S Gephine, O Le Rouzic, F Alexandre, D Bajon, M Beaumont, A Bellocq, F Caron, C Chenivesse, B Chehere, Y Darolles, M Decavele, B Degano, J Delemazure, R Gauthier, J Gonzalez-Bermejo, V Gounant, M Guecamburu, A Guerder, L Hajouji, M Hayot, N Heraud, F Herengt, A Lino, A Martin, F Maltais, H Ouksel, J Pernot, G Prieur, G Reychler, S Stelianides, E Villot Danger, M Zysman, F Costes, J M Grosbois
{"title":"[Pulmonary rehabilitation: A 2026 updated expert consensus].","authors":"S Gephine, O Le Rouzic, F Alexandre, D Bajon, M Beaumont, A Bellocq, F Caron, C Chenivesse, B Chehere, Y Darolles, M Decavele, B Degano, J Delemazure, R Gauthier, J Gonzalez-Bermejo, V Gounant, M Guecamburu, A Guerder, L Hajouji, M Hayot, N Heraud, F Herengt, A Lino, A Martin, F Maltais, H Ouksel, J Pernot, G Prieur, G Reychler, S Stelianides, E Villot Danger, M Zysman, F Costes, J M Grosbois","doi":"10.1016/j.rmr.2026.09.007","DOIUrl":"https://doi.org/10.1016/j.rmr.2026.09.007","url":null,"abstract":"<p><strong>Introduction: </strong>The effectiveness of pulmonary rehabilitation (PR) in chronic obstructive pulmonary disease is supported by a high level of evidence. More recently, the indications for PR have expanded and new models of care have emerged.</p><p><strong>State of art: </strong>This position statement summarizes recent evidence on PR regarding: 1) its objectives; 2) the key outcomes to be assessed at baseline, during, and at the end of the program, along with the recommended assessment tools; 3) its integration within the care pathway; 4) modalities of implementation, including home-based programs, telerehabilitation, and hybrid formats; 5) its core components, based on therapeutic education (including psychosocial and motivational support), exercise training, and adapted physical activity; and 6) the strategies and professionals involved in maintaining long-term benefits.</p><p><strong>Perspectives: </strong>The extension of PR indications to other respiratory conditions (interstitial lung diseases, pulmonary hypertension, thoracic oncology) and the development of new delivery models are expected to facilitate PR access.</p><p><strong>Conclusion: </strong>This position statement from French-speaking experts aims to support greater recognition of PR and to promote its integration into patient care pathways.</p>","PeriodicalId":21548,"journal":{"name":"Revue des maladies respiratoires","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F Garcin, G O Tsiambanizafy, A Pirvu, G Dubois, S Blaise
{"title":"[When pulmonary sequestration is hidden behind arteriovenous pulmonary malformation].","authors":"F Garcin, G O Tsiambanizafy, A Pirvu, G Dubois, S Blaise","doi":"10.1016/j.rmr.2026.09.004","DOIUrl":"https://doi.org/10.1016/j.rmr.2026.09.004","url":null,"abstract":"<p><p>A 33-year-old patient was stabbed, causing a perforating thoracic wound complicated by cardiorespiratory arrest due to hemorrhagic shock. Emergency surgery was performed with hemostatic and resuscitative bithoracotomy, revealing an incidental lesion suspected of being a pulmonary arteriovenous malformation (PAVM). This lesion being organized, and following embolization of the abnormal arteries arising from the descending thoracic aorta which were causing a systemic-pulmonary shunt, left lower lobectomy was performed. After anatomopathological study, a diagnosis of intralobar pulmonary sequestration was established. Pulmonary sequestration is not included in the international classification of vascular abnormalities. It is defined as a condition in which parts of pulmonary tissue are irrigated by an abnormal systemic artery. There exist two forms of pulmonary sequestration: intralobar and extralobar. Contrarily to most arteriovenous malformations, surgical excision is generally recommended, even though transcatheter embolization could be considered as an option in specific situations. Differential diagnosis of PAVM is difficult and raises questions on risks of progression, which differ between the two pathologies. While transcatheter embolization is a key component of PAVM treatment, radical surgery is usually required for pulmonary sequestration.