Seminars in Ophthalmology最新文献

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Effect of Implanted Capsular Tension Ring on Postoperative Refractive Shift: A Systematic Review and Meta-Analysis. 植入式帽状张力环对术后屈光偏移的影响:系统回顾与元分析》。
IF 1.9 4区 医学
Seminars in Ophthalmology Pub Date : 2024-07-22 DOI: 10.1080/08820538.2024.2381770
Su Xu, Yuhang Zhang, Xintong Li, Wei Si, Gengqi Tian, Yifan Yang, Yizhuo Hu, Fengyan Zhang
{"title":"Effect of Implanted Capsular Tension Ring on Postoperative Refractive Shift: A Systematic Review and Meta-Analysis.","authors":"Su Xu, Yuhang Zhang, Xintong Li, Wei Si, Gengqi Tian, Yifan Yang, Yizhuo Hu, Fengyan Zhang","doi":"10.1080/08820538.2024.2381770","DOIUrl":"https://doi.org/10.1080/08820538.2024.2381770","url":null,"abstract":"<p><strong>Background: </strong>The capsular tension ring is a novel assistant tool for cataract surgery; however, controversy exists in its co-implantation. The potential for hyperopic or myopic shift resulting from the co-implantation of the capsular tension ring and intraocular lens remains unclear. This study aimed to determine the postoperative refractive prediction error and the direction of refractive shift in cataract patients who underwent capsular tension ring co-implantation.</p><p><strong>Methods: </strong>We conducted a systematic review and meta-analysis,searching electronic databases for studies of individuals diagnosed with cataracts receiving surgery with or without capsular tension ring implantation. Systematic searches were performed based on five databases: PubMed, Cochrane Library, Web of Science, Medline, and China National Knowledge Infrastructure. The primary outcome was the mean arithmetic refractive prediction error. Secondary outcomes were mean absolute refractive prediction error and the number of eyes within a certain refractive prediction error range. We applied a fixed-effectsmodel to pool effect sizes across trials using weighted mean differences (WMD) and risk ratios (RR) with their 95% confidence intervals (95% CI). Statistical heterogeneity scores were assessed with the I<sup>2</sup>statistic.</p><p><strong>Results: </strong>A total of 407 affected eyes were included in eight independent clinical studies. Meta-analysis suggested significant differences both in short-term (≤1 month) co-implantation (WMD = 0.16, <i>p</i> < .001, 95% CI: -0.13 ~ 0.19) and long-term (≥3 months) co-implantation between the capsular tension ring co-implantation group and the control group (WMD = 0.19, <i>p</i> < .001, 95% CI: 0.15 ~ 0.23). However, no significant difference was observed in the high myopia subgroup whether capsular tension ring co-implantation (WMD = 0.03, <i>p</i> = .083, 95% CI: -0.27 ~ 0.34). Heterogeneity was not found among the studies.</p><p><strong>Conclusion: </strong>Compared to simple intraocular lens implantation, capsular tension ring co-implantation is more susceptible to developing hyperopic shifts in non-myopic cataract patients, probably related to anterior chamber depth. It requires careful consideration by clinicians when determining the target diopter preoperatively. However, interpretation is limited, because there is a lack of studies available for analysis. There still needs to be additional studies to expand the evidence base.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141749004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Finesse in Lacrimal Syringing: The Concept of Soft Observations During Lacrimal Irrigation. 泪液注射的技巧:泪道冲洗过程中的软观察概念。
IF 1.9 4区 医学
Seminars in Ophthalmology Pub Date : 2024-07-21 DOI: 10.1080/08820538.2024.2380576
Bhupendra C K Patel, Mohammad Javed Ali, Raman Malhotra
{"title":"Finesse in Lacrimal Syringing: The Concept of Soft Observations During Lacrimal Irrigation.","authors":"Bhupendra C K Patel, Mohammad Javed Ali, Raman Malhotra","doi":"10.1080/08820538.2024.2380576","DOIUrl":"10.1080/08820538.2024.2380576","url":null,"abstract":"","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-3"},"PeriodicalIF":1.9,"publicationDate":"2024-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pre-Operative Planning of a DCR Surgery Using Virtual Reality. 利用虚拟现实技术进行 DCR 手术的术前规划。
IF 1.9 4区 医学
Seminars in Ophthalmology Pub Date : 2024-07-19 DOI: 10.1080/08820538.2024.2378341
