Seminars in cell & developmental biology最新文献

Epithelial cell plasticity in metazoans: Evolutionary insights into roles and mechanisms 后生动物上皮细胞的可塑性：角色和机制的进化见解。

IF 6 2区生物学

Seminars in cell & developmental biology Pub Date : 2026-05-01 Epub Date: 2026-03-03 DOI: 10.1016/j.semcdb.2026.103670

Hiroki Nagai , Yu-ichiro Nakajima

{"title":"Epithelial cell plasticity in metazoans: Evolutionary insights into roles and mechanisms","authors":"Hiroki Nagai , Yu-ichiro Nakajima","doi":"10.1016/j.semcdb.2026.103670","DOIUrl":"10.1016/j.semcdb.2026.103670","url":null,"abstract":"<div><div>Epithelial tissues function as multicellular communities that preserve tissue integrity while adapting to diverse environmental stresses by altering cell behaviors. A striking manifestation of such adaptability is cell plasticity, the ability of differentiated cells to revert to stem-like states or adopt alternative fates. Once considered rare and confined to highly regenerative species, cell plasticity is now recognized across the metazoan tree. In early-branching animals such as sponges and cnidarians, transdifferentiation and dedifferentiation are integral to life-cycle transitions and regeneration, whereas in more complex organisms, these processes typically emerge under stress, including stem cell loss or environmental perturbations. Here, we examine epithelial cell plasticity through evolutionary, cellular, and molecular perspectives. Focusing on the intestinal epithelium, we explore findings from mammalian and <em>Drosophila</em> models showing that progenitors and even terminally differentiated cells can dedifferentiate in response to external stimuli that disrupt homeostasis, such as pathogen infection and nutrient fluctuations. We further discuss conserved mechanisms involving intercellular signaling (e.g., Notch, EGFR, and JAK-STAT) and chromatin states primed for reprogramming, modulated by metabolic cues. Together, these insights position cell plasticity as an ancient environmental adaptation strategy, shaped by conserved molecular toolkits and refined by species- and cell lineage-specific innovations.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"179 ","pages":"Article 103670"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147356337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intra- and inter-organ communications in aging and cancer: Local and global spatial perspectives 衰老和癌症中的器官间和内部通讯：局部和全局空间视角。

IF 6 2区生物学

Seminars in cell & developmental biology Pub Date : 2026-05-01 Epub Date: 2026-03-05 DOI: 10.1016/j.semcdb.2026.103672

Onkar Mulay , Aitor Benedicto , Yui Murata , Monica Suet Ying Ng , Jazmina L. Gonzalez Cruz , Quan Nguyen

{"title":"Intra- and inter-organ communications in aging and cancer: Local and global spatial perspectives","authors":"Onkar Mulay , Aitor Benedicto , Yui Murata , Monica Suet Ying Ng , Jazmina L. Gonzalez Cruz , Quan Nguyen","doi":"10.1016/j.semcdb.2026.103672","DOIUrl":"10.1016/j.semcdb.2026.103672","url":null,"abstract":"<div><div>Interactions among neighbouring cells are fundamental to tissue function and can be specifically mapped using single-cell and spatial transcriptomics data. Overall, cell-cell interactions (CCIs) are essential for proper tissue function, including cell development, maintenance of tissue homeostasis, and immune responses during disease. Cells also communicate between organs by releasing signalling molecules into the circulatory system. We examined aging and cancer progression, the two important biological processes where alterations in CCIs remodel the tissue microenvironments that drive cellular and tissue dysfunction. Identifying these dysregulated interactions can uncover potential therapeutic strategies to prevent or treat disease by targeting specific ligand-receptor interactions. Interestingly, in aging and cancer metastasis, ligands originating from one organ can influence the aging processes of distant organs, while local interactions within the tumour microenvironment are critical for not only cancer dynamics at the primary site but also for driving its progression to secondary organs. This review highlights key ligand-receptor interactions in aging and cancer metastasis and examines intra- and inter-organ communication inference tools in this emerging field.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"179 ","pages":"Article 103672"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147373134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphogenetic evolution with physical influences 受物理影响的形态发生进化

