Vitrectomy Combined with Repeated Intravitreal Injection of Ceftazidime for the Treatment of Brucellosis Endophthalmitis: A Case Report and Literature Review.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-03 DOI:10.1080/08820538.2024.2412050

Nan Guo, Yu-Jia Gui, Ying Chen

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引用次数: 0

Abstract

Purpose: To present a treatment regimen for Brucellosis endophthalmitis that resulted in a good visual outcome. Additionally, we conducted a literature review on the treatment and visual prognosis of related cases.

Case presentation: A 49-year-old woman with the chief complaint of decreased vision and redness in the right eye was initially diagnosed with noninfectious uveitis and prescribed high-dose steroids which led to transient improvement followed by a decline in vision. An infectious cause was suspected. Metagenomic next-generation sequencing of vitreous fluid and serological testing confirmed Brucella melitensis infection. The patient underwent vitrectomy combined with six intravitreal injections of ceftazidime in the right eye in addition to systemic antibiotic treatment. The intraocular inflammation was completely resolved, and the visual acuity recovered to 20/25, which is the best-documented recovery in Brucella endophthalmitis cases, as revealed by the literature review.

Conclusion: Vitrectomy combined with repeated intravitreal injections of ceftazidime can enhance the treatment for brucellosis endophthalmitis and achieve a better visual prognosis.

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玻璃体切割联合重复玻璃体内注射头孢唑肟治疗布鲁氏菌病眼内炎：病例报告与文献综述。

目的：介绍一种治疗布鲁氏菌眼内炎的方案，该方案可获得良好的视觉效果。此外，我们还对相关病例的治疗和视觉预后进行了文献综述：一名 49 岁的女性，主诉为视力下降和右眼发红，起初被诊断为非感染性葡萄膜炎，医生给她开了大剂量类固醇，结果一过性好转，随后视力下降。怀疑是感染所致。玻璃体液的元基因组下一代测序和血清学检测证实了布鲁氏菌感染。患者接受了玻璃体切除术，除了全身抗生素治疗外，还在右眼进行了六次头孢他啶玻璃体内注射。眼内炎症完全消退，视力恢复到 20/25，这是文献综述显示的布鲁氏菌眼内炎病例中恢复最好的记录：结论：玻璃体切割联合反复玻璃体内注射头孢唑肟可提高布鲁氏菌眼内炎的治疗效果，并获得更好的视力预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.