Revista de psiquiatria y salud mental最新文献

{"title":"Following a healthy/balanced diet predicts lower anxiety and depression during the COVID-19 pandemic","authors":"Joaquim Radua , Lydia Fortea , Edith Pomarol-Clotet , Eduard Vieta , Miquel Àngel Fullana , Aleix Solanes","doi":"10.1016/j.rpsm.2021.12.004","DOIUrl":"10.1016/j.rpsm.2021.12.004","url":null,"abstract":"","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":null,"pages":null},"PeriodicalIF":9.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8679503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10450816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discontinuation of maintenance electroconvulsive therapy: Lessons learned from the COVID-19 pandemic","authors":"Erika Martínez-Amorós , Pilar Serra , Adriana Bassa , Diego J. Palao , Narcís Cardoner","doi":"10.1016/j.rpsm.2021.07.005","DOIUrl":"10.1016/j.rpsm.2021.07.005","url":null,"abstract":"","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":null,"pages":null},"PeriodicalIF":9.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rpsm.2021.07.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9236221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mejora de la efectividad de la terapia electroconvulsiva mediante la determinación de la profundidad anestésica. Resultados preliminares","authors":"Òscar Alcoverro-Fortuny , Ferran Viñas Usan , Carmen Elena Sanabria , José Emilio Rojo Rodes","doi":"10.1016/j.rpsm.2021.07.006","DOIUrl":"10.1016/j.rpsm.2021.07.006","url":null,"abstract":"","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":null,"pages":null},"PeriodicalIF":9.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39367538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ketamine triggers rapid antidepressant effects by modulating synaptic plasticity in a new depressive-like mouse model based on astrocyte glutamate transporter GLT-1 knockdown in infralimbic cortex","authors":"M. Neus Fullana ,&nbsp;Verónica Paz ,&nbsp;Francesc Artigas ,&nbsp;Analia Bortolozzi","doi":"10.1016/j.rpsm.2021.09.002","DOIUrl":"10.1016/j.rpsm.2021.09.002","url":null,"abstract":"<div><h3>Objective</h3><p>Recently, we reported on a new MDD-like mouse model based on a regionally selective knockdown of astroglial glutamate transporters, GLAST/GLT-1, in infralimbic cortex (IL) which evokes widespread changes in mouse brain associated with the typical alterations found in MDD patients. To further characterize this new MDD-like mouse model, here we examine some transcriptional elements of glutamatergic/GABAergic neurotransmission and neuroplasticity in forebrain regions in the GLT-1 knockdown mice. Furthermore, we assess the acute ketamine effects on these transcriptional processes.</p></div><div><h3>Material and methods</h3><p>We used a small interfering RNA (siRNA) pool targeting GLT-1 mRNA to disrupt the GLT-1 transcription in mouse IL. Histological assays were performed to examine postsynaptic density protein-95 (PSD95), neuritin (NRN), glutamine acid descarboxilase-65 (GAD65), and GLT-1 mRNA expression in IL and hippocampus.</p></div><div><h3>Results</h3><p>Knockdown of GLT-1 in mouse IL leads to decreased expression of PSD95 and NRN neuroplasticity mRNAs in IL and hippocampus, which was reversed by an acute dose of ketamine antidepressant. Likewise, a single dose of ketamine also increased the mRNA levels of GAD65 and GLT-1 in IL of GLT-1 knockdown mice, reaching the basal values of control mice.</p></div><div><h3>Conclusions</h3><p>The glutamatergic neuronal hyperactivity and deficits in the GABA system resulting from siRNA-induced astroglial glutamate transporter knockdown in IL can compromise the integrity/plasticity of neurocircuits affected in MDD. Suitable depressive-like animal models to address the neurobiological changes in MDD are an unmet need and the development of the GLAST/GLT-1 knockdown mouse model may represent a better option to understand the rapid-acting antidepressant effects of ketamine.</p></div>","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":null,"pages":null},"PeriodicalIF":9.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73992538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Making the most of biomarkers in psychiatry","authors":"Benedicto Crespo-Facorro","doi":"10.1016/j.rpsm.2022.05.001","DOIUrl":"10.1016/j.rpsm.2022.05.001","url":null,"abstract":"","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":null,"pages":null},"PeriodicalIF":9.