Revista de psiquiatria y salud mental最新文献

{"title":"Mortalidad por COVID-19 y su relación con las búsquedas en internet sobre salud mental durante el primer año de pandemia","authors":"Juan Antonio Becerra-García, Teresa Sánchez-Gutiérrez, Sara Barbeito Resa, Ana Calvo Calvo","doi":"10.1016/j.rpsm.2022.01.005","DOIUrl":"10.1016/j.rpsm.2022.01.005","url":null,"abstract":"","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":"15 2","pages":"Pages 140-142"},"PeriodicalIF":9.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8809657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10095539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Striatal volumes as potential biomarkers in Eating Disorders: A pilot study","authors":"Rosa M. Molina-Ruiz ,&nbsp;Jeffrey C.L. Looi ,&nbsp;Mark Walterfang ,&nbsp;Tomás García-Saiz ,&nbsp;Fiona A. Wilkes ,&nbsp;Lena L. Liu ,&nbsp;Dennis Velakoulis ,&nbsp;Jose Luis Carrasco Perera ,&nbsp;Marina Diaz-Marsa","doi":"10.1016/j.rpsm.2020.01.003","DOIUrl":"10.1016/j.rpsm.2020.01.003","url":null,"abstract":"<div><h3>Introduction</h3><p>Differences in bulimic and impulsive behaviours in Eating Disorders (ED) have been associated with cortico-striatal circuit dysfunction at a neurobiological level. We sought to investigate neo-striatal volume as a biomarker in ED subgroups as well as the possible relationship with trauma history.</p></div><div><h3>Material and methods</h3><p>We studied 24 female patients: Anorexia Nervosa AN (<em>n</em> <!-->=<!--> <!-->8), Bulimia Nervosa BN (<em>n</em> <!-->=<!--> <!-->9), comorbid ED with borderline personality disorder (EDc; <em>n</em> <!-->=<!--> <!-->7), and a group of Healthy Controls (<em>n</em> <!-->=<!--> <!-->19). Binge eating behaviours and impulsivity scales were used to characterize our sample as well as Trauma Questionnaires and Magnetic resonance imaging (MRI) volumetric manual measurements of caudate and putamen nuclei (striatum).</p></div><div><h3>Results</h3><p>Our preliminary results showed a significantly larger left putaminal volume in AN compared to the other three groups [C (<em>p</em> <!-->=<!--> <!-->0.008), BN (<em>p</em> <!-->&lt;<!--> <!-->.001) and EDc (<em>p</em> <!-->=<!--> <!-->.001)] and a smaller right putaminal volume in EDc compared to controls (<em>p</em> <!-->=<!--> <!-->.045) and AN (<em>p</em> <!-->=<!--> <!-->.039).</p><p>Some negative correlations were found between bilateral putaminal volumes and self-reported general and early traumatization scores.</p></div><div><h3>Conclusion</h3><p>This pilot study suggested that striatal volumes might differentiate AN from BN and EDc at a neurobiological level with implications for treatment strategies. Larger scale studies should be carried out that allow replication of these data.</p></div>","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":"15 2","pages":"Pages 65-73"},"PeriodicalIF":9.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38023450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Another Godot who is still not coming: More on biomarkers for depression","authors":"Milena Čukić ,&nbsp;Danka Savić","doi":"10.1016/j.rpsm.2021.12.006","DOIUrl":"10.1016/j.rpsm.2021.12.006","url":null,"abstract":"","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":"15 2","pages":"Pages 153-154"},"PeriodicalIF":9.