Seminars in cell & developmental biology最新文献_第3页

Cell death in regeneration and cell turnover: Lessons from planarians and Drosophila 再生和细胞更新中的细胞死亡：来自涡虫和果蝇的教训

IF 6.2 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-03-25 DOI: 10.1016/j.semcdb.2025.103605

Teresa Adell, Francesc Cebrià, Josep F. Abril, Sofia J. Araújo, Montserrat Corominas, Marta Morey, Florenci Serras, Cristina González-Estévez

{"title":"Cell death in regeneration and cell turnover: Lessons from planarians and Drosophila","authors":"Teresa Adell, Francesc Cebrià, Josep F. Abril, Sofia J. Araújo, Montserrat Corominas, Marta Morey, Florenci Serras, Cristina González-Estévez","doi":"10.1016/j.semcdb.2025.103605","DOIUrl":"10.1016/j.semcdb.2025.103605","url":null,"abstract":"<div><div>Programmed cell death plays a crucial role during tissue turnover in all animal species, and it is also essential during regeneration, serving as a key signalling mechanism to promote tissue repair and regrowth. In freshwater planarians, remarkable regenerative abilities are supported by neoblasts, a population of adult stem cells, which enable high somatic cell turnover. Cell death in planarians occurs continuously during regeneration and adult homeostasis, underscoring its critical role in tissue remodeling and repair. However, the exact mechanisms regulating cell death in these organisms remain elusive. In contrast, <em>Drosophila melanogaster</em> serves as a powerful model for studying programmed cell death in development, metamorphosis, and adult tissue maintenance, leveraging advanced genetic tools and visualization techniques. In <em>Drosophila</em>, cell death sculpts tissues, eliminates larval structures during metamorphosis, and supports homeostasis in adulthood. Despite limited regenerative capacity compared to planarians, <em>Drosophila</em> provides unique insights into cell death's regulatory mechanisms. Comparative analysis of these two systems highlights both conserved and divergent roles of programmed cell death in tissue renewal and regeneration. This review synthesizes the latest knowledge of programmed cell death in planarians and <em>Drosophila</em>, aiming to illuminate shared principles and system-specific adaptations, with relevance to tissue repair across biological systems.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"169 ","pages":"Article 103605"},"PeriodicalIF":6.2,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Death fuels growth: Emerging players bridging apoptosis and cell proliferation in Drosophila and beyond 死亡促进生长：在果蝇和其他物种中连接细胞凋亡和细胞增殖的新兴参与者

IF 6.2 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-03-12 DOI: 10.1016/j.semcdb.2025.103602

Caitlin Hounsell, Yun Fan

引用次数: 0

Epithelial apoptosis: A back-and-forth mechanical interplay between the dying cell and its surroundings 上皮细胞凋亡：濒死细胞与周围环境之间来回的机械相互作用

IF 6.2 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-02-21 DOI: 10.1016/j.semcdb.2025.02.001

Stéphanie Arnould , Corinne Benassayag , Tatiana Merle , Bruno Monier , Marianne Montemurro , Magali Suzanne

引用次数: 0

Zebrafish tailfin as an in vivo model for capturing tissue-scale cell dynamics 斑马鱼尾鳍作为捕获组织尺度细胞动力学的体内模型。

IF 6.2 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-02-01 DOI: 10.1016/j.semcdb.2024.12.005

Yue Rong Tan, Hsiao-Yuh Roan, Chen-Hui Chen

{"title":"Zebrafish tailfin as an in vivo model for capturing tissue-scale cell dynamics","authors":"Yue Rong Tan, Hsiao-Yuh Roan, Chen-Hui Chen","doi":"10.1016/j.semcdb.2024.12.005","DOIUrl":"10.1016/j.semcdb.2024.12.005","url":null,"abstract":"<div><div>The intricate control of collective cell dynamics is crucial for enabling organismic development and tissue regeneration. Despite the availability of various <em>in vitro</em> and <em>in vivo</em> models, studies on tissue-scale cell dynamics and associated emergent properties in living systems remain methodically challenging. Here, we describe key advantages of using the adult zebrafish tailfin (caudal fin) as a robust <em>in vivo</em> model for dissecting millimeter-scale collective cell dynamics during regeneration and wound healing in a complex tissue. For researchers considering this model system, we briefly introduce the tailfin anatomy, as well as available transgenic reporter tools and live-imaging setups that may be utilized to study epidermal cell behaviors. To highlight the unique strengths of the zebrafish tailfin model, we present an example project that was made possible by techniques for tracking cell dynamics at a millimeter scale with single-cell resolution in live animals. Finally, we discuss the research directions at the interface of collective cell dynamics and regenerative biology that most excite us and can be examined using the tailfin model.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"166 ","pages":"Pages 29-35"},"PeriodicalIF":6.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advancement in the spatial immuno-oncology 空间免疫肿瘤学的最新进展。

IF 6.2 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-02-01 DOI: 10.1016/j.semcdb.2024.12.003

Alex To , Zou Yu , Ryohichi Sugimura

引用次数: 0

Collective sperm movement in mammalian reproductive tracts 哺乳动物生殖道中精子的集体运动。

IF 6.2 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-02-01 DOI: 10.1016/j.semcdb.2024.12.002

