Seminars in cell & developmental biology最新文献

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Dynamic interplay between human alpha-satellite DNA structure and centromere functions 人类α卫星DNA结构和着丝粒功能之间的动态相互作用。
IF 7.3 2区 生物学
Seminars in cell & developmental biology Pub Date : 2023-11-04 DOI: 10.1016/j.semcdb.2023.10.002
Elena Di Tommaso , Simona Giunta
{"title":"Dynamic interplay between human alpha-satellite DNA structure and centromere functions","authors":"Elena Di Tommaso ,&nbsp;Simona Giunta","doi":"10.1016/j.semcdb.2023.10.002","DOIUrl":"10.1016/j.semcdb.2023.10.002","url":null,"abstract":"<div><p><span>Maintenance of genome stability relies on functional </span>centromeres<span><span><span><span><span> for correct chromosome segregation and faithful inheritance of the </span>genetic information. The human centromere is the primary constriction within mitotic chromosomes made up of repetitive alpha-satellite </span>DNA hierarchically organized in megabase-long arrays of near-identical higher order repeats (HORs). Centromeres are epigenetically specified by the presence of the centromere-specific </span>histone H3 variant, CENP-A, which enables the assembly of the </span>kinetochore<span> for microtubule attachment. Notably, centromeric DNA is faithfully inherited as intact haplotypes from the parents to the offspring without intervening recombination, yet, outside of meiosis, centromeres are akin to common fragile sites (CFSs), manifesting crossing-overs and ongoing sequence instability. Consequences of DNA changes within the centromere are just starting to emerge, with unclear effects on intra- and inter-generational inheritance driven by centromere’s essential role in kinetochore assembly. Here, we review evidence of meiotic selection operating to mitigate centromere drive, as well as recent reports on centromere damage, recombination and repair during the mitotic cell division. We propose an antagonistic pleiotropy<span> interpretation to reconcile centromere DNA instability as both driver of aneuploidy that underlies degenerative diseases, while also potentially necessary for the maintenance of homogenized HORs for centromere function. We attempt to provide a framework for this conceptual leap taking into consideration the structural interface of centromere-kinetochore interaction and present case scenarios for its malfunctioning. Finally, we offer an integrated working model to connect DNA instability, chromatin, and structural changes with functional consequences on chromosome integrity.</span></span></span></p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"156 ","pages":"Pages 130-140"},"PeriodicalIF":7.3,"publicationDate":"2023-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71485752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The mechanisms and roles of mitochondrial dynamics in C. elegans 秀丽隐杆线虫线粒体动力学的机制和作用。
IF 7.3 2区 生物学
Seminars in cell & developmental biology Pub Date : 2023-10-31 DOI: 10.1016/j.semcdb.2023.10.006
Daniel Campbell, Steven Zuryn
{"title":"The mechanisms and roles of mitochondrial dynamics in C. elegans","authors":"Daniel Campbell,&nbsp;Steven Zuryn","doi":"10.1016/j.semcdb.2023.10.006","DOIUrl":"10.1016/j.semcdb.2023.10.006","url":null,"abstract":"<div><p>If mitochondria are the powerhouses of the cell, then mitochondrial dynamics are the power grid that regulates how that energy output is directed and maintained in response to unique physiological demands. Fission and fusion dynamics are highly regulated processes that fine-tune the mitochondrial networks of cells to enable appropriate responses to intrinsic and extrinsic stimuli, thereby maintaining cellular and organismal homeostasis. These dynamics shape many aspects of an organism’s healthspan including development, longevity, stress resistance, immunity, and response to disease. In this review, we discuss the latest findings regarding the mechanisms and roles of mitochondrial dynamics by focussing on the nematode <em>Caenorhabditis elegans</em>. Whole live-animal studies in <em>C. elegans</em> have enabled a true organismal-level understanding of the impact that mitochondrial dynamics play in homeostasis over a lifetime.</p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"156 ","pages":"Pages 266-275"},"PeriodicalIF":7.3,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1084952123002033/pdfft?md5=a0d52e7e69a0bc2a8b74d3f6825556d7&pid=1-s2.0-S1084952123002033-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71426635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DNA strand breaks at centromeres: Friend or foe? DNA链在着丝粒处断裂:朋友还是敌人?
