Psychiatry Investigation最新文献_第2页

Online Aggressive Behavior, Self-Harm Behavior, and Social Anxiety: The Mediating Effect of Social Network Sites Addictive Tendency and the Moderating Effect of Sex. 网络攻击行为、自残行为与社交焦虑：社交网站成瘾倾向的中介作用及性别的调节作用。

IF 1.8 4区医学

Psychiatry Investigation Pub Date : 2025-09-01 Epub Date: 2025-08-21 DOI: 10.30773/pi.2025.0087

Huachen Ding, Yaqiu Xu

{"title":"Online Aggressive Behavior, Self-Harm Behavior, and Social Anxiety: The Mediating Effect of Social Network Sites Addictive Tendency and the Moderating Effect of Sex.","authors":"Huachen Ding, Yaqiu Xu","doi":"10.30773/pi.2025.0087","DOIUrl":"10.30773/pi.2025.0087","url":null,"abstract":"Objective: Self-harm and online aggressive behavior, recognized as dual-harm behaviors, have become increasingly prevalent among college students, which is strongly related to social anxiety. Yet, the underlying mechanism remains unclear and social network sites (SNS) addictive tendency may have a mediating effect. In addition, the influence of sex requires further clarification.Methods: A convenient sampling method was employed and 1,608 college students (females=1,245, 77.43%; Meanage=18.95 years) were recruited. Scales measuring social anxiety, online aggressive behavior, self-harm behavior, and SNS addictive tendency were utilized. Structural equation modelling based on Mplus was conducted to testify the mediating effect of SNS addictive tendency and Wald's χ2 test was employed to clarify sex difference.Results: Social anxiety is significantly and positively related to online aggressive behavior, self-harm behavior, and SNS addictive tendency. The mediating effect of SNS addictive tendency is tested to be significant (online aggressive behavior: β=0.13, 95% confidence intervals [CIs], 0.077-0.191; self-harm behavior: β=0.05, 95% CIs, 0.000-0.104) and sex could moderate the effect of social anxiety on SNS addictive tendency. The relation between social anxiety and SNS addictive tendency is significantly stronger among males.Conclusion: The current study suggests that social anxiety could cause a higher risk of both online aggressive and self-harm behavior through SNS addictive tendency, especially among male college students. Therefore, further interventions should target assisting college students to develop interpersonal relations in the real world could be beneficial.","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":" ","pages":"1020-1030"},"PeriodicalIF":1.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144966553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contribution of Chronic Disease in Predicting Depression and Suicidal Ideation Among the Older Adult Population. 慢性疾病在预测老年人抑郁和自杀意念中的作用。

IF 1.8 4区医学

Psychiatry Investigation Pub Date : 2025-09-01 Epub Date: 2025-08-21 DOI: 10.30773/pi.2024.0106

Youngbin Seo, Hae-Young Kim, KiBong Choi, Sunmi Song, Junesun Kim

{"title":"Contribution of Chronic Disease in Predicting Depression and Suicidal Ideation Among the Older Adult Population.","authors":"Youngbin Seo, Hae-Young Kim, KiBong Choi, Sunmi Song, Junesun Kim","doi":"10.30773/pi.2024.0106","DOIUrl":"10.30773/pi.2024.0106","url":null,"abstract":"Objective: This study aimed to clarify how chronic diseases (CDs) contribute to depression and suicidal ideation (SI) prediction using machine learning (ML) techniques among the older adult population.Methods: National representative data of 5,419 older adults from the Korea National Health and Nutrition Examination Survey conducted in 2013, 2015, 2017, and 2019 were used in this study. The number and type of CDs were incorporated into Models 1 and 2, respectively, using five ML methods.Results: The average age of the participants was 72.7 years, with 43.2% males, 15.2% reporting depression, and 7.3% reporting SI. The number of CDs was correlated with increased depression and SI. The ML models showed moderate-to-good performance in the prediction of depression and SI. The area under the curve (AUC) values for Model 1 ranged from 0.729 to 0.772 for depression, and from 0.754 to 0.793 for SI. In Model 2, the AUC ranged from 0.704 to 0.768 for depression and from 0.750 to 0.785 for SI. More depression and SI were expected when the number of CDs was one or more and two or more, respectively. The top predictors of depression were osteoarthritis, myocardial infarction, diabetes, asthma, and stroke, whereas those predicting SI were stroke, hypertension, asthma, myocardial infarction, and rheumatoid arthritis.Conclusion: The number and specific types of CDs predicted depression and SI among Korean older adults. These results may help enhance cooperation with clinicians treating CDs and promote the early detection and prevention of further SI and behaviors.","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":" ","pages":"1068-1076"},"PeriodicalIF":1.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144966927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Skeletal Muscle Mass Indices and Cognitive Function Among Inpatients With Stable Schizophrenia. 住院稳定期精神分裂症患者骨骼肌质量指数与认知功能的关系