Ayelet Priel, Dor Hadida Barzilai, Shai Tejman-Yarden, Oliana Vazhgovsky, Oded Sagiv, Arkadi Yakirevitch, Gabriel Nakache, Nethanel Nagar, Noa Kapelushnik, Shaked Shivatzki, Gal Yaakov Cohen, Hadas Knoller, Ofira Zloto
{"title":"Pre-Operative Planning of a DCR Surgery Using Virtual Reality.","authors":"Ayelet Priel, Dor Hadida Barzilai, Shai Tejman-Yarden, Oliana Vazhgovsky, Oded Sagiv, Arkadi Yakirevitch, Gabriel Nakache, Nethanel Nagar, Noa Kapelushnik, Shaked Shivatzki, Gal Yaakov Cohen, Hadas Knoller, Ofira Zloto","doi":"10.1080/08820538.2024.2378341","DOIUrl":"https://doi.org/10.1080/08820538.2024.2378341","url":null,"abstract":"<p><strong>Purpose: </strong>To assess a novel Virtual Reality (VR) tool designed to enhance understanding of the nasal anatomy in patients eligible for DCR surgery.</p><p><strong>Methods: </strong>Preoperative Computed Tomography (CT) scans of the orbit were obtained and loaded as DICOM (Digital Imaging and Communications in Medicine) files onto the D2P software (3D Systems Inc. Littleton, CO) for tissue segmentation and 3D model preparation. Segmentation was performed on several anatomical structures, including the skull, lacrimal sac, nasal septum, inferior and middle turbinate. The resulting 3D model was visualized using a VR headset. After completing the segmentation procedure, ten cases were evaluated by a panel of six surgeons, including both senior and resident physicians from ENT and oculoplastic specialties.</p><p><strong>Results: </strong>The dataset under examination comprised images from 10 preoperative CT scans of the orbits of patients eligible for Endo-DCR. When evaluating the CT using the VR tool, in 73.3% of the cases <i>ENT</i> surgeons were right about the side of pathology, while only 43.3% ophthalmologists were right (chi-square, <i>p</i> = .018). In 72.8% of the cases <i>ENT</i> surgeons were evaluated right that there is a septum deviation, while only in 47.2% of the cases the ophthalmologists were right (chi-square, <i>p</i> = .094).When evaluating the CT using the VR tool, in 60% of the cases consultants were right about the pathology, while 57.7% of the residents were right (chi-square, <i>p</i> = .853). In 81.7% of the cases consultants were evaluated right that there is a septum deviation, while only in 58.3% of the cases the ophthalmologists were right (chi-square, <i>p</i> = .198).</p><p><strong>Discussion: </strong>ENT surgeons, as well as consultants, interpreted the CT better than the ophthalmologists and residents. Surprisingly, the VR system did not help them to interpret the CT better. Further, more extensive studies should be done to build a VR system that assists in the correct interpretation of the preoperative CT before DCR surgery as well as during DCR surgery.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-4"},"PeriodicalIF":1.9,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Global Perspective of Clinician Scientist Training Programs. 临床科学家培训计划的全球视角。
IF 1.9 4区 医学
Seminars in Ophthalmology Pub Date : 2024-07-14 DOI: 10.1080/08820538.2024.2379163
Mohammad Javed Ali
{"title":"A Global Perspective of Clinician Scientist Training Programs.","authors":"Mohammad Javed Ali","doi":"10.1080/08820538.2024.2379163","DOIUrl":"https://doi.org/10.1080/08820538.2024.2379163","url":null,"abstract":"","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-4"},"PeriodicalIF":1.9,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiation-Induced Acquired Lacrimal Drainage Obstructions: Management and Outcomes. 辐射引起的后天性泪腺引流障碍:管理和结果。
IF 1.9 4区 医学
Seminars in Ophthalmology Pub Date : 2024-07-14 DOI: 10.1080/08820538.2024.2376620
Nandini Bothra, Lisa Y Lin, Michael K Yoon
{"title":"Radiation-Induced Acquired Lacrimal Drainage Obstructions: Management and Outcomes.","authors":"Nandini Bothra, Lisa Y Lin, Michael K Yoon","doi":"10.1080/08820538.2024.2376620","DOIUrl":"https://doi.org/10.1080/08820538.2024.2376620","url":null,"abstract":"<p><strong>Objective: </strong>To describe the management and outcomes of patients with radiation-induced acquired lacrimal duct obstructions (RALDO).</p><p><strong>Methods: </strong>A retrospective chart review from July 2018 to December 2023 of all cases undergoing surgical intervention for RALDO by a single surgeon. Data collected included demographics, tumor type and anatomic location, radiation treatment (including radiation type, dosage, and duration), interval between radiation and reported onset of epiphora, oculoplastic clinical examination, management, and outcomes. Lacrimal irrigation was done prior to surgery in all patients.