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89020347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prefrontal abnormalities, executive dysfunction and symptoms severity are modulated by COMT Val158Met polymorphism in first episode psychosis","authors":"Elisa Rodríguez-Toscano ,&nbsp;Kenia Martínez ,&nbsp;David Fraguas ,&nbsp;Joost Janssen ,&nbsp;Laura Pina-Camacho ,&nbsp;Bárbara Arias ,&nbsp;Eduard Vieta ,&nbsp;Gisela Mezquida ,&nbsp;Silvia Amoretti ,&nbsp;Miguel Bernardo ,&nbsp;Josefina Castro-Fornieles ,&nbsp;Manuel Jesús Cuesta-Zorita ,&nbsp;Antonio Lobo ,&nbsp;Ana González-Pinto ,&nbsp;Iluminada Corripio Collado ,&nbsp;Anna Mané ,&nbsp;Celso Arango ,&nbsp;Mara Parellada ,&nbsp;PEPs Group","doi":"10.1016/j.rpsm.2021.11.002","DOIUrl":"10.1016/j.rpsm.2021.11.002","url":null,"abstract":"<div><h3>Introduction</h3><p>Core dysfunctions proposed for psychotic disorders include prefrontal cortex (PFC) dopaminergic hypoactivity, executive function (EF) deficits and reduced gray matter in the PFC. The Val variant of <em>COMT</em> Val₁₅₈Met polymorphism is associated with reduced dopaminergic signaling in the PFC. However, it is unclear how COMT Val₁₅₈Met modulates PFC gray matter reduction, EF deficits and symptom severity at the time of the first psychotic episode.</p></div><div><h3>Methods</h3><p>The effect of COMT on both EF performance and prefrontal volume (PFC-VOL) was tested in 158 first episode psychosis (FEP) patients and 141 healthy controls (HC) matched for age (range 9–35 years), sex, ethnicity, handedness and COMT Val₁₅₈Met distribution. EF and PFC-VOL were compared between FEP and HC groups within each polymorphism status (Met/Met versus Val carriers) to assess whether COMT influenced diagnostic differences. Next, correlations between PFC-VOL and EF performance were computed, as well as between both variables and other clinical characteristics of interest (PANSS scores, PAS infancy and premorbid IQ) in the FEP sample.</p></div><div><h3>Results</h3><p>COMT influenced the diagnostic differences mainly in PFC-VOL, but also in EF performance. FEP-Val carriers showed lower EF scores and reduced PFC-VOL compared to the HC group but also poorer EF performance than FEP Met/Met. Poorer EF performance was associated with smaller PFC-VOL, and both were related to increased severity of negative symptoms, poorer premorbid adjustment, and lower estimated premorbid IQ in FEP patients.</p></div><div><h3>Conclusions</h3><p>Our findings suggest that COMT Val₁₅₈Met polymorphism might contribute to PFC-VOL reductions, executive dysfunctions and symptom severity in FEP patients.</p></div>","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":"15 2","pages":"Pages 74-87"},"PeriodicalIF":9.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76494981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transient drop in the neutrophil count during COVID-19 regardless of clozapine treatment in patients with mental illness","authors":"Gabriel Vallecillo ,&nbsp;Josep Marti-Bonany ,&nbsp;Maria José Robles ,&nbsp;Joan Ramón Fortuny ,&nbsp;Fernando Lana ,&nbsp;Victor Pérez","doi":"10.1016/j.rpsm.2021.06.002","DOIUrl":"10.1016/j.rpsm.2021.06.002","url":null,"abstract":"","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":"15 2","pages":"Pages 134-137"},"PeriodicalIF":9.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rpsm.2021.06.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9235394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precuneus and insular hypoactivation during cognitive processing in first-episode psychosis: Systematic review and meta-analysis of fMRI studies","authors":"Pau Soldevila-Matías ,&nbsp;Anton Albajes-Eizagirre ,&nbsp;Joaquim Radua ,&nbsp;Gracián García-Martí ,&nbsp;José M. Rubio ,&nbsp;Diana Tordesillas-Gutierrez ,&nbsp;Inmaculada Fuentes-Durá ,&nbsp;Aleix Solanes ,&nbsp;Lydia Fortea ,&nbsp;Dominic Oliver ,&nbsp;Julio Sanjuán","doi":"10.1016/j.rpsm.2020.08.001","DOIUrl":"10.1016/j.rpsm.2020.08.001","url":null,"abstract":"<div><h3>Introduction</h3><p>The neural correlates of the cognitive dysfunction in first-episode psychosis (FEP) are still unclear. The present review and meta-analysis provide an update of the location of the abnormalities in the fMRI-measured brain response to cognitive processes in individuals with FEP.