</p>","PeriodicalId":21548,"journal":{"name":"Revue des maladies respiratoires","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149184343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Management of pulmonary infections due to non-Aspergillus filamentous fungi].","authors":"L Chantelot, É Sitterle, G Reichert, A Serris","doi":"10.1016/j.rmr.2026.07.011","DOIUrl":"https://doi.org/10.1016/j.rmr.2026.07.011","url":null,"abstract":"<p><p>Given the increased complexity of immunosuppressive treatments, the prolonged survival of immunocompromised patients, and widespread use of anti-Aspergillus prophylaxis, over recent years the incidence of pulmonary infections caused by non-Aspergillus filamentous fungi has increased. Mucorales represent the most frequently isolated group, followed by Fusarium and Scedosporium, with prevalence varying significantly in different geographic regions and clinical contexts. Although overall incidence remains low, intrinsic resistance to many antifungal agents markedly heightens the mortality associated with these infections. Generally medical as well as surgical, management comprises immunosuppression reduction whenever possible. In this context, enhanced understanding of the epidemiological, diagnostic, and therapeutic characteristics of these rare fungi is essential to achievement of improved patient outcomes.</p>","PeriodicalId":21548,"journal":{"name":"Revue des maladies respiratoires","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[What role do corticosteroids play in the treatment of community-acquired pneumonia?]","authors":"P-F Dequin","doi":"10.1016/j.rmr.2026.09.006","DOIUrl":"https://doi.org/10.1016/j.rmr.2026.09.006","url":null,"abstract":"<p><p>Some of the immediate, medium-term, and long-term complications of acute community-acquired pneumonia are correlated with the degree of inflammation in the initial phase, particularly when it is dysregulated. Among the treatments designed to control this inflammation, corticosteroid therapy has been the most extensively studied. Randomized trials conducted in hospitalized patients have generally shown faster improvement with corticosteroids and prevention of subsequent worsening. In patients admitted to intensive care units, and despite conflicting trial results, meta-analyses conclude - with a low level of evidence - that there is a reduction in one-month mortality without an increase in the incidence of hospital-acquired infections. The incidence of hyperglycemia is increased with corticosteroid therapy and is likely a barrier to their use outside of intensive care units. In influenza, data from observational studies suggest excess mortality and lead to the contraindication of corticosteroids outside of therapeutic trials. In the future, treatment will likely need to be individualized based on clinical and biologic parameters, particularly the inflammatory syndrome and immunological phenotyping.</p>","PeriodicalId":21548,"journal":{"name":"Revue des maladies respiratoires","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E Driencourt, B Daunou, L Massara, A Ollivier, G Kervoaze, C Godart, M Djouina, M Body-Malapel, P Gosset, M Pichavant
{"title":"[The impact of post-exposure Streptococcus pneumoniae infections on pulmonary immunity: The role of air pollution and IL-20 cytokines in respiratory infections].","authors":"E Driencourt, B Daunou, L Massara, A Ollivier, G Kervoaze, C Godart, M Djouina, M Body-Malapel, P Gosset, M Pichavant","doi":"10.1016/j.rmr.2026.07.009","DOIUrl":"https://doi.org/10.1016/j.rmr.2026.07.009","url":null,"abstract":"<p><p>Air pollution is responsible for more than 9 million premature deaths a year, including 48,000 in France. Fine particles (PM2.5), derived mainly from urban traffic, penetrate deeply into the lungs and trigger oxidative stress and inflammation, their key mechanisms of toxicity. They contribute to cardiorespiratory and systemic damage, increasing the risk of asthma attacks, chronic obstructive pulmonary disease (COPD) exacerbations, and respiratory infections. It is therefore essential, using experimental models, to decipher the mechanisms underlying these infection-related vulnerabilities, the objectives being to better understand the impact of PM2.5 on pulmonary immunity and to limit the repercussions of air pollution.</p>","PeriodicalId":21548,"journal":{"name":"Revue des maladies respiratoires","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L Massara, G Kervoaze, A Ollivier, M Pichavant, L Saber-Cherif, S Pons, U Maskos, V Dormoy, P Gosset
