Seminars in cell & developmental biology最新文献

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Application of stem cells in engineered vascular graft and vascularized organs 干细胞在工程血管移植及血管化器官中的应用
IF 7.3 2区 生物学
Seminars in cell & developmental biology Pub Date : 2023-07-30 DOI: 10.1016/j.semcdb.2022.10.003
Shanlan Zhao , Qiao Zhang , Min Liu , Jiahui Du , Tingting Wang , Yanzhao Li , Wen Zeng
{"title":"Application of stem cells in engineered vascular graft and vascularized organs","authors":"Shanlan Zhao ,&nbsp;Qiao Zhang ,&nbsp;Min Liu ,&nbsp;Jiahui Du ,&nbsp;Tingting Wang ,&nbsp;Yanzhao Li ,&nbsp;Wen Zeng","doi":"10.1016/j.semcdb.2022.10.003","DOIUrl":"10.1016/j.semcdb.2022.10.003","url":null,"abstract":"<div><p>Recent studies report that stem cell therapies<span> have been applied successfully to patients, This has increased anticipations that this regeneration strategy could be a potential method to treat a wide range of intractable diseases some day. Stem cells offer new prospects for the treatment of incurable diseases and for tissue regeneration<span> and repairation because of their unique biological properties. Angiogenesis<span> a key process in tissue regeneration and repairation. Vascularization of organs is one of the main challenges hindering the clinical application of engineered tissues. Efficient production of engineered vascular grafts and vascularized organs is of critical importance for regenerative medicine. In this review, we focus on the types of stem cells that are widely used in tissue engineering and regeneration, as well as their application of these stem cells in the construction of tissue-engineered vascular grafts and vascularization of tissue-engineered organs.</span></span></span></p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"144 ","pages":"Pages 31-40"},"PeriodicalIF":7.3,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9194933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Organoids as a novel tool in modelling infectious diseases 类器官作为传染病建模的新工具
IF 7.3 2区 生物学
Seminars in cell & developmental biology Pub Date : 2023-07-30 DOI: 10.1016/j.semcdb.2022.09.003
Lucas Felipe de Oliveira , Daniel Mendes Filho , Bruno Lemes Marques , Giovana Figueiredo Maciel , Ricardo Cambraia Parreira , José Rodrigues do Carmo Neto , Priscilla Elias Ferreira Da Silva , Rhanoica Oliveira Guerra , Marcos Vinicius da Silva , Helton da Costa Santiago , Alexander Birbrair , Alexandre H. Kihara , Valdo José Dias da Silva , Talita Glaser , Rodrigo R. Resende , Henning Ulrich
{"title":"Organoids as a novel tool in modelling infectious diseases","authors":"Lucas Felipe de Oliveira ,&nbsp;Daniel Mendes Filho ,&nbsp;Bruno Lemes Marques ,&nbsp;Giovana Figueiredo Maciel ,&nbsp;Ricardo Cambraia Parreira ,&nbsp;José Rodrigues do Carmo Neto ,&nbsp;Priscilla Elias Ferreira Da Silva ,&nbsp;Rhanoica Oliveira Guerra ,&nbsp;Marcos Vinicius da Silva ,&nbsp;Helton da Costa Santiago ,&nbsp;Alexander Birbrair ,&nbsp;Alexandre H. Kihara ,&nbsp;Valdo José Dias da Silva ,&nbsp;Talita Glaser ,&nbsp;Rodrigo R. Resende ,&nbsp;Henning Ulrich","doi":"10.1016/j.semcdb.2022.09.003","DOIUrl":"10.1016/j.semcdb.2022.09.003","url":null,"abstract":"<div><p>Infectious diseases worldwide affect human health and have important societal impacts. A better understanding of infectious diseases is urgently needed. In vitro and in vivo infection models have brought notable contributions to the current knowledge of these diseases. Organoids are multicellular culture systems resembling tissue architecture and function, recapitulating many characteristics of human disease and elucidating mechanisms of host–infectious agent interactions in the respiratory and gastrointestinal systems, the central nervous system and the skin. Here, we discuss the applicability of the organoid technology for modeling pathogenesis, host response and features, which can be explored for the development of preventive and therapeutic treatments.</p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"144 ","pages":"Pages 87-96"},"PeriodicalIF":7.3,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9194366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Regulatory mechanisms of stem cell differentiation: Biotechnological applications for neurogenesis 干细胞分化的调控机制:神经发生的生物技术应用