IF 1.8 4区医学

Psychiatry Investigation Pub Date : 2025-09-01 Epub Date: 2025-08-21 DOI: 10.30773/pi.2025.0024

Dan Shuai, Binyou Wang, Duanfang Cai, Yan Guo, Xiuping Lei, Kezhi Liu, Yilin Wang

{"title":"Association Between Skeletal Muscle Mass Indices and Cognitive Function Among Inpatients With Stable Schizophrenia.","authors":"Dan Shuai, Binyou Wang, Duanfang Cai, Yan Guo, Xiuping Lei, Kezhi Liu, Yilin Wang","doi":"10.30773/pi.2025.0024","DOIUrl":"10.30773/pi.2025.0024","url":null,"abstract":"Objective: To investigate the correlation between appendicular skeletal muscle mass (ASM)/height (ASMIht), ASM/body mass index (ASMIBMI), ASM/weight (ASMIwt), and ASM/waist circumference (ASMIwc) and cognitive function among inpatients with stable schizophrenia.Methods: This was a cross-sectional study of 235 stable schizophrenia inpatients, including 60% males (n=141). Patient demographic information and body composition data were collected. The Montreal Cognitive Assessment-Chinese version (MoCA-C) was used to measure cognitive function. To determine the association between the muscle mass indices and cognitive function, multiple linear regressions were established.Results: The median age of males and females were 51 years (range 42-55) and 51 (range 39-58), respectively. Spearman's correlation analysis revealed a significant association between ASMIwc and the MoCA-C scores (r=0.323, false discovery rate [FDR]=0.004) in males, while ASMIBMI, ASMIwt, and ASMIwc (r=0.268-0.421, all FDR <0.05) were significantly correlated with MoCA-C scores in females. Furthermore, covariate-adjusted multiple linear regression analysis further confirmed that only the ASMIwc was related to MoCAC scores after controlling for relevant variables (males: β=0.565, 95% confidence interval [CI], 0.156-0.974, p=0.007; females: β=0.96, 95% CI, 0.394-1.526, p=0.001).Conclusion: Our findings showed a substantial correlation between the ASMIwc and cognitive function in schizophrenia inpatients. Further validation of these data in broader study populations is now necessary.","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":" ","pages":"1048-1056"},"PeriodicalIF":1.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144966878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation of the Korean Version of the Anxiety and Preoccupation About Sleep Questionnaire and Comparisons With Other Sleep-Related Cognition Scales Among the General Population. 韩国版睡眠焦虑与关注问卷的验证及与其他睡眠相关认知量表的比较

IF 1.8 4区医学

Psychiatry Investigation Pub Date : 2025-09-01 Epub Date: 2025-08-14 DOI: 10.30773/pi.2025.0119

Young Rong Bang, Saebom Jeon, Junseok Ahn, Oli Ahmed, Soyoung Yoo, Seockhoon Chung

