The open and closed case for Class I HDACs in cardiac development

IF 6.2 2区生物学 Q1 CELL BIOLOGY

Seminars in cell & developmental biology Pub Date : 2025-06-09 DOI:10.1016/j.semcdb.2025.103621

Drishti Rajesth, Veronica Uribe , Kelly A. Smith

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引用次数: 0

Abstract

Gene expression in cardiac development is regulated through complex epigenetic mechanisms. Histone deacetylases (HDACs) are one of the many layers of epigenetic modulation, whereby they remove acetylation marks on histone tails, prompting chromatin tightening and therefore bring about gene repression. The most extensively characterised HDACs in cardiac development are HDACs 1–3, all belonging to the Class I HDAC family. Global as well as tissue-specific knockout models in mice have provided insight into the phenotypes generated by loss of these key molecular regulators. In some instances, molecular processes that individual HDACs regulate within cardiac development have also been revealed, although the epigenetic targets and binding partners of HDACs within cardiac development are still relatively understudied. Knowledge has also been contributed from in vitro studies using stem cell-derived models as well as burgeoning research using the zebrafish model. The aim of this review is to summarise the current knowledge of class I HDAC function during key stages of cardiac development, including cardiac specification and differentiation, looping morphogenesis, and second heart field development. The role of class I HDACs in non-cardiomyocyte populations, such as the endocardium, valves, and epicardium is also discussed.

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I类hdac在心脏发育中的开放和封闭案例

心脏发育过程中的基因表达受复杂的表观遗传机制调控。组蛋白去乙酰化酶（hdac）是许多层表观遗传调节中的一层，它们去除组蛋白尾部的乙酰化标记，促使染色质收紧，从而导致基因抑制。在心脏发育中最广泛表征的HDAC是HDAC 1-3，它们都属于I类HDAC家族。小鼠的全局和组织特异性敲除模型提供了对这些关键分子调节因子缺失所产生的表型的见解。在某些情况下，个别hdac调节心脏发育的分子过程也已被揭示，尽管hdac在心脏发育中的表观遗传靶点和结合伙伴的研究仍然相对不足。使用干细胞衍生模型的体外研究以及使用斑马鱼模型的新兴研究也贡献了知识。本综述的目的是总结目前对心脏发育关键阶段I类HDAC功能的了解，包括心脏规范和分化，环形态发生和第二心野发育。I类hdac在非心肌细胞群（如心内膜、瓣膜和心外膜）中的作用也进行了讨论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in cell & developmental biology 生物-发育生物学

CiteScore

15.10

自引率

1.40%

发文量

310

审稿时长

9.1 weeks

期刊介绍： Seminars in Cell and Developmental Biology is a review journal dedicated to keeping scientists informed of developments in the field of molecular cell and developmental biology, on a topic by topic basis. Each issue is thematic in approach, devoted to an important topic of interest to cell and developmental biologists, focusing on the latest advances and their specific implications. The aim of each issue is to provide a coordinated, readable, and lively review of a selected area, published rapidly to ensure currency.