Seminars in cell & developmental biology最新文献_第4页

rDNA transcription, replication and stability in Saccharomyces cerevisiae 酿酒酵母中 rDNA 的转录、复制和稳定性

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2024-01-19 DOI: 10.1016/j.semcdb.2024.01.004

Anna D’Alfonso , Gioacchino Micheli , Giorgio Camilloni

{"title":"rDNA transcription, replication and stability in Saccharomyces cerevisiae","authors":"Anna D’Alfonso , Gioacchino Micheli , Giorgio Camilloni","doi":"10.1016/j.semcdb.2024.01.004","DOIUrl":"https://doi.org/10.1016/j.semcdb.2024.01.004","url":null,"abstract":"<div><p>The ribosomal DNA locus (rDNA) is central for the functioning of cells because it encodes ribosomal RNAs, key components of ribosomes, and also because of its links to fundamental metabolic processes, with significant impact on genome integrity and aging. The repetitive nature of the rDNA gene units forces the locus to maintain sequence homogeneity through recombination processes that are closely related to genomic stability. The co-presence of basic DNA transactions, such as replication, transcription by major RNA polymerases, and recombination, in a defined and restricted area of the genome is of particular relevance as it affects the stability of the rDNA locus by both direct and indirect mechanisms. This condition is well exemplified by the rDNA of <em>Saccharomyces cerevisiae</em>. In this review we summarize essential knowledge on how the complexity and overlap of different processes contribute to the control of rDNA and genomic stability in this model organism.</p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"159 ","pages":"Pages 1-9"},"PeriodicalIF":7.3,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1084952124000107/pdfft?md5=10a0dc2a8a2a11b2e20fad7a74e89e0f&pid=1-s2.0-S1084952124000107-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139494099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stress granules and P-bodies – New ideas and experimental models worth exploring 应力颗粒和 P-体--值得探索的新观点和实验模型

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2024-01-16 DOI: 10.1016/j.semcdb.2024.01.003

J. Ross Buchan

引用次数: 0

Telomere-specific regulation of TERRA and its impact on telomere stability 端粒特异性调控 TERRA 及其对端粒稳定性的影响

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-12-11 DOI: 10.1016/j.semcdb.2023.11.001

Julieta Rivosecchi , Katarina Jurikova , Emilio Cusanelli

{"title":"Telomere-specific regulation of TERRA and its impact on telomere stability","authors":"Julieta Rivosecchi , Katarina Jurikova , Emilio Cusanelli","doi":"10.1016/j.semcdb.2023.11.001","DOIUrl":"10.1016/j.semcdb.2023.11.001","url":null,"abstract":"<div><p>TERRA is a class of telomeric repeat-containing RNAs that are expressed from telomeres in multiple organisms. TERRA transcripts play key roles in telomere maintenance and their physiological levels are essential to maintain the integrity of telomeric DNA. Indeed, deregulated TERRA expression or its altered localization can impact telomere stability by multiple mechanisms including fueling transcription-replication conflicts, promoting resection of chromosome ends, altering the telomeric chromatin, and supporting homologous recombination. Therefore, a fine-tuned control of TERRA is important to maintain the integrity of the genome. Several studies have reported that different cell lines express substantially different levels of TERRA. Most importantly, TERRA levels markedly vary among telomeres of a given cell type, indicating the existence of telomere-specific regulatory mechanisms which may help coordinate TERRA functions. TERRA molecules contain distinct subtelomeric sequences, depending on their telomere of origin, which may instruct specific post-transcriptional modifications or mediate distinct functions. In addition, all TERRA transcripts share a repetitive G-rich sequence at their 3′ end which can form DNA:RNA hybrids and fold into G-quadruplex structures. Both structures are involved in TERRA functions and can critically affect telomere stability. In this review, we examine the mechanisms controlling TERRA levels and the impact of their telomere-specific regulation on telomere stability. We compare evidence obtained in different model organisms, discussing recent advances as well as controversies in the field. Furthermore, we discuss the importance of DNA:RNA hybrids and G-quadruplex structures in the context of TERRA biology and telomere maintenance.</p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"157 ","pages":"Pages 3-23"},"PeriodicalIF":7.3,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1084952123002276/pdfft?md5=ab5cb2395f7633fd0c68eca559d8986f&pid=1-s2.0-S1084952123002276-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138568354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial: Special issue SCDB “Cell death and survival” 社论:特刊SCDB“细胞死亡和生存”:健康和疾病中的细胞死亡和恢复力。