{"title":"Validation of the Korean Version of the Anxiety and Preoccupation About Sleep Questionnaire and Comparisons With Other Sleep-Related Cognition Scales Among the General Population.","authors":"Young Rong Bang, Saebom Jeon, Junseok Ahn, Oli Ahmed, Soyoung Yoo, Seockhoon Chung","doi":"10.30773/pi.2025.0119","DOIUrl":"10.30773/pi.2025.0119","url":null,"abstract":"Objective: We developed a Korean-language version of the Anxiety and Preoccupation about Sleep Questionnaire (APSQ) and then assessed its reliability and validity among the general population by comparing its results with those of preexisting questionnaires regarding sleep-related cognition.Methods: The study participants (n=300) completed the newly translated APSQ as well as Korean versions of the Dysfunctional Beliefs and Attitudes about Sleep-16 items (DBAS-16) Scale, Metacognitions Questionnaire-Insomnia-14 items (MCQI-14), Glasgow Sleep Effort Scale (GSES), and Insomnia Severity Index (ISI) through an online platform accessible from 17-27 July 2023. A confirmatory factor analysis of the APSQ revealed good fits for both the full-scale and two-factor models, consistent with the original version.Results: The Korean version of the APSQ also demonstrated good internal consistency, showing Cronbach's alpha values of 0.965 for the full scale, 0.954 for factor I, and 0.928 for factor II. In addition, the full-scale APSQ and both subscales demonstrated good convergent validity with ISI, DBAS-16, MCQI-14, and GSES as evidenced by strong correlations between the corresponding scores. The scale information curves further revealed that the APSQ provided more information on the latent trait (worry regarding sleep) than the other sleep measures.Conclusion: The APSQ scale and its two subscales are valid tools for measuring sleep-related worry among the general South Korean population. Additional studies of specific clinical groups are required to confirm the scope of its applicability and utility for the treatment of insomnia.","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":" ","pages":"1031-1037"},"PeriodicalIF":1.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Weekend Catch-Up Sleep and Depression: Evidence From the 2017-2018 National Health and Nutrition Examination Survey. 周末补觉与抑郁症之间的关系：来自2017-2018年全国健康与营养调查的证据。

IF 1.8 4区医学

Psychiatry Investigation Pub Date : 2025-09-01 DOI: 10.30773/pi.2024.0252

Wenting Cai, Zhonghong Lai, Shan Huang, Feng Xiao, Xueqin Liu, Yuxu Zhao, Ye Luo

{"title":"Association Between Weekend Catch-Up Sleep and Depression: Evidence From the 2017-2018 National Health and Nutrition Examination Survey.","authors":"Wenting Cai, Zhonghong Lai, Shan Huang, Feng Xiao, Xueqin Liu, Yuxu Zhao, Ye Luo","doi":"10.30773/pi.2024.0252","DOIUrl":"10.30773/pi.2024.0252","url":null,"abstract":"Objective: Weekend catch-up sleep (CUS) has been associated with certain health benefits; however, there is a paucity of research regarding the correlation between CUS and depression in adults. This study aimed to investigate the association between weekend CUS and depressive symptoms in a nationally representative adult population.Methods: We analyzed data from the 2017-2018 National Health and Nutrition Examination Survey. Depression was assessed using the Patient Health Questionnaire-9, with a score ≥10 indicating clinically significant depressive symptoms. CUS duration was categorized into four groups: CUS≤0 h, 0 h<CUS≤1 h, 1 h<CUS≤2 h, and CUS>2 h. Multivariable logistic regression models adjusted for sociodemographic factors, health behaviors, and comorbidities were employed to examine associations.Results: Out of 4,450 eligible participants, 2,169 (48.7%), 943 (21.2%), 641 (14.4%), and 697 (15.7%) had weekend CUS durations of ≤0, 0 to 1, 1 to 2, and >2 h, respectively. The prevalence of depression was found to be 9.59%, 7.74%, 7.18%, and 8.75%, respectively, in these groups. Adjusted for multiple variables, the odds ratios (ORs) for depression were 0.89 (95% confidence interval [CI] 0.54-1.48), 0.71 (95% CI 0.37-1.37), and 0.97 (95% CI 0.57-1.65) for individuals with 0 h<CUS≤1 h, 1 h<CUS≤2 h, and CUS>2 h, respectively, in comparison to those with CUS≤0 h. However, subgroup analyses suggested a potential protective effect of CUS (>2 h) against depression in individuals with weekday sleep duration <6 h (OR=0.47, 95% CI 0.27-0.83).Conclusion: Weekend CUS was not associated with depression risk in the general adult population. The observed protective effect in sleep-restricted individuals warrants further investigation through prospective studies to evaluate potential causal relationships.","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":" ","pages":"997-1005"},"PeriodicalIF":1.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144966856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting 5-Year Survival and Mortality in Dementia Patients: A Data-Driven Approach Using XGBoost for Enhanced Care and Resource Allocation. 预测痴呆患者的5年生存率和死亡率：使用XGBoost增强护理和资源分配的数据驱动方法

