Seminars in cell & developmental biology最新文献_第4页

Viscoelasticity during development: What is it? and why should you care? 开发过程中的粘弹性：什么是粘弹性？你为什么要在意呢？

IF 6 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-11-01 Epub Date: 2025-09-27 DOI: 10.1016/j.semcdb.2025.103655

Yicheng Dong , Spandan Maiti , Lance A. Davidson

{"title":"Viscoelasticity during development: What is it? and why should you care?","authors":"Yicheng Dong , Spandan Maiti , Lance A. Davidson","doi":"10.1016/j.semcdb.2025.103655","DOIUrl":"10.1016/j.semcdb.2025.103655","url":null,"abstract":"<div><div>Viscoelasticity is a fundamental feature of biological tissues and plays a vital role in cells and tissues. This review explores the role of viscoelasticity in mechanobiology, emphasizing its impact on morphogenesis and organogenesis during embryonic development. We discuss the viscoelastic behavior of cells and tissues and its role in how cells and tissues absorb, dissipate, and transmit mechanical energy. We summarize experimental techniques such as Atomic Force Microscopy (AFM), Micropipette Aspiration (MA), and Tissue Stretchers, that have been used to quantify or observe the effects of viscoelasticity. Mathematical models of viscoelasticity, such as the Standard Linear Solid (SLS) model and advanced fractional models are introduced and discussed for their ability to capture the complexity of the viscoelastic behavior of biological systems. The role of subcellular complexes, including the cytoskeleton, extracellular matrix, and nucleus, are also reviewed for their contributions to tissue viscoelastic behavior. We also identify and discuss knowledge gaps, particularly in understanding how dynamic mechanical cues influence viscoelastic responses across cellular and tissue scales. A deeper exploration of these mechanisms, particularly those that determine viscoelastic behavior of cells and tissues, is needed for advancing our understanding of embryonic development and tissue morphogenesis.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"175 ","pages":"Article 103655"},"PeriodicalIF":6.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145157801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Capturing ovarian dynamics through spatial profiling of the mechano-microenvironment 通过机械微环境的空间分析捕捉卵巢动力学

IF 6 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-11-01 Epub Date: 2025-08-11 DOI: 10.1016/j.semcdb.2025.103642

Kosei Tomida , Huan Ting Ong , Jennifer L. Young , Chii Jou Chan

{"title":"Capturing ovarian dynamics through spatial profiling of the mechano-microenvironment","authors":"Kosei Tomida , Huan Ting Ong , Jennifer L. Young , Chii Jou Chan","doi":"10.1016/j.semcdb.2025.103642","DOIUrl":"10.1016/j.semcdb.2025.103642","url":null,"abstract":"<div><div>In recent years, tissue mechanics has been recognized not as a passive outcome of development but may function as upstream regulators to guide cellular functions such as proliferation, migration, and differentiation. In mammalian ovaries, cross-scale mechanical signals arising from tissue deformation, extracellular matrix architecture, and intrafollicular pressure dynamically evolve over the reproductive lifespan, contributing to a complex biomechanical landscape. Despite increasing recognition of their role in regulating follicle development, mechanical signals from ovarian microenvironment are still often considered separately from changes in gene expression and metabolic pathways. In addition, comprehensive mapping of the ovarian mechano-microenvironment remains lacking, in part due to challenges in assessing mechanical information in ovaries. Here we discuss how emerging biophysical techniques, including the latest advancement in various omics technologies, allow us to probe ovarian mechanics across multiple length scales. Such an integrated approach will provide new insights on how force transmission, matrix remodeling, and cellular signaling intersect within defined spatial niches to regulate ovarian dynamics, paving the way for future understanding of the mechanobiological basis of reproductive disorders.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"175 ","pages":"Article 103642"},"PeriodicalIF":6.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144813799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiciliated cells: Development, functions and disease relevance 多毛细胞：发育、功能和疾病相关性。

IF 6 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-11-01 Epub Date: 2025-10-08 DOI: 10.1016/j.semcdb.2025.103660

Dheeraj Rayamajhi , Sudipto Roy

引用次数: 0

Mechanics of oogenesis: Lessons from C. elegans germline cysts 卵发生机制：秀丽隐杆线虫种系囊肿的教训

IF 6 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-11-01 Epub Date: 2025-08-21 DOI: 10.1016/j.semcdb.2025.103644

