Seminars in cell & developmental biology最新文献_第2页

Designing multicellular cardiac tissue engineering technologies for clinical translation 设计用于临床翻译的多细胞心脏组织工程技术

IF 6.2 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-04-29 DOI: 10.1016/j.semcdb.2025.103612

Andrew R. Laskary , James E. Hudson , Enzo R. Porrello

{"title":"Designing multicellular cardiac tissue engineering technologies for clinical translation","authors":"Andrew R. Laskary , James E. Hudson , Enzo R. Porrello","doi":"10.1016/j.semcdb.2025.103612","DOIUrl":"10.1016/j.semcdb.2025.103612","url":null,"abstract":"<div><div>Cardiovascular diseases remain the leading cause of death worldwide—claiming one-third of all deaths every year. Current two-dimensional <em>in vitro</em> cell culture systems and animal models cannot completely recapitulate the clinical complexity of these diseases in humans. Therefore, there is a dire need for higher fidelity biological systems capable of replicating these phenotypes to inform clinical outcomes and therapeutic development. Cardiac tissue engineering (CTE) strategies have emerged to fulfill this need by the design of <em>in vitro</em> three-dimensional myocardial tissue systems from human pluripotent stem cells. In this way, CTE systems serve as highly controllable human models for a variety of applications—including for physiological and pathological modeling, drug discovery and preclinical testing platforms, and even direct therapeutic interventions in the clinic. Although significant progress has been made in the development of these CTE technologies, critical challenges remain and necessary refinements are required to derive more advanced human heart tissue technologies. In this review, we distill three focus areas for the field to address: I) Generating cardiac muscle cell types and scalable manufacturing methods, II) Engineering tissue structure, function, and analyses, and III) Curating system design for specific application. In each of our focus areas, we emphasize the importance of designing CTE systems capable of mimicking the intricate intercellular connectivity of the human heart and discuss fundamental design considerations that subsequently arise. We conclude by highlighting cutting-edge applications that use CTE technologies for clinical modeling and the direct repair of damaged and diseased hearts.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"171 ","pages":"Article 103612"},"PeriodicalIF":6.2,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143886759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of granulosa cells in oocyte development and aging: Mechanisms and therapeutic opportunities 颗粒细胞在卵母细胞发育和衰老中的作用：机制和治疗机会

IF 6.2 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-04-28 DOI: 10.1016/j.semcdb.2025.103614

HaiYang Wang

{"title":"The role of granulosa cells in oocyte development and aging: Mechanisms and therapeutic opportunities","authors":"HaiYang Wang","doi":"10.1016/j.semcdb.2025.103614","DOIUrl":"10.1016/j.semcdb.2025.103614","url":null,"abstract":"<div><div>Granulosa cells (GCs) are essential for oocyte maturation, providing metabolic support, hormonal signaling, and structural integrity critical to successful follicular development. However, advancing age disrupts these functions, driven by factors such as increased oxidative stress, mitochondrial dysfunction, and transcriptomic and proteomic alterations. These age-related changes in GCs contribute to compromised oocyte quality, diminished follicular support, and a decline in fertility, particularly in women of advanced maternal age. This review highlights recent progress in understanding the pivotal roles of GCs in maintaining oocyte health, with a focus on the mechanisms underlying their aging-related dysfunction. Furthermore, we explore promising therapeutic strategies, including antioxidant therapies, metabolic modulators, and GC-based rejuvenation techniques, aimed at mitigating the impacts of reproductive aging. By consolidating and analyzing existing research, this review provides valuable perspectives on fertility preservation and factors shaping reproductive outcomes in women of advanced maternal age.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"171 ","pages":"Article 103614"},"PeriodicalIF":6.2,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143881867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gossiping about death: Apoptosis-induced ERK waves as coordinators of multicellular fate decisions 关于死亡的八卦：凋亡诱导的ERK波作为多细胞命运决定的协调者

IF 6.2 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-04-24 DOI: 10.1016/j.semcdb.2025.103615

