Yavuz F. Yazicioglu , Robert J. Mitchell , Alexander J. Clarke
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引用次数: 0
Abstract
Mitochondria play a multitude of essential roles within mammalian cells, and understanding how they control immunity is an emerging area of study. Lymphocytes, as integral cellular components of the adaptive immune system, rely on mitochondria for their function, and mitochondria can dynamically instruct their differentiation and activation by undergoing rapid and profound remodelling. Energy homeostasis and ATP production are often considered the primary functions of mitochondria in immune cells; however, their importance extends across a spectrum of other molecular processes, including regulation of redox balance, signalling pathways, and biosynthesis. In this review, we explore the dynamic landscape of mitochondrial homeostasis in T and B cells, and discuss how mitochondrial disorders compromise adaptive immunity.
线粒体在哺乳动物细胞中发挥着多种重要作用，了解线粒体如何控制免疫是一个新兴的研究领域。淋巴细胞作为适应性免疫系统中不可或缺的细胞成分，其功能依赖于线粒体，线粒体可以通过快速而深刻的重塑，动态地指导淋巴细胞的分化和活化。能量平衡和 ATP 生成通常被认为是线粒体在免疫细胞中的主要功能；然而，线粒体的重要性还延伸到其他一系列分子过程，包括氧化还原平衡调节、信号通路和生物合成。在这篇综述中，我们将探讨 T 细胞和 B 细胞中线粒体平衡的动态变化，并讨论线粒体紊乱如何损害适应性免疫。
期刊介绍：
Seminars in Cell and Developmental Biology is a review journal dedicated to keeping scientists informed of developments in the field of molecular cell and developmental biology, on a topic by topic basis. Each issue is thematic in approach, devoted to an important topic of interest to cell and developmental biologists, focusing on the latest advances and their specific implications.
The aim of each issue is to provide a coordinated, readable, and lively review of a selected area, published rapidly to ensure currency.
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