Seminars in Ophthalmology最新文献

{"title":"Lacrimal History - Part 45: Doyens of Dacryology Series - Samuel Ernest Whitnall (1876-1950) and His Anatomical Work.","authors":"Mohammad Javed Ali","doi":"10.1080/08820538.2025.2545726","DOIUrl":"10.1080/08820538.2025.2545726","url":null,"abstract":"","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"574-578"},"PeriodicalIF":3.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Dry Eye Treatment Outcomes in Patients with or without Autoimmune Disease.","authors":"Heya Lee, Seko Li, Gina Zhu, Aishah Ahmed, Tiffany S Liu","doi":"10.1080/08820538.2025.2574618","DOIUrl":"10.1080/08820538.2025.2574618","url":null,"abstract":"<p><strong>Purpose: </strong>Assess and compare the efficacy of cyclosporine and lifitegrast in patients with dry eye disease (DED) and with or without autoimmune disease.</p><p><strong>Methods: </strong>430 DED patients from 2018 to 2023 in Wilmer Institute who did or did not receive cyclosporine and/or lifitegrast were selected. Demographics, cataract surgery status, autoimmune comorbidities, visual acuity (VA), and punctate epithelial erosions (PEE) were assessed between treatment groups. VA was assessed using Snellen measurements converted logMAR (logarithm of the minimum angle of resolution) scores. PEE was measured using the integer PEE grade scale, with 0 defined as no PEE. Chi-square and Fisher's Exact test were used to compare categorical variables across groups. Kendall correlation was used to assess the overall trend of VA and PEE grades over time and to determine the number of eyes with significant improvement. Multiple regression was used to analyze the effect of various variables on VA and PEE changes.</p><p><strong>Results: </strong>One hundred and sixty patients received cyclosporine, 45 received lifitegrast, 59 received both, and 166 were controls. The differences in race, age at visit, and sex were not found to be significantly different between treatment groups, as well as the number of autoimmune disease patients. Kendall correlation of logMAR scores revealed that out of 575 eyes with three or more best-corrected VA measurements, only 31 eyes saw significant vision improvement. The number of eyes with improved VA between treatment groups was not significantly different. Using similar statistical methods, the number of eyes with lowered PEE grades was not significantly different between groups. When analyzing changes in logMAR, multiple regression suggested that treatment with cyclosporine and both cyclosporine and lifitegrast is associated with improved visual acuity only if patients also had an autoimmune disease (cyclosporine β = 0.076, <i>p</i> = 3E-6; Both, β = 0.083, <i>p</i> = 5E-5; cyclosporine:autoimmune β = -0.072, <i>p</i> = .010; Both:autoimmune β = -0.181, <i>p</i> = 2E-6). Regression of change in PEE grades revealed that cyclosporine is similarly associated with lower grades in autoimmune patients (cyclosporine:autoimmune β = -0.520, <i>p</i> = 8E-12).</p><p><strong>Conclusions: </strong>Cyclosporine and lifitegrast treatment does not seem to significantly improve visual acuity and PEE compared to control. However, the presence of autoimmune disease significantly modulates the efficacy of DED treatment.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"619-626"},"PeriodicalIF":3.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145308974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lacrimal History - Part 40: Doyens of Dacryology Series - Reynaldo Manansala Javate (1954-) and Mohsen Bahmani Kashkouli (1967-).","authors":"Mohammad Javed Ali","doi":"10.1080/08820538.2025.2485595","DOIUrl":"10.1080/08820538.2025.2485595","url":null,"abstract":"","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"556-558"},"PeriodicalIF":3.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lacrimal History - Part 39: Doyens of Dacryology Series - Jeffrey Jay Hurwitz (1944-2022).","authors":"Ahsen Hussain, Mohammad Javed Ali","doi":"10.1080/08820538.2025.2474341","DOIUrl":"10.1080/08820538.2025.2474341","url":null,"abstract":"","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"553-555"},"PeriodicalIF":3.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology, Associations, and Treatment of Acute Exudative Polymorphous Vitelliform Maculopathy (AEPVM).","authors":"Tobin Smith, Vivian Rajeswaren, Brittany Hodges, Pradeepa Yoganathan","doi":"10.1080/08820538.2025.2583074","DOIUrl":"10.1080/08820538.2025.2583074","url":null,"abstract":"<p><strong>Purpose: </strong>Acute Exudative Polymorphous Vitelliform Maculopathy (AEPVM) is a rare retinal disorder characterized by serous subretinal detachments that progress to vitelliform lesions. In this review, we aim to summarize current knowledge of etiologies and treatments for AEPVM and its association with primary and recurrent melanoma.</p><p><strong>Methods: </strong>We performed a comprehensive search of scientific literature for articles mentioning Acute Exudative Polymorphous Vitelliform Maculopathy including all literature published through March 2025 using the online electronic databases PubMed, MEDLINE, and Embase.