Seminars in Ophthalmology最新文献

{"title":"Lacrimal History - Part 30: Doyens of Dacryology Series - Bruno Fayet (1954-2022).","authors":"Francesco Quaranta-Leoni, Mohammad Javed Ali","doi":"10.1080/08820538.2024.2441049","DOIUrl":"https://doi.org/10.1080/08820538.2024.2441049","url":null,"abstract":"","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-3"},"PeriodicalIF":1.9,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lacrimal History - Part 28: Doyens of Dacryology Series - Hirohiko Kakizaki (1970-).","authors":"Mohammad Javed Ali","doi":"10.1080/08820538.2024.2440201","DOIUrl":"https://doi.org/10.1080/08820538.2024.2440201","url":null,"abstract":"","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-3"},"PeriodicalIF":1.9,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Involvements of Anterior Segment Dysgenesis-Associated Genes in Primary Congenital Glaucoma.","authors":"Goutham Pyatla, Samir Bera, Ashish Mishra, Anil K Mandal, Subhabrata Chakrabarti","doi":"10.1080/08820538.2024.2435944","DOIUrl":"https://doi.org/10.1080/08820538.2024.2435944","url":null,"abstract":"<p><strong>Background: </strong>The anterior segment of the eye plays a crucial role in maintaining the normal intraocular pressure and vision. Developmental defects in the anterior segment structures lead to anterior segment dysgenesis (ASD) and primary congenital glaucoma (PCG), which share overlapping clinical features. Several genes have been mapped and characterized in ASD, some of which are also involved in other glaucoma phenotypes. PCG exhibits genetic heterogeneity like ASD, but the known genes do not account for the entire genetic basis of the disease. Considering the significant phenotypic and genotypic overlap between ASD and PCG, this article explores the possible involvements of ASD-associated genes in PCG pathogenesis.</p><p><strong>Methods: </strong>A nonsystematic search in PubMed was performed using various combinations of keywords related to ASD, glaucoma, genetics, and molecular mechanisms, and articles published up until March 2024 were considered. Specifically, information pertaining to ASD-associated genes (<i>FBN1, FOXE3, HMX1, LMX1B, MAF, OTX2, PAX6, PITX2, PITX3, PRDM5, PRSS56, RAX, SLC4A11, SOX2, TRIM44, VAX1</i>, and <i>WT1</i>) was extracted, and their expressions were determined from the GTEx and EMBL-EBI Expression Atlas. Interactions of these genes were determined through the Ingenuity Pathway Analysis software.</p><p><strong>Results: </strong>Most of the ASD-associated genes were found to be highly expressed in the early embryonic stages. Interactome analysis revealed that <i>TRIM44, PAX6, WT1, SOX2, OTX2, PRDM5</i>, and <i>FBN1</i> interacted through the NFκB and Akt/PI3K pathways, either directly, or through interactions with other partners. <i>FOXC1, PITX2</i>, and <i>HMX1</i> interacted through Wnt and Hedgehog signaling pathways. Both ASD and PCG present similar clinical features and harbor mutations in genes that are implicated in both these conditions. Collectively, we constructed a hypothetical model and proposed two parallel mechanisms comprising the defects in the anterior chamber angle and cell death in PCG pathogenesis.</p><p><strong>Conclusions: </strong>Our findings suggest that complex interplay of these ASD-associated genes and their interactions could potentially result in defects in the anterior chamber angle and trabecular meshwork and induce cell death, resulting in PCG pathogenesis.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-10"},"PeriodicalIF":1.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lacrimal History - Part 29: Doyens of Dacryology Series - Mikhail Krasnov (1929-2006) and Vladimir Beloglazov (1930-2012).","authors":"Vasily Yartsev, Mohammad Javed Ali","doi":"10.1080/08820538.2024.2436301","DOIUrl":"https://doi.org/10.1080/08820538.2024.2436301","url":null,"abstract":"","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-3"},"PeriodicalIF":1.9,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nodulo-Ulcerative Ocular Surface Squamous Neoplasia in 27 Patients: Clinical Presentation, Management and Outcomes.","authors":"Vijitha S Vempuluru, Anshika Luthra, Prerna Sinha, Suneetha Gavara, Swathi Kaliki","doi":"10.1080/08820538.2024.2432908","DOIUrl":"10.1080/08820538.2024.2432908","url":null,"abstract":"<p><strong>Purpose: </strong>To report the clinical presentation, management, and outcomes of nodulo-ulcerative ocular surface squamous neoplasia (nuOSSN).</p><p><strong>Methods: </strong>Retrospective interventional clinical cohort study of 27 patients from a quaternary ocular oncology center.