Seminars in cell & developmental biology最新文献_第10页

Collective mitochondrial dynamics resolve conflicting cellular tensions: From plants to general principles 集体线粒体动力学解决矛盾的细胞紧张:从植物到一般原则

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-11-30 DOI: 10.1016/j.semcdb.2023.09.005

Joanna M. Chustecki , Iain G. Johnston

{"title":"Collective mitochondrial dynamics resolve conflicting cellular tensions: From plants to general principles","authors":"Joanna M. Chustecki , Iain G. Johnston","doi":"10.1016/j.semcdb.2023.09.005","DOIUrl":"https://doi.org/10.1016/j.semcdb.2023.09.005","url":null,"abstract":"<div><p>Mitochondria play diverse and essential roles in eukaryotic cells, and plants are no exception. Plant mitochondria have several differences from their metazoan and fungal cousins: they often exist in a fragmented state, move rapidly on actin rather than microtubules, have many plant-specific metabolic features and roles, and usually contain only a subset of the complete mtDNA genome, which itself undergoes frequent recombination. This arrangement means that exchange and complementation is essential for plant mitochondria, and recent work has begun to reveal how their collective dynamics and resultant “social networks” of encounters support this exchange, connecting plant mitochondria in time rather than in space. This review will argue that this social network perspective can be extended to a “societal network”, where mitochondrial dynamics are an essential part of the interacting cellular society of organelles and biomolecules. Evidence is emerging that mitochondrial dynamics allow optimal resolutions to competing cellular priorities; we will survey this evidence and review potential future research directions, highlighting that plant mitochondria can help reveal and test principles that apply across other kingdoms of life. In parallel with this fundamental cell biology, we also highlight the translational “One Health” importance of plant mitochondrial behaviour – which is exploited in the production of a vast amount of crops consumed worldwide – and the potential for multi-objective optimisation to understand and rationally re-engineer the evolved resolutions to these tensions.</p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"156 ","pages":"Pages 253-265"},"PeriodicalIF":7.3,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1084952123001696/pdfft?md5=6b18ab25372e256cc29e0ca3feb4c2e9&pid=1-s2.0-S1084952123001696-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138466608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Apoptotic signaling: Beyond cell death 凋亡信号:超越细胞死亡。

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-11-19 DOI: 10.1016/j.semcdb.2023.11.002

Maddalena Nano , Denise J. Montell

引用次数: 1

Immunogenic cell stress and death in the treatment of cancer 癌症治疗中的免疫原性细胞应激和死亡。

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-11-16 DOI: 10.1016/j.semcdb.2023.10.007

Hui Pan , Peng Liu , Liwei Zhao , Yuhong Pan , Misha Mao , Guido Kroemer , Oliver Kepp

{"title":"Immunogenic cell stress and death in the treatment of cancer","authors":"Hui Pan , Peng Liu , Liwei Zhao , Yuhong Pan , Misha Mao , Guido Kroemer , Oliver Kepp","doi":"10.1016/j.semcdb.2023.10.007","DOIUrl":"10.1016/j.semcdb.2023.10.007","url":null,"abstract":"<div><p><span>The successful treatment of oncological malignancies which results in long-term disease control or the complete eradication of cancerous cells necessitates the onset of adaptive immune responses targeting tumor-specific antigens. Such desirable anticancer immunity can be triggered via the induction of immunogenic cell death (ICD) of cancer cells, thus converting malignant cells into an in situ vaccine that elicits </span>T cell<span> mediated adaptive immune responses and establishes durable immunological memory<span>. The exploration of ICD for cancer treatment has been subject to extensive research. However, functional heterogeneity among ICD activating therapies in many cases requires specific co-medications to achieve full-blown efficacy. Here, we described the hallmarks of ICD and classify ICD activators into three distinct functional categories namely, according to their mode of action: (i) ICD inducers, which increase the immunogenicity of malignant cells, (ii) ICD sensitizers, which prime cellular circuitries for ICD induction by conventional cytotoxic agents, and (iii) ICD enhancers, which improve the perception of ICD signals by antigen presenting dendritic cells. Altogether, ICD induction, sensitization and enhancement offer the possibility to convert well-established conventional anticancer therapies into immunotherapeutic approaches that activate T cell-mediated anticancer immunity.</span></span></p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"156 ","pages":"Pages 11-21"},"PeriodicalIF":7.3,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136399101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Persister cell plasticity in tumour drug resistance 肿瘤耐药中的持久性细胞可塑性。

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-11-16 DOI: 10.1016/j.semcdb.2023.11.003