</p><p><strong>Results: </strong>We identified 81 cases (mean age 46 ± 16.9 years, 43.2% female) with etiologies including idiopathic (43), infectious (10), paraneoplastic (19), and medication-induced (9). Several successful treatments were identified. Local or systemic corticosteroids in 17 eyes improved subretinal fluid and vision in 100% of idiopathic, 50% of infectious, and 40% of medication-induced cases. In paraneoplastic AEPVM, fluid improved with immunotherapy (2 eyes), chemotherapy (2 eyes), intravitreal methotrexate (1 eye), and aflibercept (2 eyes). Notably, AEPVM was the initial symptom of primary or metastatic melanoma in 5 cases.</p><p><strong>Conclusion: </strong>The variable response to treatment and the potential link between AEPVM and primary and recurrent melanoma highlights the need for further research. A thorough understanding of treatment options and outcomes is essential to optimize management and to encourage prompt recognition of metastatic melanoma or other conditions associated with AEPVM.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"604-618"},"PeriodicalIF":3.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145513808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements and Collaborative Dynamics in the Treatment of Retinoblastoma: A Bibliometric Analysis of Trends and Themes.","authors":"Jinying Gao, Peng Huang, Xue Leng, Yibing Zhang","doi":"10.1080/08820538.2025.2584513","DOIUrl":"10.1080/08820538.2025.2584513","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to provide a comprehensive bibliometric analysis of retinoblastoma treatment, assessing publication trends, influential research, and leading contributors.</p><p><strong>Methods: </strong>The research was conducted using the Web of Science Core Collection, focusing on retinoblastoma treatment from January 1, 1941, to June 13, 2024. Bibliometric analysis were conducted using Microsoft Excel, VOSviewer, CiteSpace, and the Bibliometrics R package.</p><p><strong>Results: </strong>The analysis identified 5,674 documents. The United States led in research output and citation impact, followed by China and Europe. The University of Toronto was the most prolific institution (488 articles). International collaborations accounted for 18.54% of publications. David H. Abramson was the most prolific author (139 articles), followed closely by C.L. Shields (100 articles). Keyword analysis revealed three major thematic clusters: (1) molecular mechanisms and oncogenesis, (2) cell cycle regulation and experimental models, and (3) clinical management and therapeutic strategies. Recent hotspots included intraarterial chemotherapy, melphalan, treatment resistance, risk stratification, and tumor biology. Retinoblastoma research centers on molecular mechanisms, cell cycle regulation, and clinical management.</p><p><strong>Conclusion: </strong>Advances in intraarterial chemotherapy, risk assessment, and molecular insights are improving survival and quality of life. Greater emphasis on real-world, multicenter, and international studies is needed to advance personalized care.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"631-643"},"PeriodicalIF":3.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145452933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lacrimal History - Part 41: Doyens of Dacryology Series - John Vincent Linberg (1945-).","authors":"Bhupendra C K Patel, Mohammad Javed Ali","doi":"10.1080/08820538.2025.2532289","DOIUrl":"10.1080/08820538.2025.2532289","url":null,"abstract":"","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"559-562"},"PeriodicalIF":3.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144620348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Diabetes Mellitus During Pregnancy as a Risk Factor for Congenital Nasolacrimal Duct Obstruction in the Offspring - a Large-Scale National Study.","authors":"Amichai Raz, Nir Amitai, Tomer Kerman, Tamar Eshkoli, Ahed Imtirat, Dor Marciano, Eyal Sheiner, Erez Tsumi","doi":"10.1080/08820538.2026.2695825","DOIUrl":"https://doi.org/10.1080/08820538.2026.2695825","url":null,"abstract":"<p><strong>Objective: </strong>To investigate whether maternal diabetes mellitus during pregnancy is a risk factor for CNLDO in offspring.</p><p><strong>Methods: </strong>This retrospective cohort study utilized electronic medical records from Clalit Health Services (CHS) in Israel, 2010-2023. Neonates were classified as born to diabetic or non-diabetic mothers. Mixed models assessed and compared demographic characteristics and ocular disorders between groups. Generalized estimating equations regression was applied to calculate odds ratios while adjusting for potential confounders.</p><p><strong>Results: </strong>505,928 births were analyzed. CNLDO prevalence was 4.1% among children born to mother with diabetes, compared to 2.9% among children to non-diabetic mothers (OR-1.44, 95% confidence interval [CI] 1.35-1.54; <i>p</i> < .001). Among children to diabetic mothers receiving pharmacological treatment, CNLDO prevalence was 5.2%, while it was 3.7% when managed by diet (OR-1.44, 95% CI 1.26-1.64; <i>p</i> < .001). CNLDO prevalence was 4.7% in children to mothers with HbA1c levels greater than 6.5%, compared to 2.9% when HbA1c levels were below 6.5% (OR-1.62, 95% CI 1.30-2.03; <i>p</i> < .001). After adjusting for confounders, significant association was found between maternal diabetes during pregnancy and CNLDO prevalence in offspring (OR-1.47, 95% CI 1.37-1.58; <i>p</i> < .001).