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72723397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortalidad por COVID-19 y su relación con las búsquedas en internet sobre salud mental durante el primer año de pandemia","authors":"Juan Antonio Becerra-García,&nbsp;Teresa Sánchez-Gutiérrez,&nbsp;Sara Barbeito Resa,&nbsp;Ana Calvo Calvo","doi":"10.1016/j.rpsm.2022.01.005","DOIUrl":"10.1016/j.rpsm.2022.01.005","url":null,"abstract":"","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":null,"pages":null},"PeriodicalIF":9.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8809657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10095539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroimaging correlates of insight in non-affective psychosis: A systematic review and meta-analysis","authors":"Pau Soldevila-Matías ,&nbsp;Georgios Schoretsanitis ,&nbsp;Diana Tordesillas-Gutierrez ,&nbsp;Manuel J. Cuesta ,&nbsp;Renato de Filippis ,&nbsp;Rosa Ayesa-Arriola ,&nbsp;Carlos González-Vivas ,&nbsp;Esther Setién-Suero ,&nbsp;Norma Verdolini ,&nbsp;Julio Sanjuán ,&nbsp;Joaquim Radua ,&nbsp;Benedicto Crespo-Facorro","doi":"10.1016/j.rpsm.2021.07.001","DOIUrl":"10.1016/j.rpsm.2021.07.001","url":null,"abstract":"<div><h3>Objective</h3><p>Neurological correlates of impaired insight in non-affective psychosis remain unclear. This study aimed to review and meta-analyze the studies assessing the grey matter volumetric correlates of impaired insight in non-affective psychosis.</p></div><div><h3>Methods</h3><p>This study consisted of a systematic review of 23 studies, and a meta-analysis with SDM-PSI of the 11 studies that were whole-brain and reported maps or peaks of correlation of studies investigating the grey matter volumetric correlates of insight assessments of non-affective psychosis, PubMed and OVID datasets were independently reviewed for articles reporting neuroimaging correlates of insight in non-affective psychosis. Quality assessment was realized following previous methodological approaches for the ABC quality assessment test of imaging studies, based on two main criteria: the statistical power and the multidimensional assessment of insight. Study peaks of correlation between grey matter volume and insight were used to recreate brain correlation maps.</p></div><div><h3>Results</h3><p>A total of 418 records were identified through database searching. Of these records, twenty-three magnetic resonance imaging (MRI) studies that used different insight scales were included. The quality of the evidence was high in 11 studies, moderate in nine, and low in three. Patients with reduced insight showed decreases in the frontal, temporal (specifically in superior temporal gyrus), precuneus, cingulate, insula, and occipital lobes cortical grey matter volume. The meta-analysis indicated a positive correlation between grey matter volume and insight in the right insula (i.e., the smaller the grey matter, the lower the insight).</p></div><div><h3>Conclusion</h3><p>Several brain areas might be involved in impaired insight in patients with non-affective psychoses. The methodologies employed, such as the applied insight scales, may have contributed to the considerable discrepancies in the findings.</p></div>","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":null,"pages":null},"PeriodicalIF":9.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39191493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"¿Son concluyentes los estudios epidemiológicos de suicidio en España?","authors":"Maite Santurtún ,&nbsp;Ana García Blanco","doi":"10.1016/j.rpsm.2020.10.001","DOIUrl":"10.1016/j.rpsm.2020.10.001","url":null,"abstract":"","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":null,"pages":null},"PeriodicalIF":9.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38505660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Striatal volumes as potential biomarkers in Eating Disorders: A pilot study","authors":"Rosa M. Molina-Ruiz ,&nbsp;Jeffrey C.L. Looi ,&nbsp;Mark Walterfang ,&nbsp;Tomás García-Saiz ,&nbsp;Fiona A. Wilkes ,&nbsp;Lena L. Liu ,&nbsp;Dennis Velakoulis ,&nbsp;Jose Luis Carrasco Perera ,&nbsp;Marina Diaz-Marsa","doi":"10.1016/j.rpsm.2020.01.003","DOIUrl":"10.1016/j.rpsm.2020.01.003","url":null,"abstract":"<div><h3>Introduction</h3><p>Differences in bulimic and impulsive behaviours in Eating Disorders (ED) have been associated with cortico-striatal circuit dysfunction at a neurobiological level. We sought to investigate neo-striatal volume as a biomarker in ED subgroups as well as the possible relationship with trauma history.