Psychiatry Investigation最新文献

{"title":"Cognitive Function as a Predictor of Short-Term Pharmacological Treatment Response in Major Depressive Disorder: Mediating Effect of Mentalization.","authors":"Seon Hee Hwang, Myung Sun Kim, Byung Joo Ham","doi":"10.30773/pi.2024.0203e","DOIUrl":"https://doi.org/10.30773/pi.2024.0203e","url":null,"abstract":"","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increase of α-Synuclein in the Peripheral Blood of Subjects with Methamphetamine Use Disorder.","authors":"Mi Ran Choi, Younghoon Chon, Joongbum Cho, Changwoo Han, Yeung-Bae Jin, Sang-Rae Lee, Dai-Jin Kim","doi":"10.30773/pi.2023.0389","DOIUrl":"https://doi.org/10.30773/pi.2023.0389","url":null,"abstract":"<p><strong>Objective: </strong>Methamphetamine (MA) use has created significant public health problems worldwide. Its chronic abuse causes neurotoxicity resulting in disruption of neural plasticity and early onset of neurodegenerative diseases. Therefore, there is need for a biomarker to evaluate the neurotoxicity caused by MA. This study investigates the expression levels of α-synuclein (α-Syn), brain-derived neurotrophic factor (BDNF), and neuron-specific enolase (NSE) in the blood of patients with MA use disorder to identify potential biomarkers.</p><p><strong>Methods: </strong>We collected blood samples from 60 subjects (30 normal healthy controls and 30 patients with MA use disorder [MA group]). We used multiplex assay kits to analyze the expression levels of α-Syn, BDNF, and NSE in the blood of these subjects.</p><p><strong>Results: </strong>Beck Depression Inventory and Beck Anxiety Inventory scale scores were significantly different between the control and MA groups. The expression level of α-Syn in the MA group was significantly increased compared to that in the control group (z value=-1.986, p=0.0473). In contrast, BDNF in the MA group tended to increase as the duration of MA use increased (r=0.323, p=0.082).</p><p><strong>Conclusion: </strong>We identified an increase of α-Syn in the blood of the MA group. This finding suggests that the α-Syn level increases in the brain after exposure to MA by passing through the blood brain barrier. This result provides useful information for potential biomarkers in diagnosis of neurodegenerative diseases caused by MA abuse.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective Associations of Serum Tumor Necrosis Factor-Alpha and Employment on Suicidal Behaviors Over 1 Year in Depressive Patients Receiving Psychopharmacotherapy.","authors":"Ha-Yeon Kim, Ju-Wan Kim, Hee-Ju Kang, Ju-Yeon Lee, Sung-Wan Kim, Il-Seon Shin, Byung Jo Chun, Min-Gon Kim, Jae-Min Kim","doi":"10.30773/pi.2025.0044","DOIUrl":"https://doi.org/10.30773/pi.2025.0044","url":null,"abstract":"<p><strong>Objective: </strong>This study explored both the individual and combined effects of serum tumor necrosis factor-alpha (sTNF-α) levels and employment status on suicidal behavior (SB) in patients with depressive disorders undergoing pharmacologic treatment.</p><p><strong>Methods: </strong>Baseline measurements of sTNF-α levels were taken, and employment status was determined. Over a 1-year period of stepwise pharmacotherapy, SB was monitored and categorized into increased suicidal severity and fatal/non-fatal suicide attempts. Logistic regression models adjusted for relevant covariates were used to analyze the individual and interactive associations between sTNF-α levels, employment status, and these two forms of SB.</p><p><strong>Results: </strong>Unemployment was significantly associated with both forms of SB, whereas sTNF-α levels alone did not show a significant correlation. However, lower sTNF-α levels combined with employment were associated with the lowest incidence rates of both SB categories, demonstrating significant interactive effects after adjustment.</p><p><strong>Conclusion: </strong>The study demonstrates that the prospective associations of sTNF-α levels for SB is enhanced when combined with employment status in patients receiving pharmacological treatment for depressive disorders. These findings suggest that integrating biological markers with socio-economic factors can improve the assessment and management of suicide risk.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Heart Rate Variability in Adolescent Patients With Tic Disorders: A 1-Year Prospective Study.","authors":"Hyeju Lee, Nahyung Lee, Yeje Lim, June Christoph Kang, Jeong-An Gim, Moon-Soo Lee","doi":"10.30773/pi.2025.0072","DOIUrl":"https://doi.org/10.30773/pi.2025.0072","url":null,"abstract":"<p><strong>Objective: </strong>This longitudinal study examined the impact of tic disorders on autonomic nervous system function using heart rate variability (HRV) as a biomarker and assessed its association with quality of life over a 1-year period.