</p></div><div><h3>Methods</h3><p>Systematic review and voxel-based meta-analysis of cross-sectional fMRI studies comparing neural responses to cognitive tasks between individuals with FEP and healthy controls (HC) according to PRISMA guidelines.</p></div><div><h3>Results</h3><p>Twenty-six studies were included, comprising 598 individuals with FEP and 567 HC. Individual studies reported statistically significant hypoactivation in the dorsolateral prefrontal cortex (6 studies), frontal lobe (8 studies), cingulate (6 studies) and insula (5 studies). The meta-analysis showed statistically significant hypoactivation in the left anterior insula, precuneus and bilateral striatum.</p></div><div><h3>Conclusions</h3><p>While the studies tend to highlight frontal hypoactivation during cognitive tasks in FEP, our meta-analytic results show that the left precuneus and insula primarily display aberrant activation in FEP that may be associated with salience attribution to external stimuli and related to deficits in perception and regulation.</p></div>","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":"15 2","pages":"Pages 101-116"},"PeriodicalIF":9.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38430463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The KDM6B mutation: Phenotype and clinical characteristics—Report of a case","authors":"Inmaculada Insa Pineda ,&nbsp;Cristina Luz Gómez González","doi":"10.1016/j.rpsm.2020.12.005","DOIUrl":"10.1016/j.rpsm.2020.12.005","url":null,"abstract":"<div><h3>Introduction</h3><p>Alterations in the genes of lysine methylation as Lysine-specific demethylase 6B (KDM6B) have been associated with multiple neurodevelopmental disorders. Until now, there are few cases in the literature attributed to KDM6B mutations. This gap may be due to the fact that the exome sequencing technique is still being implemented in routine clinical practice.</p></div><div><h3>Material and methods</h3><p>A case is presented with its clinical and phenotypic characteristics. The sequence exome analysis was done with the Nimblegen SeqCap EZ MedExome capture kit<!--> <!-->+<!--> <!-->mtDNA 47Mb. The psychopathological approach from mental health was carried out through individual and family interviews, the Conner's questionnaires, ADHD rating scale, as well as the psychometry.</p></div><div><h3>Results</h3><p>A frameshift variant in the KDM6B gene related to neurodevelopmental disorders with facial and body dysmorphia was obtained. The case was oriented as a neurodevelopmental disorder secondary to a genetic alteration and a comorbid Attention Deficit Hyperactivity Disorder (ADHD).</p></div><div><h3>Conclusions</h3><p>The clinical peculiarities shared by patients identified with the KDM6B mutation, raises the need to recognize it as a particular entity. The possibility of applying the exome sequencing technique to patients with syndromic phenotype and developmental impairment may clarify its etiopathogenesis. It is highly probable that the complexity of these cases requires an approach by a multidisciplinary team that includes genetics, neurology and psychiatry, among other specialties. The coordinated approach is essential to have a comprehensive vision of the case.</p></div>","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":"15 2","pages":"Pages 88-93"},"PeriodicalIF":9.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38823291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increase in urgent care for patients with an eating disorder during the COVID-19 pandemic in a Spanish province","authors":"María Irigoyen-Otiñano ,&nbsp;Ana González-Pinto ,&nbsp;Vicent Llorca-Bofí ,&nbsp;Marina Adrados-Pérez ,&nbsp;Laura Arenas-Pijoan ,&nbsp;Giovanni Torterolo ,&nbsp;Marta Sánchez-Cazalilla ,&nbsp;Esther Buil ,&nbsp;Eugènia Nicolau-Subires ,&nbsp;Carla Albert-Porcar ,&nbsp;Lucía Ibarra-Pertusa ,&nbsp;Margarita Puigdevall-Ruestes","doi":"10.1016/j.rpsm.2021.11.005","DOIUrl":"10.1016/j.rpsm.2021.11.005","url":null,"abstract":"<div><h3>Introduction</h3><p>The COVID-19 pandemic has had a great impact on people's mental health. Patients with eating disorders (ED) are also highly sensitive to the pandemic situation due to their physical and mental health. The objective of this study is to evaluate the impact that the COVID-19 pandemic may have had on the reasons for the urgent care of patients with an eating disorder, comparing the reasons for care with those from a previous period.