Psychiatry Investigation最新文献

{"title":"Relationship Between Trauma, Discrimination, and Suicidal Ideation Among North Korean Defectors.","authors":"Kyungho Lim, Jiwon Baek, Hokon Kim, Ocksim Kim, Sang Hui Chu, Young-Chul Jung","doi":"10.30773/pi.2023.0351","DOIUrl":"10.30773/pi.2023.0351","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to explore the relationship between suicidal ideation and specific trauma and social discrimination among North Korean defectors.</p><p><strong>Methods: </strong>A total of 448 North Korean defectors were recruited from online and offline communities and counseling centers. Participants provided sociodemographic and psychiatric history information via an online survey. Various assessment tools, including the Traumatic Event Checklist for North Korean Defectors, International Trauma Questionnaire, Experiences of Discrimination Scale, UCLA Loneliness Scale (short-form), and World Health Organization Quality of Life Instrument, Short Form (WHOQOL-BREF), were employed. Multiple logistic regression analysis was used to examine the association between suicidal ideation and different types of trauma and discrimination.</p><p><strong>Results: </strong>Among participants, 38.4% reported experiencing suicidal ideation. The most prevalent trauma was \"unwanted separation from spouse, parent, or sibling\" (69.4%), and the primary form of discrimination was \"unfairness during employment\" (35.7%). After adjusting for relevant variables, experiencing \"extreme life-threatening hardship,\" \"unwanted separation from a child,\" and \"discrimination in income\" significantly increased the likelihood of suicidal ideation. Importantly, unlike other refugee groups, interpersonal violence like torture or sexual abuse did not significantly contribute to suicidal ideation in this population. These findings highlight the unique vulnerabilities of North Korean defectors and suggest that income-related discrimination, unwanted separation from children, and life-threatening hardships are critical factors influencing suicidal ideation. Limitations such as recall biases and the cross-sectional nature of the data should be acknowledged.</p><p><strong>Conclusion: </strong>This study underscores the need for tailored psychiatric support for North Korean defectors, recognizing their distinctive needs compared to other refugee populations.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":"21 11","pages":"1203-1210"},"PeriodicalIF":1.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Moderating Effect of Resilience on the Relationship Between the Relevance to Victims With Post-Trauma Psychiatric Symptoms of Community Residents After Seoul Halloween Crowd Crush.","authors":"Se Youl Kim, Sra Jung, Mi Yeon Lee, Kang-Seob Oh, Young-Chul Shin, Dong-Won Shin, Junhyung Kim, Eun Soo Kim, Sun Wook Jung, Kwang-Yeol Lee, Nahyun Oh, Sung Joon Cho, Sang-Won Jeon","doi":"10.30773/pi.2024.0154","DOIUrl":"10.30773/pi.2024.0154","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to examine the psychiatric impact of the Seoul Halloween crowd crush on individuals related to the victims compared to the general population. It also explores the moderating effect of resilience on the relationship between trauma exposure and psychiatric symptoms.</p><p><strong>Methods: </strong>In total, 2,220 participants completed various post-incident questionnaires (Patient Health Questionnaire-9, Generalized Anxiety Disorder-7, Hwa-byung symptom scale, post-traumatic stress disorder checklist for DSM-5, and Brief Resilience Scale) 30 days after the incident. Moderation analyses were conducted using the PROCESS macro in the statistical package for the social sciences.</p><p><strong>Results: </strong>Individuals related to the victims exhibited higher symptom severity and a greater risk for clinically significant levels of depression, anxiety, anger, and post-traumatic stress disorder (PTSD) (odds ratio=3.28, 3.33, 1.51, and 4.39 respectively). The impact of relevance to victims on anxiety and PTSD symptoms was moderated by resilience, with a stronger effect observed for individuals with low resilience (β=3.51, 95% confidence interval [CI] 2.78-4.24 for anxiety and β=14.53, 95% CI 12.43-16.63 for PTSD) than for those with high resilience (β=1.69, 95% CI 0.72-2.65 for anxiety and β=8.33, 95% CI 5.56-11.09 for PTSD).