IF 7.3 2区 生物学
Seminars in cell & developmental biology Pub Date : 2023-07-30 DOI: 10.1016/j.semcdb.2022.09.014
Bruno L. Marques , Giovana Figueiredo Maciel , Marcello R. Brito Júnior , Lucas D. Dias , Sérgio Scalzo , Anderson K. Santos , Alexandre Hiroaki Kihara , Helton da Costa Santiago , Ricardo C. Parreira , Alexander Birbrair , Rodrigo R. Resende
{"title":"Regulatory mechanisms of stem cell differentiation: Biotechnological applications for neurogenesis","authors":"Bruno L. Marques ,&nbsp;Giovana Figueiredo Maciel ,&nbsp;Marcello R. Brito Júnior ,&nbsp;Lucas D. Dias ,&nbsp;Sérgio Scalzo ,&nbsp;Anderson K. Santos ,&nbsp;Alexandre Hiroaki Kihara ,&nbsp;Helton da Costa Santiago ,&nbsp;Ricardo C. Parreira ,&nbsp;Alexander Birbrair ,&nbsp;Rodrigo R. Resende","doi":"10.1016/j.semcdb.2022.09.014","DOIUrl":"10.1016/j.semcdb.2022.09.014","url":null,"abstract":"<div><p>The world population’s life expectancy is growing, and neurodegenerative disorders common in old age require more efficient therapies. In this context, neural stem cells (NSCs) are imperative for the development and maintenance of the functioning of the nervous system and have broad therapeutic applicability for neurodegenerative diseases. Therefore, knowing all the mechanisms that govern the self-renewal, differentiation, and cell signaling<span><span> of NSC is necessary. This review will address some of these aspects, including the role of growth and transcription factors, epigenetic modulators, </span>microRNAs<span>, and extracellular matrix components. Furthermore, differentiation and transdifferentiation processes will be addressed as therapeutic strategies showing their significance for stem cell-based therapy.</span></span></p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"144 ","pages":"Pages 11-19"},"PeriodicalIF":7.3,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9194503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Microfluidic organoids-on-a-chip: The future of human models 芯片上的微流控类器官:人体模型的未来
IF 7.3 2区 生物学
Seminars in cell & developmental biology Pub Date : 2023-07-30 DOI: 10.1016/j.semcdb.2022.10.001
Gloria Saorin , Isabella Caligiuri , Flavio Rizzolio
{"title":"Microfluidic organoids-on-a-chip: The future of human models","authors":"Gloria Saorin ,&nbsp;Isabella Caligiuri ,&nbsp;Flavio Rizzolio","doi":"10.1016/j.semcdb.2022.10.001","DOIUrl":"10.1016/j.semcdb.2022.10.001","url":null,"abstract":"<div><p><span>Microfluidics opened the possibility to model the physiological environment by controlling fluids flows, and therefore nutrients supply. It allows to integrate external stimuli such as electricals or mechanicals and in situ monitoring important parameters such as pH, oxygen and metabolite concentrations. Organoids are self-organized 3D organ-like clusters, which allow to closely model original organ functionalities. Applying microfluidics to organoids allows to generate powerful human models for studying organ development, diseases, and drug testing. In this review, after a brief introduction on microfluidics, organoids and organoids-on-a-chip are described by organs (brain, heart, </span>gastrointestinal tract, liver, pancreas) highlighting the microfluidic approaches since this point of view was overlooked in previously published reviews. Indeed, the review aims to discuss from a different point of view, primary microfluidics, the available literature on organoids-on-a-chip, standing out from the published literature by focusing on each specific organ.</p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"144 ","pages":"Pages 41-54"},"PeriodicalIF":7.3,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9194510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Brain organoids, consciousness, ethics and moral status 脑类器官,意识,伦理和道德地位