</p></div><div><h3>Method</h3><p>We compared the visits to the emergency room and their characteristics before and after the pandemic of patients with an eating disorder in the province of Lleida. Information regarding sociodemographic status, reason for consultation, diagnosis, characteristics of suicidal behaviour, and other data were obtained from the electronic medical records.</p></div><div><h3>Results</h3><p>Within the total emergency attendances, eating disorders increased from 1.7% in the pre-pandemic period to 3.1% during the pandemic (<em>p</em> <!-->=<!--> <!-->0.030). Regarding the reason for consultation, a change in the pattern is observed, decreasing consultations for anxious decompensation (<em>p</em> <!-->&lt;<!--> <!-->0.001) and increasing suicidal behaviour (<em>p</em> <!-->=<!--> <!-->0.016) and behavioural disorder (<em>p</em> <!-->=<!--> <!-->0.022).</p></div><div><h3>Conclusions</h3><p>In our study we ascertained an increase in urgent care given to patients with an eating disorder during the two states of alarm, while consultations for anxiety symptoms decreased notably. However, care for suicidal behaviour increased, especially in women with comorbidity of personality disorders and who were unemployed.</p></div>","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":"15 2","pages":"Pages 142-146"},"PeriodicalIF":9.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9236679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defining negative symptoms remission in schizophrenia using the Brief Negative Symptom Scale","authors":"Gurpreet Rekhi ,&nbsp;Mei San Ang ,&nbsp;Yiong Huak Chan ,&nbsp;Emilio Fernandez-Egea ,&nbsp;Brian Kirkpatrick ,&nbsp;Jimmy Lee","doi":"10.1016/j.rpsm.2021.05.003","DOIUrl":"10.1016/j.rpsm.2021.05.003","url":null,"abstract":"<div><h3>Introduction</h3><p>This study aimed to propose criteria for negative symptoms remission (NSR) in schizophrenia using the Brief Negative Symptom Scale (BNSS).</p></div><div><h3>Material and methods</h3><p>274 participants were assessed on the Positive and Negative Syndrome Scale (PANSS), BNSS and Social and Occupational Functioning Assessment Scale (SOFAS). Two criteria for NSR on the BNSS were proposed – NSR based on the BNSS domains scores (NSR_{BNSS_DOMAINS}) and NSR based on 5 key items of the BNSS (NSR_{BNSS_5ITEMS})_. A SOFAS score of 61 and above was considered as functional remission (FR). Logistic regressions were run to examine the association between FR and NSR. Receiver operating characteristic (ROC) curve analysis was performed for the NSR criteria on FR. Kappa agreement statistic was used to evaluate the agreement between the two NSR criteria.</p></div><div><h3>Results</h3><p>Eighty-nine (32.5%) participants fulfilled NSR_{BNSS_DOMAINS} criterion whereas 70 (25.6%) participants fulfilled NSR_{BNSS_5ITEMS} criterion. The two NSR criteria had substantial agreement (Kappa statistic<!--> <!-->=<!--> <!-->0.797) with each other. Sixty-one (25.3%) participants were in FR. FR was significantly associated with NSR, irrespective of the criterion used. To predict FR, the Area Under the Curve for NSR_{BNSS_DOMAINS} and NSR_{BNSS_5ITEMS} were 0.761 (CI: 0.696–0.826, <em>p</em> <!-->&lt;<!--> <!-->0.001) and 0.723 (CI: 0.656–0.790, <em>p</em> <!-->&lt;<!--> <!