</p><p><strong>Conclusion: </strong>When related to the victims, it was found that not only PTSD, but also depression, anxiety, and anger could intensify. Resilience emerged as a potential buffer against these adverse effects, emphasizing its significance in mitigating the psychiatric impact of community trauma.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":"21 11","pages":"1183-1192"},"PeriodicalIF":1.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latent Subtypes and Characteristics of Suicide Risk Among Korean Adults.","authors":"Jin Young Choi, Subin Park","doi":"10.30773/pi.2023.0432","DOIUrl":"10.30773/pi.2023.0432","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to identify subgroups of suicide risk and their characteristics among Korean adults.</p><p><strong>Methods: </strong>We used data from the National Mental Health Survey of Korea 2021. Participants were 5,511 adults aged 18-79 years. Latent class analysis was conducted to identify patterns of suicide risk using suicidal thoughts, plans, attempts, and self-harm. Sociodemographic and health-related characteristics according to the subtype of suicide risk were compared.</p><p><strong>Results: </strong>Suicide risk was classified into three latent classes: low suicide risk (89.5%, Class 3 [C3]), high suicidal ideation and low suicidal behavior (8.7%, Class 2 [C2]), and high suicidal thoughts and behavior (1.8%, Class 1 [C1]). Risk factors associated with C1 and C2 were the absence of a spouse, low educational and economic status, and unstable occupational status. C1 and C2 had more physical and psychological problems than did C3. Prevalence of mental disorders and mental health service use were higher in C1 than in C2.</p><p><strong>Conclusion: </strong>Suicide risk types have different demographic, physical health-related, and mental health-related characteristics. Therefore, a focused and individualized suicide preventive strategy should be implemented.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":"21 11","pages":"1251-1259"},"PeriodicalIF":1.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Deep Learning-Based Vocal Biomarkers for Stress Detection in Koreans.","authors":"Junghyun Namkung, Seok Min Kim, Won Ik Cho, So Young Yoo, Beomjun Min, Sang Yool Lee, Ji-Hye Lee, Heyeon Park, Soyoung Baik, Je-Yeon Yun, Nam Soo Kim, Jeong-Hyun Kim","doi":"10.30773/pi.2024.0131","DOIUrl":"10.30773/pi.2024.0131","url":null,"abstract":"<p><strong>Objective: </strong>The rapid societal changes have underscored the importance of effective stress detection and management. Chronic mental stress significantly contributes to both physical and psychological illnesses. However, many individuals often remain unaware of their stress levels until they face physical health issues, highlighting the necessity for regular stress monitoring. This study aimed to investigate the effectiveness of vocal biomarkers in detecting stress levels among healthy Korean employees and to contribute to digital healthcare solutions.</p><p><strong>Methods: </strong>We conducted a multi-center clinical study by collecting voice recordings from 115 healthy Korean employees under both relaxed and stress-induced conditions. Stress was induced using the socially evaluated cold pressor test. The Emphasized Channel Attention, Propagation and Aggregation in Time delay neural network (ECAPA-TDNN) deep learning architecture, renowned for its advanced capabilities in analyzing person-specific voice features, was employed to develop stress prediction scores.</p><p><strong>Results: </strong>The proposed model achieved a 70% accuracy rate in detecting stress. This performance underscores the potential of vocal biomarkers as a convenient and effective tool for individuals to self-monitor and manage their stress levels within digital healthcare frameworks.</p><p><strong>Conclusion: </strong>The findings emphasize the promise of voice-based mental stress assessments within the Korean population and the importance of continued research on vocal biomarkers across diverse linguistic demographics.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":"21 11","pages":"1228-1237"},"PeriodicalIF":1.