</p><p><strong>Conclusions: </strong>Maternal diabetes during pregnancy independently increases CNLDO risk, especially in infants to mothers with more severe diabetes.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-7"},"PeriodicalIF":3.1,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148353401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Spectrum and Genetics of Ocular Manifestations in Muscle Eye Brain Disease: A Literature Review.","authors":"Evita Evangelia Christou, Samantha R de Silva, C K Patel, Peter Kiraly, Noha M Soliman, Robert E MacLaren, Tariq Aslam, Jane L Ashworth","doi":"10.1080/08820538.2026.2695816","DOIUrl":"https://doi.org/10.1080/08820538.2026.2695816","url":null,"abstract":"<p><strong>Purpose: </strong>Muscle eye brain (MEB) disease is a rare genetic disorder characterized by congenital muscular dystrophy, structural brain malformations and ocular abnormalities. We review the literature on ophthalmic manifestations and highlight key features that may facilitate the diagnosis of this rare condition.</p><p><strong>Methods: </strong>A literature search was conducted in the National Centre form Biotechnology Information (NCBI) PubMed, Embase, Web of Science and Scopus databases from inception through April 2026 to identify all relevant studies reporting ocular manifestations in MEB disease.</p><p><strong>Results: </strong>The current literature on ocular manifestations in MEB disease demonstrates phenotypic variability. MEB disease is caused by homozygous or compound heterozygous mutations in the POMGnT1 gene and the clinical presentation varies in terms of age of onset, disease pattern and rate of progression. Patients with a genetically established diagnosis may present with a wide range of ocular findings, ranging from mild to severe abnormalities. The spectrum mainly includes ocular motility disorders, high myopia, glaucoma, cataract, optic nerve hypoplasia and retinal dysplastic and degenerative changes, while retinal detachment and microphthalmia are less commonly reported.</p><p><strong>Conclusion: </strong>The variation in phenotype and disease progression, along with the limited number of reported cases highlights the need for further research to guide clinical practice, improve risk assessment and optimize patient management. This review discusses the ocular manifestations of the disorder and emphasizes the importance of reporting additional cases of this rare condition to contribute to future research.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-8"},"PeriodicalIF":3.1,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome Wide Pleiotropic Analysis Reveals Shared Genetic Architecture and Pathological Basis Between Retinitis Pigmentosa and Relevant Ocular Comorbidities.","authors":"Jiawei Chen, Xiang-Ling Yuan, Xinyue Zhang, Qiuling Huang, Xiaoyu Zhou, Dan Ji, Wenxiang Zhu, Xuanchu Duan","doi":"10.1080/08820538.2026.2694713","DOIUrl":"https://doi.org/10.1080/08820538.2026.2694713","url":null,"abstract":"<p><strong>Purpose: </strong>Retinitis pigmentosa (RP) is a leading cause of irreversible blindness in working-age populations and frequently cooccurs with multiple ocular disorders. As their shared genetic basis remains poorly understood, this study aimed to elucidate the shared genetic architecture underlying RP and relevant ocular comorbidities.</p><p><strong>Methods: </strong>Using large-scale genome-wide association data, we systematically investigated pleiotropy, genetic correlation, cell-type specificity, and genetically predicted causality between RP and major ophthalmic comorbidities.</p><p><strong>Results: </strong>We observed significant genetic correlations and pleiotropic enrichment between RP and retinal detachments and breaks (RDAB), retinal vascular occlusion (RVO), and age-related macular degeneration (AMD), with notable SNP-level overlap between RP and primary open-angle glaucoma (POAG). RP and RDAB, as well as AMD, shared genetic associations at chr1:196176201-197311241 and chr10:123900764-125869042. Totally, 41, 25, 114, and 397 pleiotropic loci were identified between RP and RDAB, RVO, POAG, and AMD, implicating pathways related to cell division, metabolic regulation, immune activation, and complement activation. A novel causal variant (rs36212731) and four pleiotropic genes (ARMS2, HTRA1, CFH, PLEKHA1) were discovered between RP and RDAB. Ten causal variants and 24 pleiotropic genes were identified between RP and AMD. MR analyses demonstrated a genetically causal effect of RP on an increased risk of RDAB and RVO (P˂0.05), and AMD was associated with an increased risk of RP. Cell-type enrichment analyses highlighted vascular smooth muscle cells and retinal pigment epithelium as key mediators of shared susceptibility between RP and RDAB, and POAG.</p><p><strong>Conclusions: </strong>This study reveals robust genetic and potential causal links between RP and RDAB, RVO, as well as AMD, along with complex pleiotropic associations with glaucoma. These findings provide novel genetic insights into the shared pathogenic mechanisms and generate hypotheses for future biological, translational, and clinical research.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-20"},"PeriodicalIF":3.1,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148339911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}