</p><p><strong>Results: </strong>Twenty-seven patients were diagnosed with nuOSSN during the six-year study period. The mean age at presentation was 53 years (median, 51 years; range, 25 to 81 years). Misdiagnosis was noted in 7 (26%) patients, and the mean lag time from symptom onset to presentation at our center was 14 months (median, 6 months; range, 1 to 96 months). The bulbar conjunctiva was the commonest epicenter (<i>n</i> = 19, 70%), and the temporal quadrant was most commonly involved (<i>n</i> = 13, 48%). The mean tumor diameter and thickness were 18 mm (median, 16 mm; range, 8 to 60 mm) and 3 mm (median, 2 mm; range, 1 to 5 mm), respectively. Corneal, limbal, and scleral thinning were seen in 15 (56%), 18 (67%), and 10 (37%) patients, respectively. Peripheral corneal opacification was seen in 18 (67%), and thickening around the area of scleral thinning was seen in 12 (44%) patients. Tumors belonged to the American Joint Committee for Cancer classification T2 (<i>n</i> = 2, 7%), T3 (<i>n</i> = 19, 70%), and T4 (<i>n</i> = 6, 22%) categories. Primary treatment (<i>n</i> = 19) included topical 1% 5-fluorouracil (5FU) eye drops (<i>n</i> = 1, 4%), excisional biopsy (<i>n</i> = 4, 14%), extended enucleation (<i>n</i> = 11, 41%), and orbital exenteration (<i>n</i> = 3, 11%). At a mean follow-up of 9 months (median, 3 months; range 1 to 46 months) in 19 patients who received treatment, the outcomes included local tumor recurrence in 2 patients (11%), tumor control in 16 (84%), globe salvage in 3 (16%), and lymph node metastasis in 2 patients (11%).</p><p><strong>Conclusion: </strong>nuOSSN is an aggressive form of the disease that is frequently misdiagnosed due to the presence of corneoscleral thinning. Globe salvage rates are poor owing to the advanced stage of presentation.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular Immune-Related Adverse Events Associated with PD-1 Inhibitors: From Molecular Mechanisms to Clinical Management.","authors":"Yuqi Gong, Yushuai Liu, Fagang Jiang, Xinghua Wang","doi":"10.1080/08820538.2024.2433636","DOIUrl":"https://doi.org/10.1080/08820538.2024.2433636","url":null,"abstract":"<p><p><b>Purpose:</b> To help ophthalmologists and oncologists better understand the ocular irAEs secondary to PD-1 inhibitors , enabling early detection and management of ocular complications.<b>Methods:</b> We reviewed case reports and related literatures on ocular irAEs secondary to PD-1 inhibitors in PubMed, including a total of 70 case reports, summarizing and analyzing the specific conditions of these patients.<b>Results:</b> The most common malignant tumors were melanoma (<i>n</i> = 41; 58.6%) and lung cancer (<i>n</i> = 13; 18.6%). The main PD-1 inhibitors used were pembrolizumab (<i>n</i> = 38; 54.3%) and nivolumab (<i>n</i> = 28; 40%). They may result in various ocular complications, with the most common being uveitis (<i>n</i> = 35; 50%) and myasthenia gravis (<i>n</i> = 13; 18.57%). Adverse events concerning the cornea and the retina were reported in 8 cases each (11.43%). Neuro-ophthalmic adverse events were reported in 6 cases (8.57%). Most of these toxicities responded to topical and systemic steroids. Severe manifestations, however, may require temporary or permanent cessation of PD-1 inhibitors treatment.<b>Conclusions:</b> With the increasing use of PD-1 inhibitors, ophthalmologists need to remain sensitive to the clinical manifestations of adverse events to ensure timely diagnosis and management. To improve their quality of life and reduce mortality, oncologists and ophthalmologists should maintain close cooperation and implement multi-disciplinary treatment.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-18"},"PeriodicalIF":1.9,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Conditional and Conditional Metastasis of Uveal Melanoma Per Millimeter-By-Millimeter in Thickness in 8034 Patients.","authors":"Hidayet Sener, Rolika Bansal, Thomas Catapano, Jerry A Shields, Carol L Shields","doi":"10.1080/08820538.2024.2432907","DOIUrl":"https://doi.org/10.1080/08820538.2024.2432907","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the impact of uveal melanoma thickness on patient survival from the date of presentation and at specific time intervals following metastasis-free survival.</p><p><strong>Methods: </strong>In this retrospective cohort study, we evaluated data from 8034 consecutive uveal melanoma patients diagnosed at a tertiary care ocular oncology center between May 1972 and August 2007. The patients were categorized on the basis of tumor thickness (per each 1-mm increment) and evaluated for non-conditional survival (from date of presentation) and conditional survival (with 3-years, 5-years, and 10-years of metastasis-free survival) on the cumulative incidence of melanoma-related metastasis at 5-, 10-, 15-, 20-, 25- and 30-years.</p><p><strong>Results: </strong>For the entire cohort, Non-conditional incidence of metastasis at 5-, 10-, 15-, and 30-years was 8%, 11%, 12%, and 12%. Conditional cumulative incidence of metastasis with 5-year and 10-year metastasis-free survival revealed 30-year incidence of metastasis at 10% and 8%, respectively. The multivariate Cox regression analysis showed that each 1-mm increase in tumor thickness was associated with a significant (<i>p</i> < .05) increase in the risk of metastasis [HR: 1.08 (95% CI: 1.05-1.11) for non-conditional survival, HR: 1.07 (95% CI: 1.03-1.11) for 3-year metastasis-free survival, HR: 1.09 (95% CI: 1.03-1.15) for 5-year metastasis-free survival, and HR: 1.17 (95% CI: 1.05-1.30) for 10-year metastasis-free survival].