Precuneus and insular hypoactivation during cognitive processing in first-episode psychosis: Systematic review and meta-analysis of fMRI studies

IF 5.2 3区医学 Q1 PSYCHIATRY

Revista de psiquiatria y salud mental Pub Date : 2022-04-01 DOI:10.1016/j.rpsm.2020.08.001

Pau Soldevila-Matías , Anton Albajes-Eizagirre , Joaquim Radua , Gracián García-Martí , José M. Rubio , Diana Tordesillas-Gutierrez , Inmaculada Fuentes-Durá , Aleix Solanes , Lydia Fortea , Dominic Oliver , Julio Sanjuán

{"title":"Precuneus and insular hypoactivation during cognitive processing in first-episode psychosis: Systematic review and meta-analysis of fMRI studies","authors":"Pau Soldevila-Matías , Anton Albajes-Eizagirre , Joaquim Radua , Gracián García-Martí , José M. Rubio , Diana Tordesillas-Gutierrez , Inmaculada Fuentes-Durá , Aleix Solanes , Lydia Fortea , Dominic Oliver , Julio Sanjuán","doi":"10.1016/j.rpsm.2020.08.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>The neural correlates of the cognitive dysfunction in first-episode psychosis (FEP) are still unclear. The present review and meta-analysis provide an update of the location of the abnormalities in the fMRI-measured brain response to cognitive processes in individuals with FEP.</p></div><div><h3>Methods</h3><p>Systematic review and voxel-based meta-analysis of cross-sectional fMRI studies comparing neural responses to cognitive tasks between individuals with FEP and healthy controls (HC) according to PRISMA guidelines.</p></div><div><h3>Results</h3><p>Twenty-six studies were included, comprising 598 individuals with FEP and 567 HC. Individual studies reported statistically significant hypoactivation in the dorsolateral prefrontal cortex (6 studies), frontal lobe (8 studies), cingulate (6 studies) and insula (5 studies). The meta-analysis showed statistically significant hypoactivation in the left anterior insula, precuneus and bilateral striatum.</p></div><div><h3>Conclusions</h3><p>While the studies tend to highlight frontal hypoactivation during cognitive tasks in FEP, our meta-analytic results show that the left precuneus and insula primarily display aberrant activation in FEP that may be associated with salience attribution to external stimuli and related to deficits in perception and regulation.</p></div>","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":"15 2","pages":"Pages 101-116"},"PeriodicalIF":5.2000,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"12","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista de psiquiatria y salud mental","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1888989120301002","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 12

Abstract

Introduction

The neural correlates of the cognitive dysfunction in first-episode psychosis (FEP) are still unclear. The present review and meta-analysis provide an update of the location of the abnormalities in the fMRI-measured brain response to cognitive processes in individuals with FEP.

Methods

Systematic review and voxel-based meta-analysis of cross-sectional fMRI studies comparing neural responses to cognitive tasks between individuals with FEP and healthy controls (HC) according to PRISMA guidelines.

Results

Twenty-six studies were included, comprising 598 individuals with FEP and 567 HC. Individual studies reported statistically significant hypoactivation in the dorsolateral prefrontal cortex (6 studies), frontal lobe (8 studies), cingulate (6 studies) and insula (5 studies). The meta-analysis showed statistically significant hypoactivation in the left anterior insula, precuneus and bilateral striatum.

Conclusions

While the studies tend to highlight frontal hypoactivation during cognitive tasks in FEP, our meta-analytic results show that the left precuneus and insula primarily display aberrant activation in FEP that may be associated with salience attribution to external stimuli and related to deficits in perception and regulation.

查看原文本刊更多论文

首发精神病认知加工过程中的楔前叶和岛叶失活:功能磁共振成像研究的系统回顾和荟萃分析

首发精神病(FEP)中认知功能障碍的神经相关机制尚不清楚。本综述和荟萃分析提供了fmri测量的FEP患者大脑对认知过程反应异常位置的最新信息。方法系统回顾和基于体素的横断面fMRI研究，比较FEP患者和健康对照(HC)根据PRISMA指南对认知任务的神经反应。结果共纳入26项研究，其中FEP患者598例，HC患者567例。个别研究报告了背外侧前额叶皮层(6项研究)、额叶(8项研究)、扣带(6项研究)和脑岛(5项研究)的活性降低具有统计学意义。荟萃分析显示，左前叶岛、楔前叶和双侧纹状体的活性降低具有统计学意义。虽然研究倾向于强调FEP认知任务中额叶失活，但我们的meta分析结果显示，左侧楔前叶和脑岛在FEP中主要表现出异常激活，这可能与外部刺激的显著性归因有关，并与感知和调节缺陷有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Revista de psiquiatria y salud mental PSYCHIATRY-

自引率

3.30%

发文量

期刊介绍： The Spanish Journal of Psychiatry and Mental Health (SJPMH), incorporated into ISSN 1888-9891, is the official scientific publication of the Spanish Society of Psychiatry and Mental Health. The journal focuses on studying mental illnesses, their pathological processes, and their psychosocial consequences, and aims to disseminate scientific advances in all areas related to mental health and illness. SJPMH accepts unpublished works on psychiatry and mental health, including their medical and social implications. The journal provides space for research in the biological, clinical, and psychosocial fields. Manuscripts undergo peer-review by external reviewers before being accepted for publication. SJPMH is indexed in Index Medicus/Medline, IBECS, Social Sciences Citation Index Journal Citation Reports/Social Sciences Edition, and Current Contents/Social and Behavioral Sciences.