Striatal volumes as potential biomarkers in Eating Disorders: A pilot study

IF 5.2 3区医学 Q1 PSYCHIATRY

Revista de psiquiatria y salud mental Pub Date : 2022-04-01 DOI:10.1016/j.rpsm.2020.01.003

Rosa M. Molina-Ruiz , Jeffrey C.L. Looi , Mark Walterfang , Tomás García-Saiz , Fiona A. Wilkes , Lena L. Liu , Dennis Velakoulis , Jose Luis Carrasco Perera , Marina Diaz-Marsa

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引用次数: 1

Abstract

Introduction

Differences in bulimic and impulsive behaviours in Eating Disorders (ED) have been associated with cortico-striatal circuit dysfunction at a neurobiological level. We sought to investigate neo-striatal volume as a biomarker in ED subgroups as well as the possible relationship with trauma history.

Material and methods

We studied 24 female patients: Anorexia Nervosa AN (n = 8), Bulimia Nervosa BN (n = 9), comorbid ED with borderline personality disorder (EDc; n = 7), and a group of Healthy Controls (n = 19). Binge eating behaviours and impulsivity scales were used to characterize our sample as well as Trauma Questionnaires and Magnetic resonance imaging (MRI) volumetric manual measurements of caudate and putamen nuclei (striatum).

Results

Our preliminary results showed a significantly larger left putaminal volume in AN compared to the other three groups [C (p = 0.008), BN (p < .001) and EDc (p = .001)] and a smaller right putaminal volume in EDc compared to controls (p = .045) and AN (p = .039).

Some negative correlations were found between bilateral putaminal volumes and self-reported general and early traumatization scores.

Conclusion

This pilot study suggested that striatal volumes might differentiate AN from BN and EDc at a neurobiological level with implications for treatment strategies. Larger scale studies should be carried out that allow replication of these data.

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纹状体体积作为饮食失调的潜在生物标志物:一项初步研究

在神经生物学水平上，饮食失调(ED)患者暴食和冲动行为的差异与皮质纹状体回路功能障碍有关。我们试图研究新纹状体体积作为ED亚组的生物标志物以及与创伤史的可能关系。材料与方法我们研究了24例女性患者:神经性厌食症(n = 8)，神经性贪食症(n = 9)， ED合并边缘型人格障碍(EDc;n = 7)和健康对照组(n = 19)。暴食行为和冲动量表被用来描述我们的样本，以及创伤问卷和磁共振成像(MRI)的尾状核和壳核(纹状体)的体积手工测量。结果我们的初步结果显示，与其他三组相比，AN组的左包膜体积显著大于C组(p = 0.008)， BN组(p <与对照组(p = .045)和AN组(p = .039)相比，EDc组右核容积较小(p = .001)。双侧皮膜体积与自我报告的一般和早期创伤得分之间存在负相关。结论本初步研究提示纹状体体积可能在神经生物学水平上区分AN与BN和EDc，并对治疗策略具有指导意义。应该进行更大规模的研究，以便复制这些数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista de psiquiatria y salud mental PSYCHIATRY-

自引率

3.30%

发文量

期刊介绍： The Spanish Journal of Psychiatry and Mental Health (SJPMH), incorporated into ISSN 1888-9891, is the official scientific publication of the Spanish Society of Psychiatry and Mental Health. The journal focuses on studying mental illnesses, their pathological processes, and their psychosocial consequences, and aims to disseminate scientific advances in all areas related to mental health and illness. SJPMH accepts unpublished works on psychiatry and mental health, including their medical and social implications. The journal provides space for research in the biological, clinical, and psychosocial fields. Manuscripts undergo peer-review by external reviewers before being accepted for publication. SJPMH is indexed in Index Medicus/Medline, IBECS, Social Sciences Citation Index Journal Citation Reports/Social Sciences Edition, and Current Contents/Social and Behavioral Sciences.