-->0.001), respectively. Hence, both NSR criteria demonstrated a fair ability to discriminate between functional remitters and non-remitters.</p></div><div><h3>Conclusions</h3><p>Depending on the setting and needs, clinicians and researchers might employ either the full BNSS or an abbreviated 5-item BNSS scale to identify NSR in schizophrenia. More research is needed to further examine the validity of these criteria in schizophrenia.</p></div>","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":"15 1","pages":"Pages 3-13"},"PeriodicalIF":9.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1888989121000604/pdfft?md5=c1ea3e2e72957ea8041b865bff6109ad&pid=1-s2.0-S1888989121000604-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38956414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of a European Spanish-version of the Self-Evaluation of Negative Symptoms (SNS) in patients with schizophrenia","authors":"Leticia García-Álvarez ,&nbsp;Clara Martínez-Cao ,&nbsp;Teresa Bobes-Bascarán ,&nbsp;Almudena Portilla ,&nbsp;Philippe Courtet ,&nbsp;Lorena de la Fuente-Tomás ,&nbsp;Ángela Velasco ,&nbsp;Leticia González-Blanco ,&nbsp;Paula Zurrón-Madera ,&nbsp;Eduardo Fonseca-Pedrero ,&nbsp;Pilar A. Sáiz ,&nbsp;María Paz García-Portilla ,&nbsp;Julio Bobes","doi":"10.1016/j.rpsm.2020.04.011","DOIUrl":"10.1016/j.rpsm.2020.04.011","url":null,"abstract":"<div><h3>Introduction</h3><p>Negative symptoms can be grouped into five domains: apathy/avolition, anhedonia, asociality, alogia, and affective flattening. There are few validate self-rated measures that assess these five dimensions. Therefore, this study aimed to validate the Self-Evaluation of Negative Symptoms (SNS) in Spanish patients with schizophrenia.</p></div><div><h3>Material and methods</h3><p>Cross-sectional, validation study in 104 outpatients with schizophrenia evaluated using the Spanish version of the following scales: Clinical Assessment Interview for Negative Symptoms (CAINS), Positive and Negative Syndrome Scale (PANSS), Clinical Global Impression Scale for Schizophrenia (CGI-SCH), Personal and Social Performance (PSP), Motivation and Pleasure Scale – Self-Report (MAP-SR), 36-item Short-Form Health Survey (SF-36) and the Self-Evaluation of Negative Symptoms (SNS).</p></div><div><h3>Results Reliability</h3><p>Internal consistency (Cronbach's <em>alpha</em>) was 0.915. Convergent validity: The Pearson correlation coefficient between MAP-SR and SNS Total scores was 0.660 (<em>p</em> <!-->&lt;<!--> <!-->0.001). For PANSS-N, the correlation was 0.437 (<em>p</em> <!-->&lt;<!--> <!-->0.005) and with the CAINS-Total was 0.478 (<em>p</em> <!-->&lt;<!--> <!-->0.005). Divergent validity: The Pearson correlation coefficient between SNS and PSP was <em>r</em> <!-->=<!--> <!-->−0.372 (<em>p</em> <!-->≤<!--> <!-->0.001), and with SF-36 Physical and Mental Summary Component scores were <em>r</em> <!-->=<!--> <!-->−0.213 (<em>p</em> <!-->=<!--> <!-->0.066) and <em>r</em> <!-->=<!--> <!-->−0.144 (<em>p</em> <!-->=<!--> <!-->0.219), respectively. Discriminant validity: SNS Total scores were significantly statistically different according to the severity of the negative symptomatology rated by the CGI-SCH negative scale (<em>p</em> <!-->&lt;<!--> <!-->0.001).</p></div><div><h3>Conclusion</h3><p>The SNS is a reliable and valid instrument to self-rate the five domains of negative symptoms in patients with schizophrenia and seems to be appropriate for use in everyday clinical practice as a complementary measure to the evaluation performed by the clinician.</p></div>","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":"15 1","pages":"Pages 14-21"},"PeriodicalIF":9.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1888989120300367/pdfft?md5=4413150016d07160eb5ff4f46763b9e0&pid=1-s2.0-S1888989120300367-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38030617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}