{"title":"[Respiratory mucus: Exploring its viscoelastic properties and their relationship with mucociliary clearance abnormalities].","authors":"T Bonneault, C Sallon, C Taillé, S Létuvé","doi":"10.1016/j.rmr.2026.09.001","DOIUrl":"https://doi.org/10.1016/j.rmr.2026.09.001","url":null,"abstract":"<p><p>Following an introduction on the structure and function of the respiratory mucus, we describe the viscoelastic properties of mucus, a key determinant of mucociliary clearance, along with the types of measurement devices most commonly used in laboratories. More specifically, this review presents macro- and micro-rheological methods for characterization of the respiratory mucus by means of small sample volumes. We discuss how study of the viscoelastic properties of mucus facilitates understanding of mucus abnormalities in respiratory muco-obstructive diseases and paves the way for the development of therapies effectively targeting mucin cross-linking molecules in view of enhancing patient management.</p>","PeriodicalId":21548,"journal":{"name":"Revue des maladies respiratoires","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149017997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J-M Perotin, L Guilleminault, C Chenivesse, J-P Oster, L Portel, G Garcia, E Blanchard, G Peiffer, J Perriot, A Bourdin, J-F Papon, G Chassagnon, E Burnet, V Doyen, C Taille, C Barnig
{"title":"[French guidelines for severe asthma management].","authors":"J-M Perotin, L Guilleminault, C Chenivesse, J-P Oster, L Portel, G Garcia, E Blanchard, G Peiffer, J Perriot, A Bourdin, J-F Papon, G Chassagnon, E Burnet, V Doyen, C Taille, C Barnig","doi":"10.1016/j.rmr.2026.07.005","DOIUrl":"https://doi.org/10.1016/j.rmr.2026.07.005","url":null,"abstract":"","PeriodicalId":21548,"journal":{"name":"Revue des maladies respiratoires","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148797640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Toward novel therapeutic strategies: Targeting the extracellular matrix to broaden the therapeutic window].","authors":"S Kunz, L Seguin, C C Féral","doi":"10.1016/j.rmr.2026.07.006","DOIUrl":"https://doi.org/10.1016/j.rmr.2026.07.006","url":null,"abstract":"<p><p>Lung cancer is a major public health concern, ranking as the third most common cancer in women and the second in men, entailing significant mortality. Immune checkpoint inhibitors (ICIs, anti-PD-1/PD-L1) have transformed the treatment of advanced lung adenocarcinoma, thereby prolonging survival. However, many patients develop therapeutic resistance. Increased stiffness of the extracellular matrix (ECM) of the tumor represents a critical obstacle to immunotherapy efficacy, limiting lymphocyte infiltration. Modulation through integrins of the mechanical properties of the ECM could restore immune accessibility and potentiate ICIs, opening new therapeutic perspectives for treatment of advanced lung cancer.</p>","PeriodicalId":21548,"journal":{"name":"Revue des maladies respiratoires","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K Thiam, B El Bérichi, N Ben Oualid, F B R Mbaye, P M Soumaré, M F Cissé, Y Dia Kane, N O Touré
{"title":"[Pleural sarcoidosis: A diagnostic challenge in countries with high tuberculosis prevalence].","authors":"K Thiam, B El Bérichi, N Ben Oualid, F B R Mbaye, P M Soumaré, M F Cissé, Y Dia Kane, N O Touré","doi":"10.1016/j.rmr.2026.07.002","DOIUrl":"https://doi.org/10.1016/j.rmr.2026.07.002","url":null,"abstract":"<p><p>A 70-year-old female patient presented with exudative, lymphocytic left-sided pleural effusion. Blind pleural biopsy histology revealed granuloma without caseous necrosis. Oral corticosteroid therapy was well tolerated and proved effective following one month of treatment.</p>","PeriodicalId":21548,"journal":{"name":"Revue des maladies respiratoires","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148707514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C Brasseur, I Ba, P Revy, C Kannengiesser, A Guyard, T Baccary, M Jaillet, A A Mailleux, B Crestani, R Borie, Q Philippot