</p><p><strong>Methods: </strong>The patient group comprised 39 individuals, of whom 19 were followed up after 1 year, whereas the control group included 30 individuals. Tic severity and quality of life were assessed using the Yale Global Tic Severity Scale and KIDSCREEN-27 questionnaire, respectively. HRV parameters were used to measure autonomic function during this period.</p><p><strong>Results: </strong>At baseline, patients with tic disorders demonstrated lower HRV, particularly in low-frequency (LF) power, and a higher standard deviation of the average normal-to-normal intervals, indicating significant autonomic dysregulation compared to control participants. Over the 1-year follow-up period, these patients demonstrated a decline in HRV indices, particularly LF power. HRV metrics and quality of life scores exhibited significant correlations at baseline, indicating that a better autonomic balance status was associated with perceived better quality of life. During follow-up, the correlations between HRV measures and psychological/behavioral scales observed at baseline were altered and no longer significant, potentially reflecting the effects of treatment and homeostatic adaptation over time.</p><p><strong>Conclusion: </strong>Tic disorders are associated with persistent autonomic dysfunction, which progressively impair physiological regulation and quality of life. The findings of this study elucidate the significance of incorporating strategies for autonomic modulation into treatment plans for patients with tic disorders.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Graph Machine Learning With Systematic Hyper-Parameter Selection on Hidden Networks and Mental Health Conditions in the Middle-Aged and Old.","authors":"Kwang-Sig Lee, Byung-Joo Ham","doi":"10.30773/pi.2024.0249e","DOIUrl":"https://doi.org/10.30773/pi.2024.0249e","url":null,"abstract":"","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on Haenyeo: Insights Into Human Adaptations to Extreme Environments.","authors":"Joon Hyuk Park, Ki Woong Kim","doi":"10.30773/pi.2024.0394","DOIUrl":"https://doi.org/10.30773/pi.2024.0394","url":null,"abstract":"<p><p>Haenyeo, Korea's traditional female breath-hold divers, represent a unique model for studying brain adaptation to extreme environmental stressors. Diving daily without breathing equipment, they endure hypoxia, hydrostatic pressure, and cold exposure, often well into their senior years. Research on haenyeo has broader implications for fields such as aging research, space exploration, and underwater medicine. Haenyeo provide an extraordinary lens through which to explore human brain resilience and adaptability. Their experiences demonstrate the brain's capacity for enduring and adapting to extreme physical and cognitive demands over a lifetime. Studying haenyeo offers valuable insights into protecting brain health in extreme environments and aging populations.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Forkhead Box O1 Single Nucleotide Polymorphisms on Cortical Thickness and White Matter Integrity in High Suicide Risk Patients.","authors":"Daun Shin, Youbin Kang, Aram Kim, Woo Suk Tae, Mi-Ryung Han, Kyu-Man Han, Byung-Joo Ham","doi":"10.30773/pi.2024.0044e","DOIUrl":"https://doi.org/10.30773/pi.2024.0044e","url":null,"abstract":"","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediating Effect of Psychological Inflexibility, Insomnia, and Resilience on the Association Between Pain and Depression Among Patients With Chronic Pain.","authors":"Hussein Makhour, Seockhoon Chung","doi":"10.30773/pi.2025.0065","DOIUrl":"https://doi.org/10.30773/pi.2025.0065","url":null,"abstract":"<p><strong>Objective: </strong>Chronic pain, impacting roughly 20% of the population, significantly affects quality of life and productivity. This study explored the mediating effects of psychological inflexibility, insomnia, and resilience on the association between pain and depression in patients with chronic pain.</p><p><strong>Methods: </strong>Data on demographics, pain characteristics, and psychological factors were obtained through an online survey involving 100 patients from the Asan Medical Center Pain Clinic. Measures included the Patient Health Questionnaire-9, Insomnia Severity Index (ISI), Acceptance and Action Questionnaire-II (AAQ-II), and Brief Resilience Scale (BRS). Statistical analyses involved correlation, linear regression, and mediation analyses.</p><p><strong>Results: </strong>A linear regression analysis revealed that the severity of depression was predicted by pain severity (β=0.18, p=0.018), ISI (β=0.22, p=0.010), AAQ-II (β=0.32, p<0.001), and BRS (β=-0.28, p=0.002). The mediation analysis showed that pain severity directly influenced depression severity. This relationship was partially mediated by ISI, AAQ-II, and BRS.</p><p><strong>Conclusion: </strong>This study underscores the necessity for holistic approaches in chronic pain management that address the mediating effect of psychological factors. Targeted interventions focusing on insomnia, psychological inflexibility, and resilience can significantly enhance mental health outcomes for patients with chronic pain.