Seminars in Ophthalmology最新文献_第10页

Differential Sex-Based Enrolment into US-Registered Glaucoma Clinical Trials: A Cross-Sectional Study. 在美国注册的青光眼临床试验中基于性别的差异入组：一项横断面研究。

IF 2.3 4区医学

Seminars in Ophthalmology Pub Date : 2026-05-01 Epub Date: 2025-08-28 DOI: 10.1080/08820538.2025.2553697

Brendan K Tao, Jim S Xie, Anastasiya Vinokurtseva, John Liu, Hareshan Suntharalingam, Manvis Xia, Nawaaz Nathoo, Matthew Schlenker, Kulbir Gill, Cindy M L Hutnik

{"title":"Differential Sex-Based Enrolment into US-Registered Glaucoma Clinical Trials: A Cross-Sectional Study.","authors":"Brendan K Tao, Jim S Xie, Anastasiya Vinokurtseva, John Liu, Hareshan Suntharalingam, Manvis Xia, Nawaaz Nathoo, Matthew Schlenker, Kulbir Gill, Cindy M L Hutnik","doi":"10.1080/08820538.2025.2553697","DOIUrl":"10.1080/08820538.2025.2553697","url":null,"abstract":"Purpose: We conducted a cross-sectional study of sex, racial, and ethnic patient enrolment to glaucoma-related randomized controlled trials (RCTs) registered on ClinicalTrials.gov (to January 2023).Methods: Trials were included if they were at least double-masked, completed, and had published results through the registry or a scholarly journal. Sex-based glaucoma disease burden was identified using the Global Burden of Disease database. Pooled population-to-prevalence ratios (PPRs) with 95% confidence intervals (CI) were calculated for female sex, with values between 0.8 and 1.2 constituting sufficient study enrolment.Results: From 1061 records, we identified 177 trials (N = 38.475; 56.2% females) for inclusion in the study. The pooled female PPR was 1.05 [95% CI 1.02, 1.08]. Sub-group analysis revealed equitable female enrolment across study characteristics, although studies published prior to 1997 were indeterminate on whether they under-enrolled female participants.Conclusions: Overall, US-registered, glaucoma-related trials enrolled acceptable proportions of females based on real-world disease burden. Future trial enrolment should strive for equitable demographic representation.","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"542-546"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lacrimal History - Part 63: Doyens of Dacryology Series - Jacob Parsons Schaeffer (1878-1970) and the Embryology of the Lacrimal Drainage System. 泪史-第63部分：泪学系列-雅各布·帕森斯·谢弗（1878-1970）和泪道引流系统的胚胎学。

IF 2.3 4区医学

Seminars in Ophthalmology Pub Date : 2026-05-01 Epub Date: 2025-10-11 DOI: 10.1080/08820538.2025.2574190

Mohammad Javed Ali

引用次数: 0

Paradoxical Development of IgG4-Related Ophthalmic Disease During Dupilumab Therapy. 杜比单抗治疗期间igg4相关眼科疾病的矛盾发展

IF 2.3 4区医学

Seminars in Ophthalmology Pub Date : 2026-05-01 Epub Date: 2026-01-13 DOI: 10.1080/08820538.2026.2614750

Isana Nakajima, Ken Fukuda, Masato Okada, Kenji Yamashiro, Hideki Tsuji

引用次数: 0

Large Language Models Use in Dry Eye Disease: Correspondence. 大型语言模型在干眼病中的应用：对应。

IF 3.1 4区医学

Seminars in Ophthalmology Pub Date : 2026-05-01 Epub Date: 2026-02-18 DOI: 10.1080/08820538.2026.2633400

Hinpetch Daungsupawong, Viroj Wiwanitkit

引用次数: 0

Protocol for a Randomized Controlled Trial Comparing Intravitreal Brolucizumab with Placebo for Chronic Central Serous Chorioretinopathy with Persistent Macular Fluid Without Choroidal Neovascular Membrane - BRICS Report #1. 一项比较玻璃体内布卢珠单抗与安慰剂治疗慢性中枢性浆液性脉络膜视网膜病变的随机对照试验方案- BRICS报告#1

IF 2.3 4区医学

Seminars in Ophthalmology Pub Date : 2026-05-01 Epub Date: 2025-03-28 DOI: 10.1080/08820538.2025.2478072

Srishti Raksheeth Ramamurthy, Saarang Hansraj, Ritesh Narula, SriniVas R Sadda, Sobha Sivaprasad, Jay K Chhablani, Mudit Tyagi, Nikitha Gurram Reddy, Umesh Chandra Behera, Raja Narayanan