IF 7.3 2区 生物学
Seminars in cell & developmental biology Pub Date : 2023-10-21 DOI: 10.1016/j.semcdb.2023.10.004
Emily Graham, Fumiko Esashi
{"title":"DNA strand breaks at centromeres: Friend or foe?","authors":"Emily Graham,&nbsp;Fumiko Esashi","doi":"10.1016/j.semcdb.2023.10.004","DOIUrl":"10.1016/j.semcdb.2023.10.004","url":null,"abstract":"<div><p>Centromeres are large structural regions in the genomic DNA, which are essential for accurately transmitting a complete set of chromosomes to daughter cells during cell division. In humans, centromeres consist of highly repetitive α-satellite DNA sequences and unique epigenetic components, forming large proteinaceous structures required for chromosome segregation. Despite their biological importance, there is a growing body of evidence for centromere breakage across the cell cycle, including periods of quiescence. In this review, we provide an up-to-date examination of the distinct centromere environments at different stages of the cell cycle, highlighting their plausible contribution to centromere breakage. Additionally, we explore the implications of these breaks on centromere function, both in terms of negative consequences and potential positive effects.</p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"156 ","pages":"Pages 141-151"},"PeriodicalIF":7.3,"publicationDate":"2023-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1084952123001738/pdfft?md5=f7c17a7115d2df972c619584c6dc0d4d&pid=1-s2.0-S1084952123001738-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49692285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The implications of satellite DNA instability on cellular function and evolution 卫星DNA不稳定性对细胞功能和进化的影响。
IF 7.3 2区 生物学
Seminars in cell & developmental biology Pub Date : 2023-10-17 DOI: 10.1016/j.semcdb.2023.10.005
Jullien M. Flynn , Yukiko M. Yamashita
{"title":"The implications of satellite DNA instability on cellular function and evolution","authors":"Jullien M. Flynn ,&nbsp;Yukiko M. Yamashita","doi":"10.1016/j.semcdb.2023.10.005","DOIUrl":"10.1016/j.semcdb.2023.10.005","url":null,"abstract":"<div><p>Abundant tandemly repeated satellite DNA<span><span> is present in most eukaryotic genomes. Previous limitations including a pervasive view that it was uninteresting junk DNA, combined with challenges in studying it, are starting to dissolve - and recent studies have found important functions for satellite DNAs. The observed rapid evolution and implied instability of satellite DNA now has important significance for their functions and maintenance within the genome. In this review, we discuss the processes that lead to satellite DNA copy number instability, and the importance of mechanisms to manage the potential negative effects of instability. Satellite DNA is vulnerable to challenges during replication and repair, since it forms difficult-to-process secondary structures and its homology within tandem arrays can result in various types of recombination. Satellite DNA instability may be managed by DNA or chromatin-binding proteins ensuring proper nuclear localization and repair, or by proteins that process aberrant structures that satellite DNAs tend to form. We also discuss the pattern of satellite </span>DNA mutations<span> from recent mutation accumulation (MA) studies that have tracked changes in satellite DNA for up to 1000 generations with minimal selection. Finally, we highlight examples of satellite evolution from studies that have characterized satellites across millions of years of Drosophila fruit fly evolution, and discuss possible ways that selection might act on the satellite DNA composition.</span></span></p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"156 ","pages":"Pages 152-159"},"PeriodicalIF":7.3,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49682104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Emerging roles of DNA repair factors in the stability of centromeres DNA修复因子在着丝粒稳定性中的新作用。
IF 7.3 2区 生物学
Seminars in cell & developmental biology Pub Date : 2023-10-16 DOI: 10.1016/j.semcdb.2023.10.001
Francesca Marcon , Simona Giunta , Margherita Bignami
{"title":"Emerging roles of DNA repair factors in the stability of centromeres","authors":"Francesca Marcon ,&nbsp;Simona Giunta ,&nbsp;Margherita Bignami","doi":"10.1016/j.semcdb.2023.10.001","DOIUrl":"10.1016/j.semcdb.2023.10.001","url":null,"abstract":"<div><p><span>Satellite DNA sequences are an integral part of </span>centromeres<span><span>, regions critical for faithful segregation of chromosomes during cell division. Because of their complex repetitive structure, satellite DNA<span><span> may act as a barrier to DNA replication and other DNA based transactions ultimately resulting in chromosome breakage. Over the past two decades, several </span>DNA repair proteins have been shown to bind and function at centromeres. While the importance of these repair factors is highlighted by various structural and numerical chromosome aberrations resulting from their inactivation, their roles in helping to maintain </span></span>genome stability<span><span> by solving the intrinsic difficulties of satellite DNA replication or promoting their repair are just starting to emerge. In this review, we summarize the current knowledge on the role of DNA repair and DNA damage response proteins in maintaining the structure and function of centromeres in different contexts. We also report the recent connection between the roles of specific DNA repair factors at these genomic loci with age-related increase of </span>chromosomal instability under physiological and pathological conditions.