IF 6 2区生物学

Seminars in cell & developmental biology Pub Date : 2026-05-01 Epub Date: 2026-03-09 DOI: 10.1016/j.semcdb.2026.103671

Tzu-Yi Huang , Steffen Lemke , Yu-Chiun Wang

{"title":"Morphogenetic evolution with physical influences","authors":"Tzu-Yi Huang , Steffen Lemke , Yu-Chiun Wang","doi":"10.1016/j.semcdb.2026.103671","DOIUrl":"10.1016/j.semcdb.2026.103671","url":null,"abstract":"<div><div>Morphogenesis is the process in which cells, tissues, organs and embryos acquire orderedness, patterns, shapes and higher order organizations. Most morphogenetic processes are known to be controlled by genetic programs, and experimental and theoretical studies have indeed provided strong support that evolutionary changes of morphogenetic mechanisms can largely be attributed to genetic modifications. Studies in the last decades had begun to reveal the contribution of physical mechanisms in a growing number of morphogenetic contexts, wherein they act in parallel with, and at times independent of, genes, leading to stochastic and self-organized behaviors. The involvement of physical mechanisms raises intriguing questions as to how they might influence the evolutionary dynamics of morphogenesis, and whether there might be themes and patterns that have not been previously conceptualized. In this review, we examine an ensemble of physical factors and mechanical processes shown recently in empirical and theoretical studies to be critical contributors of morphogenetic mechanisms. We ask whether some of these might have arisen prior to, and possibly shaped, the emergence of genetic programs. We consider conceptual frameworks that could support these hypothetical scenarios, and further propose a ‘leap-and-patch’ model, whereby morphogenetic systems exhibit a phase transition-like shift to a distinct phenotypic regime in response to changes in physical parameters (‘leaps’), thereby facilitating genetic accommodation or evolutionary innovation of novel morphogenetic mechanisms (‘patches’). Our discussion suggests the possibility that physical factors might be more than a contributor of morphogenesis, but a facilitator of evolutionary transition or innovation.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"179 ","pages":"Article 103671"},"PeriodicalIF":6.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147388150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machines all the way up and cognition all the way down: Updating the machine metaphor in biology 机器一路向上，认知一路向下：更新生物学中的机器隐喻。

IF 6 2区生物学

Seminars in cell & developmental biology Pub Date : 2026-02-01 Epub Date: 2026-02-23 DOI: 10.1016/j.semcdb.2026.103668

Michael Levin , Richard Watson

{"title":"Machines all the way up and cognition all the way down: Updating the machine metaphor in biology","authors":"Michael Levin , Richard Watson","doi":"10.1016/j.semcdb.2026.103668","DOIUrl":"10.1016/j.semcdb.2026.103668","url":null,"abstract":"<div><div>Cell and developmental biology (CDB) offer numerous remarkable examples of collective adaptive plasticity, as cells coordinate to implement large-scale form and function. Despite the gaps in understanding, it is often assumed that the machine metaphor (dominating molecular and cell biology) will explain all of the adaptive complexity involved, from molecules up. In the case of goal-driven intentional agents, however, living tissues have cognitive properties that seem different from machines. So what is the relationship between cognition and CDB, and can the machine metaphor accommodate it? The relationship between ‘ordinary’ machine-like matter and minded agents is often treated naively, as if: a) a complexity threshold exists above which memory, learning, problem solving and intelligence are possible, but below which there is no such thing, b) this putative threshold lies far outside the remit of day-to-day CDB, and c) the identification of mechanisms (e.g. cell signalling, morphogens and pathways) confirms the absence of cognition, as if mechanism and ‘real cognition’ were mutually exclusive. In this paper, we argue that, in fact, CDB is the only discipline that can possibly naturalise the cognition of biological matter avoiding such exceptionalist and dualist positions, and that doing so requires a multiscale approach that also offers interdisciplinary insight in the other direction. Specifically, characterizing a continuum of cognitive competencies (without a naïve threshold) and identifying its mechanisms (without explaining it away) illuminates the gaps in our understanding of CDB’s extraordinary collective adaptive plasticity.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"177 ","pages":"Article 103668"},"PeriodicalIF":6.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147284289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A cellular and molecular perspective on organotypic lymphatic (dys)function 器官型淋巴（天）功能的细胞和分子观点

