首发精神病患者的前额叶异常、执行功能障碍和症状严重程度受COMT Val158Met多态性的调节

IF 5.2 3区 医学 Q1 PSYCHIATRY
Elisa Rodríguez-Toscano , Kenia Martínez , David Fraguas , Joost Janssen , Laura Pina-Camacho , Bárbara Arias , Eduard Vieta , Gisela Mezquida , Silvia Amoretti , Miguel Bernardo , Josefina Castro-Fornieles , Manuel Jesús Cuesta-Zorita , Antonio Lobo , Ana González-Pinto , Iluminada Corripio Collado , Anna Mané , Celso Arango , Mara Parellada , PEPs Group
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引用次数: 2

摘要

精神障碍的核心功能障碍包括前额叶皮质(PFC)多巴胺能活性低下、执行功能(EF)缺陷和PFC灰质减少。COMT Val158Met多态性的Val变异与PFC多巴胺能信号传导减少有关。然而,尚不清楚COMT Val158Met如何调节PFC灰质减少、EF缺陷和首次精神病发作时的症状严重程度。方法对158例首发精神病(FEP)患者和141例年龄(9 ~ 35岁)、性别、种族、利手性和COMT Val158Met分布相匹配的健康对照(HC)进行COMT对EF表现和前额叶容积(PFC-VOL)的影响。比较FEP组和HC组在每种多态性状态下(Met/Met与Val携带者)的EF和PFC-VOL,以评估COMT是否影响诊断差异。接下来,计算FEP样本中PFC-VOL与EF表现之间的相关性,以及这两个变量与其他感兴趣的临床特征(PANSS评分、PAS婴儿期和病前智商)之间的相关性。结果comt主要影响PFC-VOL的诊断差异,但也影响EF表现。与HC组相比,FEP- val携带者的EF得分较低,PFC-VOL降低,但EF表现也比FEP Met/Met差。较差的EF表现与较小的PFC-VOL相关,并且两者都与FEP患者阴性症状的严重程度增加、较差的病前调整和较低的病前估计智商有关。结论COMT Val158Met多态性可能与FEP患者PFC-VOL降低、执行功能障碍和症状严重程度有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prefrontal abnormalities, executive dysfunction and symptoms severity are modulated by COMT Val158Met polymorphism in first episode psychosis

Introduction

Core dysfunctions proposed for psychotic disorders include prefrontal cortex (PFC) dopaminergic hypoactivity, executive function (EF) deficits and reduced gray matter in the PFC. The Val variant of COMT Val158Met polymorphism is associated with reduced dopaminergic signaling in the PFC. However, it is unclear how COMT Val158Met modulates PFC gray matter reduction, EF deficits and symptom severity at the time of the first psychotic episode.

Methods

The effect of COMT on both EF performance and prefrontal volume (PFC-VOL) was tested in 158 first episode psychosis (FEP) patients and 141 healthy controls (HC) matched for age (range 9–35 years), sex, ethnicity, handedness and COMT Val158Met distribution. EF and PFC-VOL were compared between FEP and HC groups within each polymorphism status (Met/Met versus Val carriers) to assess whether COMT influenced diagnostic differences. Next, correlations between PFC-VOL and EF performance were computed, as well as between both variables and other clinical characteristics of interest (PANSS scores, PAS infancy and premorbid IQ) in the FEP sample.

Results

COMT influenced the diagnostic differences mainly in PFC-VOL, but also in EF performance. FEP-Val carriers showed lower EF scores and reduced PFC-VOL compared to the HC group but also poorer EF performance than FEP Met/Met. Poorer EF performance was associated with smaller PFC-VOL, and both were related to increased severity of negative symptoms, poorer premorbid adjustment, and lower estimated premorbid IQ in FEP patients.

Conclusions

Our findings suggest that COMT Val158Met polymorphism might contribute to PFC-VOL reductions, executive dysfunctions and symptom severity in FEP patients.

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来源期刊
自引率
3.30%
发文量
58
期刊介绍: The Spanish Journal of Psychiatry and Mental Health (SJPMH), incorporated into ISSN 1888-9891, is the official scientific publication of the Spanish Society of Psychiatry and Mental Health. The journal focuses on studying mental illnesses, their pathological processes, and their psychosocial consequences, and aims to disseminate scientific advances in all areas related to mental health and illness. SJPMH accepts unpublished works on psychiatry and mental health, including their medical and social implications. The journal provides space for research in the biological, clinical, and psychosocial fields. Manuscripts undergo peer-review by external reviewers before being accepted for publication. SJPMH is indexed in Index Medicus/Medline, IBECS, Social Sciences Citation Index Journal Citation Reports/Social Sciences Edition, and Current Contents/Social and Behavioral Sciences.
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