Linda A Cernichiaro-Espinosa, Benjamin A King, David Taylor Gonzalez, Cigdem Ozturk, Aleksander Kruglov, Rachel C Brennan, Ibrahim Qaddoumi, Carlos Rodriguez-Galindo, Matthew W Wilson, Mary E Hoehn
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Delayed Periocular and Anterior Segment Complications Following Locally Administered Chemotherapy for Vitreous Seeding in Retinoblastoma.
Background: Long-term follow-up is essential for retinoblastoma survivors, as treatment-related sequelae can emerge years after therapy.
Methods: This case series reviews 67 eyes treated with periocular and/or intravitreal chemotherapy from 2005 through 2020.
Results: Periocular chemotherapy was associated with orbital fibrosis in 79.1% of cases, with risk increasing concomitantly with the number of injections. Cataracts developed in 19.4% of eyes, with 10 out of 13 requiring cataract extraction. Other complications included chronic conjunctivitis and limbal stem cell deficiency (3% each), while strabismus was observed in 29.9% of which 7.5% underwent strabismus surgery. Comparative analyses of periocular and anterior segment complications from other retrospective studies are included to contextualize our findings.
Conclusions: Understanding these long-term sequelae is crucial for appropriately following and managing retinoblastoma survivors who were treated during this era. We highlight the importance of vigilant surveillance as treatment protocols continue to evolve.
期刊介绍：
Seminars in Ophthalmology offers current, clinically oriented reviews on the diagnosis and treatment of ophthalmic disorders. Each issue focuses on a single topic, with a primary emphasis on appropriate surgical techniques.
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