Seminars in cell & developmental biology最新文献_第10页

Impacts of altered exercise volume, intensity, and duration on the activation of AMPK and CaMKII and increases in PGC-1α mRNA 改变运动量、强度和持续时间对AMPK和CaMKII的激活以及PGC-1α mRNA的增加的影响

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-07-15 DOI: 10.1016/j.semcdb.2022.05.016

Brendon J. Gurd , Eveline Soares Menezes , Benjamin B. Arhen , Hashim Islam

{"title":"Impacts of altered exercise volume, intensity, and duration on the activation of AMPK and CaMKII and increases in PGC-1α mRNA","authors":"Brendon J. Gurd , Eveline Soares Menezes , Benjamin B. Arhen , Hashim Islam","doi":"10.1016/j.semcdb.2022.05.016","DOIUrl":"10.1016/j.semcdb.2022.05.016","url":null,"abstract":"<div>The purpose of this review is to explore and discuss the impacts of augmented training volume, intensity, and duration on the phosphorylation/activation of key signaling protein – AMPK, CaMKII and PGC-1α - involved in the initiation of mitochondrial biogenesis. Specifically, we explore the impacts of augmented exercise protocols on AMP/ADP and Ca2+ signaling and changes in post exercise PGC − 1α gene expression. Although AMP/ADP concentrations appear to increase with increasing intensity and during extended durations of higher intensity exercise AMPK activation results are varied with some results supporting and intensity/duration effect and others not. Similarly, CaMKII activation and signaling results following exercise of different intensities and durations are inconsistent. The PGC-1α literature is equally inconsistent with only some studies demonstrating an effect of intensity on post exercise mRNA expression. We present a novel meta-analysis that suggests that the inconsistency in the PGC-1α literature may be due to sample size and statistical power limitations owing to the effect of intensity on PGC-1α expression being small. There is little data available regarding the impact of exercise duration on PGC-1α expression. We highlight the need for future well designed, adequately statistically powered, studies to clarify our understanding of the effects of volume, intensity, and duration on the induction of mitochondrial biogenesis by exercise.</div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":null,"pages":null},"PeriodicalIF":7.3,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9189286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Mitochondria: Key modulators of skeletal muscle remodeling 线粒体:骨骼肌重塑的关键调节剂

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-07-15 DOI: 10.1016/j.semcdb.2022.10.004

Joe Quadrilatero

引用次数: 2

Transient changes to metabolic homeostasis initiate mitochondrial adaptation to endurance exercise 代谢稳态的短暂变化启动线粒体对耐力运动的适应

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-07-15 DOI: 10.1016/j.semcdb.2022.03.022

Jessica R. Dent , Ben Stocks , Dean G. Campelj , Andrew Philp

引用次数: 2

Mitochondrial-derived vesicles in skeletal muscle remodeling and adaptation 骨骼肌重构和适应中的线粒体源性囊泡

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-07-15 DOI: 10.1016/j.semcdb.2022.03.023

Anna Picca , Flora Guerra , Riccardo Calvani , Roberta Romano , Hélio José Coelho-Junior , Cecilia Bucci , Christiaan Leeuwenburgh , Emanuele Marzetti

{"title":"Mitochondrial-derived vesicles in skeletal muscle remodeling and adaptation","authors":"Anna Picca , Flora Guerra , Riccardo Calvani , Roberta Romano , Hélio José Coelho-Junior , Cecilia Bucci , Christiaan Leeuwenburgh , Emanuele Marzetti","doi":"10.1016/j.semcdb.2022.03.023","DOIUrl":"10.1016/j.semcdb.2022.03.023","url":null,"abstract":"<div>Mitochondrial remodeling is crucial to meet the bioenergetic demand to support muscle contractile activity during daily tasks and muscle regeneration following injury. A set of mitochondrial quality control (MQC) processes, including mitochondrial biogenesis, dynamics, and mitophagy, are in place to maintain a well-functioning mitochondrial network and support muscle regeneration. Alterations in any of these pathways compromises mitochondrial quality and may potentially lead to impaired myogenesis, defective muscle regeneration, and ultimately loss of muscle function.Among MQC processes, mitophagy has gained special attention for its implication in the clearance of dysfunctional mitochondria via crosstalk with the endo-lysosomal system, a major cell degradative route. Along this pathway, additional opportunities for mitochondrial disposal have been identified that may also signal at the systemic level. This communication occurs via inclusion of mitochondrial components within membranous shuttles named mitochondrial-derived vesicles (MDVs).Here, we discuss MDV generation and release as a mitophagy-complementing route for the maintenance of mitochondrial homeostasis in skeletal myocytes. We also illustrate the possible role of muscle-derived MDVs in immune signaling during muscle remodeling and adaptation.</div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":null,"pages":null},"PeriodicalIF":7.3,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9248063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Mitochondrial Apoptotic Signaling Involvement in Remodeling During Myogenesis and Skeletal Muscle Atrophy 线粒体凋亡信号参与肌发生和骨骼肌萎缩过程中的重塑

