泪膜和干眼症特征是 374 名干眼症患者畏光的预测因素。

IF 1.9 4区医学 Q2 OPHTHALMOLOGY

Seminars in Ophthalmology Pub Date : 2024-11-19 DOI:10.1080/08820538.2024.2429630

Swati Singh, Moumi Maity, Md Hasnat Ali, Sayan Basu

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引用次数: 0

摘要

目的：评估与干眼症（DED）畏光相关的泪膜参数：使用 Oculus keratograph 5 M（TMH、NIBUT、Meibography）、Lipiview 干涉仪（LLT）和 TearLab 渗透压系统对 374 名 DED 患者（平均年龄为 42.2 ± 12.8 岁）的泪膜和 OSDI 评分进行评估。通过多变量逻辑回归分析，使用 OSDI 表中的畏光评分计算几率。结果：374人中，127人患有缺水性干眼症（ADE），247人患有蒸发性干眼症。畏光患者与无畏光或轻度畏光患者的平均年龄、女性性别、Schirmer I、TMH、NIBUT、LLT 和泪液渗透压值分别为 42.2 岁 vs. 40.9 岁、42% vs. 40%、11.6 mm vs. 10.5 mm、0.27 mm vs. 0.29 mm、4.6 vs. 4.7s、60.3 nm vs. 60.9 nm 和 305 mOsm/L vs. 307 mOsm/L。多变量分析显示，蒸发性 DED 患者的泪膜参数不能预测畏光症状，而 ADDE 患者的泪液渗透压与畏光症状呈弱负相关（几率比 0.96，95% C.I，0.92-1，p = .04）：结论：泪膜参数不能预测 DED 患者是否存在畏光症状，但与 ADDE 患者的泪液渗透压有微弱的负相关。结论：泪膜参数不能预测 DED 患者是否畏光，但与 ADDE 患者的泪液渗透压有微弱的反向关系。这表明中枢敏感性在调节 DED 患者的畏光中起着重要作用。

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Tear Film and Dry Eye Characteristics as Predictors of Photophobia in 374 Patients with Dry Eye Disease.

Purpose: To assess the tear film parameters associated with photophobia in dry eye disease (DED).

Methods: Three hundred seventy-four patients with DED (mean age, 42.2 ± 12.8 years) had their tear film and OSDI scores evaluated using Oculus keratograph 5 M (TMH, NIBUT, Meibography), Lipiview interferometer (LLT), and TearLab osmolarity system. Photophobia scoring from OSDI sheets was used to calculate the odds ratio via multivariate logistic regression analysis. Data from the eye with severely affected NIBUT was used.

Results: Of 374, 127 had aqueous deficient dry eye disease (ADDE), and 247 had evaporative DED. The mean age, female sex, Schirmer I, TMH, NIBUT, LLT, and tear osmolarity values in patients with photophobia versus no or mild photophobia were 42.2. vs. 40.9 years, 42% vs. 40%, 11.6 vs. 10.5 mm, 0.27 vs. 0.29 mm, 4.6 vs. 4.7s, 60.3 vs. 60.9 nm and 305 vs. 307 mOsm/L, respectively. Multivariate analysis revealed no tear film parameters predictive of photophobia in evaporative DED, whereas tear osmolarity had a weak negative association with photophobia (odds ratio of 0.96, 95% C.I, 0.92-1, p = .04) in ADDE patients.

Conclusion: Tear film parameters do not predict the presence or absence of photophobia in DED except for a weak inverse association with tear osmolarity in ADDE. This suggests the role of central sensitization in regulating photophobia in DED patients.

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来源期刊

Seminars in Ophthalmology OPHTHALMOLOGY-

CiteScore

3.20

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Seminars in Ophthalmology offers current, clinically oriented reviews on the diagnosis and treatment of ophthalmic disorders. Each issue focuses on a single topic, with a primary emphasis on appropriate surgical techniques.