Seminars in Ophthalmology最新文献

{"title":"Ciliary Body Medulloepithelioma: Clinical and Pathologic Challenges with a Focus on Molecular Genetics.","authors":"Ari H August, Linda A Cernichiaro-Espinosa, Mariana Moctezuma-Davila, Turner D Wibbelsman, Matthew W Wilson, Patricia Chévez-Barrios, Carol L Shields, Sara E Lally, Charles G Eberhart, Brent A Orr, Edward Simpson, Ralph C Eagle, Tatyana Milman","doi":"10.1080/08820538.2025.2457066","DOIUrl":"https://doi.org/10.1080/08820538.2025.2457066","url":null,"abstract":"<p><strong>Objective: </strong>Ciliary body medulloepithelioma (CBME), a pediatric intraocular tumor with potential for locally aggressive behavior and metastasis, may present with a diverse spectrum of clinical and histopathologic features leading to diagnostic and management challenges. Examination of unusual CBME cases highlights challenges and modern diagnostic techniques which facilitate accurate diagnosis and guide management.</p><p><strong>Methods: </strong>A retrospective clinicopathologic analysis of 6 patients with unusual clinical or pathologic features of CBME was performed.</p><p><strong>Results: </strong>The mean duration of delay in accurate diagnosis was 5.7 years (SD: 8.2, median: 3, range: 0-22). All patients developed cataract, 4 (67%) were diagnosed with glaucoma, and 4 (67%) underwent surgery prior to accurate diagnosis. At initial presentation, only one patient with a known history of genetically confirmed DICER1 syndrome underwent appropriate imaging leading to a timely identification of a ciliary body mass and no delay in diagnosis. Following identification of intraocular mass, 4 (67%) patients underwent enucleation. Two patients (33%) underwent exenteration for extraocular extension of CBME. Initial histopathologic differential diagnosis included CBME, melanoma, adenoma or adenocarcinoma of the pigmented ciliary body epithelium, retinoblastoma, sarcoma, and malignant teratoma. Immunohistochemistry and genetic testing assisted in the diagnosis of CBME. Two patients (33%) had a germline DICER1 variant; this was known prior to CBME diagnosis in one patient and discovered after CBME diagnosis in the second patient.</p><p><strong>Conclusion: </strong>This series highlights the unusual clinical and histopathologic features of CBME that contribute to delays in diagnosis. Modern aids including genetic testing, ancillary imaging studies, and immunohistochemistry facilitate a timely accurate diagnosis of CBME and guide management.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-11"},"PeriodicalIF":1.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lacrimal History - Part 35: Doyens of Dacryology Series - Friedrich Paul Paulsen (1965-).","authors":"Mohammad Javed Ali","doi":"10.1080/08820538.2025.2459481","DOIUrl":"https://doi.org/10.1080/08820538.2025.2459481","url":null,"abstract":"","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-4"},"PeriodicalIF":1.9,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143041807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Survey of the Congenital Glaucoma Surgery Practice Patterns in the Indian Pediatric Glaucoma Society.","authors":"Anil K Mandal, Zayn Al-Timimi, Vijaya K Gothwal, Sushmita Kaushik, Sirisha Senthil, Viney Gupta, Shanta Balekudaru, Suneeta Dubey, Manju R Pillai","doi":"10.1080/08820538.2025.2457590","DOIUrl":"https://doi.org/10.1080/08820538.2025.2457590","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the practice patterns among the Indian Pediatric Glaucoma Society (IPGS) members in the management of children with primary congenital glaucoma (PCG).</p><p><strong>Methods: </strong>An anonymous 74-question survey was administered online via Qualtrics (Qualtrics, Provo, Utah, USA) using a link sent by email to the 88 IPGS members. The questionnaire comprised five sections and was designed to gather information regarding respondent demographics and specialty training, clinic composition and volume, surgical practices and preferences, follow-up practices, and additional services. The survey was closed after 10 weeks. Data were analyzed using descriptive statistics and Chi-square tests. Statistical significance was set at <i>p</i> < .05.</p><p><strong>Results: </strong>The response rate was 82%. Of the 71 respondents, 49 (69%) reported possessing glaucoma fellowship training that included specialist training in pediatric glaucoma. By comparison, 8 respondents (11%) reported possessing pediatric ophthalmology fellowship training that included specialist training in pediatric glaucoma, and this difference was statistically significant (69% <i>vs</i>. 11%; χ² = 47.37; <i>p</i> < .0001). The majority of the respondents were in ophthalmic institution-based practice (83%) and were located in South India (58%). In cases of hazy cornea, the most common surgery (95%) performed was combined trabeculotomy-trabeculectomy while goniotomy was most preferred (49%) in cases of clear cornea. Approximately, one-half of the respondents (56%) preferred to operate on each eye in separate sessions, whereas 46% preferred to operate on both eyes in the same session. One-half of the respondents (51%) preferred to use mitomycin-C in primary surgery. The most common challenges in providing care were patient-related, including delayed presentation, high travel costs, and low socioeconomic status.