{"title":"[Pathophysiology of pulmonary fibrosis associated with monogenic defects of telomere homeostasis].","authors":"C Brasseur, I Ba, P Revy, C Kannengiesser, A Guyard, T Baccary, M Jaillet, A A Mailleux, B Crestani, R Borie, Q Philippot","doi":"10.1016/j.rmr.2026.07.010","DOIUrl":"https://doi.org/10.1016/j.rmr.2026.07.010","url":null,"abstract":"<p><p>Fibrosing interstitial lung diseases, including idiopathic pulmonary fibrosis (IPF), are frequently associated with abnormalities in telomere homeostasis. Heterozygous pathogenic variants in telomere-related genes (TRGs) are found in 20-35% of patients with familial pulmonary fibrosis. These genetic defects are associated with impaired telomere homeostasis, which can lead to cellular senescence. Type II pneumocytes, the progenitor cells of the alveolar epithelium, are particularly sensitive to these genetic defects. Their senescence disrupts alveolar regeneration and promotes fibrosis by the production of profibrotic mediators. Autosomal dominant PARN deficiency provides a model for understanding the molecular mechanisms underlying pulmonary fibrosis associated with monogenic defects in telomere homeostasis, and developing targeted therapies.</p>","PeriodicalId":21548,"journal":{"name":"Revue des maladies respiratoires","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148707554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[The role and utilization of transcutaneous capnography in respiratory failure patients. Chronicles: A review of the literature and an expert opinion].","authors":"L Grassion, M Delorme, J P Janssens","doi":"10.1016/j.rmr.2026.07.003","DOIUrl":"https://doi.org/10.1016/j.rmr.2026.07.003","url":null,"abstract":"<p><strong>Introduction: </strong>Transcutaneous capnography (P<sub>tc</sub>CO<sub>2</sub>) provides a non-invasive estimate of partial arterial pressure of carbon dioxide in the blood and is an increasingly widely used tool for assessing alveolar hypoventilation, particularly nocturnal hypoventilation, in patients with chronic respiratory failure. That much said, its reliability in clinical practice requires satisfactory understanding of the relevant technical principles, conditions of implementation, and analysis methods.</p><p><strong>Methods of analysis: </strong>This work is based on expert opinions from the Ventilatory Assistance and Oxygen Therapy Group (GAVO<sub>2</sub>) of the French-speaking Pulmonology Society (SPLF). The data available in the literature were analyzed and discussed in view of providing practical advice on the performance, analysis, and interpretation of nocturnal P<sub>tc</sub>CO<sub>2</sub> recordings in adults.</p><p><strong>Results: </strong>Under optimal technical conditions, P<sub>tc</sub>CO<sub>2</sub> correlates well with PaCO<sub>2</sub>, with bias generally lower than 0.5kPa. The quality of recording is a determining factor and depends on proper sensor placement, continuous recording for a sufficient amount of time, and prior analysis of the curves aimed at identifying artifacts and measurement drifts. Definitions of nocturnal hypoventilation based on P<sub>tc</sub>CO<sub>2</sub> remain heterogeneous and are based primarily on expert opinion.</p><p><strong>Conclusion: </strong>Transcutaneous capnography is a relevant non-invasive tool ensuring assessment of alveolar hypoventilation in adults with chronic respiratory failure, provided that the technical and interpretative aspects are fully mastered and rigorously applied. It should complement blood gases as part and parcel of a comprehensive clinical approach.</p>","PeriodicalId":21548,"journal":{"name":"Revue des maladies respiratoires","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148689899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Imaging of the diaphragm: A multimodal approach, and the role of MRI].","authors":"S Boussouar, A Redheuil","doi":"10.1016/j.rmr.2026.07.004","DOIUrl":"https://doi.org/10.1016/j.rmr.2026.07.004","url":null,"abstract":"<p><p>As the primary muscle of ventilation, the diaphragm is potentially involved in a wide range of acute and chronic respiratory conditions. However, diaphragmatic dysfunction often remains underrecognized because of its non-specific clinical presentation, which may include exertional dyspnea, orthopnea, functional limitation, and/or respiratory failure. Exploration relies on a multimodal approach combining clinical assessment, pulmonary function testing, and imaging. Chest radiography is often the first imaging study to raise suspicion of diaphragmatic abnormalities. Given its accessibility and ease of use, ultrasound has evolved into the main first-line dynamic imaging modality. Computed tomography remains essential to morphological and etiological assessment, particularly when phrenic nerve involvement is suspected. Dynamic magnetic resonance imaging ensures a comprehensive, non-ionizing, three-dimensional evaluation of diaphragmatic morphology and kinetics. The following review presents a practical approach to diaphragm imaging, from the clinical situations that should raise suspicion of diaphragmatic disease to the appropriate selection of functional and morphological imaging modalities. Recent developments in dynamic and quantitative imaging are highlighted.