Control of coronary vascular cell fate in development and regeneration

IF 6.2 2区 生物学 Q1 CELL BIOLOGY
Ian R. McCracken, Nicola Smart
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引用次数: 0

Abstract

The coronary vasculature consists of a complex hierarchal network of arteries, veins, and capillaries which collectively function to perfuse the myocardium. However, the pathways controlling the temporally and spatially restricted mechanisms underlying the formation of this vascular network remain poorly understood. In recent years, the increasing use and refinement of transgenic mouse models has played an instrumental role in offering new insights into the cellular origins of the coronary vasculature, as well as identifying a continuum of transitioning cell states preceding the full maturation of the coronary vasculature. Coupled with the emergence of single cell RNA sequencing platforms, these technologies have begun to uncover the key regulatory factors mediating the convergence of distinct cellular origins to ensure the formation of a collectively functional, yet phenotypically diverse, vascular network. Furthermore, improved understanding of the key regulatory factors governing coronary vessel formation in the embryo may provide crucial clues into future therapeutic strategies to reactivate these developmentally functional mechanisms to drive the revascularisation of the ischaemic adult heart.

冠状血管细胞发育和再生过程中命运的控制。
冠状血管系统由复杂的动脉、静脉和毛细血管组成,它们共同起到灌注心肌的作用。然而,控制这种血管网络形成的时间和空间限制机制的途径仍然知之甚少。近年来,转基因小鼠模型的日益使用和完善在为冠状血管系统的细胞起源提供新的见解,以及在冠状血管系统完全成熟之前识别连续的过渡细胞状态方面发挥了重要作用。再加上单细胞RNA测序平台的出现,这些技术已经开始揭示介导不同细胞起源融合的关键调控因素,以确保形成具有共同功能但表型多样的血管网络。此外,对控制胚胎中冠状血管形成的关键调控因素的进一步了解可能为未来的治疗策略提供重要线索,以重新激活这些发育功能机制,从而推动缺血性成年心脏的血运重建。
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来源期刊
CiteScore
15.10
自引率
1.40%
发文量
310
审稿时长
9.1 weeks
期刊介绍: Seminars in Cell and Developmental Biology is a review journal dedicated to keeping scientists informed of developments in the field of molecular cell and developmental biology, on a topic by topic basis. Each issue is thematic in approach, devoted to an important topic of interest to cell and developmental biologists, focusing on the latest advances and their specific implications. The aim of each issue is to provide a coordinated, readable, and lively review of a selected area, published rapidly to ensure currency.
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