Kenji Kimura, Fumio Motegi

{"title":"Mechanics of oogenesis: Lessons from C. elegans germline cysts","authors":"Kenji Kimura, Fumio Motegi","doi":"10.1016/j.semcdb.2025.103644","DOIUrl":"10.1016/j.semcdb.2025.103644","url":null,"abstract":"<div><div>Germ cells are organized into a syncytial architecture, wherein individual cells remain connected via intercellular bridges. Within this structural framework, known as germline cysts, a subset of germ cells enlarges and develops into oocytes, while others shrink and are eliminated through cell death. Recent studies with <em>Caenorhabditis elegans</em> have revealed that both apoptosis-mediated germ cell death and enlargement of surviving germ cells are regulated by mechanical forces. Germ cells exhibit stochastic fluctuations in volume driven by actomyosin contractility. This initial size heterogeneity is progressively amplified due to mechanical instability driven by differential hydrostatic pressure within the cyst, which biases smaller cells toward shrinkage and subsequent apoptotic death. This mechanical instability is further reinforced by the RAS/MAPK signaling cascade and the ECT-2/RhoA pathway, both of which enhance actomyosin contractility. Surviving germ cells continue to grow by acquiring the cytoplasmic materials through actomyosin contractility-mediated hydrodynamic flow within the cyst. Collectively, these findings highlight the critical role of mechanical forces in modulating cell fate decisions between survival and death, facilitating cell volume dynamics and maintaining germline homeostasis during oogenesis.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"175 ","pages":"Article 103644"},"PeriodicalIF":6.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144886523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Start early and pack light: Collaborative adventures in theory and experiment 尽早开始，轻装上阵：理论和实验的合作冒险

IF 6.2 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-10-01 Epub Date: 2025-07-26 DOI: 10.1016/j.semcdb.2025.103624

Erin L. Barnhart , Elena F. Koslover

{"title":"Start early and pack light: Collaborative adventures in theory and experiment","authors":"Erin L. Barnhart , Elena F. Koslover","doi":"10.1016/j.semcdb.2025.103624","DOIUrl":"10.1016/j.semcdb.2025.103624","url":null,"abstract":"<div><div>Collaboration between experimental and theoretical work is crucial to unraveling the complexity of living systems. To be productive, such collaborations require some often-scarce resources: most importantly, the time, manpower, and perseverance to iterate through multiple model formulations and experimental measurements. We argue that much can be learned from models which are highly simplified and initially ‘wrong’ or inconsistent with observations, and that the goal of theory in biology should not be primarily to provide a fit to existent experimental data. Instead, theoretical models should shed light on the key features of the system, providing insight on the missing pieces in our conceptual pictures and suggesting new measurements which can help fill in the gaps. Here, we describe a case-study from our own collaborative experience, focused on understanding the distribution of mitochondria in dendritic arbors. This story proceeded in an iterative manner from initial observations of dendritic structure and mitochondrial dynamics, to the construction of simple models, and back to original measurements and model refinement. Along the way, we came to appreciate some general principles for productive theory — experiment collaboration, which we proceed to highlight here.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"174 ","pages":"Article 103624"},"PeriodicalIF":6.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144704272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Start-Shape-Stop: Cell communication mechanisms controlling organ size. 开始-形状-停止：控制器官大小的细胞通讯机制。

IF 6 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-10-01 Epub Date: 2025-08-09 DOI: 10.1016/j.semcdb.2025.103641

Lucas Ribas, Rita Mateus

引用次数: 0

Biophysical, cellular, and mouse model approaches to investigate the mechanical regulation of folliculogenesis 生物物理，细胞和小鼠模型方法来研究卵泡发生的机械调节

IF 6 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-10-01 Epub Date: 2025-08-30 DOI: 10.1016/j.semcdb.2025.103649

Sara Pietroforte, Farners Amargant

{"title":"Biophysical, cellular, and mouse model approaches to investigate the mechanical regulation of folliculogenesis","authors":"Sara Pietroforte, Farners Amargant","doi":"10.1016/j.semcdb.2025.103649","DOIUrl":"10.1016/j.semcdb.2025.103649","url":null,"abstract":"<div><div>Folliculogenesis, which is the process by which ovarian follicles develop to support oogenesis and hormone production, is essential for female fertility. Although hormonal and biochemical signaling pathways regulating folliculogenesis have been extensively studied, increasing evidence suggests that mechanical cues within the ovary also play a critical role. The ovary is composed of follicles, corpora lutea, and stroma, each contributing to a biomechanical microenvironment that might change across the reproductive lifespan. Additionally, the spatial organization of the ovary, with a collagen-rich cortex and a softer medulla, may influence follicle activation and growth. This review explores the hypothesis that mechanical properties of the ovary regulate folliculogenesis, integrating current knowledge on ovarian architecture, extracellular matrix composition, and mechanotransduction pathways. We highlight recent findings supporting mechanical regulation of folliculogenesis, discuss contradictory data, and describe the tools and models used to investigate this concept. By considering mechanical forces alongside hormonal and biochemical signals, we propose a more integrated view of the factors governing follicle development, with implications for understanding ovarian physiology and pathology.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"174 ","pages":"Article 103649"},"PeriodicalIF":6.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144920273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gradients, waves and nematics: quantitative perspectives on regeneration 梯度，波和向列：再生的定量观点

