Seminars in cell & developmental biology最新文献_第9页

Regulatory mechanisms of stem cell differentiation: Biotechnological applications for neurogenesis 干细胞分化的调控机制:神经发生的生物技术应用

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-07-30 DOI: 10.1016/j.semcdb.2022.09.014

Bruno L. Marques , Giovana Figueiredo Maciel , Marcello R. Brito Júnior , Lucas D. Dias , Sérgio Scalzo , Anderson K. Santos , Alexandre Hiroaki Kihara , Helton da Costa Santiago , Ricardo C. Parreira , Alexander Birbrair , Rodrigo R. Resende

引用次数: 3

Microfluidic organoids-on-a-chip: The future of human models 芯片上的微流控类器官:人体模型的未来

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-07-30 DOI: 10.1016/j.semcdb.2022.10.001

Gloria Saorin , Isabella Caligiuri , Flavio Rizzolio

引用次数: 16

Brain organoids, consciousness, ethics and moral status 脑类器官，意识，伦理和道德地位

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-07-30 DOI: 10.1016/j.semcdb.2022.03.020

Jacob Jeziorski , Reuven Brandt , John H. Evans , Wendy Campana , Michael Kalichman , Evan Thompson , Lawrence Goldstein , Christof Koch , Alysson R. Muotri

{"title":"Brain organoids, consciousness, ethics and moral status","authors":"Jacob Jeziorski , Reuven Brandt , John H. Evans , Wendy Campana , Michael Kalichman , Evan Thompson , Lawrence Goldstein , Christof Koch , Alysson R. Muotri","doi":"10.1016/j.semcdb.2022.03.020","DOIUrl":"10.1016/j.semcdb.2022.03.020","url":null,"abstract":"<div><p>Advances in the field of human stem cells are often a source of public and ethical controversy. Researchers must frequently balance diverse societal perspectives on questions of morality with the pursuit of medical therapeutics and innovation. Recent developments in brain organoids make this challenge even more acute. Brain organoids are a new class of brain surrogate generated from human pluripotent stem cells (hPSCs). They have gained traction as a model for studying the intricacies of the human brain by using advancements in stem cell biology to recapitulate aspects of the developing human brain <em>in vitro</em><span>. However, recent observation of neural oscillations spontaneously emerging from these organoids raises the question of whether brain organoids are or could become conscious. At the same time, brain organoids offer a potentially unique opportunity to scientifically understand consciousness. To address these issues, experimental biologists, philosophers, and ethicists united to discuss the possibility of consciousness in human brain organoids and the consequent ethical and moral implications.</span></p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"144 ","pages":"Pages 97-102"},"PeriodicalIF":7.3,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9195442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Retinal organoids from human-induced pluripotent stem cells: From studying retinal dystrophies to early diagnosis of Alzheimer’s and Parkinson’s disease 来自人类诱导的多能干细胞的视网膜类器官:从研究视网膜营养不良到阿尔茨海默病和帕金森病的早期诊断

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-07-30 DOI: 10.1016/j.semcdb.2022.09.011

Marília Inês Móvio , Théo Henrique de Lima-Vasconcellos , Gabrieli Bovi dos Santos , Marcela Bermudez Echeverry , Elisabetta Colombo , Leonardo S. Mattos , Rodrigo Ribeiro Resende , Alexandre Hiroaki Kihara

{"title":"Retinal organoids from human-induced pluripotent stem cells: From studying retinal dystrophies to early diagnosis of Alzheimer’s and Parkinson’s disease","authors":"Marília Inês Móvio , Théo Henrique de Lima-Vasconcellos , Gabrieli Bovi dos Santos , Marcela Bermudez Echeverry , Elisabetta Colombo , Leonardo S. Mattos , Rodrigo Ribeiro Resende , Alexandre Hiroaki Kihara","doi":"10.1016/j.semcdb.2022.09.011","DOIUrl":"10.1016/j.semcdb.2022.09.011","url":null,"abstract":"<div><p>Human-induced pluripotent stem cells (hiPSCs) have provided new methods to study neurodegenerative diseases. In addition to their wide application in neuronal disorders, hiPSCs technology can also encompass specific conditions, such as inherited retinal dystrophies. The possibility of evaluating alterations related to retinal disorders in 3D organoids increases the truthfulness of <em>in vitro</em><span><span> models. Moreover, both Alzheimer's (AD) and Parkinson’s disease (PD) have been described as causing early retinal alterations, generating beta-amyloid protein accumulation, or affecting dopaminergic </span>amacrine cells. This review addresses recent advances and future perspectives obtained from </span><em>in vitro</em><span> modeling of retinal diseases, focusing on retinitis pigmentosa (RP). Additionally, we depicted the possibility of evaluating changes related to AD and PD in retinal organoids obtained from potential patients long before the onset of the disease, constituting a valuable tool in early diagnosis. With this, we pointed out prospects in the study of retinal dystrophies and early diagnosis of AD and PD.</span></p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"144 ","pages":"Pages 77-86"},"PeriodicalIF":7.3,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9194376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Modelling adult stem cells and their niche in health and disease with epithelial organoids 用上皮类器官模拟成体干细胞及其在健康和疾病中的生态位

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-07-30 DOI: 10.1016/j.semcdb.2022.09.006

Lili Szabó , Anna C. Seubert , Kai Kretzschmar

引用次数: 4

Thrombospondin-1 in vascular development, vascular function, and vascular disease 血栓反应蛋白-1在血管发育、血管功能和血管疾病中的作用。