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Danshensu Interventions Mediate Rapid Antidepressant Effects by Activating the Mammalian Target of Rapamycin Signaling and Brain-Derived Neurotrophic Factor Release.","authors":"Han-Wen Chuang, Chih-Chia Huang, Kuang-Ti Chen, Yen-Yu Kuo, Jou-Hua Ren, Tse-Yen Wang, Mang-Hung Tsai, Po-Ting Chen, I-Hua Wei","doi":"10.30773/pi.2024.0238","DOIUrl":"10.30773/pi.2024.0238","url":null,"abstract":"<p><strong>Objective: </strong>Danshensu, a phenylpropanoid compound, is derived from the dry root and rhizome of Danshen (Salvia miltiorrhiza), a traditional Chinese medicinal herb. Evidence suggests that danshensu protects isolated rat hearts against ischemia/reperfusion injury by activating the protein kinase B (Akt)/extracellular signal-regulated kinase (ERK) pathway or by inhibiting autophagy and apoptosis through the activation of mammalian target of rapamycin (mTOR) signaling. Furthermore, danshensu promotes the postischemic regeneration of brain cells by upregulating the expression of brain-derived neurotrophic factor (BDNF) in the peri-infarct region. However, basic and clinical studies are needed to investigate the antidepressant effects danshensu and determine whether brain mTOR signaling and BDNF activation mediate these effects. The aforementioned need prompted us to conduct the present study.</p><p><strong>Methods: </strong>Using a C57BL/6 mouse model, we investigated the antidepressant-like effects of danshensu and the mechanisms that mediate these effects. To elucidate the mechanisms, we analyzed the roles of Akt/ERK-mTOR signaling and BDNF activation in mediating the antidepressant-like effects of danshensu.</p><p><strong>Results: </strong>Danshensu exerted its antidepressant-like effects by activating the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) of Akt/ERK-mTOR signaling and promoting BDNF release. Treatment with danshensu increased the level of glutamate receptor 1 phosphorylation at the protein kinase A site.</p><p><strong>Conclusion: </strong>Our study may be the first to demonstrate that the antidepressant effects of danshensu are dependent on the activation of the AMPAR-mTOR signaling pathway, are correlated with the elevation of BDNF level, and facilitate the insertion of AMPAR into the postsynaptic membrane. This study also pioneers in unveiling the potential of danshensu against depressive disorders.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":"21 11","pages":"1286-1298"},"PeriodicalIF":1.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpersonal Factors and Resilience Mediate the Association Between Work-Related Stress in Response to a Viral Epidemic and Depression Among Healthcare Workers in the COVID-19 Pandemic.","authors":"C Hyung Keun Park, Seockhoon Chung, Seong Yoon Kim","doi":"10.30773/pi.2024.0087","DOIUrl":"10.30773/pi.2024.0087","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to explore the association between work-related stress of healthcare workers in response to the coronavirus disease-2019 (COVID-19) pandemic and their depressive symptoms. Additionally, it focuses on the impact of insomnia symptoms, interpersonal factors, and resilience on depressive symptoms.</p><p><strong>Methods: </strong>The results of an anonymous survey of 329 healthcare workers were analyzed, including the Stress and Anxiety to Viral Epidemics-3 items, Insomnia Severity Index, Interpersonal Needs Questionnaire, Connor-Davidson Resilience Scale-2 items, and Patient Health Questionnaire-9 items. Mediation analysis assessed whether insomnia symptoms, resilience, and interpersonal factors mediate the association between work-related stress and depressive symptoms.</p><p><strong>Results: </strong>Work-related stress directly influenced depressive symptoms (standardized estimator=0.11, p=0.010, 95% confidence interval [CI] 0.03-0.19). The association between the former and latter was positively mediated by insomnia symptoms (standardized estimator=0.10, p<0.001, 95% CI 0.05-0.14), thwarted belongingness (standardized estimator=0.04, p=0.006, 95% CI 0.01-0.07), and perceived burdensomeness (standardized estimator=0.05, p=0.002, 95% CI 0.02-0.08) and was negatively mediated by resilience (standardized estimator=0.02, p=0.041, 95% CI 0.0001-0.04).</p><p><strong>Conclusion: </strong>This study highlights the connection between heightened work-related stress experienced by healthcare workers amid the COVID-19 pandemic and the subsequent development of depressive symptoms mediated by insomnia, interpersonal factors, and resilience. Interventions that focus on building resilience could be pivotal in mitigating the detrimental mental health consequences of workplace stress among healthcare workers in a viral epidemic.