Seminars in cell & developmental biology最新文献_第10页

Modelling adult stem cells and their niche in health and disease with epithelial organoids 用上皮类器官模拟成体干细胞及其在健康和疾病中的生态位

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-07-30 DOI: 10.1016/j.semcdb.2022.09.006

Lili Szabó , Anna C. Seubert , Kai Kretzschmar

引用次数: 4

Thrombospondin-1 in vascular development, vascular function, and vascular disease 血栓反应蛋白-1在血管发育、血管功能和血管疾病中的作用。

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-07-27 DOI: 10.1016/j.semcdb.2023.07.011

Bo Liu , Huan Yang , Yong-Seok Song , Christine M. Sorenson , Nader Sheibani

{"title":"Thrombospondin-1 in vascular development, vascular function, and vascular disease","authors":"Bo Liu , Huan Yang , Yong-Seok Song , Christine M. Sorenson , Nader Sheibani","doi":"10.1016/j.semcdb.2023.07.011","DOIUrl":"10.1016/j.semcdb.2023.07.011","url":null,"abstract":"<div><p>Angiogenesis is vital to developmental, regenerative and repair processes. It is normally regulated by a balanced production of pro- and anti-angiogenic factors. Alterations in this balance under pathological conditions are generally mediated through up-regulation of pro-angiogenic and/or downregulation of anti-angiogenic factors, leading to growth of new and abnormal blood vessels. The pathological manifestation of many diseases including cancer, ocular and vascular diseases are dependent on the growth of these new and abnormal blood vessels. Thrompospondin-1 (TSP1) was the first endogenous angiogenesis inhibitor identified and its anti-angiogenic and anti-inflammatory activities have been the subject of many studies. Studies examining the role TSP1 plays in pathogenesis of various ocular diseases and vascular dysfunctions are limited. Here we will discuss the recent studies focused on delineating the role TSP1 plays in ocular vascular development and homeostasis, and pathophysiology of various ocular and vascular diseases with a significant clinical relevance to human health.</p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"155 ","pages":"Pages 32-44"},"PeriodicalIF":7.3,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9951001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Molecular cell types as functional units of the efferent vagus nerve 输出迷走神经功能单位的分子细胞类型

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-07-26 DOI: 10.1016/j.semcdb.2023.07.007

Tatiana C. Coverdell , Stephen B.G. Abbott , John N. Campbell

引用次数: 0

Vagal pathways for systemic regulation of glucose metabolism 迷走神经通路对葡萄糖代谢的全身调节

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-07-26 DOI: 10.1016/j.semcdb.2023.07.010

Diba Borgmann , Henning Fenselau

{"title":"Vagal pathways for systemic regulation of glucose metabolism","authors":"Diba Borgmann , Henning Fenselau","doi":"10.1016/j.semcdb.2023.07.010","DOIUrl":"10.1016/j.semcdb.2023.07.010","url":null,"abstract":"<div><p><span>Maintaining blood glucose at an appropriate physiological level requires precise coordination of multiple organs and tissues. The vagus nerve bidirectionally connects the central nervous system with peripheral organs crucial to glucose mobilization, nutrient storage, and food absorption, thereby presenting a key pathway for the central control of blood </span>glucose levels<span>. However, the precise mechanisms by which vagal populations that target discrete tissues participate in glucoregulation are much less clear. Here we review recent advances unraveling the cellular identity, neuroanatomical organization, and functional contributions of both vagal efferents and vagal afferents in the control of systemic glucose metabolism<span>. We focus on their involvement in relaying glucoregulatory cues from the brain to peripheral tissues, particularly the pancreatic islet, and by sensing and transmitting incoming signals from ingested food to the brain. These recent findings - largely driven by advances in viral approaches, RNA sequencing, and cell-type selective manipulations and tracings - have begun to clarify the precise vagal neuron populations involved in the central coordination of glucose levels, and raise interesting new possibilities for the treatment of glucose metabolism disorders such as diabetes.</span></span></p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"156 ","pages":"Pages 244-252"},"PeriodicalIF":7.3,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9885651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood endothelium transition and phenotypic plasticity: A key regulator of integrity/permeability in response to ischemia 血内皮转换和表型可塑性:缺血反应中完整性/通透性的关键调节因子。

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-07-20 DOI: 10.1016/j.semcdb.2023.07.004

Nicolas Bréchot , Alexandre Rutault , Iris Marangon , Stéphane Germain

{"title":"Blood endothelium transition and phenotypic plasticity: A key regulator of integrity/permeability in response to ischemia","authors":"Nicolas Bréchot , Alexandre Rutault , Iris Marangon , Stéphane Germain","doi":"10.1016/j.semcdb.2023.07.004","DOIUrl":"10.1016/j.semcdb.2023.07.004","url":null,"abstract":"<div><p>In the human body, the 10<sup>13</sup> blood endothelial cells (ECs) which cover a surface of 500–700 m<sup>2</sup> (Mai et al., 2013) are key players of tissue homeostasis, remodeling and regeneration. Blood vessel ECs play a major role in the regulation of metabolic and gaz exchanges, cell trafficking, blood coagulation, vascular tone, blood flow and fluid extravasation (also referred to as blood vascular permeability). ECs are heterogeneous in various capillary beds and have the exquisite capacity to cope with environmental changes by regulating their gene expression. Ischemia has major detrimental effects on the endothelium and ischemia-induced regulation of vascular integrity is of paramount importance for human health, as small amounts of fluid accumulation in the interstitium may be responsible for major effects on organ functions and patients outcome. In this review, we will here focus on the stimuli and the molecular mechanisms that control blood endothelium maintenance and phenotypic plasticity/transition involved in controlling blood capillary leakage that might open new avenues for therapeutic applications.</p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"155 ","pages":"Pages 16-22"},"PeriodicalIF":7.3,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9905386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Death and survival from executioner caspase activation 死亡和生存来自刽子手半胱天冬酶的激活