IF 7.3 2区 生物学
Seminars in cell & developmental biology Pub Date : 2023-07-30 DOI: 10.1016/j.semcdb.2022.03.020
Jacob Jeziorski , Reuven Brandt , John H. Evans , Wendy Campana , Michael Kalichman , Evan Thompson , Lawrence Goldstein , Christof Koch , Alysson R. Muotri
{"title":"Brain organoids, consciousness, ethics and moral status","authors":"Jacob Jeziorski ,&nbsp;Reuven Brandt ,&nbsp;John H. Evans ,&nbsp;Wendy Campana ,&nbsp;Michael Kalichman ,&nbsp;Evan Thompson ,&nbsp;Lawrence Goldstein ,&nbsp;Christof Koch ,&nbsp;Alysson R. Muotri","doi":"10.1016/j.semcdb.2022.03.020","DOIUrl":"10.1016/j.semcdb.2022.03.020","url":null,"abstract":"<div><p>Advances in the field of human stem cells are often a source of public and ethical controversy. Researchers must frequently balance diverse societal perspectives on questions of morality with the pursuit of medical therapeutics and innovation. Recent developments in brain organoids make this challenge even more acute. Brain organoids are a new class of brain surrogate generated from human pluripotent stem cells (hPSCs). They have gained traction as a model for studying the intricacies of the human brain by using advancements in stem cell biology to recapitulate aspects of the developing human brain <em>in vitro</em><span>. However, recent observation of neural oscillations spontaneously emerging from these organoids raises the question of whether brain organoids are or could become conscious. At the same time, brain organoids offer a potentially unique opportunity to scientifically understand consciousness. To address these issues, experimental biologists, philosophers, and ethicists united to discuss the possibility of consciousness in human brain organoids and the consequent ethical and moral implications.</span></p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"144 ","pages":"Pages 97-102"},"PeriodicalIF":7.3,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9195442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Retinal organoids from human-induced pluripotent stem cells: From studying retinal dystrophies to early diagnosis of Alzheimer’s and Parkinson’s disease 来自人类诱导的多能干细胞的视网膜类器官:从研究视网膜营养不良到阿尔茨海默病和帕金森病的早期诊断
IF 7.3 2区 生物学
Seminars in cell & developmental biology Pub Date : 2023-07-30 DOI: 10.1016/j.semcdb.2022.09.011
Marília Inês Móvio , Théo Henrique de Lima-Vasconcellos , Gabrieli Bovi dos Santos , Marcela Bermudez Echeverry , Elisabetta Colombo , Leonardo S. Mattos , Rodrigo Ribeiro Resende , Alexandre Hiroaki Kihara
{"title":"Retinal organoids from human-induced pluripotent stem cells: From studying retinal dystrophies to early diagnosis of Alzheimer’s and Parkinson’s disease","authors":"Marília Inês Móvio ,&nbsp;Théo Henrique de Lima-Vasconcellos ,&nbsp;Gabrieli Bovi dos Santos ,&nbsp;Marcela Bermudez Echeverry ,&nbsp;Elisabetta Colombo ,&nbsp;Leonardo S. Mattos ,&nbsp;Rodrigo Ribeiro Resende ,&nbsp;Alexandre Hiroaki Kihara","doi":"10.1016/j.semcdb.2022.09.011","DOIUrl":"10.1016/j.semcdb.2022.09.011","url":null,"abstract":"<div><p>Human-induced pluripotent stem cells (hiPSCs) have provided new methods to study neurodegenerative diseases. In addition to their wide application in neuronal disorders, hiPSCs technology can also encompass specific conditions, such as inherited retinal dystrophies. The possibility of evaluating alterations related to retinal disorders in 3D organoids increases the truthfulness of <em>in vitro</em><span><span> models. Moreover, both Alzheimer's (AD) and Parkinson’s disease (PD) have been described as causing early retinal alterations, generating beta-amyloid protein accumulation, or affecting dopaminergic </span>amacrine cells. This review addresses recent advances and future perspectives obtained from </span><em>in vitro</em><span> modeling of retinal diseases, focusing on retinitis pigmentosa (RP). Additionally, we depicted the possibility of evaluating changes related to AD and PD in retinal organoids obtained from potential patients long before the onset of the disease, constituting a valuable tool in early diagnosis. With this, we pointed out prospects in the study of retinal dystrophies and early diagnosis of AD and PD.