</p><p><strong>Results: </strong>Seventeen eyes of 16 patients with a mean age at presentation of 63.3 years and over half the patients being females (56.3%) were included in the study. The right lacrimal drainage system (LDS) was involved in 4 (23.6%), and the left side was involved in 13 (76.4%). The mean onset of epiphora symptoms after radiation was 9.5 months. The underlying tumor type were intraocular having uveal melanoma in four, cutaneous squamous cell carcinoma in 2, basal cell carcinoma involving forehead and nose in one and sino-nasal indications present in 8 patients. One patient had metastasis to the orbit and eyelid. Four patients (25%) received external beam radiotherapy (XRT) (one case had bilateral LDS involvement), 6 patients (37.5%) received intensity-modulated radiation therapy (IMRT), 5 patients (31.25%) received proton beam irradiation (PBI), and one (6.25%) received stereotactic body radiotherapy (SBRT). Mean radiation dosage was 61.31 Gy in 15 patients (data was missing in 1 patient). Punctum was effaced in 3, canalicular stenosis in 1, proximal canalicular obstruction in 8, distal canalicular obstruction in 2, and nasolacrimal duct obstruction (NLDO) in 3. Treatment was based on the site and nature of obstruction and varied from minimally invasive techniques like serial dilatation with bicanalicular silicone tube or Guibor tube to surgical interventions like dacryocystorhinostomy (DCR) or conjunctivo-dacryocystorhinostomy (C-DCR). Only 10% with primary lacrimal intubation had good response. Of the six cases that underwent C-DCR with Jones tube either as primary or secondary procedure, four cases showed improvement in epiphora (67%). Three with NLDO did well after external DCR. In total, four patients had a secondary procedure after the first failed while 7 with failed initial surgery elected against secondary surgery. The mean follow-up was 9.6 months (range 2-24 months).</p><p><strong>Conclusions: </strong>In patients with RALDO, salvage treatment with silicone lacrimal intubation has poor results, CDCR with Jones tube has better results, although imperfect and in cases with NLDO, DCR has good outcomes.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-5"},"PeriodicalIF":1.9,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Variations in Citations Across Databases: Implications for Journal Impact Factors. 不同数据库中引文的变化:对期刊影响因子的影响》。
IF 1.9 4区 医学
Seminars in Ophthalmology Pub Date : 2024-07-01 Epub Date: 2024-02-28 DOI: 10.1080/08820538.2024.2322428
Khaled Moustafa
{"title":"Variations in Citations Across Databases: Implications for Journal Impact Factors.","authors":"Khaled Moustafa","doi":"10.1080/08820538.2024.2322428","DOIUrl":"10.1080/08820538.2024.2322428","url":null,"abstract":"<p><p>The Journal Impact Factor (JIF) is a widely used metric for ranking journals based on the number of citations garnered by papers published over a specific timeframe. To assess the accuracy of JIF values, I compared citation counts for 30 of my own publications across six major bibliography databases: CrossRef, Web of Science, Publisher records, Google Scholar, PubMed and Scopus. The analysis revealed noteworthy variations in citation counts, ranging from 10% to over 50% between the lowest and highest citation counts. Google Scholar records the highest citation numbers, while PubMed reported the lowest. Notably, Web of Science, whose citation data are used in JIF calculations, tend to underestimate citation counts compared to other databases. These observations raise concerns about the accuracy of JIF calculation based on Web of Science's citation data. The real JIF values for most journals would differ from those annually reported by Clarivate's journal citation reports (JCR). These citation discrepancies underscore the importance of comprehensive data collection and the necessity to include additional citation sources. Not because a paper is cited in one journal rather than another should it have a less or more citation weight. Ultimately, one citation remains one citation, regardless of its origin. Clarivate Analytics may thus need to consider integrating all citation sources for more accurate JIF values. Alternatively, Google Scholar could potentially develop its own journal or citation impact based on its extensive journal citation records. However, while making adjustments to how the Journal Impact Factor is calculated can make it more mathematically precise, it doesn't address the fundamental biases built into the metric. Even with refinements, the Journal Impact Factor will remain skewed due to how it's defined and used.