Paul C. McDonald , Shoukat Dedhar

{"title":"Persister cell plasticity in tumour drug resistance","authors":"Paul C. McDonald , Shoukat Dedhar","doi":"10.1016/j.semcdb.2023.11.003","DOIUrl":"10.1016/j.semcdb.2023.11.003","url":null,"abstract":"<div><p><span>The emergence of therapeutic resistance remains a formidable barrier to durable responses by cancer patients and is a major cause of cancer-related deaths. It is increasingly recognized that non-genetic mechanisms of acquired resistance are important in many cancers. These mechanisms of resistance rely on inherent cellular plasticity where cancer cells can switch between multiple phenotypic states without </span>genetic alterations<span>, providing a dynamic, reversible resistance landscape. Such mechanisms underlie the generation of drug-tolerant persister (DTP) cells, a subpopulation of tumour cells that contributes to heterogeneity within tumours and that supports therapeutic resistance. In this review, we provide an overview of the major features of DTP cells, focusing on phenotypic and metabolic plasticity as two key drivers of tolerance and persistence. We discuss the link between DTP cell plasticity and the potential vulnerability of these cells to ferroptosis. We also discuss the relationship between DTP cells and cells that survive the induction of apoptosis, a process termed anastasis, and discuss the properties of such cells in the context of increased metastatic potential and sensitivity to cell death mechanisms such as ferroptosis.</span></p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"156 ","pages":"Pages 1-10"},"PeriodicalIF":7.3,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136399102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Dynamic interplay between human alpha-satellite DNA structure and centromere functions 人类α卫星DNA结构和着丝粒功能之间的动态相互作用。

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-11-04 DOI: 10.1016/j.semcdb.2023.10.002

Elena Di Tommaso , Simona Giunta

{"title":"Dynamic interplay between human alpha-satellite DNA structure and centromere functions","authors":"Elena Di Tommaso , Simona Giunta","doi":"10.1016/j.semcdb.2023.10.002","DOIUrl":"10.1016/j.semcdb.2023.10.002","url":null,"abstract":"<div><p><span>Maintenance of genome stability relies on functional </span>centromeres<span><span><span><span><span> for correct chromosome segregation and faithful inheritance of the </span>genetic information. The human centromere is the primary constriction within mitotic chromosomes made up of repetitive alpha-satellite </span>DNA hierarchically organized in megabase-long arrays of near-identical higher order repeats (HORs). Centromeres are epigenetically specified by the presence of the centromere-specific </span>histone H3 variant, CENP-A, which enables the assembly of the </span>kinetochore<span> for microtubule attachment. Notably, centromeric DNA is faithfully inherited as intact haplotypes from the parents to the offspring without intervening recombination, yet, outside of meiosis, centromeres are akin to common fragile sites (CFSs), manifesting crossing-overs and ongoing sequence instability. Consequences of DNA changes within the centromere are just starting to emerge, with unclear effects on intra- and inter-generational inheritance driven by centromere’s essential role in kinetochore assembly. Here, we review evidence of meiotic selection operating to mitigate centromere drive, as well as recent reports on centromere damage, recombination and repair during the mitotic cell division. We propose an antagonistic pleiotropy<span> interpretation to reconcile centromere DNA instability as both driver of aneuploidy that underlies degenerative diseases, while also potentially necessary for the maintenance of homogenized HORs for centromere function. We attempt to provide a framework for this conceptual leap taking into consideration the structural interface of centromere-kinetochore interaction and present case scenarios for its malfunctioning. Finally, we offer an integrated working model to connect DNA instability, chromatin, and structural changes with functional consequences on chromosome integrity.</span></span></span></p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"156 ","pages":"Pages 130-140"},"PeriodicalIF":7.3,"publicationDate":"2023-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71485752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The mechanisms and roles of mitochondrial dynamics in C. elegans 秀丽隐杆线虫线粒体动力学的机制和作用。

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-10-31 DOI: 10.1016/j.semcdb.2023.10.006

Daniel Campbell, Steven Zuryn

引用次数: 0

DNA strand breaks at centromeres: Friend or foe? DNA链在着丝粒处断裂：朋友还是敌人？

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-10-21 DOI: 10.1016/j.semcdb.2023.10.004

Emily Graham, Fumiko Esashi

引用次数: 0

The implications of satellite DNA instability on cellular function and evolution 卫星DNA不稳定性对细胞功能和进化的影响。

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-10-17 DOI: 10.1016/j.semcdb.2023.10.005

