation of two tetracycline-inducible NGN2 iN iPSC lines carrying a heterozygous floating-Harbor syndrome SRCAP truncating mutation","authors":"Inbal Kantor ,&nbsp;Jordan L. Wright ,&nbsp;David J. Amor ,&nbsp;Paul J. Lockhart","doi":"10.1016/j.scr.2026.103922","DOIUrl":"10.1016/j.scr.2026.103922","url":null,"abstract":"<div><div>Floating-Harbor syndrome (FHS) is a rare neurodevelopmental disorder caused by truncating variants in the last two exons of the gene encoding the chromatin remodeler SRCAP. We used CRISPR-Cas9 genome editing to introduce a monoallelic c.7330C &gt; T (p.Arg2444*) truncating mutation into a published WTC11 iPSC line containing a tetracycline-inducible NGN2 transgene. We characterised two independent lines that maintained a normal karyotype, pluripotency and the ability to differentiate <em>in vitro</em> into all three embryonic germ layers. These lines can be rapidly differentiated into cortical neurons through the addition of doxycycline, making them a useful model for understanding the pathogenic mechanisms underlying FHS.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"91 ","pages":"Article 103922"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of an induced pluripotent stem cell line (SDCHi010-A) from a young patient with epilepsy 来自年轻癫痫患者的诱导多能干细胞系（SDCHi010-A）的表征
IF 0.7 4区 医学
Stem cell research Pub Date : 2026-03-01 Epub Date: 2026-02-04 DOI: 10.1016/j.scr.2026.103923
Qiaorong Li , Huan Zhang , Wandong Hu , Wenchao Zhang , Pingping Tian
{"title":"Characterization of an induced pluripotent stem cell line (SDCHi010-A) from a young patient with epilepsy","authors":"Qiaorong Li ,&nbsp;Huan Zhang ,&nbsp;Wandong Hu ,&nbsp;Wenchao Zhang ,&nbsp;Pingping Tian","doi":"10.1016/j.scr.2026.103923","DOIUrl":"10.1016/j.scr.2026.103923","url":null,"abstract":"<div><div>Epilepsy is a group of chronic brain disorders characterized by recurrent, episodic, and transient dysfunction of the central nervous system caused by abnormal, excessive neuronal discharges. In this study, peripheral blood mononuclear cells (PBMCs) were isolated from a young patient bearing an FGF12 gene mutation and suffering from clinically and genetically diagnosed epilepsy. Induced pluripotent stem cells (iPSCs) were established using a non-integrative method involving plasmids carrying OCT4, SOX2, KLF4, BCL-XL, and C-MYC. The resulting iPSCs exhibited typical pluripotent cell morphology, a normal karyotype, and the potential to differentiate into all three germ layers.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"91 ","pages":"Article 103923"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of iPSC and isogenic gene-corrected lines from a patient with RPS7 (c.277_279delGTC)-mutated Diamond-Blackfan anemia syndrome 来自RPS7 （c.277_279delGTC）突变的Diamond-Blackfan贫血综合征患者的iPSC和等基因基因校正系的生成
IF 0.7 4区 医学
Stem cell research Pub Date : 2026-03-01 Epub Date: 2026-01-07 DOI: 10.1016/j.scr.2026.103908
Shruthi Suryaprakash , Yan Ju , James P. Papizan , Shondra M. Pruett-Miller , Marcin W. Wlodarski , Mitchell J. Weiss , Lei Han , Senthil Velan Bhoopalan
{"title":"Generation of iPSC and isogenic gene-corrected lines from a patient with RPS7 (c.277_279delGTC)-mutated Diamond-Blackfan anemia syndrome","authors":"Shruthi Suryaprakash ,&nbsp;Yan Ju ,&nbsp;James P. Papizan ,&nbsp;Shondra M. Pruett-Miller ,&nbsp;Marcin W. Wlodarski ,&nbsp;Mitchell J. Weiss ,&nbsp;Lei Han ,&nbsp;Senthil Velan Bhoopalan","doi":"10.1016/j.scr.2026.103908","DOIUrl":"10.1016/j.scr.2026.103908","url":null,"abstract":"<div><div>Diamond-Blackfan anemia syndrome (DBAS) is a heterogeneous genetic bone marrow failure disorder characterized by erythroid hypoplasia in young children. Most forms of DBAS are caused by heterozygous loss-of-function mutations in one of the 24 different ribosomal protein genes. We generated an iPSC line from a patient with a heterozygous <em>RPS7</em> (c.277_279delGTC) mutation, along with a corresponding isogenic cell line wherein the mutation was corrected using Cas9-mediated homology-directed repair.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"91 ","pages":"Article 103908"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation and characterization of POMC-tdTomato reporter human pluripotent stem cell lines POMC-tdTomato报告人多能干细胞系的制备与鉴定