</p>","PeriodicalId":21548,"journal":{"name":"Revue des maladies respiratoires","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148689785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[The key role of chest CT in severe asthma phenotyping].","authors":"M-P Debray, C Taillé","doi":"10.1016/j.rmr.2026.06.003","DOIUrl":"https://doi.org/10.1016/j.rmr.2026.06.003","url":null,"abstract":"<p><p>Before initiating biological therapy, chest CT is indicated as a means of initial evaluation of severe asthma. While its primary role is to identify potential differential diagnoses, it concomitantly provides information effectively contributing to asthma phenotyping. In routine practice, analysis focuses on bronchial wall thickening, of which the extent correlates with disease severity and degree of bronchial obstruction. In cases of severe asthma, absent wall thickening is unusual, and may prompt a search for either an alternative diagnosis, or potential comorbidities such as rhinosinusitis, which may be symptomatic. Assessment of expiratory air trapping is useful in the event of fixed obstructive ventilatory impairment, of which the extent correlates with the degree of bronchial obstruction. Pathobiology of mucus plugs, a phenotyping tool regarding T2 inflammation and a marker of severity, has recently drawn increased interest. The density of these plugs should be analysed, given that spontaneous hyperattenuation, most often within dilated bronchi, facilitates establishment of the diagnosis of allergic bronchopulmonary aspergillosis. To sum up, investigation of bronchial wall thickening, expiratory air trapping, and mucus plugs represent potential means of assessing treatment response.</p>","PeriodicalId":21548,"journal":{"name":"Revue des maladies respiratoires","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148689737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N Adrouche, V Bunger, C Ribet, W Alkoussa, S Marshal, C Josserand, M Baqué-Juston, K Risso, E Chamorey, F Vandenbos
{"title":"[Screening of children residing in the same household as patients with contagious tuberculosis].","authors":"N Adrouche, V Bunger, C Ribet, W Alkoussa, S Marshal, C Josserand, M Baqué-Juston, K Risso, E Chamorey, F Vandenbos","doi":"10.1016/j.rmr.2026.05.007","DOIUrl":"https://doi.org/10.1016/j.rmr.2026.05.007","url":null,"abstract":"<p><strong>Introduction: </strong>Children are particularly vulnerable to tuberculosis. We report on the results of screenings conducted among children residing in tuberculosis patients' households.</p><p><strong>Materials and methods: </strong>This was a retrospective study conducted at the Alpes-Maritimes tuberculosis control centre between January 2023 and December 2025.</p><p><strong>Results: </strong>During this period, 60 children were screened across 36 different contact investigations. All of them shared a household with the index case (IC). Median age was 8 years, with 27 boys and 33 girls. Among the 60 children, screening identified 12 (20%) cases of active tuberculosis (TB disease) and 21 (35%) cases of latent tuberculosis infection (LTBI). Risk factors (P<0.05) for TB disease were age<5 years and sleeping in the same room as the IC. Risk factors (P<0.05) for LTBI were a positive sputum smear and/or cavitation in the IC, and another case of TB disease or LTBI within the household.</p><p><strong>Conclusion: </strong>Children residing in the same household as patients with contagious pulmonary tuberculosis bear a substantial burden regarding this contagious disease.</p>","PeriodicalId":21548,"journal":{"name":"Revue des maladies respiratoires","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148405814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[French version of the guidelines for connective tissue disease-associated ILD].","authors":"D Taïeb, M Zerari, C Diou, Y Uzunhan","doi":"10.1016/j.rmr.2026.05.006","DOIUrl":"https://doi.org/10.1016/j.rmr.2026.05.006","url":null,"abstract":"","PeriodicalId":21548,"journal":{"name":"Revue des maladies respiratoires","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148219604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}