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-07-15 DOI: 10.1016/j.semcdb.2022.01.011

Fasih Ahmad Rahman, Joe Quadrilatero

{"title":"Mitochondrial Apoptotic Signaling Involvement in Remodeling During Myogenesis and Skeletal Muscle Atrophy","authors":"Fasih Ahmad Rahman, Joe Quadrilatero","doi":"10.1016/j.semcdb.2022.01.011","DOIUrl":"10.1016/j.semcdb.2022.01.011","url":null,"abstract":"<div>Mitochondria play a major role in apoptotic signaling. In addition to its role in eliminating dysfunctional cells, mitochondrial apoptotic signaling is implicated as a key component of myogenic differentiation and skeletal muscle atrophy. For example, the activation of cysteine-aspartic proteases (caspases; CASP's) can aid in the initial remodeling stages of myogenic differentiation by cleaving protein kinases, transcription factors, and cytoskeletal proteins. Precise regulation of these signals is needed to prevent excessive cell disassemble and subsequent cell death. During skeletal muscle atrophy, the activation of CASP's and mitochondrial derived nucleases participate in myonuclear fragmentation, a potential loss of myonuclei, and cleavage of contractile structures within skeletal muscle. The B cell leukemia/lymphoma 2 (BCL2) family of proteins play a significant role in regulating myogenesis and skeletal muscle atrophy by governing the initiating steps of mitochondrial apoptotic signaling. This review discusses the role of mitochondrial apoptotic signaling in skeletal muscle remodeling during myogenic differentiation and skeletal muscle pathological states, including aging, disuse, and muscular dystrophy.</div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":null,"pages":null},"PeriodicalIF":7.3,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9253601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Emerging role of mitophagy in myoblast differentiation and skeletal muscle remodeling 线粒体自噬在成肌细胞分化和骨骼肌重塑中的作用。

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-07-15 DOI: 10.1016/j.semcdb.2021.11.026

Fasih Ahmad Rahman, Joe Quadrilatero

{"title":"Emerging role of mitophagy in myoblast differentiation and skeletal muscle remodeling","authors":"Fasih Ahmad Rahman, Joe Quadrilatero","doi":"10.1016/j.semcdb.2021.11.026","DOIUrl":"10.1016/j.semcdb.2021.11.026","url":null,"abstract":"<div>Mitochondrial turnover in the form of mitophagy is emerging as a central process in maintaining cellular function. The degradation of damaged mitochondria through mitophagy is particularly important in cells/tissues that exhibit high energy demands. Skeletal muscle is one such tissue that requires precise turnover of mitochondria in several conditions in order to optimize energy production and prevent bioenergetic crisis. For instance, the formation of skeletal muscle (i.e., myogenesis) is accompanied by robust turnover of low-functioning mitochondria to eventually allow the formation of high-functioning mitochondria. In mature skeletal muscle, alterations in mitophagy-related signaling occur during exercise, aging, and various disease states. Nonetheless, several questions regarding the direct role of mitophagy in various skeletal muscle conditions remain unknown. Furthermore, given the heterogenous nature of skeletal muscle with respect to various cellular and molecular properties, and the plasticity in these properties in various conditions, the involvement and characterization of mitophagy requires more careful consideration in this tissue. Therefore, this review will highlight the known mechanisms of mitophagy in skeletal muscle, and discuss their involvement during myogenesis and various skeletal muscle conditions. This review also provides important considerations for the accurate measurement of mitophagy and interpretation of data in skeletal muscle.</div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":null,"pages":null},"PeriodicalIF":7.3,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9193474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Implications of mitochondrial fusion and fission in skeletal muscle mass and health 线粒体融合和裂变对骨骼肌质量和健康的影响

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-07-15 DOI: 10.1016/j.semcdb.2022.02.011

Vanina Romanello , Marco Sandri

引用次数: 10

Mitochondrial protein import and UPRmt in skeletal muscle remodeling and adaptation 骨骼肌重塑和适应中的线粒体蛋白输入和UPRmt

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-07-15 DOI: 10.1016/j.semcdb.2022.01.002

Brandon J. Richards, Mikhaela Slavin, Ashley N. Oliveira, Victoria C. Sanfrancesco, David A. Hood