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-07-27 DOI: 10.1016/j.semcdb.2023.07.011

Bo Liu , Huan Yang , Yong-Seok Song , Christine M. Sorenson , Nader Sheibani

{"title":"Thrombospondin-1 in vascular development, vascular function, and vascular disease","authors":"Bo Liu , Huan Yang , Yong-Seok Song , Christine M. Sorenson , Nader Sheibani","doi":"10.1016/j.semcdb.2023.07.011","DOIUrl":"10.1016/j.semcdb.2023.07.011","url":null,"abstract":"<div><p>Angiogenesis is vital to developmental, regenerative and repair processes. It is normally regulated by a balanced production of pro- and anti-angiogenic factors. Alterations in this balance under pathological conditions are generally mediated through up-regulation of pro-angiogenic and/or downregulation of anti-angiogenic factors, leading to growth of new and abnormal blood vessels. The pathological manifestation of many diseases including cancer, ocular and vascular diseases are dependent on the growth of these new and abnormal blood vessels. Thrompospondin-1 (TSP1) was the first endogenous angiogenesis inhibitor identified and its anti-angiogenic and anti-inflammatory activities have been the subject of many studies. Studies examining the role TSP1 plays in pathogenesis of various ocular diseases and vascular dysfunctions are limited. Here we will discuss the recent studies focused on delineating the role TSP1 plays in ocular vascular development and homeostasis, and pathophysiology of various ocular and vascular diseases with a significant clinical relevance to human health.</p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"155 ","pages":"Pages 32-44"},"PeriodicalIF":7.3,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9951001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Molecular cell types as functional units of the efferent vagus nerve 输出迷走神经功能单位的分子细胞类型

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-07-26 DOI: 10.1016/j.semcdb.2023.07.007

Tatiana C. Coverdell , Stephen B.G. Abbott , John N. Campbell

引用次数: 0

Vagal pathways for systemic regulation of glucose metabolism 迷走神经通路对葡萄糖代谢的全身调节

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-07-26 DOI: 10.1016/j.semcdb.2023.07.010

Diba Borgmann , Henning Fenselau

{"title":"Vagal pathways for systemic regulation of glucose metabolism","authors":"Diba Borgmann , Henning Fenselau","doi":"10.1016/j.semcdb.2023.07.010","DOIUrl":"10.1016/j.semcdb.2023.07.010","url":null,"abstract":"<div><p><span>Maintaining blood glucose at an appropriate physiological level requires precise coordination of multiple organs and tissues. The vagus nerve bidirectionally connects the central nervous system with peripheral organs crucial to glucose mobilization, nutrient storage, and food absorption, thereby presenting a key pathway for the central control of blood </span>glucose levels<span>. However, the precise mechanisms by which vagal populations that target discrete tissues participate in glucoregulation are much less clear. Here we review recent advances unraveling the cellular identity, neuroanatomical organization, and functional contributions of both vagal efferents and vagal afferents in the control of systemic glucose metabolism<span>. We focus on their involvement in relaying glucoregulatory cues from the brain to peripheral tissues, particularly the pancreatic islet, and by sensing and transmitting incoming signals from ingested food to the brain. These recent findings - largely driven by advances in viral approaches, RNA sequencing, and cell-type selective manipulations and tracings - have begun to clarify the precise vagal neuron populations involved in the central coordination of glucose levels, and raise interesting new possibilities for the treatment of glucose metabolism disorders such as diabetes.</span></span></p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"156 ","pages":"Pages 244-252"},"PeriodicalIF":7.3,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9885651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood endothelium transition and phenotypic plasticity: A key regulator of integrity/permeability in response to ischemia 血内皮转换和表型可塑性:缺血反应中完整性/通透性的关键调节因子。

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-07-20 DOI: 10.1016/j.semcdb.2023.07.004

Nicolas Bréchot , Alexandre Rutault , Iris Marangon , Stéphane Germain

{"title":"Blood endothelium transition and phenotypic plasticity: A key regulator of integrity/permeability in response to ischemia","authors":"Nicolas Bréchot , Alexandre Rutault , Iris Marangon , Stéphane Germain","doi":"10.1016/j.semcdb.2023.07.004","DOIUrl":"10.1016/j.semcdb.2023.07.004","url":null,"abstract":"<div><p>In the human body, the 10<sup>13</sup> blood endothelial cells (ECs) which cover a surface of 500–700 m<sup>2</sup> (Mai et al., 2013) are key players of tissue homeostasis, remodeling and regeneration. Blood vessel ECs play a major role in the regulation of metabolic and gaz exchanges, cell trafficking, blood coagulation, vascular tone, blood flow and fluid extravasation (also referred to as blood vascular permeability). ECs are heterogeneous in various capillary beds and have the exquisite capacity to cope with environmental changes by regulating their gene expression. Ischemia has major detrimental effects on the endothelium and ischemia-induced regulation of vascular integrity is of paramount importance for human health, as small amounts of fluid accumulation in the interstitium may be responsible for major effects on organ functions and patients outcome. In this review, we will here focus on the stimuli and the molecular mechanisms that control blood endothelium maintenance and phenotypic plasticity/transition involved in controlling blood capillary leakage that might open new avenues for therapeutic applications.</p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"155 ","pages":"Pages 16-22"},"PeriodicalIF":7.3,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9905386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Death and survival from executioner caspase activation 死亡和生存来自刽子手半胱天冬酶的激活

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-07-18 DOI: 10.1016/j.semcdb.2023.07.005

Gongping Sun

引用次数: 2