Seminars in cell & developmental biology最新文献

Start-Shape-Stop: Cell communication mechanisms controlling organ size. 开始-形状-停止：控制器官大小的细胞通讯机制。

IF 6 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-10-01 Epub Date: 2025-08-09 DOI: 10.1016/j.semcdb.2025.103641

Lucas Ribas, Rita Mateus

引用次数: 0

In vitro modeling of cell types in cardiogenesis and congenital heart disease 心脏发生和先天性心脏病细胞类型的体外建模。

IF 6 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-09-29 DOI: 10.1016/j.semcdb.2025.103656

Sanjeev S. Ranade

{"title":"In vitro modeling of cell types in cardiogenesis and congenital heart disease","authors":"Sanjeev S. Ranade","doi":"10.1016/j.semcdb.2025.103656","DOIUrl":"10.1016/j.semcdb.2025.103656","url":null,"abstract":"<div><div>Congenital heart defects (CHD) are present in nearly 1 % of live births and are a leading cause of infant mortality. Despite advances in genome sequencing technologies and an increased understanding of the genes necessary for heart development, the etiology of a majority of CHD cases remains undefined. Recent breakthroughs in single-cell genomics, lineage tracing, and live imaging in animal models of cardiogenesis have revealed the precise spatiotemporal dynamics of discrete cell types in heart development. Here, I review how these findings have informed the development of new human pluripotent stem cell methods to generate a diverse range of cells in cardiogenesis. A key unifying theme is that multipotent cardiac progenitor cells are extraordinarily responsive to slight changes to signaling factors administered at various stages of cardiac differentiation. I highlight how the ability to make a range of cardiac cell types can be used to define context specific mechanisms of CHD. I then describe how <em>in vitro</em> human models of cardiogenesis are especially important in cases of severe forms of CHD, such as single ventricle disorders, for which the complex genetic underlying mechanisms are poorly defined and animal models are lacking.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"175 ","pages":"Article 103656"},"PeriodicalIF":6.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145200934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Viscoelasticity during development: What is it? and why should you care? 开发过程中的粘弹性：什么是粘弹性？你为什么要在意呢？

IF 6 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-09-27 DOI: 10.1016/j.semcdb.2025.103655

Yicheng Dong , Spandan Maiti , Lance A. Davidson

{"title":"Viscoelasticity during development: What is it? and why should you care?","authors":"Yicheng Dong , Spandan Maiti , Lance A. Davidson","doi":"10.1016/j.semcdb.2025.103655","DOIUrl":"10.1016/j.semcdb.2025.103655","url":null,"abstract":"<div><div>Viscoelasticity is a fundamental feature of biological tissues and plays a vital role in cells and tissues. This review explores the role of viscoelasticity in mechanobiology, emphasizing its impact on morphogenesis and organogenesis during embryonic development. We discuss the viscoelastic behavior of cells and tissues and its role in how cells and tissues absorb, dissipate, and transmit mechanical energy. We summarize experimental techniques such as Atomic Force Microscopy (AFM), Micropipette Aspiration (MA), and Tissue Stretchers, that have been used to quantify or observe the effects of viscoelasticity. Mathematical models of viscoelasticity, such as the Standard Linear Solid (SLS) model and advanced fractional models are introduced and discussed for their ability to capture the complexity of the viscoelastic behavior of biological systems. The role of subcellular complexes, including the cytoskeleton, extracellular matrix, and nucleus, are also reviewed for their contributions to tissue viscoelastic behavior. We also identify and discuss knowledge gaps, particularly in understanding how dynamic mechanical cues influence viscoelastic responses across cellular and tissue scales. A deeper exploration of these mechanisms, particularly those that determine viscoelastic behavior of cells and tissues, is needed for advancing our understanding of embryonic development and tissue morphogenesis.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"175 ","pages":"Article 103655"},"PeriodicalIF":6.0,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145157801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The interplay of tissue mechanics and gene regulatory networks in the evolution of morphogenesis 组织力学和基因调控网络在形态发生进化中的相互作用

IF 6 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-09-26 DOI: 10.1016/j.semcdb.2025.103654

James DiFrisco, Rashmi Priya

引用次数: 0

Zebrafish as a model system for studying cilia biology and ciliopathies 斑马鱼作为研究纤毛生物学和纤毛病的模型系统

IF 6 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-09-25 DOI: 10.1016/j.semcdb.2025.103652

Mengfan Wu , Jiongchen Lin , Chengjie Yu , Chengtian Zhao , Haibo Xie

{"title":"Zebrafish as a model system for studying cilia biology and ciliopathies","authors":"Mengfan Wu , Jiongchen Lin , Chengjie Yu , Chengtian Zhao , Haibo Xie","doi":"10.1016/j.semcdb.2025.103652","DOIUrl":"10.1016/j.semcdb.2025.103652","url":null,"abstract":"<div><div>Cilia are highly conserved, microtubule-based, hair-like organelles that project from the surface of most eukaryotic cells. They perform essential functions in signal transduction, cellular motility, and the regulation of fluid flow within tissues. Foundational insights into ciliary biology have largely been derived from invertebrate models such as <em>Chlamydomonas reinhardtii</em> and <em>Caenorhabditis elegans</em>, which each possess a relatively uniform cilium type. In contrast, vertebrates display remarkable diversity in ciliary subtypes, with distinct structures and functions tailored to specific tissues. This diversity underlies the broad physiological importance of cilia, and it also explains why defects in ciliary assembly or function result in a wide spectrum of human genetic disorders collectively known as ciliopathies. As a result, vertebrate models have become indispensable for uncovering the roles of cilia in both normal development and disease pathogenesis. Among them, zebrafish has emerged as a particularly versatile and powerful model system. Its unique experimental advantages—including optical transparency during embryogenesis, external fertilization, high fecundity, and compatibility with large-scale genetic and pharmacological screening—make it ideally suited for studying ciliary biology in vivo. In this review, we summarize recent advances in our understanding of ciliary function using zebrafish, with particular emphasis on studies of ciliopathy-associated genes and newly uncovered roles of cilia in processes such as spinal development and meiosis. Finally, we discuss current challenges and outline future research directions, highlighting how zebrafish will continue to drive discoveries in cilia biology and ciliopathy research.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"175 ","pages":"Article 103652"},"PeriodicalIF":6.0,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145157803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lessons for cardiac regeneration from non-mammalian model organisms 非哺乳动物模式生物心脏再生的经验教训。