</p><p><strong>Conclusion: </strong>In this study, we emphasize that increasing the thickness of uveal melanoma at presentation demonstrates a poorer ultimate prognosis. However, those with longer metastasis-free intervals were found to have a lower risk of ultimate metastatic disease, highlighting the importance of conditional and non-conditional survival.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-8"},"PeriodicalIF":1.9,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging Artificial Intelligence for Diabetic Retinopathy Screening and Management: History and Current Advances.","authors":"Ramachandran Rajalakshmi, Thyparambil Aravindakshan PramodKumar, Abdul Subhan Naziyagulnaaz, Ranjit Mohan Anjana, Rajiv Raman, Suchetha Manikandan, Viswanathan Mohan","doi":"10.1080/08820538.2024.2432902","DOIUrl":"https://doi.org/10.1080/08820538.2024.2432902","url":null,"abstract":"<p><strong>Aim: </strong>Regular screening of large number of people with diabetes for diabetic retinopathy (DR) with the support of available human resources alone is a global challenge. Digital health innovation is a boon in screening for DR. Multiple artificial intelligence (AI)-based deep learning (DL) algorithms have shown promise for accurate diagnosis of referable DR (RDR). The aim of this review is to evaluate the use of AI for DR screening and the various currently available automated DR detection algorithms.</p><p><strong>Methods: </strong>We reviewed articles published up to May 15th 2024, on the use of AI for DR by searching PubMed, Medline, Embase, Scopus, and Google Scholar using keywords like diabetic retinopathy, retinal imaging, teleophthalmology, automated detection, artificial intelligence, deep learning and fundus photography.</p><p><strong>Results: </strong>This narrative review, traces the advent of AI and its use in digital health, the key concepts in AI and DL algorithm development for diagnosis of DR, some crucial AI algorithms that have been validated for detection of DR and the benefits and challenges of use of AI in detection and management of DR. While there are many approved AI algorithms that are in use globally for DR detection, IDx-DR, EyeArt, and AEYE Diagnostic Screening (AEYE-DS) are the algorithms that have been approved so far by USFDA for automated DR screening.</p><p><strong>Conclusion: </strong>AI has revolutionized screening of DR by enabling early automated detection. Continuous advances in AI technology, combined with high-quality retinal imaging, can lead to early diagnosis of sight-threatening DR, appropriate referrals, and better outcomes.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-8"},"PeriodicalIF":1.9,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Susac Syndrome: A Multidisciplinary Approach to Diagnosis and Management with an Emphasis on Ophthalmic Involvement.","authors":"Oliwia Kamieniecka","doi":"10.1080/08820538.2024.2432904","DOIUrl":"https://doi.org/10.1080/08820538.2024.2432904","url":null,"abstract":"<p><strong>Background: </strong>Susac syndrome is a rare autoimmune microangiopathy that affects the small vessels of the retina, brain, and inner ear, leading to a characteristic triad of encephalopathy, branch retinal artery occlusions, and sensorineural hearing loss. The syndrome often presents diagnostic challenges due to its overlapping symptoms with other conditions. Immunosuppressive therapies remain the cornerstone of treatment.</p><p><strong>Methods: </strong>A retrospective review of the literature from PubMed (1998-2024).</p><p><strong>Results: </strong>Special emphasis is placed on the role of ophthalmologists, who play a pivotal role in the diagnostic process. This article provides a comprehensive overview of the disease, focusing on the pathogenesis, clinical presentation, diagnostic process, and treatment approaches.</p><p><strong>Conclusion: </strong>By highlighting the role of ophthalmologists in recognizing and managing Susac Syndrome, this review underscores the importance of a multidisciplinary approach to improve outcomes in this complex, multisystem disease.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-6"},"PeriodicalIF":1.9,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lacrimal History - Part VII: Doyens of Dacryology Series - The Contributions from the Anatomical School of Padua: Andreas Vesalius, Gabriele Falloppio, and Giovanni Battista Morgagni.","authors":"Mohammad Javed Ali","doi":"10.1080/08820538.2024.2429863","DOIUrl":"10.1080/08820538.2024.2429863","url":null,"abstract":"","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}