Jullien M. Flynn , Yukiko M. Yamashita

{"title":"The implications of satellite DNA instability on cellular function and evolution","authors":"Jullien M. Flynn , Yukiko M. Yamashita","doi":"10.1016/j.semcdb.2023.10.005","DOIUrl":"10.1016/j.semcdb.2023.10.005","url":null,"abstract":"<div><p>Abundant tandemly repeated satellite DNA<span><span> is present in most eukaryotic genomes. Previous limitations including a pervasive view that it was uninteresting junk DNA, combined with challenges in studying it, are starting to dissolve - and recent studies have found important functions for satellite DNAs. The observed rapid evolution and implied instability of satellite DNA now has important significance for their functions and maintenance within the genome. In this review, we discuss the processes that lead to satellite DNA copy number instability, and the importance of mechanisms to manage the potential negative effects of instability. Satellite DNA is vulnerable to challenges during replication and repair, since it forms difficult-to-process secondary structures and its homology within tandem arrays can result in various types of recombination. Satellite DNA instability may be managed by DNA or chromatin-binding proteins ensuring proper nuclear localization and repair, or by proteins that process aberrant structures that satellite DNAs tend to form. We also discuss the pattern of satellite </span>DNA mutations<span> from recent mutation accumulation (MA) studies that have tracked changes in satellite DNA for up to 1000 generations with minimal selection. Finally, we highlight examples of satellite evolution from studies that have characterized satellites across millions of years of Drosophila fruit fly evolution, and discuss possible ways that selection might act on the satellite DNA composition.</span></span></p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"156 ","pages":"Pages 152-159"},"PeriodicalIF":7.3,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49682104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Emerging roles of DNA repair factors in the stability of centromeres DNA修复因子在着丝粒稳定性中的新作用。

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-10-16 DOI: 10.1016/j.semcdb.2023.10.001

Francesca Marcon , Simona Giunta , Margherita Bignami

{"title":"Emerging roles of DNA repair factors in the stability of centromeres","authors":"Francesca Marcon , Simona Giunta , Margherita Bignami","doi":"10.1016/j.semcdb.2023.10.001","DOIUrl":"10.1016/j.semcdb.2023.10.001","url":null,"abstract":"<div><p><span>Satellite DNA sequences are an integral part of </span>centromeres<span><span>, regions critical for faithful segregation of chromosomes during cell division. Because of their complex repetitive structure, satellite DNA<span><span> may act as a barrier to DNA replication and other DNA based transactions ultimately resulting in chromosome breakage. Over the past two decades, several </span>DNA repair proteins have been shown to bind and function at centromeres. While the importance of these repair factors is highlighted by various structural and numerical chromosome aberrations resulting from their inactivation, their roles in helping to maintain </span></span>genome stability<span><span> by solving the intrinsic difficulties of satellite DNA replication or promoting their repair are just starting to emerge. In this review, we summarize the current knowledge on the role of DNA repair and DNA damage response proteins in maintaining the structure and function of centromeres in different contexts. We also report the recent connection between the roles of specific DNA repair factors at these genomic loci with age-related increase of </span>chromosomal instability under physiological and pathological conditions.</span></span></p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"156 ","pages":"Pages 121-129"},"PeriodicalIF":7.3,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49682103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Fatal attraction: How Phytophthora zoospores find their host 致命的吸引力:疫霉菌游动孢子如何找到它们的宿主

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-10-01 DOI: 10.1016/j.semcdb.2023.01.014

Michiel Kasteel , Tijs Ketelaar , Francine Govers

{"title":"Fatal attraction: How Phytophthora zoospores find their host","authors":"Michiel Kasteel , Tijs Ketelaar , Francine Govers","doi":"10.1016/j.semcdb.2023.01.014","DOIUrl":"10.1016/j.semcdb.2023.01.014","url":null,"abstract":"<div><p>Oomycete plant pathogens, such as <em>Phytophthora</em> and <em>Pythium</em> species produce motile dispersal agents called zoospores that actively target host plants. Zoospores are exceptional in their ability to display taxis to chemical, electrical and physical cues to navigate the phyllosphere and reach stomata, wound sites and roots. Many components of root exudates have been shown attractive or repulsive to zoospores. Although some components possess very strong attractiveness, it seems that especially the mix of components exuded by the primary host is most attractive to zoospores. Zoospores actively approach attractants with swimming behaviour reminiscent of other microswimmers. To achieve a unified description of zoospore behaviour when sensing an attractant, we propose the following terms for the successive stages of the homing response: reorientation, approaching, retention and settling. How zoospores sense and process attractants is poorly understood but likely involves signal perception via cell surface receptors. Since zoospores are important for infection, undermining their activity by luring attractants or blocking receptors seem promising strategies for disease control.</p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"148 ","pages":"Pages 13-21"},"PeriodicalIF":7.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9604191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3