</span></p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"144 ","pages":"Pages 77-86"},"PeriodicalIF":7.3,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9194376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Modelling adult stem cells and their niche in health and disease with epithelial organoids 用上皮类器官模拟成体干细胞及其在健康和疾病中的生态位
IF 7.3 2区 生物学
Seminars in cell & developmental biology Pub Date : 2023-07-30 DOI: 10.1016/j.semcdb.2022.09.006
Lili Szabó , Anna C. Seubert , Kai Kretzschmar
{"title":"Modelling adult stem cells and their niche in health and disease with epithelial organoids","authors":"Lili Szabó ,&nbsp;Anna C. Seubert ,&nbsp;Kai Kretzschmar","doi":"10.1016/j.semcdb.2022.09.006","DOIUrl":"10.1016/j.semcdb.2022.09.006","url":null,"abstract":"<div><p>Adult stem cells<span> are responsible for homoeostasis<span> and regeneration of epithelial tissues. Stem cell function is regulated by both cell autonomous mechanisms as well as the niche. Deregulated stem cell function contributes to diseases such as cancer. Epithelial organoid cultures generated from tissue-resident adult stem cells have allowed unprecedented insights into the biology of epithelial tissues. The subsequent adaptation of organoid technology enabled the modelling of the communication of stem cells with their cellular and non-cellular niche as well as diseases. Starting from its first model described in 2009, the murine small intestinal organoid, we discuss here how epithelial organoid cultures have been become a prime in vitro research tool for cell and developmental biology, bioengineering, and biomedicine in the last decade.</span></span></p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"144 ","pages":"Pages 20-30"},"PeriodicalIF":7.3,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9200929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Thrombospondin-1 in vascular development, vascular function, and vascular disease 血栓反应蛋白-1在血管发育、血管功能和血管疾病中的作用。
IF 7.3 2区 生物学
Seminars in cell & developmental biology Pub Date : 2023-07-27 DOI: 10.1016/j.semcdb.2023.07.011
Bo Liu , Huan Yang , Yong-Seok Song , Christine M. Sorenson , Nader Sheibani
{"title":"Thrombospondin-1 in vascular development, vascular function, and vascular disease","authors":"Bo Liu ,&nbsp;Huan Yang ,&nbsp;Yong-Seok Song ,&nbsp;Christine M. Sorenson ,&nbsp;Nader Sheibani","doi":"10.1016/j.semcdb.2023.07.011","DOIUrl":"10.1016/j.semcdb.2023.07.011","url":null,"abstract":"<div><p>Angiogenesis is vital to developmental, regenerative and repair processes. It is normally regulated by a balanced production of pro- and anti-angiogenic factors. Alterations in this balance under pathological conditions are generally mediated through up-regulation of pro-angiogenic and/or downregulation of anti-angiogenic factors, leading to growth of new and abnormal blood vessels. The pathological manifestation of many diseases including cancer, ocular and vascular diseases are dependent on the growth of these new and abnormal blood vessels. Thrompospondin-1 (TSP1) was the first endogenous angiogenesis inhibitor identified and its anti-angiogenic and anti-inflammatory activities have been the subject of many studies. Studies examining the role TSP1 plays in pathogenesis of various ocular diseases and vascular dysfunctions are limited. Here we will discuss the recent studies focused on delineating the role TSP1 plays in ocular vascular development and homeostasis, and pathophysiology of various ocular and vascular diseases with a significant clinical relevance to human health.</p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"155 ","pages":"Pages 32-44"},"PeriodicalIF":7.3,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9951001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Molecular cell types as functional units of the efferent vagus nerve 输出迷走神经功能单位的分子细胞类型