IF 6 2区生物学

Seminars in cell & developmental biology Pub Date : 2026-01-01 Epub Date: 2025-12-15 DOI: 10.1016/j.semcdb.2025.103665

Sanjay Sunil Kumar , Katharina Uphoff , Sophie Hötte , Verena Prokosch , Stefan Schulte-Merker , Dörte Schulte-Ostermann

{"title":"A cellular and molecular perspective on organotypic lymphatic (dys)function","authors":"Sanjay Sunil Kumar , Katharina Uphoff , Sophie Hötte , Verena Prokosch , Stefan Schulte-Merker , Dörte Schulte-Ostermann","doi":"10.1016/j.semcdb.2025.103665","DOIUrl":"10.1016/j.semcdb.2025.103665","url":null,"abstract":"<div><div>The lymphatic vascular system maintains fluid homeostasis, allows uptake of dietary lipids, and serves as a conduit for immune cell trafficking. Functional aspects of the lymphatic vasculature are governed by specific features of lymphatic endothelial cells that line these vessels. Dysfunction of lymphatic endothelial cells can result in various consequences at the organ and at the systemic level including lymphedema formation. In this review, we explore the underlying molecular mechanisms and signaling cascades that drive lymphatic development and vessel formation. We discuss human genetic disorders that lead to primary lymphedema and corresponding <em>in vivo</em> disease models that have helped to expand our molecular understanding pertaining to the signaling cascades governing lymphatic vessel development and maturation, in particular the VEGFC/VEGFR3 and ANG/TIE signaling axes. Furthermore, we highlight recent advancements regarding the anatomy and function of meningeal lymphatics and the Schlemm's canal in the context of development and disease.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"176 ","pages":"Article 103665"},"PeriodicalIF":6.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145753861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial for special issue: Environmental control of oogenesis and ovulatory dynamics 特刊社论：卵子发生和排卵动力学的环境控制。

IF 6 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-11-01 Epub Date: 2025-10-08 DOI: 10.1016/j.semcdb.2025.103659

Chii Jou Chan

引用次数: 0

The interplay of tissue mechanics and gene regulatory networks in the evolution of morphogenesis 组织力学和基因调控网络在形态发生进化中的相互作用

IF 6 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-11-01 Epub Date: 2025-09-26 DOI: 10.1016/j.semcdb.2025.103654

James DiFrisco, Rashmi Priya

引用次数: 0

Mechanical mechanisms of morphogenesis as potential substrates for evolutionary change 形态发生的机械机制作为进化变化的潜在底物

IF 6 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-11-01 Epub Date: 2025-08-23 DOI: 10.1016/j.semcdb.2025.103645

Suhrid Ghosh , Chandrashekar Kuyyamudi , Beatrice L. Steinert , Cassandra G. Extavour

{"title":"Mechanical mechanisms of morphogenesis as potential substrates for evolutionary change","authors":"Suhrid Ghosh , Chandrashekar Kuyyamudi , Beatrice L. Steinert , Cassandra G. Extavour","doi":"10.1016/j.semcdb.2025.103645","DOIUrl":"10.1016/j.semcdb.2025.103645","url":null,"abstract":"<div><div>The first quarter of this century has seen a resurgence of interest in the mechanical and physical mechanisms that drive cellular behaviors in the context of morphogenesis. Far from being a new discovery, the fact that the material properties of cells and the physical forces that they exert and experience must play decisive roles in development, was an important part of the field of experimental embryology well over a century ago. Following the birth of molecular biology, and the development of live imaging approaches that can capture the dynamics of both cellular properties and materials, and the activity of genes and gene products, the current manifestation of this field promises to link mechanical and molecular genetic mechanisms. Here we review recent advances in understanding the relationships between mechanical and molecular genetic mechanisms, and suggest paths forward that could yield answers to the pressing questions of whether and how evolutionary forces act not only on functional morphologies, but also on the mechanical forces that create them.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"175 ","pages":"Article 103645"},"PeriodicalIF":6.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144890493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How growth-induced stresses guide shape changes during animal morphogenesis: Mechanisms and implications 生长诱导的应激如何在动物形态发生过程中引导形状变化：机制和意义。