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"400-403"},"PeriodicalIF":1.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139983691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Taser-Related Ocular Injuries: A Review of the Literature and Medico-Legal Implications. 泰瑟枪导致的眼部伤害:文献综述和医学法律意义。
IF 1.7 4区 医学
Seminars in Ophthalmology Pub Date : 2024-07-01 Epub Date: 2024-03-19 DOI: 10.1080/08820538.2024.2322452
Giovanni Aulino, Federico Giannuzzi, Matteo Mario Carlà, Giorgia Guarnieri, Domenico Spagnolo, Domenico Lepore, Francesca Cittadini, Stanislao Rizzo
{"title":"Taser-Related Ocular Injuries: A Review of the Literature and Medico-Legal Implications.","authors":"Giovanni Aulino, Federico Giannuzzi, Matteo Mario Carlà, Giorgia Guarnieri, Domenico Spagnolo, Domenico Lepore, Francesca Cittadini, Stanislao Rizzo","doi":"10.1080/08820538.2024.2322452","DOIUrl":"10.1080/08820538.2024.2322452","url":null,"abstract":"<p><strong>Purpose: </strong>Electric weapons have dangers associated with their use, such as burns and trauma related with the impacts of uncontrolled falls, even though they often minimize morbidity and mortality. The exact visual outcome of the damage inflicted is unknown, even though numerous studies have been documented in the literature about the ocular damage induced by the use of these tools.</p><p><strong>Methods: </strong>We present a narrative review of types of eye damage associated with the use of the Taser. The following search terms were used to identify eligible articles through the PubMed database: \"TASER\", \"Conducted Electric Weapons\", \"CEWs\".</p><p><strong>Results: </strong>A total of 15 articles were included with information about 38 patients with eye damage associated with the use of taser. The majority of patients were males. In most cases the mechanism of injury was the penetration of the probe inside the eye. Clinical manifestations of ocular damage were present in only 18 out of 38 cases and varied according to the type of damage mechanism. Indeed, the cases in which the probe had penetrated the eye showed more severe clinical manifestations with a poor visual outcome.</p><p><strong>Conclusion: </strong>In conclusion, the introduction of taser use for law enforcement requires serious consideration and adequate training for officers.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"334-339"},"PeriodicalIF":1.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140158969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corneal Hysteresis as a Marker for Patients with Secondary Glaucoma. 作为继发性青光眼患者标志的角膜滞后。
IF 1.7 4区 医学
Seminars in Ophthalmology Pub Date : 2024-07-01 Epub Date: 2024-03-11 DOI: 10.1080/08820538.2024.2322443
Marko Oydanich, Aditya Uppuluri, Hadeel Sadek, Albert S Khouri
{"title":"Corneal Hysteresis as a Marker for Patients with Secondary Glaucoma.","authors":"Marko Oydanich, Aditya Uppuluri, Hadeel Sadek, Albert S Khouri","doi":"10.1080/08820538.2024.2322443","DOIUrl":"10.1080/08820538.2024.2322443","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate and compare the association of corneal hysteresis (CH) in patients with secondary glaucoma to control patients and patients with primary open-angle glaucoma (POAG). Additionally, to determine the consistency of CH measurements in patients with secondary glaucoma.</p><p><strong>Methods: </strong>A total of 84 patients (121 eyes) were prospectively included in this study. Twenty-three patients (46 eyes) were healthy controls, 24 patients (40 eyes) were diagnosed with POAG, and 27 patients (35 eyes) were diagnosed with a form of secondary glaucoma. CH and intraocular pressure (IOP) were measured using the Ocular Response Analyzer. Three measurements per eye were performed and used for the analysis and to determine fluctuations in CH data. One-way ANOVA with post-hoc Bonferroni analysis and Chi-Squared testing was done to determine differences between groups.