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of Two Primary Screening Instruments (K-SCQ and K-SRS-2) and Setting of New Cutoff Values to Improve Diagnostic Accuracy of Autism Spectrum Disorder in Young Children.","authors":"Yoojeong Lee, Guiyoung Bong, Da-Yea Song, Heejeong Yoo","doi":"10.30773/pi.2025.0015","DOIUrl":"https://doi.org/10.30773/pi.2025.0015","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to explore the diagnostic validity of primary screening instruments (Korean version of the Social Communication Questionnaire [K-SCQ] and Korean version of Social Responsiveness Scale second edition [K-SRS-2]) in Korean children aged 10-60 months and to examine patterns of validity across age. Additionally, we aimed to propose new cutoff values specific to age subgroups.</p><p><strong>Methods: </strong>The study included 1,326 children (autism spectrum disorder [ASD], n=822, M=41.79, SD=10.28; non-ASD, n=504, M=32.48, SD=10.88) divided by age (10-17, 18-29, 30-41, 42-53, and 54-60 months) who completed the instruments and underwent clinical best-estimate diagnostic evaluation. An optimal screening strategy was sought by calculating sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) based on instrument combinations. Receiver operating characteristic (ROC) analysis was conducted to determine the optimal novel cutoff values for the instruments in each age subgroup.</p><p><strong>Results: </strong>The validity of individual instruments varied significantly across age subgroups. However, there was some improvement in validity when applying \"either K-SCQ or K-SRS-2,\" especially in children aged 30 months and older (sensitivity, 83.3%-94.9%; specificity, 58.1%-90.9%; PPV, 21.7%-98.5%; NPV, 65.3%-96.2%). Estimated cutoff for K-SCQ were 13.5, 9.5, 10.5, 7.5, and 9.5 for ages 10-17, 18-29, 30-41, 42-53, and 54-60 months respectively (sensitivity, 82.4%-92.2%; specificity, 74.8%-90.9%). Estimated cutoffs for K-SRS-2 were 58.5, 54.5, 55.5, 55.5, and 52.5 for ages 10-17, 18-29, 30-41, 42-53, and 54-60 months, respectively (sensitivity, 50.0%-94.1%; specificity, 80.3%-97.7%).</p><p><strong>Conclusion: </strong>In children aged 30 to 60 months, the combination of either K-SCQ or K-SRS-2 allowed for accurate screening of ASD. To further improve accuracy, adjusted cutoff values can be applied based on age subgroups.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological Impact and Differences in Child and Adolescent Victims of Sexual Violence in South Korea: Using Data From a Sunflower Center in South Korea From 2015 to 2022.","authors":"Minha Hong, Hyun-Soo Kim, Kyoung-Hoon Kim, Jiali Emily Koh, Changwoo Han, Seunghoon Lee, Jin Sun Ryu, Ah Rah Lee, Sang Min Lee","doi":"10.30773/pi.2024.0381","DOIUrl":"10.30773/pi.2024.0381","url":null,"abstract":"<p><strong>Objective: </strong>Sexual violence against children and adolescents is a serious social problem. The characteristics of child and adolescent victims differ based on their varying developmental processes. Therefore, we conducted a comparative analysis to assess the same.</p><p><strong>Methods: </strong>Data were collected from victims of sexual violence between 2015 and 2022, from a Sunflower Center, which is a government-sponsored center for victims of sexual violence. The participants were classified into two groups: children under age 12 and adolescents over age 13 years. To compare and analyze data, we collected demographic information, information related to victimization events, and scores on the Children's Depression Inventory, Revised Children's Manifest Anxiety Scale, and Children's Revised Impact of Event Scale. A descriptive analysis, χ 2 test, Fisher's exact test, and multiple logistic regression analysis were performed.</p><p><strong>Results: </strong>Among 255 participants, 95 and 160 were children and adolescents, respectively. The percentage of forced molestation was significantly higher in children at 71.6% (n=68, p<0.001). Children included significantly more male participants (14.7%, n=14, p=0.007) than adolescents. Significant differences were observed between children and adolescents' depression, anxiety, and posttraumatic stress scores (p<0.001). Compared with children, adolescents demonstrated an adjusted odds ratio of 2.9 for high post-traumatic stress symptoms, 2.26 for high depressive symptoms, and 3.0 for high anxiety symptoms.</p><p><strong>Conclusion: </strong>We identified differences in the characteristics of sexual violence victims, particularly children and adolescents, and found that adolescent victims were more vulnerable to the psychological repercussions of abuse than child victims.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":"22 6","pages":"660-667"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}