用简短阴性症状量表定义精神分裂症的阴性症状缓解

IF 5.2 3区 医学 Q1 PSYCHIATRY
Gurpreet Rekhi , Mei San Ang , Yiong Huak Chan , Emilio Fernandez-Egea , Brian Kirkpatrick , Jimmy Lee
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引用次数: 3

摘要

本研究旨在使用简短阴性症状量表(BNSS)提出精神分裂症阴性症状缓解(NSR)的标准。材料与方法对274名被试进行Positive and Negative Syndrome Scale (PANSS)、BNSS和Social and Occupational Functioning Assessment Scale (SOFAS)评估。提出了基于BNSS域分数的NSR (NSRBNSS_DOMAINS)和基于BNSS 5个关键条目的NSR (NSRBNSS_5ITEMS)两个NSR标准。SOFAS评分61分及以上为功能缓解(FR)。Logistic回归检验FR和NSR之间的关系。采用受试者工作特征(ROC)曲线分析FR的NSR标准,采用Kappa一致性统计评价两个NSR标准之间的一致性。结果89例(32.5%)被试满足NSRBNSS_DOMAINS标准,70例(25.6%)被试满足NSRBNSS_5ITEMS标准。两种“噪音感应强”标准之间存在显著的一致性(Kappa统计量= 0.797)。61名(25.3%)参与者发生FR。无论使用何种标准,FR与NSR显著相关。预测FR时,NSRBNSS_DOMAINS和NSRBNSS_5ITEMS的曲线下面积为0.761 (CI: 0.696-0.826, p <0.001)和0.723 (CI: 0.656-0.790, p <分别为0.001)。因此,两个NSR标准都显示出区分功能性缓解者和非缓解者的公平能力。结论根据环境和需要,临床医生和研究人员可以采用完整的BNSS量表或简化的5项BNSS量表来识别精神分裂症患者的NSR。需要更多的研究来进一步检验这些标准在精神分裂症中的有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Defining negative symptoms remission in schizophrenia using the Brief Negative Symptom Scale

Introduction

This study aimed to propose criteria for negative symptoms remission (NSR) in schizophrenia using the Brief Negative Symptom Scale (BNSS).

Material and methods

274 participants were assessed on the Positive and Negative Syndrome Scale (PANSS), BNSS and Social and Occupational Functioning Assessment Scale (SOFAS). Two criteria for NSR on the BNSS were proposed – NSR based on the BNSS domains scores (NSRBNSS_DOMAINS) and NSR based on 5 key items of the BNSS (NSRBNSS_5ITEMS). A SOFAS score of 61 and above was considered as functional remission (FR). Logistic regressions were run to examine the association between FR and NSR. Receiver operating characteristic (ROC) curve analysis was performed for the NSR criteria on FR. Kappa agreement statistic was used to evaluate the agreement between the two NSR criteria.

Results

Eighty-nine (32.5%) participants fulfilled NSRBNSS_DOMAINS criterion whereas 70 (25.6%) participants fulfilled NSRBNSS_5ITEMS criterion. The two NSR criteria had substantial agreement (Kappa statistic = 0.797) with each other. Sixty-one (25.3%) participants were in FR. FR was significantly associated with NSR, irrespective of the criterion used. To predict FR, the Area Under the Curve for NSRBNSS_DOMAINS and NSRBNSS_5ITEMS were 0.761 (CI: 0.696–0.826, p < 0.001) and 0.723 (CI: 0.656–0.790, p < 0.001), respectively. Hence, both NSR criteria demonstrated a fair ability to discriminate between functional remitters and non-remitters.

Conclusions

Depending on the setting and needs, clinicians and researchers might employ either the full BNSS or an abbreviated 5-item BNSS scale to identify NSR in schizophrenia. More research is needed to further examine the validity of these criteria in schizophrenia.

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来源期刊
自引率
3.30%
发文量
58
期刊介绍: The Spanish Journal of Psychiatry and Mental Health (SJPMH), incorporated into ISSN 1888-9891, is the official scientific publication of the Spanish Society of Psychiatry and Mental Health. The journal focuses on studying mental illnesses, their pathological processes, and their psychosocial consequences, and aims to disseminate scientific advances in all areas related to mental health and illness. SJPMH accepts unpublished works on psychiatry and mental health, including their medical and social implications. The journal provides space for research in the biological, clinical, and psychosocial fields. Manuscripts undergo peer-review by external reviewers before being accepted for publication. SJPMH is indexed in Index Medicus/Medline, IBECS, Social Sciences Citation Index Journal Citation Reports/Social Sciences Edition, and Current Contents/Social and Behavioral Sciences.
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