Paolo Armando Gagliardi , Olivier Pertz

{"title":"Gossiping about death: Apoptosis-induced ERK waves as coordinators of multicellular fate decisions","authors":"Paolo Armando Gagliardi , Olivier Pertz","doi":"10.1016/j.semcdb.2025.103615","DOIUrl":"10.1016/j.semcdb.2025.103615","url":null,"abstract":"<div><div>Apoptosis is now recognized as a highly dynamic process that involves the release of a large set of signaling molecules that convey information to cells neighboring an apoptotic site. Recent studies in epithelial systems have discovered that apoptotic cells trigger waves of pulses of mitogen-activated protein kinase (MAPK) / extracellular signal-regulated kinase (ERK) pathway activity in their neighbors. At the single-cell level, the ERK pulses emerge from the MAPK pathway's excitable network properties, such as ultrasensitivity and adaptation. At the cell population level, apoptosis-induced ERK waves (AiEWs) emerge from propagation of ERK pulses across cells via a mechanism that involves mechanical inputs and paracrine signaling. AiEWs enable cell populations to dynamically coordinate fate decision signaling during tissue homeostasis and development. This spatio-temporal signaling mechanism can be hijacked by cancer cells to induce drug-tolerant persister states when apoptosis is triggered by cytotoxic or targeted therapies, undermining treatment efficacy. In this review, we summarize our current understanding of AiEWs, including their initiation, propagation, and coordination of fate decision signaling within a population. We discuss how the relatively simple properties of single cells, and their interactions within a collective coordinate these dynamic signaling patterns. We highlight their implication in resistance to cancer therapy and explore potential strategies to target these waves to re-sensitize cancer cells. Finally, we discuss emerging technologies and future directions to expand the study of this biological phenomenon.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"171 ","pages":"Article 103615"},"PeriodicalIF":6.2,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging roles for microproteins as critical regulators of endoplasmic reticulum function and cellular homeostasis 微蛋白作为内质网功能和细胞稳态的关键调节因子的新角色

IF 6.2 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-04-17 DOI: 10.1016/j.semcdb.2025.103608

Taylor M. Coughlin , Catherine A. Makarewich

{"title":"Emerging roles for microproteins as critical regulators of endoplasmic reticulum function and cellular homeostasis","authors":"Taylor M. Coughlin , Catherine A. Makarewich","doi":"10.1016/j.semcdb.2025.103608","DOIUrl":"10.1016/j.semcdb.2025.103608","url":null,"abstract":"<div><div>The endoplasmic reticulum (ER) is a multifunctional organelle essential for key cellular processes including protein synthesis, calcium homeostasis, and the cellular stress response. It is composed of distinct domains, such as the rough and smooth ER, as well as membrane regions that facilitate direct communication with other organelles, enabling its diverse functions. While many well-characterized ER proteins contribute to these processes, recent studies have revealed a previously underappreciated class of small proteins that play critical regulatory roles. Microproteins, typically under 100 amino acids in length, were historically overlooked due to size-based biases in genome annotation and often misannotated as noncoding RNAs. Advances in ribosome profiling, mass spectrometry, and computational approaches have now enabled the discovery of numerous previously unrecognized microproteins, significantly expanding our understanding of the proteome. While some ER-associated microproteins, such as phospholamban and sarcolipin, were identified decades ago, newly discovered microproteins share similar fundamental characteristics, underscoring the need to refine our understanding of the coding potential of the genome. Molecular studies have demonstrated that ER microproteins play essential roles in calcium regulation, ER stress response, organelle communication, and protein translocation. Moreover, growing evidence suggests that ER microproteins contribute to cellular homeostasis and are implicated in disease processes, including cardiovascular disease and cancer. This review examines the shared and unique functions of ER microproteins, their implications for health and disease, and their potential as therapeutic targets for conditions associated with ER dysfunction.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"170 ","pages":"Article 103608"},"PeriodicalIF":6.2,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical force-driven cell competition ensures robust morphogen gradient formation 机械力驱动的细胞竞争确保了强大的形态梯度形成

IF 6.2 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-04-13 DOI: 10.1016/j.semcdb.2025.103607

Kana Aoki , Tohru Ishitani

{"title":"Mechanical force-driven cell competition ensures robust morphogen gradient formation","authors":"Kana Aoki , Tohru Ishitani","doi":"10.1016/j.semcdb.2025.103607","DOIUrl":"10.1016/j.semcdb.2025.103607","url":null,"abstract":"<div><div>Morphogen gradients provide positional data and maintain tissue patterns by instructing cells to adopt distinct fates. In contrast, morphogen gradient-forming tissues undergo dynamic morphogenetic movements that generate mechanical forces and can disturb morphogen signal transduction. However, the interactions between morphogen gradients and these forces remain largely unknown. In this study, we described how mechanical force-mediated cell competition corrects noisy morphogen gradients to ensure robust tissue patterns. The Wnt/β-catenin morphogen gradient—that patterns the embryonic anterior-posterior axis—generates cadherin-actomyosin interaction-mediated intercellular tension gradients—termed mechano-gradients. Naturally generated unfit cells that produce noisy Wnt/β-catenin gradients induce local deformation of the mechano-gradients. Neighboring fit cells sense this deformation, resulting in the activation of Piezo family mechanosensitive calcium channels and secretion of annexinA1, which specifically kills unfit cells to recover morphogen gradients. Therefore, mechanical force-mediated cell competition between the morphogen-receiver cells supports robust gradient formation. Additionally, we discuss the potential roles of mechanical force-driven cell competition in other contexts, including organogenesis and cancer.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"170 ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143823192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Why some hearts heal and others don’t: The phylogenetic landscape of cardiac regenerative capacity 为什么有些心脏能愈合而有些不能：心脏再生能力的系统发育图景