{"title":"Protocol for a Randomized Controlled Trial Comparing Intravitreal Brolucizumab with Placebo for Chronic Central Serous Chorioretinopathy with Persistent Macular Fluid Without Choroidal Neovascular Membrane - BRICS Report #1.","authors":"Srishti Raksheeth Ramamurthy, Saarang Hansraj, Ritesh Narula, SriniVas R Sadda, Sobha Sivaprasad, Jay K Chhablani, Mudit Tyagi, Nikitha Gurram Reddy, Umesh Chandra Behera, Raja Narayanan","doi":"10.1080/08820538.2025.2478072","DOIUrl":"10.1080/08820538.2025.2478072","url":null,"abstract":"Purpose: Established consensus is lacking for the management of chronic central serous chorioretinopathy (CSCR). The role of anti-VEGF agents in treating chronic CSCR in the absence of choroidal neovascular membrane (CNVM) is equivocal. We aim to study intravitreal brolucizumab in the treatment of persistent macular fluid in chronic CSCR without CNVM.Methods: This study is a prospective randomized, placebo-controlled trial to be conducted among 42 patients with chronic CSCR (>3 months duration) with persistent intraretinal and/or subretinal fluid. Patients will be randomized in a 1:1 ratio to receive brolucizumab or oral multivitamins. Primary endpoint will be fluid resolution on OCT at 1 and 3 months. Secondary outcome measures will include the best-corrected visual acuity, microperimetry and NEI-VFQ 25 subjective questionnaire.Conclusion: The results of this study will provide an understanding of the efficacy and safety of brolucizumab in achieving fluid resolution in chronic CSCR without CNVM.","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"508-514"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fibrin Glue-Assisted Repair in Recurrent Retinal Detachment Following Post-Viral Retinitis: A Retrospective Analysis of 12 Cases in HIV-Positive Patients. 纤维蛋白胶辅助修复病毒性视网膜炎后复发性视网膜脱离：12例hiv阳性患者的回顾性分析。

IF 2.3 4区医学

Seminars in Ophthalmology Pub Date : 2026-05-01 Epub Date: 2025-08-12 DOI: 10.1080/08820538.2025.2547322

Vikas Ambiya, Gaurav Kapoor, Mehak Aggarwal, Vijay K Sharma, Sunandan Bhatta

{"title":"Fibrin Glue-Assisted Repair in Recurrent Retinal Detachment Following Post-Viral Retinitis: A Retrospective Analysis of 12 Cases in HIV-Positive Patients.","authors":"Vikas Ambiya, Gaurav Kapoor, Mehak Aggarwal, Vijay K Sharma, Sunandan Bhatta","doi":"10.1080/08820538.2025.2547322","DOIUrl":"10.1080/08820538.2025.2547322","url":null,"abstract":"Purpose: To evaluate the anatomical and functional outcomes of fibrin glue application in the surgical management of recurrent rhegmatogenous retinal detachment (RRD) in patients with healed post-viral retinitis and HIV infection.Methods: A retrospective review was conducted of 40 cases of RRD secondary to viral retinitis in HIV-positive patients. Among these, 12 eyes exhibited recurrent detachment under silicone oil and were managed with silicone oil exchange, using fibrin glue to close persistent retinal breaks. Pre- and postoperative visual acuity, anatomical reattachment, and complications were assessed. The time to fibrin glue resorption and any evidence of epiretinal membrane formation were also recorded.Results: All 12 cases achieved successful retinal reattachment post fibrin glue application. Silicone oil removal was performed between 3 to 4 months postoperatively. Best corrected visual acuity improved in all eyes (mean preoperative LogMAR VA 1.2 ± 0.13 improved to 0.53 ± 0.13, p < .001). There were no pre-operative or post-operative complications. Nineteen of the total 40 cases required concurrent cataract surgery.Conclusion: Fibrin glue is a safe and effective adjunct for managing persistent retinal breaks in recurrent RRD under silicone oil in HIV-positive individuals with resolved viral retinitis. It promotes retinal reattachment and improves visual outcomes with minimal complications.","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"532-536"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144822402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lacrimal History - Part 46: Doyens of Dacryology Series - James Ware (1756-1815) and His Three Lacrimal Treatises. 泪史-第46部分：泪学系列-詹姆斯·韦尔（1756-1815）和他的三篇泪学论文。

IF 2.3 4区医学

Seminars in Ophthalmology Pub Date : 2026-05-01 Epub Date: 2025-08-14 DOI: 10.1080/08820538.2025.2547159

Mohammad Javed Ali

引用次数: 0

Lacrimal History - Part 73: Doyens of Dacryology Series - Lawrence Webster Fox (1853-1931) and His Lacrimal Skiagraphs. 泪史-第73部分：泪学系列的几十年-劳伦斯·韦伯斯特福克斯（1853-1931）和他的泪史。

IF 2.3 4区医学

Seminars in Ophthalmology Pub Date : 2026-05-01 Epub Date: 2025-11-01 DOI: 10.1080/08820538.2025.2582793

Mohammad Javed Ali

引用次数: 0

Lacrimal History - Part 58: Doyens of Dacryology Series - Solomon Sawrey (1765-1825), and His Retrograde Approach for Nasolacrimal Duct Recanalization. 泪史-第58部分：泪学系列的几十年-索罗门·索里（1765-1825）和他的鼻泪管再通的逆行方法。