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-12-02 DOI: 10.1016/j.semcdb.2023.11.004

Maddalena Nano, Denise J. Montell

引用次数: 0

Collective mitochondrial dynamics resolve conflicting cellular tensions: From plants to general principles 集体线粒体动力学解决矛盾的细胞紧张:从植物到一般原则

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-11-30 DOI: 10.1016/j.semcdb.2023.09.005

Joanna M. Chustecki , Iain G. Johnston

{"title":"Collective mitochondrial dynamics resolve conflicting cellular tensions: From plants to general principles","authors":"Joanna M. Chustecki , Iain G. Johnston","doi":"10.1016/j.semcdb.2023.09.005","DOIUrl":"https://doi.org/10.1016/j.semcdb.2023.09.005","url":null,"abstract":"<div><p>Mitochondria play diverse and essential roles in eukaryotic cells, and plants are no exception. Plant mitochondria have several differences from their metazoan and fungal cousins: they often exist in a fragmented state, move rapidly on actin rather than microtubules, have many plant-specific metabolic features and roles, and usually contain only a subset of the complete mtDNA genome, which itself undergoes frequent recombination. This arrangement means that exchange and complementation is essential for plant mitochondria, and recent work has begun to reveal how their collective dynamics and resultant “social networks” of encounters support this exchange, connecting plant mitochondria in time rather than in space. This review will argue that this social network perspective can be extended to a “societal network”, where mitochondrial dynamics are an essential part of the interacting cellular society of organelles and biomolecules. Evidence is emerging that mitochondrial dynamics allow optimal resolutions to competing cellular priorities; we will survey this evidence and review potential future research directions, highlighting that plant mitochondria can help reveal and test principles that apply across other kingdoms of life. In parallel with this fundamental cell biology, we also highlight the translational “One Health” importance of plant mitochondrial behaviour – which is exploited in the production of a vast amount of crops consumed worldwide – and the potential for multi-objective optimisation to understand and rationally re-engineer the evolved resolutions to these tensions.</p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"156 ","pages":"Pages 253-265"},"PeriodicalIF":7.3,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1084952123001696/pdfft?md5=6b18ab25372e256cc29e0ca3feb4c2e9&pid=1-s2.0-S1084952123001696-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138466608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Apoptotic signaling: Beyond cell death 凋亡信号:超越细胞死亡。

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-11-19 DOI: 10.1016/j.semcdb.2023.11.002

Maddalena Nano , Denise J. Montell

引用次数: 1

Immunogenic cell stress and death in the treatment of cancer 癌症治疗中的免疫原性细胞应激和死亡。

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-11-16 DOI: 10.1016/j.semcdb.2023.10.007

Hui Pan , Peng Liu , Liwei Zhao , Yuhong Pan , Misha Mao , Guido Kroemer , Oliver Kepp

{"title":"Immunogenic cell stress and death in the treatment of cancer","authors":"Hui Pan , Peng Liu , Liwei Zhao , Yuhong Pan , Misha Mao , Guido Kroemer , Oliver Kepp","doi":"10.1016/j.semcdb.2023.10.007","DOIUrl":"10.1016/j.semcdb.2023.10.007","url":null,"abstract":"<div><p><span>The successful treatment of oncological malignancies which results in long-term disease control or the complete eradication of cancerous cells necessitates the onset of adaptive immune responses targeting tumor-specific antigens. Such desirable anticancer immunity can be triggered via the induction of immunogenic cell death (ICD) of cancer cells, thus converting malignant cells into an in situ vaccine that elicits </span>T cell<span> mediated adaptive immune responses and establishes durable immunological memory<span>. The exploration of ICD for cancer treatment has been subject to extensive research. However, functional heterogeneity among ICD activating therapies in many cases requires specific co-medications to achieve full-blown efficacy. Here, we described the hallmarks of ICD and classify ICD activators into three distinct functional categories namely, according to their mode of action: (i) ICD inducers, which increase the immunogenicity of malignant cells, (ii) ICD sensitizers, which prime cellular circuitries for ICD induction by conventional cytotoxic agents, and (iii) ICD enhancers, which improve the perception of ICD signals by antigen presenting dendritic cells. Altogether, ICD induction, sensitization and enhancement offer the possibility to convert well-established conventional anticancer therapies into immunotherapeutic approaches that activate T cell-mediated anticancer immunity.</span></span></p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"156 ","pages":"Pages 11-21"},"PeriodicalIF":7.3,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136399101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Persister cell plasticity in tumour drug resistance 肿瘤耐药中的持久性细胞可塑性。