</p></div><div><h3>Material and methods</h3><p>We studied 24 female patients: Anorexia Nervosa AN (<em>n</em> <!-->=<!--> <!-->8), Bulimia Nervosa BN (<em>n</em> <!-->=<!--> <!-->9), comorbid ED with borderline personality disorder (EDc; <em>n</em> <!-->=<!--> <!-->7), and a group of Healthy Controls (<em>n</em> <!-->=<!--> <!-->19). Binge eating behaviours and impulsivity scales were used to characterize our sample as well as Trauma Questionnaires and Magnetic resonance imaging (MRI) volumetric manual measurements of caudate and putamen nuclei (striatum).</p></div><div><h3>Results</h3><p>Our preliminary results showed a significantly larger left putaminal volume in AN compared to the other three groups [C (<em>p</em> <!-->=<!--> <!-->0.008), BN (<em>p</em> <!-->&lt;<!--> <!-->.001) and EDc (<em>p</em> <!-->=<!--> <!-->.001)] and a smaller right putaminal volume in EDc compared to controls (<em>p</em> <!-->=<!--> <!-->.045) and AN (<em>p</em> <!-->=<!--> <!-->.039).</p><p>Some negative correlations were found between bilateral putaminal volumes and self-reported general and early traumatization scores.</p></div><div><h3>Conclusion</h3><p>This pilot study suggested that striatal volumes might differentiate AN from BN and EDc at a neurobiological level with implications for treatment strategies. Larger scale studies should be carried out that allow replication of these data.</p></div>","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":null,"pages":null},"PeriodicalIF":9.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38023450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prefrontal abnormalities, executive dysfunction and symptoms severity are modulated by COMT Val158Met polymorphism in first episode psychosis","authors":"Elisa Rodríguez-Toscano ,&nbsp;Kenia Martínez ,&nbsp;David Fraguas ,&nbsp;Joost Janssen ,&nbsp;Laura Pina-Camacho ,&nbsp;Bárbara Arias ,&nbsp;Eduard Vieta ,&nbsp;Gisela Mezquida ,&nbsp;Silvia Amoretti ,&nbsp;Miguel Bernardo ,&nbsp;Josefina Castro-Fornieles ,&nbsp;Manuel Jesús Cuesta-Zorita ,&nbsp;Antonio Lobo ,&nbsp;Ana González-Pinto ,&nbsp;Iluminada Corripio Collado ,&nbsp;Anna Mané ,&nbsp;Celso Arango ,&nbsp;Mara Parellada ,&nbsp;PEPs Group","doi":"10.1016/j.rpsm.2021.11.002","DOIUrl":"10.1016/j.rpsm.2021.11.002","url":null,"abstract":"<div><h3>Introduction</h3><p>Core dysfunctions proposed for psychotic disorders include prefrontal cortex (PFC) dopaminergic hypoactivity, executive function (EF) deficits and reduced gray matter in the PFC. The Val variant of <em>COMT</em> Val₁₅₈Met polymorphism is associated with reduced dopaminergic signaling in the PFC. However, it is unclear how COMT Val₁₅₈Met modulates PFC gray matter reduction, EF deficits and symptom severity at the time of the first psychotic episode.</p></div><div><h3>Methods</h3><p>The effect of COMT on both EF performance and prefrontal volume (PFC-VOL) was tested in 158 first episode psychosis (FEP) patients and 141 healthy controls (HC) matched for age (range 9–35 years), sex, ethnicity, handedness and COMT Val₁₅₈Met distribution. EF and PFC-VOL were compared between FEP and HC groups within each polymorphism status (Met/Met versus Val carriers) to assess whether COMT influenced diagnostic differences. Next, correlations between PFC-VOL and EF performance were computed, as well as between both variables and other clinical characteristics of interest (PANSS scores, PAS infancy and premorbid IQ) in the FEP sample.</p></div><div><h3>Results</h3><p>COMT influenced the diagnostic differences mainly in PFC-VOL, but also in EF performance. FEP-Val carriers showed lower EF scores and reduced PFC-VOL compared to the HC group but also poorer EF performance than FEP Met/Met. Poorer EF performance was associated with smaller PFC-VOL, and both were related to increased severity of negative symptoms, poorer premorbid adjustment, and lower estimated premorbid IQ in FEP patients.</p></div><div><h3>Conclusions</h3><p>Our findings suggest that COMT Val₁₅₈Met polymorphism might contribute to PFC-VOL reductions, executive dysfunctions and symptom severity in FEP patients.</p></div>","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":null,"pages":null},"PeriodicalIF":9.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76494981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}