{"title":"[Nicotinic receptor polymorphism amplifies cigarette smoke-induced inflammation in COPD, a silent epidemic].","authors":"L Massara, G Kervoaze, A Ollivier, M Pichavant, L Saber-Cherif, S Pons, U Maskos, V Dormoy, P Gosset","doi":"10.1016/j.rmr.2026.07.008","DOIUrl":"https://doi.org/10.1016/j.rmr.2026.07.008","url":null,"abstract":"<p><p>Chronic obstructive pulmonary disease (COPD) is the third leading cause of mortality and morbidity. Recent studies on genetic polymorphism highlight the CHRNA5/3/B4 locus, coding for nicotinic subunit receptors such as rs16969968 polymorphism (α5SNP), as genetic determinants of pulmonary vulnerability, acting independently of smoking intensity. We have demonstrated that altered α5 nicotinic receptor expression influences epithelial differentiation, promotes inflammation, and drives airway remodeling. These findings point to a functional role of the pulmonary nicotinic system in COPD pathogenesis and underline the need for precision medicine approaches combining genetic, environmental, and clinical markers so as to better predict disease risk and develop relevant preventive strategies.</p>","PeriodicalId":21548,"journal":{"name":"Revue des maladies respiratoires","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L Gassiat, I Gauthereau, G Cardouat, P Robillard, C M Pilard, B Pere, E Dumas-De-La-Roque, F Sauvestre, F Pelluard, S Berenguer, L Sentilhes, F Coatleven, M Vincienne, P Berger, C Guibert
{"title":"[The role of thrombomodulin in pulmonary hypertension associated with bronchopulmonary dysplasia in preterm infants].","authors":"L Gassiat, I Gauthereau, G Cardouat, P Robillard, C M Pilard, B Pere, E Dumas-De-La-Roque, F Sauvestre, F Pelluard, S Berenguer, L Sentilhes, F Coatleven, M Vincienne, P Berger, C Guibert","doi":"10.1016/j.rmr.2026.07.007","DOIUrl":"https://doi.org/10.1016/j.rmr.2026.07.007","url":null,"abstract":"<p><p>Bronchopulmonary dysplasia (BPD) is the most common chronic respiratory disease in premature newborns born before 32 weeks of gestation. It is characterized by arrested lung growth (hypoalveolarization), rarefaction of microvascularisation (hypoangiogenesis), and inflammation. BPD can be complicated by pulmonary hypertension (PH-BPD), which increases the mortality rate by nearly 50% within two years after diagnosis. Thrombomodulin is a glycoprotein mainly expressed on vascular endothelial cells. It plays a central role in hemostasis, but also contributes to inflammation and angiogenesis and is used as a biomarker in certain cardiopulmonary pathologies. Deregulation of its expression may therefore play an important role in the development of inflammatory diseases and/or angiogenesis defects, such as PH-BPD.</p>","PeriodicalId":21548,"journal":{"name":"Revue des maladies respiratoires","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149017977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I Mansouri, D Benchaji, A Errami, S Zridi, F Ailal, J El Bakkouri, I Benhsaien, F Adnane, S Salam, A A Bousfiha, N Amenzoui
{"title":"[Bronchiectasis in children: An underdiagnosed disease with accessible screening and etiological assessment].","authors":"I Mansouri, D Benchaji, A Errami, S Zridi, F Ailal, J El Bakkouri, I Benhsaien, F Adnane, S Salam, A A Bousfiha, N Amenzoui","doi":"10.1016/j.rmr.2026.07.001","DOIUrl":"https://doi.org/10.1016/j.rmr.2026.07.001","url":null,"abstract":"<p><p>Long considered as a rare and neglected disease, non-cystic fibrosis bronchiectasis in children is now recognized as an emerging cause of chronic respiratory morbidity worldwide. Its incidence is strikingly variable, ranging from 0.2-2.3 per 100,000 children annually in high-income countries to more than 700 per 100,000 in some groups of children living in highly deprived socio-economic settings. Recent data from the Child-BEAR-Net international registry confirm the predominance of post-infectious forms (∼30%) and immunodeficiencies (∼20%), while