</span></span></p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"156 ","pages":"Pages 121-129"},"PeriodicalIF":7.3,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49682103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Fatal attraction: How Phytophthora zoospores find their host 致命的吸引力:疫霉菌游动孢子如何找到它们的宿主
IF 7.3 2区 生物学
Seminars in cell & developmental biology Pub Date : 2023-10-01 DOI: 10.1016/j.semcdb.2023.01.014
Michiel Kasteel , Tijs Ketelaar , Francine Govers
{"title":"Fatal attraction: How Phytophthora zoospores find their host","authors":"Michiel Kasteel ,&nbsp;Tijs Ketelaar ,&nbsp;Francine Govers","doi":"10.1016/j.semcdb.2023.01.014","DOIUrl":"10.1016/j.semcdb.2023.01.014","url":null,"abstract":"<div><p>Oomycete plant pathogens, such as <em>Phytophthora</em> and <em>Pythium</em> species produce motile dispersal agents called zoospores that actively target host plants. Zoospores are exceptional in their ability to display taxis to chemical, electrical and physical cues to navigate the phyllosphere and reach stomata, wound sites and roots. Many components of root exudates have been shown attractive or repulsive to zoospores. Although some components possess very strong attractiveness, it seems that especially the mix of components exuded by the primary host is most attractive to zoospores. Zoospores actively approach attractants with swimming behaviour reminiscent of other microswimmers. To achieve a unified description of zoospore behaviour when sensing an attractant, we propose the following terms for the successive stages of the homing response: reorientation, approaching, retention and settling. How zoospores sense and process attractants is poorly understood but likely involves signal perception via cell surface receptors. Since zoospores are important for infection, undermining their activity by luring attractants or blocking receptors seem promising strategies for disease control.</p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"148 ","pages":"Pages 13-21"},"PeriodicalIF":7.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9604191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Recent developments in plant-downy mildew interactions 植物与霜霉相互作用的最新进展
IF 7.3 2区 生物学
Seminars in cell & developmental biology Pub Date : 2023-10-01 DOI: 10.1016/j.semcdb.2023.01.010
Mahmut Tör , Tom Wood , Anne Webb , Deniz Göl , John M. McDowell
{"title":"Recent developments in plant-downy mildew interactions","authors":"Mahmut Tör ,&nbsp;Tom Wood ,&nbsp;Anne Webb ,&nbsp;Deniz Göl ,&nbsp;John M. McDowell","doi":"10.1016/j.semcdb.2023.01.010","DOIUrl":"10.1016/j.semcdb.2023.01.010","url":null,"abstract":"<div><p>Downy mildews are obligate oomycete pathogens that attack a wide range of plants and can cause significant economic impacts on commercial crops and ornamental plants. Traditionally, downy mildew disease control relied on an integrated strategies, that incorporate cultural practices, deployment of resistant cultivars, crop rotation, application of contact and systemic pesticides, and biopesticides. Recent advances in genomics provided data that significantly advanced understanding of downy mildew evolution, taxonomy and classification. In addition, downy mildew genomics also revealed that these obligate oomycetes have reduced numbers of virulence factor genes in comparison to hemibiotrophic and necrotrophic oomycetes. However, downy mildews do deploy significant arrays of virulence proteins, including so-called RXLR proteins that promote virulence or are recognized as avirulence factors. Pathogenomics are being applied to downy mildew population studies to determine the genetic diversity within the downy mildew populations and manage disease by selection of appropriate varieties and management strategies. Genome editing technologies have been used to manipulate host disease susceptibility genes in different plants including grapevine and sweet basil and thereby provide new soucres of resistance genes against downy mildews. Previously, it has proved difficult to transform and manipulate downy mildews because of their obligate lifestyle. However, recent exploitation of RNA interference machinery through Host-Induced Gene Silencing (HIGS) and Spray-Induced Gene Silencing (SIGS) indicate that functional genomics in downy mildews is now possible. Altogether, these breakthrough technologies and attendant fundamental understanding will advance our ability to mitigate downy mildew diseases.</p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"148 ","pages":"Pages 42-50"},"PeriodicalIF":7.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9601143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Getting to the root of Ralstonia invasion 探究拉尔斯顿尼亚入侵的根源