IF 0.7 4区 医学
Stem cell research Pub Date : 2026-03-01 Epub Date: 2026-01-04 DOI: 10.1016/j.scr.2026.103905
Vukasin M. Jovanovic , Rick Rausch , Maria Caterina DeRosa , David Castellano , Cody McKee , Chaitali Sen , Fiona Daly , Claudia A. Doege , Carlos A. Tristan
{"title":"Generation and characterization of POMC-tdTomato reporter human pluripotent stem cell lines","authors":"Vukasin M. Jovanovic ,&nbsp;Rick Rausch ,&nbsp;Maria Caterina DeRosa ,&nbsp;David Castellano ,&nbsp;Cody McKee ,&nbsp;Chaitali Sen ,&nbsp;Fiona Daly ,&nbsp;Claudia A. Doege ,&nbsp;Carlos A. Tristan","doi":"10.1016/j.scr.2026.103905","DOIUrl":"10.1016/j.scr.2026.103905","url":null,"abstract":"<div><div>Proopiomelanocortin (POMC) is a precursor polypeptide that undergoes extensive, tissue-specific post-translational processing. It is expressed in several tissues, including pituitary gland, hypothalamus, brain stem, and skin. The hypothalamic POMC neurons in the arcuate nucleus are major neuronal populations involved in the regulation of body weight. In these neurons, POMC is processed into several peptides, among them the anorexigenic alpha-melanocyte stimulating hormone. Thus, the POMC neurons in the ARC have been named “satiety” neurons and are highly desirable drug targets. Here, we performed CRISPR/Cas9-mediated insertion of tdTomato reporter at the endogenous <em>POMC</em> locus, enabling direct visualization of POMC expression through tdTomato fluorescence in human pluripotent stem cell (hPSC)-derived hypothalamic neurons. This reporter line enables real-time visualization of POMC neuron differentiation, and selective enrichment of these populations for molecular, functional, and pharmacological studies. This line is readily available as new alternative method (NAM) platform, to support disease modeling and drug discovery in metabolic and neuroendocrine disorders within a human context.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"91 ","pages":"Article 103905"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146038988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of induced pluripotent stem cells from a patient with CHARGE syndrome with athymia, harboring a heterozygous mutation in CHD7 从患有胸腺疾患的CHARGE综合征患者中产生诱导多能干细胞，携带CHD7杂合突变
IF 0.7 4区 医学
Stem cell research Pub Date : 2026-03-01 Epub Date: 2026-01-13 DOI: 10.1016/j.scr.2026.103912
Jin Zhao , Rong Hu , Kuan Chen Lai , Yaling Liu , Gordon G. Carmichael , Donna M. Martin , Laijun Lai
{"title":"Generation of induced pluripotent stem cells from a patient with CHARGE syndrome with athymia, harboring a heterozygous mutation in CHD7","authors":"Jin Zhao ,&nbsp;Rong Hu ,&nbsp;Kuan Chen Lai ,&nbsp;Yaling Liu ,&nbsp;Gordon G. Carmichael ,&nbsp;Donna M. Martin ,&nbsp;Laijun Lai","doi":"10.1016/j.scr.2026.103912","DOIUrl":"10.1016/j.scr.2026.103912","url":null,"abstract":"<div><div>CHARGE syndrome is a rare, complex congenital disorder affecting multiple organ systems, with <em>CHD7</em> identified as its primary causative gene. Individuals with CHARGE syndrome can exhibit T cell immunodeficiency, which compromises adaptive immunity and increases susceptibility to infections. T cell immunodeficiency in CHARGE syndrome is largely attributed to thymic hypo/aplasia. In this study, we generated an induced pluripotent stem cell (iPSC) line from the blood of a 21-month-old female with CHARGE syndrome and athymia who carries a <em>de novo CHD7</em> pathogenic variant, c.1366C &gt; T (p.Q456*). This iPSC line provides a valuable model for investigating the pathogenesis of CHARGE-associated T cell immunodeficiency.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"91 ","pages":"Article 103912"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145980562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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