IF 7.3 2区 生物学
Seminars in cell & developmental biology Pub Date : 2023-07-26 DOI: 10.1016/j.semcdb.2023.07.007
Tatiana C. Coverdell , Stephen B.G. Abbott , John N. Campbell
{"title":"Molecular cell types as functional units of the efferent vagus nerve","authors":"Tatiana C. Coverdell ,&nbsp;Stephen B.G. Abbott ,&nbsp;John N. Campbell","doi":"10.1016/j.semcdb.2023.07.007","DOIUrl":"10.1016/j.semcdb.2023.07.007","url":null,"abstract":"<div><p><span>The vagus nerve vitally connects the brain and body to coordinate digestive, cardiorespiratory, and immune functions. Its efferent neurons, which project their axons from the brainstem to the viscera, are thought to comprise “functional units” - neuron populations dedicated to the control of specific </span>vagal reflexes<span> or organ functions. Previous research indicates that these functional units differ from one another anatomically, neurochemically, and physiologically but have yet to define their identity in an experimentally tractable way. However, recent work with genetic technology and single-cell genomics suggests that genetically distinct subtypes of neurons may be the functional units of the efferent vagus. Here we review how these approaches are revealing the organizational principles of the efferent vagus in unprecedented detail.</span></p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"156 ","pages":"Pages 210-218"},"PeriodicalIF":7.3,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9888172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vagal pathways for systemic regulation of glucose metabolism 迷走神经通路对葡萄糖代谢的全身调节
IF 7.3 2区 生物学
Seminars in cell & developmental biology Pub Date : 2023-07-26 DOI: 10.1016/j.semcdb.2023.07.010
Diba Borgmann , Henning Fenselau
{"title":"Vagal pathways for systemic regulation of glucose metabolism","authors":"Diba Borgmann ,&nbsp;Henning Fenselau","doi":"10.1016/j.semcdb.2023.07.010","DOIUrl":"10.1016/j.semcdb.2023.07.010","url":null,"abstract":"<div><p><span>Maintaining blood glucose at an appropriate physiological level requires precise coordination of multiple organs and tissues. The vagus nerve bidirectionally connects the central nervous system with peripheral organs crucial to glucose mobilization, nutrient storage, and food absorption, thereby presenting a key pathway for the central control of blood </span>glucose levels<span>. However, the precise mechanisms by which vagal populations that target discrete tissues participate in glucoregulation are much less clear. Here we review recent advances unraveling the cellular identity, neuroanatomical organization, and functional contributions of both vagal efferents and vagal afferents in the control of systemic glucose metabolism<span>. We focus on their involvement in relaying glucoregulatory cues from the brain to peripheral tissues, particularly the pancreatic islet, and by sensing and transmitting incoming signals from ingested food to the brain. These recent findings - largely driven by advances in viral approaches, RNA sequencing, and cell-type selective manipulations and tracings - have begun to clarify the precise vagal neuron populations involved in the central coordination of glucose levels, and raise interesting new possibilities for the treatment of glucose metabolism disorders such as diabetes.</span></span></p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"156 ","pages":"Pages 244-252"},"PeriodicalIF":7.3,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9885651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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