IF 7.3 2区 生物学
Seminars in cell & developmental biology Pub Date : 2023-10-01 DOI: 10.1016/j.semcdb.2022.12.002
Katherine Rivera-Zuluaga, Rachel Hiles, Pragya Barua, Denise Caldwell, Anjali S. Iyer-Pascuzzi
{"title":"Getting to the root of Ralstonia invasion","authors":"Katherine Rivera-Zuluaga,&nbsp;Rachel Hiles,&nbsp;Pragya Barua,&nbsp;Denise Caldwell,&nbsp;Anjali S. Iyer-Pascuzzi","doi":"10.1016/j.semcdb.2022.12.002","DOIUrl":"10.1016/j.semcdb.2022.12.002","url":null,"abstract":"<div><p>Plant diseases caused by soilborne pathogens are a major limiting factor in crop production. Bacterial wilt disease, caused by soilborne bacteria in the <span><span>Ralstonia solanacearum</span></span> Species Complex (<em>Ralstonia</em>), results in significant crop loss throughout the world. <em>Ralstonia</em> invades root systems and colonizes plant xylem, changing plant physiology and ultimately causing plant wilting in susceptible varieties. Elucidating how <em>Ralstonia</em> invades and colonizes plants is central to developing strategies for crop protection. Here we review <em>Ralstonia</em> pathogenesis from root detection and attachment, early root colonization, xylem invasion and subsequent wilting. We focus primarily on studies in tomato from the last 5–10 years. Recent work has identified elegant mechanisms <em>Ralstonia</em> uses to adapt to the plant xylem, and has discovered new genes that function in <em>Ralstonia</em> fitness <em>in planta</em>. A picture is emerging of an amazingly versatile pathogen that uses multiple strategies to make its surrounding environment more hospitable and can adapt to new environments.</p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"148 ","pages":"Pages 3-12"},"PeriodicalIF":7.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9598321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
All eggs in one basket: How potyvirus infection is controlled at a single cap-independent translation event 所有鸡蛋放在一个篮子里:如何在一个帽独立的翻译事件中控制痘病毒感染
IF 7.3 2区 生物学
Seminars in cell & developmental biology Pub Date : 2023-10-01 DOI: 10.1016/j.semcdb.2022.12.011
Helena Jaramillo-Mesa, Aurélie M. Rakotondrafara
{"title":"All eggs in one basket: How potyvirus infection is controlled at a single cap-independent translation event","authors":"Helena Jaramillo-Mesa,&nbsp;Aurélie M. Rakotondrafara","doi":"10.1016/j.semcdb.2022.12.011","DOIUrl":"10.1016/j.semcdb.2022.12.011","url":null,"abstract":"<div><p><span>Regulation of protein synthesis is a strong determinant of potyviral pathogenicity. The </span><span><em>Potyviridae</em></span><span> family is the largest family of plant-infecting positive sense RNA viruses. Similar to the animal-infecting </span><span><em>Picornaviridae</em></span><span> family, the potyviral RNA<span> genome lacks a 5′ cap, and instead has a viral protein (VPg) linked to its 5′ end. Potyviral genomes are mainly translated into one large polyprotein relying on a single translation event to express all their protein repertoire. In the absence of the 5′ cap, the </span></span><em>Potyviridae</em> family depends on <em>cis</em><span>-acting elements in their 5′ untranslated regions (UTR) to recruit the translation machinery. In this review, we summarize the diverse 5′UTR-driven, cap-independent translation mechanisms employed by the </span><em>Potyviridae</em><span> family including scanning-dependent mechanism, internal initiation, and the stimulatory role of the VPg. These mechanisms have direct implications on potyviral pathogenicity, including host range specificity and resistance. Finally, we discuss how these viral strategies could not only inform new avenues for engineering and/or breeding for crop resistance but would also provide opportunities for the development of biotechnological tools for large-scale protein production in plant systems.</span></p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"148 ","pages":"Pages 51-61"},"PeriodicalIF":7.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9956010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Plant pathogens: Masters of manipulation 植物病原体:操控大师
IF 7.3 2区 生物学
Seminars in cell & developmental biology Pub Date : 2023-10-01 DOI: 10.1016/j.semcdb.2023.03.013
Brian Kvitko
{"title":"Plant pathogens: Masters of manipulation","authors":"Brian Kvitko","doi":"10.1016/j.semcdb.2023.03.013","DOIUrl":"10.1016/j.semcdb.2023.03.013","url":null,"abstract":"","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"148 ","pages":"Pages 1-2"},"PeriodicalIF":7.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9789987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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