IF 6.2 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-04-11 DOI: 10.1016/j.semcdb.2025.103609

Makoto Nakamura , Guo N. Huang

{"title":"Why some hearts heal and others don’t: The phylogenetic landscape of cardiac regenerative capacity","authors":"Makoto Nakamura , Guo N. Huang","doi":"10.1016/j.semcdb.2025.103609","DOIUrl":"10.1016/j.semcdb.2025.103609","url":null,"abstract":"<div><div>The limited ability of adult humans to replenish lost heart muscle cells after a heart attack has attracted scientists to explore natural heart regeneration capabilities in the animal kingdom. In particular, research has accelerated since the landmark discovery more than twenty years ago that zebrafish can completely regrow myocardial tissue. In this review, we survey heart regeneration studies in diverse model and non-model animals, aiming to gain insights into both the evolutionary trends in cardiac regenerative potential and the variations among closely related species. Differences in cardiomyogenesis, vasculature formation, and the communication between cardiovascular cells and other players have been investigated to understand the cellular basis, although the precise molecular and genetic causes underlying the stark differences in cardiac regenerative potential among certain close cousins remain largely unknown. By studying cardiovascular regeneration and repair in diverse organisms, we may uncover distinct mechanisms, offering new perspectives for advancing regenerative medicine.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"170 ","pages":"Article 103609"},"PeriodicalIF":6.2,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143815656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac enhancers: Gateway to the regulatory mechanisms of heart regeneration 心脏增强剂：心脏再生调控机制的门户

IF 6.2 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-04-10 DOI: 10.1016/j.semcdb.2025.103610

Ian J. Begeman, Megan E. Guyer, Junsu Kang

引用次数: 0

Geometric factors for cell arrangement: How do cells determine their position in vivo? 细胞排列的几何因素：细胞如何决定它们在体内的位置？

IF 6.2 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-04-05 DOI: 10.1016/j.semcdb.2025.103604

Sungrim Seirin-Lee , Akatsuki Kimura

{"title":"Geometric factors for cell arrangement: How do cells determine their position in vivo?","authors":"Sungrim Seirin-Lee , Akatsuki Kimura","doi":"10.1016/j.semcdb.2025.103604","DOIUrl":"10.1016/j.semcdb.2025.103604","url":null,"abstract":"<div><div>The spatial arrangement of cells plays a crucial role in ensuring robust development of organisms, directing cells to their specific fates in the right place and at the right time. In early embryogenesis, the cell arrangement is determined by several factors such as the cell division axis, cell-cell interactions, and surrounding geometric constraints. While many species utilize similar principles to determine the cell arrangement, the precise dynamics of cell arrangement differ among species, even at early stages. In particular, geometric constraints significantly impact cell arrangement. Nematode species exhibit diverse cell arrangement dynamics due to their rigid eggshells, which intensively confine the internal cells. In this paper, we review the mechanisms of cell arrangement with a focus on geometric constraints, drawing from interdisciplinary perspectives. We also review mathematical models developed to enhance our understanding of these mechanisms and discuss future directions for theoretical approaches in exploring geometric effects on cell arrangement in various tissues of various species.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"169 ","pages":"Article 103604"},"PeriodicalIF":6.2,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143777554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cilia and flagella – Current understanding and recent advances in divergent experimental systems 纤毛和鞭毛——目前对不同实验系统的理解和最新进展

IF 6.2 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-04-03 DOI: 10.1016/j.semcdb.2025.103606

Junmin Pan

引用次数: 0

The ever-diversifying landscape of intra-genomic conflict 不断多样化的基因组内部冲突

IF 6.2 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-03-26 DOI: 10.1016/j.semcdb.2025.103603

Mia T. Levine, Sarah E. Zanders

引用次数: 0