Seminars in cell & developmental biology最新文献_第2页

Cover image of cell death and resilience in health and disease 健康和疾病中的细胞死亡与恢复能力的封面图片

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2024-04-17 DOI: 10.1016/j.semcdb.2024.04.003

Hadley Hanson , Jane Feng

引用次数: 0

Mitochondrial control of lymphocyte homeostasis 线粒体对淋巴细胞平衡的控制

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2024-04-11 DOI: 10.1016/j.semcdb.2024.03.002

Yavuz F. Yazicioglu , Robert J. Mitchell , Alexander J. Clarke

引用次数: 0

Genetic conflicts in budding yeast: The 2μ plasmid as a model selfish element 芽殖酵母中的遗传冲突：2μ质粒是自私元素的典范

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2024-04-10 DOI: 10.1016/j.semcdb.2024.04.002

Michelle Hays

引用次数: 0

Symbiotic symphony: Understanding host-microbiota dialogues in a spatial context 共生交响乐：从空间角度理解宿主与微生物群的对话

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2024-04-01 DOI: 10.1016/j.semcdb.2024.03.001

Soumi Chatterjee , Steven T. Leach , Kei Lui , Archita Mishra

{"title":"Symbiotic symphony: Understanding host-microbiota dialogues in a spatial context","authors":"Soumi Chatterjee , Steven T. Leach , Kei Lui , Archita Mishra","doi":"10.1016/j.semcdb.2024.03.001","DOIUrl":"https://doi.org/10.1016/j.semcdb.2024.03.001","url":null,"abstract":"<div><p>Modern precision sequencing techniques have established humans as a holobiont that live in symbiosis with the microbiome. Microbes play an active role throughout the life of a human ranging from metabolism and immunity to disease tolerance. Hence, it is of utmost significance to study the eukaryotic host in conjunction with the microbial antigens to obtain a complete picture of the host-microbiome crosstalk. Previous attempts at profiling host-microbiome interactions have been either superficial or been attempted to catalogue eukaryotic transcriptomic profile and microbial communities in isolation. Additionally, the nature of such immune-microbial interactions is not random but spatially organised. Hence, for a holistic clinical understanding of the interplay between hosts and microbiota, it's imperative to concurrently analyze both microbial and host genetic information, ensuring the preservation of their spatial integrity. Capturing these interactions as a snapshot in time at their site of action has the potential to transform our understanding of how microbes impact human health. In examining early-life microbial impacts, the limited presence of communities compels analysis within reduced biomass frameworks. However, with the advent of spatial transcriptomics we can address this challenge and expand our horizons of understanding these interactions in detail. In the long run, simultaneous spatial profiling of host-microbiome dialogues can have enormous clinical implications especially in gaining mechanistic insights into the disease prognosis of localised infections and inflammation. This review addresses the lacunae in host-microbiome research and highlights the importance of profiling them together to map their interactions while preserving their spatial context.</p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"161 ","pages":"Pages 22-30"},"PeriodicalIF":7.3,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140338770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondrial dynamics: Regulating cell metabolism, homoeostasis, health and disease 线粒体动力学：调节细胞代谢、平衡、健康和疾病

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2024-03-19 DOI: 10.1016/j.semcdb.2024.02.002

Karoline D. Raven , Ronan Kapetanovic

引用次数: 0

The interplay between mitochondrial dynamics and autophagy: From a key homeostatic mechanism to a driver of pathology 线粒体动力学与自噬之间的相互作用：从关键的平衡机制到病理学的驱动因素

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2024-03-01 DOI: 10.1016/j.semcdb.2024.02.001

Alice Lacombe , Luca Scorrano

引用次数: 0

PSRs: Selfish chromosomes that manipulate reproductive development PSRs：操纵生殖发育的自私染色体

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2024-02-22 DOI: 10.1016/j.semcdb.2024.01.008

Xinmi Zhang, Patrick M. Ferree

{"title":"PSRs: Selfish chromosomes that manipulate reproductive development","authors":"Xinmi Zhang, Patrick M. Ferree","doi":"10.1016/j.semcdb.2024.01.008","DOIUrl":"https://doi.org/10.1016/j.semcdb.2024.01.008","url":null,"abstract":"<div><p>B chromosomes are intriguing “selfish” genetic elements, many of which exhibit higher-than-Mendelian transmission. This perspective highlights a group of B chromosomes known as Paternal Sex Ratio chromosomes (PSRs), which are found in several insects with haplo-diploid reproduction. PSRs harshly alter the organism’s reproduction to facilitate their own inheritance. A manifestation of this effect is the conversion of female destined individuals into males. Key to this conversion is the mysterious ability of PSRs to cause elimination of the sperm-inherited half of the genome during zygote formation. Here we discuss how PSRs were discovered, what is known about how they alter paternal chromatin dynamics to cause sex conversion, and how PSR-induced genome elimination is different from other forms of programmed genome elimination in different insects. PSRs also stand out because their DNA sequence compositions differ in remarkable ways from their insect’s essential chromosomes, a characteristic suggestive of interspecies origins. Broadly, we also highlight poorly understood aspects of PSR dynamics that need to be investigated.</p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"159 ","pages":"Pages 66-73"},"PeriodicalIF":7.3,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139935405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maintenance of satellite DNA stability 保持卫星 DNA 的稳定性

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2024-02-15 DOI: 10.1016/j.semcdb.2024.01.009

Simona Giunta

引用次数: 0

The role of mitochondrial dynamics in oocyte and early embryo development 线粒体动力学在卵母细胞和早期胚胎发育中的作用。

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2024-02-08 DOI: 10.1016/j.semcdb.2024.01.007

Raziye Melike Yildirim, Emre Seli

{"title":"The role of mitochondrial dynamics in oocyte and early embryo development","authors":"Raziye Melike Yildirim, Emre Seli","doi":"10.1016/j.semcdb.2024.01.007","DOIUrl":"10.1016/j.semcdb.2024.01.007","url":null,"abstract":"<div><p>Mitochondrial dysfunction is widely implicated in various human diseases, through mechanisms that go beyond mitochondria’s well-established role in energy generation. These dynamic organelles exert vital control over numerous cellular processes, including calcium regulation, phospholipid synthesis, innate immunity, and apoptosis. While mitochondria's importance is acknowledged in all cell types, research has revealed the exceptionally dynamic nature of the mitochondrial network in oocytes and embryos, finely tuned to meet unique needs during gamete and pre-implantation embryo development. Within oocytes, both the quantity and morphology of mitochondria can significantly change during maturation and post-fertilization. These changes are orchestrated by fusion and fission processes (collectively known as mitochondrial dynamics), crucial for energy production, content exchange, and quality control as mitochondria adjust to the shifting energy demands of oocytes and embryos. The roles of proteins that regulate mitochondrial dynamics in reproductive processes have been primarily elucidated through targeted deletion studies in animal models. Notably, impaired mitochondrial dynamics have been linked to female reproductive health, affecting oocyte quality, fertilization, and embryo development. Dysfunctional mitochondria can lead to fertility problems and can have an impact on the success of pregnancy, particularly in older reproductive age women.</p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"159 ","pages":"Pages 52-61"},"PeriodicalIF":7.3,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139707791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The wonderful wanderer 奇妙的流浪者

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2024-02-08 DOI: 10.1016/j.semcdb.2024.01.001

Sara Prescott

引用次数: 0