Ploidy in cardiovascular development and regeneration

IF 6.2 2区生物学 Q1 CELL BIOLOGY

Seminars in cell & developmental biology Pub Date : 2025-05-20 DOI:10.1016/j.semcdb.2025.103618

Tian Lan , Sabrina Kaminsky , Chi-Chung Wu

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Abstract

Somatic polyploidy, a non-inheritable form of genome multiplication, plays cell-type specific and context-dependent roles in organ development and regeneration. In the mammalian heart, embryonic cardiomyocytes are primarily diploid, which lose their ability to complete cell division and become polyploid as they mature. Unlike lower vertebrates like zebrafish, polyploid cardiomyocytes are commonly found across mammals, including humans. Intriguingly, the degree, timing, and modes of cardiomyocyte polyploidization vary greatly between species. In addition to the association with cardiomyocyte development and maturation, recent studies have established polyploidy as a barrier against cardiomyocyte proliferation and heart regeneration following cardiac injury. Hence, a thorough understanding of how and why cardiomyocyte become polyploid will provide insights into heart development and may help develop therapeutic strategies for heart regeneration. Here, we review the dynamics of cardiomyocyte polyploidization across species and how cardiomyocyte-intrinsic, -extrinsic, and environmental factors regulate this process as well as the impact of cardiomyocyte polyploidization on heart development and regeneration.

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心血管发育和再生的倍性

体细胞多倍体是一种非遗传的基因组增殖形式，在器官发育和再生中起着细胞类型特异性和环境依赖性的作用。在哺乳动物心脏中，胚胎心肌细胞主要是二倍体，当它们成熟时失去完成细胞分裂的能力而变成多倍体。与斑马鱼等低等脊椎动物不同，多倍体心肌细胞在包括人类在内的哺乳动物中普遍存在。有趣的是，不同物种之间心肌细胞多倍体化的程度、时间和模式差异很大。除了与心肌细胞的发育和成熟有关外，最近的研究已经确定多倍体是心脏损伤后心肌细胞增殖和心脏再生的屏障。因此，彻底了解心肌细胞如何以及为什么会变成多倍体将为心脏发育提供见解，并可能有助于制定心脏再生的治疗策略。在这里，我们回顾了跨物种心肌细胞多倍体化的动力学，以及心肌细胞内在、外在和环境因素如何调节这一过程，以及心肌细胞多倍体化对心脏发育和再生的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in cell & developmental biology 生物-发育生物学

CiteScore

15.10

自引率

1.40%

发文量

310

审稿时长

9.1 weeks

期刊介绍： Seminars in Cell and Developmental Biology is a review journal dedicated to keeping scientists informed of developments in the field of molecular cell and developmental biology, on a topic by topic basis. Each issue is thematic in approach, devoted to an important topic of interest to cell and developmental biologists, focusing on the latest advances and their specific implications. The aim of each issue is to provide a coordinated, readable, and lively review of a selected area, published rapidly to ensure currency.