The Association of Zolpidem and Suicidality in Psychiatric Outpatients With Insomnia.

IF 1.8 4区医学 Q3 PSYCHIATRY

Psychiatry Investigation Pub Date : 2025-09-01 DOI:10.30773/pi.2024.0397

Jin Young Jung, Hyewon Yeo, Haein Kim, Yunsu Kim, Sujung Yoon, In Kyoon Lyoo, Seog Ju Kim

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引用次数: 0

Abstract

Objective: Zolpidem is widely prescribed to psychiatric outpatients for the management of insomnia due to its rapid and potent efficacy. However, concerns persist regarding its potential association with suicidal tendencies. While studies have suggested that Z-drugs may influence suicidal behavior in the general population, the specific association of Z-drug use and suicide risk in psychiatric outpatients with insomnia remains unclear. This study aims to investigate the association of zolpidem use and suicidal tendencies in this population.

Methods: This retrospective study analyzed the medical records of psychiatric outpatients who visited a mental health clinic between January 2018 and December 2022. Of the 6,193 patients assessed, 3,128 (average age: 49.4 years; 36.6% male) reported insomnia, and 364 (11.6%) were prescribed zolpidem. Suicidal tendencies including past suicide attempts, current suicidal ideation, and plans were evaluated in relation to zolpidem use.

Results: Psychiatric outpatients with insomnia who used zolpidem demonstrated significantly higher rates of suicidal tendencies (χ2=3.97, p=0.046) and suicide attempts (χ2=8.12, p=0.004, 23.6% in zolpidem users) compared to non-users. Logistic regression analysis revealed that zolpidem use was significantly associated with increased suicidal tendencies (β=0.314, standard error=0.137, odds ratio= 1.368, 95% confidence interval [CI] 1.05-1.79, p=0.022), suicidal ideation (β=0.326, standard error=0.138, odds ratio=1.386, 95% CI 1.06-1.82, p=0.018), and suicide attempts (β=0.379, standard error=0.157, odds ratio=1.460, 95% CI 1.07-1.98, p=0.016), even after adjusting for relevant clinical factors.

Conclusion: This study highlights a significant association of zolpidem use and elevated suicidal tendencies among psychiatric outpatients with insomnia. Although a causal relationship cannot be definitively established, these findings highlight the critical importance of thorough suicide risk assessment and ongoing monitoring in patients prescribed zolpidem.

查看原文本刊更多论文

精神科门诊失眠症患者唑吡坦与自杀的关系。

目的：唑吡坦因其快速有效的治疗失眠症被广泛应用于精神科门诊患者。然而，人们仍然担心它可能与自杀倾向有关。虽然研究表明z -药物可能影响一般人群的自杀行为，但z -药物使用与失眠精神病门诊患者自杀风险的具体关联尚不清楚。本研究旨在调查该人群中唑吡坦使用与自杀倾向的关系。方法：回顾性分析2018年1月至2022年12月在某精神卫生诊所就诊的精神科门诊患者的病历。在评估的6193例患者中，3128例（平均年龄：49.4岁；36.6%为男性）报告失眠，364例（11.6%）服用唑吡坦。自杀倾向，包括过去的自杀企图，目前的自杀意念，并计划评估有关唑吡坦的使用。结果：精神科门诊失眠患者使用唑吡坦的自杀倾向（χ2=3.97, p=0.046）和自杀未遂率（χ2=8.12, p=0.004, 23.6%）明显高于未使用唑吡坦的患者。Logistic回归分析显示，唑吡坦的使用与自杀倾向（β=0.314，标准误差=0.137，比值比= 1.368,95%可信区间[CI] 1.05 ~ 1.79, p=0.022）、自杀意念（β=0.326，标准误差=0.138，比值比=1.386,95% CI 1.06 ~ 1.82, p=0.018）、自杀企图（β=0.379，标准误差=0.157，比值比=1.460,95% CI 1.07 ~ 1.98, p=0.016）的增加显著相关。结论：本研究强调了精神病门诊失眠患者使用唑吡坦与自杀倾向升高之间的显著关联。虽然因果关系不能确定，但这些发现强调了对服用唑吡坦的患者进行彻底的自杀风险评估和持续监测的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychiatry Investigation PSYCHIATRY-

CiteScore

4.10

自引率

3.70%

发文量

105

审稿时长

6-12 weeks

期刊介绍： The Psychiatry Investigation is published on the 25th day of every month in English by the Korean Neuropsychiatric Association (KNPA). The Journal covers the whole range of psychiatry and neuroscience. Both basic and clinical contributions are encouraged from all disciplines and research areas relevant to the pathophysiology and management of neuropsychiatric disorders and symptoms, as well as researches related to cross cultural psychiatry and ethnic issues in psychiatry. The Journal publishes editorials, review articles, original articles, brief reports, viewpoints and correspondences. All research articles are peer reviewed. Contributions are accepted for publication on the condition that their substance has not been published or submitted for publication elsewhere. Authors submitting papers to the Journal (serially or otherwise) with a common theme or using data derived from the same sample (or a subset thereof) must send details of all relevant previous publications and simultaneous submissions. The Journal is not responsible for statements made by contributors. Material in the Journal does not necessarily reflect the views of the Editor or of the KNPA. Manuscripts accepted for publication are copy-edited to improve readability and to ensure conformity with house style.