IF 6 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-09-18 DOI: 10.1016/j.semcdb.2025.103653

Yusuke Watanabe, Kazu Kikuchi

引用次数: 0

Chlamydomonas as a model system for the study of cilia and eukaryotic flagella 衣单胞菌作为研究纤毛和真核鞭毛的模式系统。

IF 6 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-09-18 DOI: 10.1016/j.semcdb.2025.103658

Xuecheng Li , Qingqing Liu , Junmin Pan

{"title":"Chlamydomonas as a model system for the study of cilia and eukaryotic flagella","authors":"Xuecheng Li , Qingqing Liu , Junmin Pan","doi":"10.1016/j.semcdb.2025.103658","DOIUrl":"10.1016/j.semcdb.2025.103658","url":null,"abstract":"<div><div><em>Chlamydomonas</em> is a haploid, unicellular green alga that serves as an excellent model system for studying ciliary biology. It possesses two motile cilia of equal length, making it ideal for investigating both ciliogenesis and ciliary motility, as well as cilia-based signaling. The organism's ease of cultivation, the simplicity of cilia isolation, and the availability of well-established experimental systems for rapid and synchronous cilia regeneration and disassembly contribute to its utility in laboratory research. Furthermore, <em>Chlamydomonas</em> is highly amenable to a variety of genetic approaches, enhancing its value as a model organism. Due to the high degree of conservation in the core mechanisms governing ciliary structure and function, discoveries made in <em>Chlamydomonas</em> have significantly advanced our understanding of cilia across species and have provided important insights into cilia-related human disorders. In this overview, we summarize the key cellular features, life cycle stages, ciliary architecture and dynamics, ciliary behavior, biochemical and genetic advantages of <em>Chlamydomonas</em> as a model organism. Our goal is to provide a foundational perspective for those new to ciliary research in <em>Chlamydomonas</em> - including early-career scientists, experienced researchers transitioning from other fields, and cilia experts working with alternative model systems.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"175 ","pages":"Article 103658"},"PeriodicalIF":6.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mammalian motile cilia: Structure, formation, organization, and function 哺乳动物活动纤毛：结构、形成、组织和功能

IF 6 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-09-06 DOI: 10.1016/j.semcdb.2025.103651

Xueliang Zhu

引用次数: 0

Decoding zebrafish oogenesis: From primordial germ cell development to fertilization 解码斑马鱼的卵发生：从原始生殖细胞发育到受精

IF 6 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-09-05 DOI: 10.1016/j.semcdb.2025.103650

Laura Hofmann, Carl-Philipp Heisenberg

引用次数: 0

Approximating the living 贴近生活

IF 6 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-09-01 DOI: 10.1016/j.semcdb.2025.103646

Rob Phillips

{"title":"Approximating the living","authors":"Rob Phillips","doi":"10.1016/j.semcdb.2025.103646","DOIUrl":"10.1016/j.semcdb.2025.103646","url":null,"abstract":"<div><div>Is a herd of wildebeest better thought of as a series of individual animals, each with its own glorious and unmanageable volition, or as a field of moving arrows? Are the morphogen gradients that set up the coordinate systems for embryonic anterior–posterior patterning a smooth and continuous concentration field or instead a chaotic collection of protein molecules each jiggling about in the haphazard way first described by Robert Brown in his microscopical observations of pollen? Is water, the great liquid ether of the living world, a collection of discrete molecules or instead a perfectly continuous medium with a density of <span><math><mo>≈</mo></math></span>1000 kg/m<span><math><msup><mrow></mrow><mrow><mn>3</mn></mrow></msup></math></span>? In this article, I will argue that these questions pose a false dichotomy since there are many different and powerful representations of the world around us. Different representations suit us differently at different times and it is often useful to be able to hold these seemingly contradictory notions in our heads simultaneously. Indeed, mathematics is not only the language of representation, but often is also the engine of reconciliation of such disparate views. In a letter to Alfred Russel Wallace on 14 April 1869, Charles Darwin noted that Lord Kelvin’s “views on the recent age of the world have been for some time one of my sorest troubles”. Here, I will argue that one of the highest attainments of the scientific enterprise is a coherent picture of the world, a picture in which our stories about the geological age of the Earth are coherent with our stories of how whales populated the oceans, our understanding of the living jibes with our understanding of the inanimate, our insights into the dynamics of genes and molecular structures are consonant with our physical understanding of the laws of statistical physics. The underpinnings of such coherency are often best revealed when viewed through the lens of mathematics.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"175 ","pages":"Article 103646"},"PeriodicalIF":6.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144922768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0