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-11-16 DOI: 10.1016/j.semcdb.2023.11.003

Paul C. McDonald , Shoukat Dedhar

{"title":"Persister cell plasticity in tumour drug resistance","authors":"Paul C. McDonald , Shoukat Dedhar","doi":"10.1016/j.semcdb.2023.11.003","DOIUrl":"10.1016/j.semcdb.2023.11.003","url":null,"abstract":"<div><p><span>The emergence of therapeutic resistance remains a formidable barrier to durable responses by cancer patients and is a major cause of cancer-related deaths. It is increasingly recognized that non-genetic mechanisms of acquired resistance are important in many cancers. These mechanisms of resistance rely on inherent cellular plasticity where cancer cells can switch between multiple phenotypic states without </span>genetic alterations<span>, providing a dynamic, reversible resistance landscape. Such mechanisms underlie the generation of drug-tolerant persister (DTP) cells, a subpopulation of tumour cells that contributes to heterogeneity within tumours and that supports therapeutic resistance. In this review, we provide an overview of the major features of DTP cells, focusing on phenotypic and metabolic plasticity as two key drivers of tolerance and persistence. We discuss the link between DTP cell plasticity and the potential vulnerability of these cells to ferroptosis. We also discuss the relationship between DTP cells and cells that survive the induction of apoptosis, a process termed anastasis, and discuss the properties of such cells in the context of increased metastatic potential and sensitivity to cell death mechanisms such as ferroptosis.</span></p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"156 ","pages":"Pages 1-10"},"PeriodicalIF":7.3,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136399102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Dynamic interplay between human alpha-satellite DNA structure and centromere functions 人类α卫星DNA结构和着丝粒功能之间的动态相互作用。

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-11-04 DOI: 10.1016/j.semcdb.2023.10.002

Elena Di Tommaso , Simona Giunta

{"title":"Dynamic interplay between human alpha-satellite DNA structure and centromere functions","authors":"Elena Di Tommaso , Simona Giunta","doi":"10.1016/j.semcdb.2023.10.002","DOIUrl":"10.1016/j.semcdb.2023.10.002","url":null,"abstract":"<div><p><span>Maintenance of genome stability relies on functional </span>centromeres<span><span><span><span><span> for correct chromosome segregation and faithful inheritance of the </span>genetic information. The human centromere is the primary constriction within mitotic chromosomes made up of repetitive alpha-satellite </span>DNA hierarchically organized in megabase-long arrays of near-identical higher order repeats (HORs). Centromeres are epigenetically specified by the presence of the centromere-specific </span>histone H3 variant, CENP-A, which enables the assembly of the </span>kinetochore<span> for microtubule attachment. Notably, centromeric DNA is faithfully inherited as intact haplotypes from the parents to the offspring without intervening recombination, yet, outside of meiosis, centromeres are akin to common fragile sites (CFSs), manifesting crossing-overs and ongoing sequence instability. Consequences of DNA changes within the centromere are just starting to emerge, with unclear effects on intra- and inter-generational inheritance driven by centromere’s essential role in kinetochore assembly. Here, we review evidence of meiotic selection operating to mitigate centromere drive, as well as recent reports on centromere damage, recombination and repair during the mitotic cell division. We propose an antagonistic pleiotropy<span> interpretation to reconcile centromere DNA instability as both driver of aneuploidy that underlies degenerative diseases, while also potentially necessary for the maintenance of homogenized HORs for centromere function. We attempt to provide a framework for this conceptual leap taking into consideration the structural interface of centromere-kinetochore interaction and present case scenarios for its malfunctioning. Finally, we offer an integrated working model to connect DNA instability, chromatin, and structural changes with functional consequences on chromosome integrity.</span></span></span></p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"156 ","pages":"Pages 130-140"},"PeriodicalIF":7.3,"publicationDate":"2023-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71485752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The mechanisms and roles of mitochondrial dynamics in C. elegans 秀丽隐杆线虫线粒体动力学的机制和作用。

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-10-31 DOI: 10.1016/j.semcdb.2023.10.006

Daniel Campbell, Steven Zuryn

引用次数: 0