IF 1.8 4区医学

Psychiatry Investigation Pub Date : 2025-09-01 DOI: 10.30773/pi.2024.0351

Yi-Guang Wang, Hsin-An Chang, Mu-Hong Chen, Nian-Sheng Tzeng, Jin Narumoto, Chih-Sung Liang, Ta-Chuan Yeh

{"title":"Predicting 5-Year Survival and Mortality in Dementia Patients: A Data-Driven Approach Using XGBoost for Enhanced Care and Resource Allocation.","authors":"Yi-Guang Wang, Hsin-An Chang, Mu-Hong Chen, Nian-Sheng Tzeng, Jin Narumoto, Chih-Sung Liang, Ta-Chuan Yeh","doi":"10.30773/pi.2024.0351","DOIUrl":"10.30773/pi.2024.0351","url":null,"abstract":"Objective: This study develops an eXtreme Gradient Boosting (XGBoost) regression model to identify key predictors of mortality and 5-year survival in dementia patients, highlighting the role of comorbidities. The findings highlight key risk factors that may facilitate targeted adjustments in clinical care and resource allocation for high-risk patients.Methods: We used Taiwan's National Health Insurance dataset to develop and validate an XGBoost model predicting 5-year survival in dementia patients aged 65 years or older. The cohort (n=6,556) was split into 80% for training, 10% for validation, and 10% for testing. A total of 24 variables, including comorbidities and demographic factors, were selected as predictors. Hyperparameters were tuned to optimize performance, with a learning rate of 0.1, 1,000 estimators, and a maximum depth of 10. Regularization techniques were applied to prevent overfitting.Results: The XGBoost model achieved 81.86% accuracy in predicting 5-year survival, with a receiver operating characteristic area under the curve of 0.81 and a log loss of 0.61. Of the 37 initial features, 24 were included, and the top 10 predictors were nasogastric tube insertion, chronic kidney disease, cancer, lung disease, urinary tract infection, fracture, peripheral vascular disease, antidepressant use, hypertension, and upper gastrointestinal issues.Conclusion: The XGBoost model effectively predicts 5-year survival in dementia patients, identifying key predictors that can guide targeted care, preventive strategies, and healthcare resource planning.","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":" ","pages":"1057-1067"},"PeriodicalIF":1.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144966571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Frequency-Specific Transcranial Alternating Current Stimulations on Cognitive Function in Patients With Mild Cognitive Impairment. 频率特异性经颅交流电刺激对轻度认知障碍患者认知功能的影响比较。

IF 1.8 4区医学

Psychiatry Investigation Pub Date : 2025-09-01 Epub Date: 2025-08-12 DOI: 10.30773/pi.2025.0057

Seungchan Park, Gwan Gyu Lee, Jiheon Kim, Do Hoon Kim

{"title":"Comparison of Frequency-Specific Transcranial Alternating Current Stimulations on Cognitive Function in Patients With Mild Cognitive Impairment.","authors":"Seungchan Park, Gwan Gyu Lee, Jiheon Kim, Do Hoon Kim","doi":"10.30773/pi.2025.0057","DOIUrl":"10.30773/pi.2025.0057","url":null,"abstract":"Objective: This study aimed to compare the effects of theta and gamma transcranial alternating current stimulation (tACS) on cognitive function and memory in individuals with mild cognitive impairment (MCI).Methods: The participants were assigned to one of three conditions: sham, theta (5 Hz), or gamma (40 Hz) tACS, targeting the dorsolateral prefrontal cortex (DLPFC) for approximately 30 min. Cognitive tasks were conducted before and after stimulation, including the Digit Span and Trail Making Test A (TMT-A).Results: The results indicated significant improvements in the gamma tACS group, specifically a reduction in TMT-A errors. In contrast, no significant effects were observed in the sham or theta groups.Conclusion: These findings suggest that gamma tACS enhances working memory, processing speed, and cognitive flexibility, potentially due to its modulating neural activity within the DLPFC and restoring effective theta-gamma coupling. Conversely, theta tACS did not yield improvements, likely because of the elevated baseline theta levels and disrupted oscillatory dynamics observed in patients with MCI. This study underscores the potential of gamma tACS as a promising intervention for cognitive decline in MCI and further suggests the necessity of a comprehensive approach that considers the electrophysiological abnormalities and dynamic oscillatory patterns in MCI.","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":" ","pages":"1012-1019"},"PeriodicalIF":1.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Pathophysiology of Psychiatric Disorders and the Therapeutic Potential of Mesenchymal Stem Cells. 精神疾病的病理生理学和间充质干细胞的治疗潜力。