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":"21 11","pages":"1221-1227"},"PeriodicalIF":1.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consensus in Psychiatric Emergencies Using the Delphi Technique.","authors":"Hyerin Lee, Jin-Won Noh, Joonho Choi, Heeyoon Cho, Kyoung-Beom Kim, Sungsook Seo, Somi Yun, Eun Hee Hong","doi":"10.30773/pi.2024.0193","DOIUrl":"10.30773/pi.2024.0193","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to elicit expert consensus on the necessary components of a seclusion room module required to accommodate and manage psychiatric emergency patients requiring both medical and surgical interventions in infectious disease situations.</p><p><strong>Methods: </strong>A two-round Delphi survey was conducted among 38 medical professionals, architects, and spatial design experts. The survey assessed the effectiveness, feasibility, and urgency of spatial scales, spatial organization, and movement system domains related to the necessary elements of a seclusion room.</p><p><strong>Results: </strong>In the spatial scale domain, items such as \"sufficient width to comply with disability standards (wheelchair accessible)\" and \"larger space should be provided for patients with a large range of motion or requiring special medical procedures\" emerged as priorities. In the movement system domain, priorities included \"anticipating situations where stable patients need to be pushed on a stretcher cart from both sides, necessitating a wider passage.\" In the spatial organization domain, priorities included \"installing interior elements (wall images, media panels, etc.) that aid patient stability, although a separate area for patients' activities reflecting psychiatric characteristics is not necessary.\"</p><p><strong>Conclusion: </strong>Expert consensus was achieved regarding the spatial scales, spatial organization, and movement system domains related to the necessary elements of a seclusion room for psychiatric emergency patients.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":"21 11","pages":"1260-1267"},"PeriodicalIF":1.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychiatric Considerations of Infertility.","authors":"Yoon Jung Hwang, Junhee Lee, Jihyun Hwang, Hyeonhee Sim, Namwoo Kim, Tae-Suk Kim","doi":"10.30773/pi.2024.0239","DOIUrl":"10.30773/pi.2024.0239","url":null,"abstract":"<p><strong>Objective: </strong>Infertility, the inability to achieve pregnancy within a year despite normal attempts to conceive without contraception, causes psychosocial burden for individuals and couples. This review summarized the interrelationship between infertility and psychological stress and suggested various forms of psychological intervention for infertility.</p><p><strong>Methods: </strong>The PubMed, Google Scholar, and Korean Studies Information Service System databases were searched for English- and Korean-language articles published from 1990 to 2024.</p><p><strong>Results: </strong>Infertility leads to emotional distress from diagnosis to treatment. Also, psychological stress affects the trajectory of infertility. This distress may cause psychiatric illnesses, negatively affecting pregnancy. Psychotherapies, psychopharmacotherapies, and biological treatments can be used for the management of psychiatric illnesses in infertile patients. Digital therapeutics also have the potential to be a competitive treatment option.</p><p><strong>Conclusion: </strong>Regular assessment and management of psychological stress in infertile couples are essential during the course of infertility treatment. Psychological intervention of infertile patients should be implemented according to a personalized plan that completely reflects the individual clinical characteristics.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":"21 11","pages":"1175-1182"},"PeriodicalIF":1.