Tsuyoshi Hirashima , Sound W.P. , Taichi Noda

{"title":"Collective sperm movement in mammalian reproductive tracts","authors":"Tsuyoshi Hirashima , Sound W.P. , Taichi Noda","doi":"10.1016/j.semcdb.2024.12.002","DOIUrl":"10.1016/j.semcdb.2024.12.002","url":null,"abstract":"<div><div>Mammalian sperm cells travel from their origin in the male reproductive tract to fertilization in the female tract through a complex process driven by coordinated mechanical and biochemical mechanisms. Recent experimental and theoretical advances have illuminated the collective behaviors of sperm both <em>in vivo</em> and <em>in vitro</em>. However, our understanding of the underlying mechano-chemical processes remains incomplete. This review integrates current insights into sperm group movement, examining both immotile and motile states, which are essential for passive transport and active swimming through the reproductive tracts. We provide an overview of the current understanding of collective sperm movement, focusing on the experimental and theoretical mechanisms behind these behaviors. We also explore how sperm motility is regulated through the coordination of mechanical and chemical processes. Emerging evidence highlights the mechanosensitive properties of a sperm flagellum, suggesting that mechanical stimuli regulate flagellar beating at both individual and collective levels. This self-regulatory, mechano-chemical system reflects a broader principle observed in multicellular systems, offering a system-level insight into the regulation of motility and collective dynamics in biological systems.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"166 ","pages":"Pages 13-21"},"PeriodicalIF":6.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Collective mechanics of small migrating cell groups 小迁移细胞群的集体机制。

IF 6.2 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-02-01 DOI: 10.1016/j.semcdb.2024.12.001

Wenzheng Shi , Selena Gupta , Calina Copos , Alex Mogilner

引用次数: 0

Spatiotemporal dissection of collective cell migration and tissue morphogenesis during development by optogenetics 光遗传学对发育过程中集体细胞迁移和组织形态发生的时空解剖。

IF 6.2 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-02-01 DOI: 10.1016/j.semcdb.2024.12.004

Sijia Zhou , Bing Liu , Jiaying Liu , Bin Yi , Xiaobo Wang

{"title":"Spatiotemporal dissection of collective cell migration and tissue morphogenesis during development by optogenetics","authors":"Sijia Zhou , Bing Liu , Jiaying Liu , Bin Yi , Xiaobo Wang","doi":"10.1016/j.semcdb.2024.12.004","DOIUrl":"10.1016/j.semcdb.2024.12.004","url":null,"abstract":"<div><div>Collective cell migration and tissue morphogenesis play a variety of important roles in the development of many species. Tissue morphogenesis often generates mechanical forces that alter cell shapes and arrangements, resembling collective cell migration-like behaviors. Genetic methods have been widely used to study collective cell migration and its like behavior, advancing our understanding of these processes during development. However, a growing body of research shows that collective cell migration during development is not a simple behavior but is often combined with other cellular and tissue processes. In addition, different surrounding environments can also influence migrating cells, further complicating collective cell migration during development. Due to the complexity of developmental processes and tissues, traditional genetic approaches often encounter challenges and limitations. Thus, some methods with spatiotemporal control become urgent in dissecting collective cell migration and tissue morphogenesis during development. Optogenetics is a method that combines optics and genetics, providing a perfect strategy for spatiotemporally controlling corresponding protein activity in subcellular, cellular or tissue levels. In this review, we introduce the basic mechanisms underlying different optogenetic tools. Then, we demonstrate how optogenetic methods have been applied <em>in vivo</em> to dissect collective cell migration and tissue morphogenesis during development. Additionally, we describe some promising optogenetic approaches for advancing this field. Together, this review will guide and facilitate future studies of collective cell migration <em>in vivo</em> and tissue morphogenesis by optogenetics.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"166 ","pages":"Pages 36-51"},"PeriodicalIF":6.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding the blueprints of embryo development with single-cell and spatial omics 用单细胞和空间组学解码胚胎发育蓝图。

IF 6.2 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-01-31 DOI: 10.1016/j.semcdb.2025.01.002

Chang Liu , Xuerong Li , Qinan Hu , Zihan Jia , Qing Ye , Xianzhe Wang , Kaichen Zhao , Longqi Liu , Mingyue Wang

{"title":"Decoding the blueprints of embryo development with single-cell and spatial omics","authors":"Chang Liu , Xuerong Li , Qinan Hu , Zihan Jia , Qing Ye , Xianzhe Wang , Kaichen Zhao , Longqi Liu , Mingyue Wang","doi":"10.1016/j.semcdb.2025.01.002","DOIUrl":"10.1016/j.semcdb.2025.01.002","url":null,"abstract":"<div><div>Embryonic development is a complex and intricately regulated process that encompasses precise control over cell differentiation, morphogenesis, and the underlying gene expression changes. Recent years have witnessed a remarkable acceleration in the development of single-cell and spatial omic technologies, enabling high-throughput profiling of transcriptomic and other multi-omic information at the individual cell level. These innovations offer fresh and multifaceted perspectives for investigating the intricate cellular and molecular mechanisms that govern embryonic development. In this review, we provide an in-depth exploration of the latest technical advancements in single-cell and spatial multi-omic methodologies and compile a systematic catalog of their applications in the field of embryonic development. We deconstruct the research strategies employed by recent studies that leverage single-cell sequencing techniques and underscore the unique advantages of spatial transcriptomics. Furthermore, we delve into both the current applications, data analysis algorithms and the untapped potential of these technologies in advancing our understanding of embryonic development. With the continuous evolution of multi-omic technologies, we anticipate their widespread adoption and profound contributions to unraveling the intricate molecular foundations underpinning embryo development in the foreseeable future.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"167 ","pages":"Pages 22-39"},"PeriodicalIF":6.2,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards deciphering the bone marrow microenvironment with spatial multi-omics 空间多组学对骨髓微环境的解读。

IF 6.2 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-01-30 DOI: 10.1016/j.semcdb.2025.01.001

Raymond K.H. Yip , Edwin D. Hawkins , Rory Bowden , Kelly L. Rogers

引用次数: 0