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-07-18 DOI: 10.1016/j.semcdb.2023.07.005

Gongping Sun

引用次数: 2

Impacts of altered exercise volume, intensity, and duration on the activation of AMPK and CaMKII and increases in PGC-1α mRNA 改变运动量、强度和持续时间对AMPK和CaMKII的激活以及PGC-1α mRNA的增加的影响

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-07-15 DOI: 10.1016/j.semcdb.2022.05.016

Brendon J. Gurd , Eveline Soares Menezes , Benjamin B. Arhen , Hashim Islam

{"title":"Impacts of altered exercise volume, intensity, and duration on the activation of AMPK and CaMKII and increases in PGC-1α mRNA","authors":"Brendon J. Gurd , Eveline Soares Menezes , Benjamin B. Arhen , Hashim Islam","doi":"10.1016/j.semcdb.2022.05.016","DOIUrl":"10.1016/j.semcdb.2022.05.016","url":null,"abstract":"<div><p><span><span>The purpose of this review is to explore and discuss the impacts of augmented training volume, intensity, and duration on the phosphorylation/activation of key signaling protein – AMPK, CaMKII and PGC-1α - involved in the initiation of </span>mitochondrial biogenesis. Specifically, we explore the impacts of augmented exercise protocols on AMP/ADP and Ca</span><sup>2+</sup> signaling and changes in post exercise PGC − 1α gene expression. Although AMP/ADP concentrations appear to increase with increasing intensity and during extended durations of higher intensity exercise AMPK activation results are varied with some results supporting and intensity/duration effect and others not. Similarly, CaMKII activation and signaling results following exercise of different intensities and durations are inconsistent. The PGC-1α literature is equally inconsistent with only some studies demonstrating an effect of intensity on post exercise mRNA expression. We present a novel meta-analysis that suggests that the inconsistency in the PGC-1α literature may be due to sample size and statistical power limitations owing to the effect of intensity on PGC-1α expression being small. There is little data available regarding the impact of exercise duration on PGC-1α expression. We highlight the need for future well designed, adequately statistically powered, studies to clarify our understanding of the effects of volume, intensity, and duration on the induction of mitochondrial biogenesis by exercise.</p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"143 ","pages":"Pages 17-27"},"PeriodicalIF":7.3,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9189286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Mitochondria: Key modulators of skeletal muscle remodeling 线粒体:骨骼肌重塑的关键调节剂

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-07-15 DOI: 10.1016/j.semcdb.2022.10.004

Joe Quadrilatero

引用次数: 2

Mitochondrial-derived vesicles in skeletal muscle remodeling and adaptation 骨骼肌重构和适应中的线粒体源性囊泡

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-07-15 DOI: 10.1016/j.semcdb.2022.03.023

Anna Picca , Flora Guerra , Riccardo Calvani , Roberta Romano , Hélio José Coelho-Junior , Cecilia Bucci , Christiaan Leeuwenburgh , Emanuele Marzetti

{"title":"Mitochondrial-derived vesicles in skeletal muscle remodeling and adaptation","authors":"Anna Picca , Flora Guerra , Riccardo Calvani , Roberta Romano , Hélio José Coelho-Junior , Cecilia Bucci , Christiaan Leeuwenburgh , Emanuele Marzetti","doi":"10.1016/j.semcdb.2022.03.023","DOIUrl":"10.1016/j.semcdb.2022.03.023","url":null,"abstract":"<div><p><span><span>Mitochondrial remodeling is crucial to meet the bioenergetic demand to support muscle contractile activity during daily tasks and </span>muscle regeneration following injury. A set of mitochondrial quality control (MQC) processes, including </span>mitochondrial biogenesis<span>, dynamics, and mitophagy<span>, are in place to maintain a well-functioning mitochondrial network and support muscle regeneration. Alterations in any of these pathways compromises mitochondrial quality and may potentially lead to impaired myogenesis, defective muscle regeneration, and ultimately loss of muscle function.</span></span></p><p>Among MQC processes, mitophagy has gained special attention for its implication in the clearance of dysfunctional mitochondria via crosstalk with the endo-lysosomal system, a major cell degradative route. Along this pathway, additional opportunities for mitochondrial disposal have been identified that may also signal at the systemic level. This communication occurs via inclusion of mitochondrial components within membranous shuttles named mitochondrial-derived vesicles (MDVs).</p><p>Here, we discuss MDV generation and release as a mitophagy-complementing route for the maintenance of mitochondrial homeostasis in skeletal myocytes. We also illustrate the possible role of muscle-derived MDVs in immune signaling during muscle remodeling and adaptation.</p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"143 ","pages":"Pages 37-45"},"PeriodicalIF":7.3,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9248063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Transient changes to metabolic homeostasis initiate mitochondrial adaptation to endurance exercise 代谢稳态的短暂变化启动线粒体对耐力运动的适应

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-07-15 DOI: 10.1016/j.semcdb.2022.03.022

Jessica R. Dent , Ben Stocks , Dean G. Campelj , Andrew Philp

引用次数: 2