</p><p><strong>Results: </strong>All patients were matched for age. Patients in both POAG and secondary glaucoma groups were matched for age and IOP. All groups had similar sex and racial compositions as well as similar proportions of diabetes, hypertension, and hyperlipidemia. CH was lower (<i>p</i> < .05) in patients with POAG (9.32 ± 1.64) and secondary glaucoma (7.89 ± 3.18) when compared to healthy controls (11.16 ± 1.60). Fluctuations in CH measurements were minimal in all groups. Further analysis of the secondary glaucoma group revealed no differences in CH between different types of secondary glaucoma (<i>p</i> > .05).</p><p><strong>Conclusion: </strong>Patients with secondary glaucoma have lower CH when compared to POAG or control groups. The ORA exhibits precision of CH measurements for control, POAG, and secondary glaucoma groups, making it a reliable tool in management of secondary forms of glaucoma.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"376-380"},"PeriodicalIF":1.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140094567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction. 更正。
IF 1.7 4区 医学
Seminars in Ophthalmology Pub Date : 2024-07-01 Epub Date: 2024-05-29 DOI: 10.1080/08820538.2024.2348326
{"title":"Correction.","authors":"","doi":"10.1080/08820538.2024.2348326","DOIUrl":"https://doi.org/10.1080/08820538.2024.2348326","url":null,"abstract":"","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":"39 5","pages":"404-405"},"PeriodicalIF":1.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141176271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New Multi-Parameters Combination of Technetium-99m-Diethylene-Triamine-Pentaacetate Orbital Single-Photon Emission Computed Tomography/Computed Tomography for the Evaluation of Graves' Orbitopathy Activity. 锝-99m-二乙撑三胺-五乙酸酯眼眶单光子发射计算机断层扫描/计算机断层扫描多参数新组合用于评估巴塞杜氏眼眶病的活动。
IF 1.7 4区 医学
Seminars in Ophthalmology Pub Date : 2024-07-01 Epub Date: 2024-02-27 DOI: 10.1080/08820538.2024.2324070
Lixin Sun, Ruchen Peng, Rongxin Sun
{"title":"New Multi-Parameters Combination of Technetium-99m-Diethylene-Triamine-Pentaacetate Orbital Single-Photon Emission Computed Tomography/Computed Tomography for the Evaluation of Graves' Orbitopathy Activity.","authors":"Lixin Sun, Ruchen Peng, Rongxin Sun","doi":"10.1080/08820538.2024.2324070","DOIUrl":"10.1080/08820538.2024.2324070","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigates the new combined parameters of <sup>99m</sup>Tc-DTPA orbital single-photon emission computed tomography/computed tomography (SPECT/CT) for the evaluation of Graves' orbitopathy (GO) activity.</p><p><strong>Methods: </strong>A retrospective analysis was performed on 41 patients. All the patients undergone the 99mTc-DTPA orbital SPECT/CT and were categorized into active and inactive group based on the standard combined by the clinical active score (CAS), magnet resonance imaging (MRI) and/or follow-up results. Quantitative parameters of lacrimal gland (LG) including the protruding degree of lacrimal gland herniation (LGH) and uptake ratios (URs) of region of interest (ROI) drawn on lacrimal gland and occipital bone. SPECT/CT reading results were based on visual analysis. Parameters were compared between the two groups and the diagnostic value on discrimination of GO activity was also evaluated.</p><p><strong>Results: </strong>All parameters of SPECT/CT for active GO groups were significantly higher than those of the inactive groups (<i>p</i><.05). There were notable linear positive correlations between the assumption standard and readings as well as combination models 2 and 3 (<i>r</i> = .794, <i>r</i> = .772, <i>r</i> = .760, respectively). ROC analysis indicated that model 2 provided the highest diagnostic performance, exhibiting an area under the curve (AUC) of .947, a sensitivity of 92.7%, and a specificity of 88.6%.</p><p><strong>Conclusions: </strong>The combined use of SPECT/CT reading results and DTPA uptake parameters of LG offers a more objective and precise evaluation of active GO. This study further recommends <sup>99m</sup>Tc-DTPA SPECT/CT might be serving as a supplementary beneficial approach for CAS in evaluating GO activity.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"387-393"},"PeriodicalIF":1.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139973353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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