IF 6.2 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-10-01 Epub Date: 2025-07-22 DOI: 10.1016/j.semcdb.2025.103632

Tristan Guyomar, Alessandro De Simone

{"title":"Gradients, waves and nematics: quantitative perspectives on regeneration","authors":"Tristan Guyomar, Alessandro De Simone","doi":"10.1016/j.semcdb.2025.103632","DOIUrl":"10.1016/j.semcdb.2025.103632","url":null,"abstract":"<div><div>Regeneration restores a damaged body part to its original size, shape and structure. Research over the last decades identified signaling pathways, cell types and cellular processes that are key for regeneration. Moreover, mechanical cues and electric potentials are increasingly implicated in modulating regenerative processes. An intriguing open question regards how these chemical, mechanical and electric signals are dynamically organized to coordinate cell behaviors across large regenerating tissues and long regenerative timescales for proper morphogenesis. In addition, it is less explored how regeneration is stopped once tissues reach their proper final form. These questions and related models cross-talk with physical notions like information, pattern formation, self-organization, and control. An interdisciplinary approach combining methods and concepts of developmental biology and physics is offering new quantitative insights on these questions. In this approach, researchers characterize the spatial organization and temporal dynamics of chemical, mechanical and electric signal inputs and relate them to cell and tissue behaviors. Initial observations inform theory; in turn, theory guides experiments and data analysis, while state-of-the-art perturbations allow testing these models. After illustrating this approach, we provide examples of its application to animal regeneration <em>in vivo</em>. These works are extending the notion of “morphogen”, contributing to establishing the emerging field of quantitative regeneration and uncovering principles of multicellular organization.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"174 ","pages":"Article 103632"},"PeriodicalIF":6.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144679191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retinal photoreceptor cilia and ciliopathies: Molecular mechanisms and therapeutic strategies 视网膜光感受器纤毛和纤毛病：分子机制和治疗策略

IF 6 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-10-01 Epub Date: 2025-07-28 DOI: 10.1016/j.semcdb.2025.103635

Lin Li , Jun Zhou , Jie Ran

{"title":"Retinal photoreceptor cilia and ciliopathies: Molecular mechanisms and therapeutic strategies","authors":"Lin Li , Jun Zhou , Jie Ran","doi":"10.1016/j.semcdb.2025.103635","DOIUrl":"10.1016/j.semcdb.2025.103635","url":null,"abstract":"<div><div>Photoreceptor outer segments are specialized sensory cilia that are filled with flattened membranous discs responsible for transducing light into neural signals. These cilia maintain a dynamic system in which daily shedding of outer segments at distal tips balances continuous membrane synthesis, ensuring photoreceptor homeostasis. Mutations in ciliary genes impair the biogenesis or shedding of outer segments, leading to retinal ciliopathies. Recent studies have elucidated molecular mechanisms governing photoreceptor ciliary formation, maintenance, and renewal. In this review, we summarize current understanding of the spatiotemporal regulation of photoreceptor ciliogenesis and disc renewal, structural adaptations enabling light detection and protein trafficking, and pathogenic pathways from defective ciliary transport to photoreceptor degeneration. We further discuss emerging therapeutic strategies targeting cilia, including gene therapy and pharmacological intervention, as well as the potential application of targeted protein degradation and retinal organoid technologies, aimed at restoring ciliary function and photoreceptor viability.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"174 ","pages":"Article 103635"},"PeriodicalIF":6.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144722084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

C. elegans: An elegant experimental system for the study of cilia biology 秀丽隐杆线虫：研究纤毛生物学的一个优雅的实验系统

IF 6.2 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-10-01 Epub Date: 2025-07-26 DOI: 10.1016/j.semcdb.2025.103636

Inna Nechipurenko , Piali Sengupta

引用次数: 0