Rosa M. Molina-Ruiz , Jeffrey C.L. Looi , Mark Walterfang , Tomás García-Saiz , Fiona A. Wilkes , Lena L. Liu , Dennis Velakoulis , Jose Luis Carrasco Perera , Marina Diaz-Marsa
{"title":"纹状体体积作为饮食失调的潜在生物标志物:一项初步研究","authors":"Rosa M. Molina-Ruiz , Jeffrey C.L. Looi , Mark Walterfang , Tomás García-Saiz , Fiona A. Wilkes , Lena L. Liu , Dennis Velakoulis , Jose Luis Carrasco Perera , Marina Diaz-Marsa","doi":"10.1016/j.rpsm.2020.01.003","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>Differences in bulimic and impulsive behaviours in Eating Disorders (ED) have been associated with cortico-striatal circuit dysfunction at a neurobiological level. We sought to investigate neo-striatal volume as a biomarker in ED subgroups as well as the possible relationship with trauma history.</p></div><div><h3>Material and methods</h3><p>We studied 24 female patients: Anorexia Nervosa AN (<em>n</em> <!-->=<!--> <!-->8), Bulimia Nervosa BN (<em>n</em> <!-->=<!--> <!-->9), comorbid ED with borderline personality disorder (EDc; <em>n</em> <!-->=<!--> <!-->7), and a group of Healthy Controls (<em>n</em> <!-->=<!--> <!-->19). Binge eating behaviours and impulsivity scales were used to characterize our sample as well as Trauma Questionnaires and Magnetic resonance imaging (MRI) volumetric manual measurements of caudate and putamen nuclei (striatum).</p></div><div><h3>Results</h3><p>Our preliminary results showed a significantly larger left putaminal volume in AN compared to the other three groups [C (<em>p</em> <!-->=<!--> <!-->0.008), BN (<em>p</em> <!--><<!--> <!-->.001) and EDc (<em>p</em> <!-->=<!--> <!-->.001)] and a smaller right putaminal volume in EDc compared to controls (<em>p</em> <!-->=<!--> <!-->.045) and AN (<em>p</em> <!-->=<!--> <!-->.039).</p><p>Some negative correlations were found between bilateral putaminal volumes and self-reported general and early traumatization scores.</p></div><div><h3>Conclusion</h3><p>This pilot study suggested that striatal volumes might differentiate AN from BN and EDc at a neurobiological level with implications for treatment strategies. Larger scale studies should be carried out that allow replication of these data.</p></div>","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":null,"pages":null},"PeriodicalIF":5.2000,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Striatal volumes as potential biomarkers in Eating Disorders: A pilot study\",\"authors\":\"Rosa M. Molina-Ruiz , Jeffrey C.L. Looi , Mark Walterfang , Tomás García-Saiz , Fiona A. Wilkes , Lena L. Liu , Dennis Velakoulis , Jose Luis Carrasco Perera , Marina Diaz-Marsa\",\"doi\":\"10.1016/j.rpsm.2020.01.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><p>Differences in bulimic and impulsive behaviours in Eating Disorders (ED) have been associated with cortico-striatal circuit dysfunction at a neurobiological level. We sought to investigate neo-striatal volume as a biomarker in ED subgroups as well as the possible relationship with trauma history.</p></div><div><h3>Material and methods</h3><p>We studied 24 female patients: Anorexia Nervosa AN (<em>n</em> <!-->=<!--> <!-->8), Bulimia Nervosa BN (<em>n</em> <!-->=<!--> <!-->9), comorbid ED with borderline personality disorder (EDc; <em>n</em> <!-->=<!--> <!-->7), and a group of Healthy Controls (<em>n</em> <!-->=<!--> <!-->19). Binge eating behaviours and impulsivity scales were used to characterize our sample as well as Trauma Questionnaires and Magnetic resonance imaging (MRI) volumetric manual measurements of caudate and putamen nuclei (striatum).</p></div><div><h3>Results</h3><p>Our preliminary results showed a significantly larger left putaminal volume in AN compared to the other three groups [C (<em>p</em> <!-->=<!--> <!-->0.008), BN (<em>p</em> <!--><<!--> <!-->.001) and EDc (<em>p</em> <!-->=<!--> <!-->.001)] and a smaller right putaminal volume in EDc compared to controls (<em>p</em> <!-->=<!--> <!-->.045) and AN (<em>p</em> <!-->=<!--> <!-->.039).</p><p>Some negative correlations were found between bilateral putaminal volumes and self-reported general and early traumatization scores.</p></div><div><h3>Conclusion</h3><p>This pilot study suggested that striatal volumes might differentiate AN from BN and EDc at a neurobiological level with implications for treatment strategies. 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Striatal volumes as potential biomarkers in Eating Disorders: A pilot study
Introduction
Differences in bulimic and impulsive behaviours in Eating Disorders (ED) have been associated with cortico-striatal circuit dysfunction at a neurobiological level. We sought to investigate neo-striatal volume as a biomarker in ED subgroups as well as the possible relationship with trauma history.
Material and methods
We studied 24 female patients: Anorexia Nervosa AN (n = 8), Bulimia Nervosa BN (n = 9), comorbid ED with borderline personality disorder (EDc; n = 7), and a group of Healthy Controls (n = 19). Binge eating behaviours and impulsivity scales were used to characterize our sample as well as Trauma Questionnaires and Magnetic resonance imaging (MRI) volumetric manual measurements of caudate and putamen nuclei (striatum).
Results
Our preliminary results showed a significantly larger left putaminal volume in AN compared to the other three groups [C (p = 0.008), BN (p < .001) and EDc (p = .001)] and a smaller right putaminal volume in EDc compared to controls (p = .045) and AN (p = .039).
Some negative correlations were found between bilateral putaminal volumes and self-reported general and early traumatization scores.
Conclusion
This pilot study suggested that striatal volumes might differentiate AN from BN and EDc at a neurobiological level with implications for treatment strategies. Larger scale studies should be carried out that allow replication of these data.
期刊介绍：
The Spanish Journal of Psychiatry and Mental Health (SJPMH), incorporated into ISSN 1888-9891, is the official scientific publication of the Spanish Society of Psychiatry and Mental Health. The journal focuses on studying mental illnesses, their pathological processes, and their psychosocial consequences, and aims to disseminate scientific advances in all areas related to mental health and illness. SJPMH accepts unpublished works on psychiatry and mental health, including their medical and social implications. The journal provides space for research in the biological, clinical, and psychosocial fields. Manuscripts undergo peer-review by external reviewers before being accepted for publication. SJPMH is indexed in Index Medicus/Medline, IBECS, Social Sciences Citation Index Journal Citation Reports/Social Sciences Edition, and Current Contents/Social and Behavioral Sciences.
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