also highlighting the role of primary ciliary dyskinesia (∼10-15%) and rarer etiologies such as congenital malformations or allergic bronchopulmonary aspergillosis. In low-resource settings, pediatric bronchiectasis remains underdiagnosed and frequently misinterpreted as asthma or tuberculosis, leading to delayed management and worsened bronchial damage. However, unlike in adults, the pediatric bronchial tree retains capacity for remodeling, and if promptly treated, early lesions may regress. Recognizing chronic productive cough as a cardinal symptom, combined with early screening and a multidisciplinary approach (respiratory physiotherapy, targeted antibiotic therapy, immunoglobulin replacement, and nutritional support), can significantly improve outcomes. Future priorities include dissemination of international guidelines (ERS 2021), establishment of national registries, and development of screening programs tailored to low-resource contexts. Some forms of pediatric bronchiectasis, particularly post-infectious forms, may be preventable, and early lesions in selected children may improve following timely diagnosis and management.</p>","PeriodicalId":21548,"journal":{"name":"Revue des maladies respiratoires","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149017928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Role of energy metabolism in pediatric asthma].","authors":"E Celle, T Trian, P Esteves","doi":"10.1016/j.rmr.2026.09.002","DOIUrl":"https://doi.org/10.1016/j.rmr.2026.09.002","url":null,"abstract":"<p><p>Asthma, which is the most common chronic respiratory disease in children, results from complex interactions between genetic factors, immune responses and environmental stimuli. Increasing evidence highlights energy metabolism and mitochondrial function as major contributors to the pathophysiology of pediatric asthma. Several mitochondrial genes have been identified as potential biomarkers associated with the disease, and at the cellular level, mitochondrial dysfunction has been linked to bronchial smooth muscle remodeling, one of the key aspects of disease severity. Taken together, these insights underscore the importance of characterizing energy metabolism and mitochondrial function in view of identifying new therapeutic targets for pediatric asthma.</p>","PeriodicalId":21548,"journal":{"name":"Revue des maladies respiratoires","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149018011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G Perceval, G Riley, L Schnedecker, J Staentzel, G Treffel
{"title":"[Paraganglioma diagnosed by EBUS-TBNA: A case report].","authors":"G Perceval, G Riley, L Schnedecker, J Staentzel, G Treffel","doi":"10.1016/j.rmr.2026.05.008","DOIUrl":"https://doi.org/10.1016/j.rmr.2026.05.008","url":null,"abstract":"<p><strong>Introduction: </strong>Paragangliomas are rare neuroendocrine tumors occasionally found in the mediastinum. A characteristic CT presentation suffices to raise suspicions. Biopsy specimens are usually avoided, and diagnosis is generally based on a combination of biological, clinical and iconographic evidence.</p><p><strong>Case report: </strong>We report on the case of an 84-year old female patient without adrenergic signs, who presented with an isolated mid-mediastinal lesion, which was found on FDG-TEP to be hypermetabolic. Its appearance was suggestive of a neuroendocrine tumor or a clear cell renal tumor, leading to investigation by EBUS-TBNA. The cytology aspirations subsequently performed were complicated by moderate bleeding, which was controlled by local instillations of adrenalized serum. An anatomopathological diagnosis of paraganglioma ensued, and was confirmed by further endocrinologic investigations.</p><p><strong>Conclusions: </strong>Notwithstanding its technical feasibility, assessment of mediastinal paragangliomas by EBUS-TBNA may present an increased risk of moderate to severe bleeding. Appropriate safety measures should be considered, as well as diagnosis by non-invasive methods alone.</p>","PeriodicalId":21548,"journal":{"name":"Revue des maladies respiratoires","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149018021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}