</p><p><strong>Conclusions: </strong>Although a substantial consensus was found in most areas of management, a few areas, for example, use of MMC in primary surgery, showed diversity. The information gathered will enable glaucomatologists to compare their practices with those of their colleagues. In addition, this survey provides a baseline, allowing future trends in management to be determined.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-11"},"PeriodicalIF":1.9,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lacrimal History - Part 36: Doyens of Dacryology Series - Michael McDonogh.","authors":"Mohammad Javed Ali, Peter John Wormald","doi":"10.1080/08820538.2025.2452088","DOIUrl":"https://doi.org/10.1080/08820538.2025.2452088","url":null,"abstract":"","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-2"},"PeriodicalIF":1.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asymmetric Intraocular Pressure Changes in Dominant and Contralateral Eyes: The Dark Room Prone Provocative Test.","authors":"Junwei Wang, Jun Wang, Tsz Kin Ng, Chukai Huang","doi":"10.1080/08820538.2024.2443972","DOIUrl":"https://doi.org/10.1080/08820538.2024.2443972","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate changes in intraocular pressure (IOP) in dominant and contralateral eyes following the dark room prone provocative test (DRPPT) in the study subjects with shallow anterior chamber.</p><p><strong>Methods: </strong>This was a prospective, single-center, non-randomized controlled trial of 43 subjects (86 eyes) with shallow anterior chamber. The dominant eye was identified using the card-hole method. The study subjects underwent the DRPPT for one hour. Pre- and post-DRPPT IOP was measured using an I-Care tonometer, and pupillary parameters, including amplitude of constriction, peak constriction velocity, and peak re-dilation velocity, were also measured using the RAPDx® dynamic pupillometer.</p><p><strong>Results: </strong>Significant increases in IOP were observed in both the dominant and contralateral eyes after DRPPT, compared to their respective pre-DRPPT IOP levels. (<i>p</i> < .01). Moreover, IOP variation before and after DRPPT was significantly greater in the dominant eye than in the contralateral eye (median 3.60 mmHg vs. 2.70 mmHg, <i>p</i> < .05). The dominant eyes exhibited a smaller amplitude of constriction (1.07 ± 0.35 mm vs 1.14 ± 0.34 mm, P < .05) and slower constriction velocity (3.71 ± 1.12 mm/s vs 3.78 ± 1.11 mm/s, P < .05) as compared to the contralateral eyes.</p><p><strong>Conclusions: </strong>This study demonstrated that the dominant eye exhibited greater IOP changes after DRPPT than the contralateral eye. Additionally, it showed smaller pupil constriction and slower contraction, indicating a higher likelihood of pupil blockage in the dominant eye with shallow anterior chambers. This asymmetry partially explains the monocular onset of acute angle-closure attacks.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complications After Incisional/Excisional Minimally Invasive Glaucoma Surgery-An Update and Literature Review.","authors":"Aparna Rao, Manikanta Damagantla, Rashmi Krishnamurthy, Sirisha Senthil","doi":"10.1080/08820538.2025.2450687","DOIUrl":"https://doi.org/10.1080/08820538.2025.2450687","url":null,"abstract":"<p><strong>Purpose: </strong>To discuss comprehensively the varied complications after stent-less incisional or excisional minimally invasive glaucoma surgery (MIGS).</p><p><strong>Method: </strong>A review of reported complications after stent-less MIGS procedures including gonioscopy-assisted transluminal trabeculotomy (GATT), bent needle goniectomy (BANG), Kahook-dual blade goniotomy, and microincisional trabeculectomy (MIT) published between 2014-2024, were analyzed and summarized.</p><p><strong>Results: </strong>Apart from hyphema, peripheral anterior synechiae, and intraocular pressure spikes, other vision-threatening complications like cyclodialysis, Descemet's detachment, corneal edema, iridodilalysis, vitreous loss or vitreous hemorrhage can also occur intra- or postoperatively after any incisional or excisional MIGS procedures.</p><p><strong>Conclusion: </strong>All possible complications are to be kept in mind during MIGS despite the procedures being minimally invasive. Adequate care should be taken during different stages of the surgery to avoid these complications.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143011060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Readership Awareness Series - Paper 15: How the ICMJE 2025 Recommendations Update Impact the Scientific Community?","authors":"Mohammad Javed Ali, Ali Djalilian","doi":"10.1080/08820538.2025.2454851","DOIUrl":"https://doi.org/10.1080/08820538.2025.2454851","url":null,"abstract":"","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-2"},"PeriodicalIF":1.9,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143011065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-Level Red Light for the Progression Myopia in Children: A Meta-Analysis.","authors":"Xian Yang, Lin Yao, Gang Sun, Haoyan Zhang, Haolin Yu, Haiqing Bai","doi":"10.1080/08820538.2025.2452885","DOIUrl":"https://doi.org/10.1080/08820538.2025.2452885","url":null,"abstract":"<p><strong>Purposes: </strong>This meta-analysis aims to systematically analyze the efficacy of low-level red light (LRL) therapy for myopia control and prevention in children.