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Forkhead Box O1 Single Nucleotide Polymorphisms on Cortical Thickness and White Matter Integrity in High Suicide Risk Patients.","authors":"Daun Shin, Youbin Kang, Aram Kim, Woo Suk Tae, Mi-Ryung Han, Kyu-Man Han, Byung-Joo Ham","doi":"10.30773/pi.2024.0044","DOIUrl":"10.30773/pi.2024.0044","url":null,"abstract":"<p><strong>Objective: </strong>Neuroinflammation's role is increasingly emphasized in the pathology of major depressive disorder (MDD), and its close association with the risk of suicide is being reported. The Forkhead Box O1 (FoxO1) gene is known to play a role in regulating mood and emotion and is associated with susceptibility to suicidality in relation to environmental stress. This research aims to explore the relationship between FoxO1 and the risk of suicide in individuals with MDD.</p><p><strong>Methods: </strong>We enrolled 127 healthy controls (HC) and 231 patients diagnosed with MDD, including 119 individuals with high suicide risk (HSR). All participants underwent the Hamilton Rating Scale for Depression Assessment and magnetic resonance imaging. Cortical thickness and white matter integrity were evaluated.</p><p><strong>Results: </strong>In the HSR group, cortical thinning was observed in the left triangular part of the inferior frontal gyrus and right transverse frontopolar gyrus compared to HC. Additionally, fractional anisotropy (FA) values were decreased in the left posterior thalamic radiation, sagittal stratum, and uncinate fasciculus. Although no differences were observed based on allele variations for the two FoxO1 single nucleotide polymorphisms (SNPs), those with the minor allele of FoxO1 rs34733279, especially in the HSR group, displayed increased cortical thinning and reduced FA values in the left cingulum.</p><p><strong>Conclusion: </strong>Our study reveals close association between the minor allele of the FoxO1 gene rs34733279 and suicide risk in the left cingulum highlights the potential key role of the FoxO1 gene rs34733279 in the context of suicidal vulnerability. Further investigations are warranted to elucidate the underlying biological mechanisms.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":"21 11","pages":"1238-1250"},"PeriodicalIF":1.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparative Analysis of Neurocognitive Function in Community- and Hospital-Based Patients With Schizophrenia.","authors":"Seri Maeng, Hee Seon Kim, Tae Joo Lee, Hoon Jung Koo, Won-Hyoung Kim","doi":"10.30773/pi.2024.0077","DOIUrl":"10.30773/pi.2024.0077","url":null,"abstract":"<p><strong>Objective: </strong>The study compared differences in various neurocognitive characteristics across treatment modalities among schizophrenia patients recruited in one city between July 2020 and June 2023 who were on regular medication.</p><p><strong>Methods: </strong>Of the 151 participants, 113 were included in the analysis. Participants were divided into community-based and hospital-based groups, and their demographics and clinical characteristics, including insight, quality of life, positive and negative symptoms, and personal and social functioning, were examined. In addition, several aspects of cognition were assessed using neurocognitive assessments such as the Trail Making Test (TMT), Stroop test, and Wisconsin Card Sorting Test (WCST). After adjusting for age differences between groups, the final analysis included data from 42 participants in the community-based group and 33 participants in the hospital-based group.</p><p><strong>Results: </strong>Hospital-based group participants completed Stroop-W more rapidly, excelled in Rey-Osterrieth Complex Figure Test recall and recognition, and incurred fewer TMT Part B (TMT-B) and Stroop-C errors. Additionally, they outperformed in WCST total, non-persistent errors, and categories completed. Contrastingly, community-based group participants showed superior outcomes in WCST persistent responses and errors, suggesting specific neurocognitive strengths.</p><p><strong>Conclusion: </strong>We found differences in neurocognitive characteristics between the two groups. These differences were consistent across a range of cognitive domains, including attention, visual discrimination, memory, and executive functioning. Further large-scale study is needed to generalize cognitive characteristics across treatment modalities.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":"21 10","pages":"1110-1119"},"PeriodicalIF":1.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11513869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142506955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}