{"title":"Mitochondrial protein import and UPRmt in skeletal muscle remodeling and adaptation","authors":"Brandon J. Richards, Mikhaela Slavin, Ashley N. Oliveira, Victoria C. Sanfrancesco, David A. Hood","doi":"10.1016/j.semcdb.2022.01.002","DOIUrl":"https://doi.org/10.1016/j.semcdb.2022.01.002","url":null,"abstract":"<div>The biogenesis of mitochondria requires the coordinated expression of the nuclear and the mitochondrial genomes. However, the vast majority of gene products within the organelle are encoded in the nucleus, synthesized in the cytosol, and imported into mitochondria via the protein import machinery, which permit the entry of proteins to expand the mitochondrial network. Once inside, proteins undergo a maturation and folding process brought about by enzymes comprising the unfolded protein response (UPRmt). Protein import and UPRmt activity must be synchronized and matched with mtDNA-encoded subunit synthesis for proper assembly of electron transport chain complexes to avoid proteotoxicity. This review discusses the functions of the import and UPRmt systems in mammalian skeletal muscle, as well as how exercise alters the equilibrium of these pathways in a time-dependent manner, leading to a new steady state of mitochondrial content resulting in enhanced oxidative capacity and improved muscle health.</div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":null,"pages":null},"PeriodicalIF":7.3,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49724594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Maintenance of neuronal identity in C. elegans and beyond: Lessons from transcription and chromatin factors 秀丽隐杆线虫及其后神经元身份的维持：转录和染色质因子的经验教训。

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-07-11 DOI: 10.1016/j.semcdb.2023.07.001

Honorine Destain , Manasa Prahlad , Paschalis Kratsios

{"title":"Maintenance of neuronal identity in C. elegans and beyond: Lessons from transcription and chromatin factors","authors":"Honorine Destain , Manasa Prahlad , Paschalis Kratsios","doi":"10.1016/j.semcdb.2023.07.001","DOIUrl":"10.1016/j.semcdb.2023.07.001","url":null,"abstract":"<div>Neurons are remarkably long-lived, non-dividing cells that must maintain their functional features (e.g., electrical properties, chemical signaling) for extended periods of time – decades in humans. How neurons accomplish this incredible feat is poorly understood. Here, we review recent advances, primarily in the nematode C. elegans, that have enhanced our understanding of the molecular mechanisms that enable post-mitotic neurons to maintain their functionality across different life stages. We begin with “terminal selectors” - transcription factors necessary for the establishment and maintenance of neuronal identity. We highlight new findings on five terminal selectors (CHE-1 [Glass], UNC-3 [Collier/Ebf1–4], LIN-39 [Scr/Dfd/Hox4–5], UNC-86 [Acj6/Brn3a-c], AST-1 [Etv1/ER81]) from different transcription factor families (ZNF, COE, HOX, POU, ETS). We compare the functions of these factors in specific neuron types of C. elegans with the actions of their orthologs in other invertebrate (D. melanogaster) and vertebrate (M. musculus) systems, highlighting remarkable functional conservation. Finally, we reflect on recent findings implicating chromatin-modifying proteins, such as histone methyltransferases and Polycomb proteins, in the control of neuronal terminal identity. Altogether, these new studies on transcription factors and chromatin modifiers not only shed light on the fundamental problem of neuronal identity maintenance, but also outline mechanistic principles of gene regulation that may operate in other long-lived, post-mitotic cell types.</div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":null,"pages":null},"PeriodicalIF":7.3,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9776693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Shedding light on mitochondrial outer-membrane permeabilization and membrane potential: State of the art methods and biosensors 揭示线粒体外膜通透性和膜电位:最新的方法和生物传感器

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-07-10 DOI: 10.1016/j.semcdb.2023.07.003

Nikolay Popgeorgiev , Clara Gil , Kevin Berthenet , Giulia Bertolin , Gabriel Ichim

{"title":"Shedding light on mitochondrial outer-membrane permeabilization and membrane potential: State of the art methods and biosensors","authors":"Nikolay Popgeorgiev , Clara Gil , Kevin Berthenet , Giulia Bertolin , Gabriel Ichim","doi":"10.1016/j.semcdb.2023.07.003","DOIUrl":"10.1016/j.semcdb.2023.07.003","url":null,"abstract":"<div>Membrane structural integrity is essential for optimal mitochondrial function. These organelles produce the energy needed for all vital processes, provided their outer and inner membranes are intact. This prevents the release of mitochondrial apoptogenic factors into the cytosol and ensures intact mitochondrial membrane potential (ΔΨm) to sustain ATP production. Cell death by apoptosis is generally triggered by outer mitochondrial membrane permeabilization (MOMP), tightly coupled with loss of ΔΨ m. As these two processes are essential for both mitochondrial function and cell death, researchers have devised various techniques to assess them. Here, we discuss current methods and biosensors available for detecting MOMP and measuring ΔΨ m, focusing on their advantages and limitations and discuss what new imaging tools are needed to improve our knowledge of mitochondrial function.</div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":null,"pages":null},"PeriodicalIF":7.3,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1084952123001416/pdfft?md5=4dd5a1e3e399fa93e846078f9d164c82&pid=1-s2.0-S1084952123001416-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9776692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4