</p><p><strong>Methods: </strong>All the data were searched from the PubMed, EMBASE, and the Cochrane Library. The Cochrane Handbook was used to evaluate the quality of the included studies. Additionally, this meta-analysis was performed by using the Revman 5.4 software. Inclusion criteria was randomized controlled trials (RCTs), and the patient populations were younger than 18 years.</p><p><strong>Results: </strong>Eight RCTs were included in this study. Compared with control group, LRL treatment could reduce the progression in spherical equivalent refractive (SER) for myopia children (MD, 0.49; 95% CI, 0.27 to 0.71; <i>p</i> < .00001). Also, less change in axial length (AL) and increase in subfoveal choroid thickness (SFCT) was shown in the LRL group for both myopia and premyopia children (MD, -0.24, 28.16; 95% CI, -0.32 to -0.17, 18.78 to 37.55; <i>p</i> < .00001, respectively).</p><p><strong>Conclusion: </strong>Our meta-analysis shows that LRL therapy could delay the refraction progression of myopia children. It also could reduce progression in axial length and SFCT thinning in both myopia and premoypia children.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-6"},"PeriodicalIF":1.9,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143011063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Pediatric Rhegmatogenous Retinal Detachment.","authors":"Theodore Bowe, Olufemi E Adams, Yoshihiro Yonekawa","doi":"10.1080/08820538.2024.2440725","DOIUrl":"https://doi.org/10.1080/08820538.2024.2440725","url":null,"abstract":"<p><strong>Introduction and primary objective: </strong>Pediatric rhegmatogenous retinal detachment (RRD) presents unique challenges in diagnosis and management. A thorough evaluation of family, medical, and ocular history is helpful, as systemic and genetic conditions can predispose children to RRD. Trauma, high myopia, and history of prematurity are also common risk factors. Examining young children in the outpatient setting may have limitations, but the yield can be maximized by modifying examination techniques and utilizing imaging technologies. In this manscript, the considerations for diagnosis and management of pediatric rhegmatogenous retinal detachment are outlined.</p><p><strong>Conclusions: </strong>Primary scleral buckling is the treatment of choice for the vast majority of pediatric RRDs, as it offers a higher single surgery success rate in these young eyes with firmly adherent posterior hyaloid. Primary vitrectomy is not recommended due to this reason. Scleral buckling is the mainstay of pediatric RRD surgery, even in cases that may typically undergo vitrectomy in adults. Prophylactic treatment of the fellow eye may also be warranted in certain clinical scenarios. Understanding the unique challenges these patients face is important for early diagnosis, timely intervention, and tailored surgical strategies to optimize visual outcomes in this vulnerable patient population.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-5"},"PeriodicalIF":1.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143011064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of Consumer Product-Related Ocular Injuries in the Incarcerated Population.","authors":"David Mothy, Hassaam S Choudhry, Aneesh P Reddy, Mohammad H Dastjerdi","doi":"10.1080/08820538.2025.2450685","DOIUrl":"https://doi.org/10.1080/08820538.2025.2450685","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize the epidemiology of consumer product-related ocular injury in the United States (US) incarcerated population, and identify preventable causes.</p><p><strong>Methods: </strong>The National Electronic Injury Surveillance System (NEISS) database was queried for cases of eye injury from 2014 to 2023. Incarcerated cases were identified using the keywords \"prison\", \"jail\", \"inmate\", and \"incarcerate\". Year of injury, diagnosis, product code, and demographic information were gathered and compared between the incarcerated and general US populations using SPSS version 29 (IBM Corp.). A narrative analysis categorized cases of ocular trauma in the incarcerated by common causes of injury.</p><p><strong>Results: </strong>Between 2014 and 2023, there were an estimated 1,644,841 cases of consumer-product related ocular injury the US, with 2683 cases occurring in the incarcerated. A higher percentage of ocular injury cases in the incarcerated involved African American individuals (43.42% vs. 17.18%), males (92.22% vs 68.54%), alcohol use (4.11% vs. 0.64%), drug use (3.91% vs. 0.82%), and hospitalization (4.96% vs. 1.39%). Contusions were less common in the incarcerated population (27.21% vs. 41.31%), while foreign body injuries were more common (24.38% vs. 18.75%). Penal labor, including cleaning (13.74%), welding (8.25%), yardwork (5.92%), and power grinding (5.72%), accounted for 36.36% of injuries. 26.50% of injuries were sports-related, with basketball involved in 16.82%.</p><p><strong>Conclusions: </strong>The epidemiology of ocular injury in the incarcerated differs from the general US population. Penal labor and sports-related ocular injury represent a majority of cases, underscoring the need for protective eyewear.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-6"},"PeriodicalIF":1.9,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}