芽殖酵母中的遗传冲突：2μ质粒是自私元素的典范

IF 6.2 2区生物学 Q1 CELL BIOLOGY

Seminars in cell & developmental biology Pub Date : 2024-04-10 DOI:10.1016/j.semcdb.2024.04.002

Michelle Hays

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引用次数: 0

摘要

基因冲突引起的对抗性共同进化可以推动快速进化和生物创新。生物体之间和基因组内部都可能产生冲突。这篇综述以芽殖酵母为模型系统，探讨基因组内和基因组间的遗传冲突，特别强调 2 微米（2μ）质粒作为自私元素的模型。2μ 质粒广泛存在于酿酒酵母（Saccharomyces cerevisiae）的实验室菌株和工业分离菌株中，长期以来一直被认为会导致宿主健康缺陷。然而，在遗传、适应性和进化研究中，人们经常忽视这种质粒。在此，我提出了进一步探索 2μ 质粒以及芽殖酵母中其他自私元素对进化的影响的理由，讨论了最近的研究进展，最后提出了该领域的未来发展方向。

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Genetic conflicts in budding yeast: The 2μ plasmid as a model selfish element

Antagonistic coevolution, arising from genetic conflict, can drive rapid evolution and biological innovation. Conflict can arise both between organisms and within genomes. This review focuses on budding yeasts as a model system for exploring intra- and inter-genomic genetic conflict, highlighting in particular the 2-micron (2μ) plasmid as a model selfish element. The 2μ is found widely in laboratory strains and industrial isolates of Saccharomyces cerevisiae and has long been known to cause host fitness defects. Nevertheless, the plasmid is frequently ignored in the context of genetic, fitness, and evolution studies. Here, I make a case for further exploring the evolutionary impact of the 2μ plasmid as well as other selfish elements of budding yeasts, discuss recent advances, and, finally, future directions for the field.

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来源期刊

Seminars in cell & developmental biology 生物-发育生物学

CiteScore

15.10

自引率

1.40%

发文量

310

审稿时长

9.1 weeks

期刊介绍： Seminars in Cell and Developmental Biology is a review journal dedicated to keeping scientists informed of developments in the field of molecular cell and developmental biology, on a topic by topic basis. Each issue is thematic in approach, devoted to an important topic of interest to cell and developmental biologists, focusing on the latest advances and their specific implications. The aim of each issue is to provide a coordinated, readable, and lively review of a selected area, published rapidly to ensure currency.