IF 6 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-11-01 Epub Date: 2025-10-16 DOI: 10.1016/j.semcdb.2025.103661

A. Erlich , S. Harmansa

{"title":"How growth-induced stresses guide shape changes during animal morphogenesis: Mechanisms and implications","authors":"A. Erlich , S. Harmansa","doi":"10.1016/j.semcdb.2025.103661","DOIUrl":"10.1016/j.semcdb.2025.103661","url":null,"abstract":"<div><div>Morphogenesis, the process by which an organism develops its shape, is orchestrated by a complex interplay of genetic, biochemical, and mechanical factors. While myosin-driven contractility has been widely acknowledged as a critical driver of tissue shaping, emerging evidence suggests that differential growth (i.e. variations in growth rates within or between tissues) plays an equally vital role. Differential growth generates mechanical stresses that drive deformations at both cellular and tissue scales, shaping functional organ morphologies. This review introduces the core principles of growth mechanics in animal tissues and demonstrates how differential growth contributes to the generation of mechanical stresses that shape organs through processes such as folding, bending, and buckling, especially when different tissue layers or extracellular matrices impose external constraints. Furthermore, because cells can sense and respond to stresses, we highlight how integrating theoretical modelling with experimental data deepens our understanding of the feedback loops by which growth-induced stresses arise and mechanically guide functional shapes. Our aim is to engage developmental biologists by highlighting well-established insights from solid mechanics and plant biology on differential growth as a means to generate stress and shape tissue, complementing and extending the traditional focus on contractility.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"175 ","pages":"Article 103661"},"PeriodicalIF":6.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145313543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent insights into atrial chamber formation 最近对房室形成的见解。

IF 6 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-11-01 Epub Date: 2025-11-20 DOI: 10.1016/j.semcdb.2025.103664

Marga Albu , David Sedmera , Didier Y.R. Stainier

{"title":"Recent insights into atrial chamber formation","authors":"Marga Albu , David Sedmera , Didier Y.R. Stainier","doi":"10.1016/j.semcdb.2025.103664","DOIUrl":"10.1016/j.semcdb.2025.103664","url":null,"abstract":"<div><div>The sinus node, at the venous end of the heart, automatically generates the electrical impulses that initiate each heart beat and set the heart’s rhythm. From the sinus node, these action potentials are transmitted by specialized structures including initially the atrial inner muscle bundles. Congenital malformations of the atrial wall and the corrective procedures used to treat them frequently disrupt atrial physiology, thereby increasing the risk of arrhythmias. Understanding how the atrial inner muscle bundles develop could therefore facilitate therapeutic strategies. Here, we discuss recent findings on the development of the atrial inner wall and contextualize it with the better understood process of ventricular wall development. Atrial wall architecture varies across species, leading to differences in the patterns of action potential propagation and cardiac contractions. More basal vertebrates such as fish and amphibians (e.g., axolotls) display a webbed-like atrial inner myocardium, whereas mammals develop hierarchically patterned atrial inner muscle structures. This architectural evolution may be associated with the higher cardiovascular requirements of homeothermic organisms. Although the complexity of the atrial inner wall appears to be critical for cardiac function, how it emerges has only recently started being investigated. Oriented action potential propagation correlates with the appearance of the first inner muscle bundles in the chick atrium. Recent studies in zebrafish have shown that atrial cardiomyocytes elongate and intercalate to form multilayered inner structures important for optimal cardiac function. Notably, the cellular and molecular mechanisms behind inner wall emergence differ between the atrium and ventricle. Altogether, these findings lay the foundation for future research into atrial morphogenesis and chamber-specific therapies for congenital heart defects.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"175 ","pages":"Article 103664"},"PeriodicalIF":6.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0