IF 1.8 4区医学

Psychiatry Investigation Pub Date : 2025-09-01 Epub Date: 2025-08-12 DOI: 10.30773/pi.2025.0079

Sena Inal Azizoglu

引用次数: 0

White Matter Integrity of the Three Subdivisions of the Superior Longitudinal Fasciculi in First-Episode Psychosis Patients. 首发精神病患者上纵束神经束三个分支的白质完整性。

IF 1.8 4区医学

Psychiatry Investigation Pub Date : 2025-09-01 Epub Date: 2025-08-14 DOI: 10.30773/pi.2025.0116

Jongrak Kim, Hyungyou Park, Inkyung Park, Jiseon Jang, Minah Kim, Jun Soo Kwon

{"title":"White Matter Integrity of the Three Subdivisions of the Superior Longitudinal Fasciculi in First-Episode Psychosis Patients.","authors":"Jongrak Kim, Hyungyou Park, Inkyung Park, Jiseon Jang, Minah Kim, Jun Soo Kwon","doi":"10.30773/pi.2025.0116","DOIUrl":"10.30773/pi.2025.0116","url":null,"abstract":"Objective: The superior longitudinal fasciculus (SLF) is a white matter (WM) bundle connecting the frontal and parietal lobes. SLF subdivisions have distinct functions (e.g., attention, working memory, and language processing), and abnormalities in specific subdivisions may differentially contribute to the pathophysiology of first-episode psychosis (FEP). However, previous diffusion magnetic resonance imaging (MRI) studies have not fully examined SLF subdivisions, limiting our understanding of their role in FEP patients. The aim of this study was to assess whether WM integrity differs in SLF subdivisions between FEP patients and healthy controls (HCs) using advanced diffusion tensor imaging.Methods: 3T diffusion MRI scans were obtained from 39 FEP patients and 110 HCs. Deterministic tractography was used to reconstruct the three SLF subdivisions (SLF I, II, and III). We analyzed the fractional anisotropy (FA), mean diffusivity (MD), and radial diffusivity (RD) of these subdivisions and compared the results between FEP patients and HCs.Results: There were no significant group differences in the FA, MD, or RD between the FEP patients and HCs.Conclusion: No significant differences in WM integrity between FEP patients and HCs were found. These results suggest that significant WM changes may develop later in the disease course rather than in the early stages of psychotic disorders such as FEP.","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":" ","pages":"1077-1085"},"PeriodicalIF":1.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychotropic Polypharmacy and Related Factors in Children and Adolescents. 儿童和青少年的精神药物综合用药及其相关因素。

IF 1.8 4区医学

Psychiatry Investigation Pub Date : 2025-09-01 Epub Date: 2025-08-22 DOI: 10.30773/pi.2025.0137

Mutlu Muhammed Özbek, Ekin Atay, Doğa Sevinçok, Hasan Can Özbay, Tuğçe Canol Özbek, Mehmet Akif Cansız

{"title":"Psychotropic Polypharmacy and Related Factors in Children and Adolescents.","authors":"Mutlu Muhammed Özbek, Ekin Atay, Doğa Sevinçok, Hasan Can Özbay, Tuğçe Canol Özbek, Mehmet Akif Cansız","doi":"10.30773/pi.2025.0137","DOIUrl":"10.30773/pi.2025.0137","url":null,"abstract":"Objective: We aimed to investigate the clinical characteristics of patients presenting to child and adolescent psychiatry outpatient clinics across different age groups, and to assess the prevalence of polypharmacy along with its associated factors within a clinical sample.Methods: A total of 569 patients with complete file data were included in the study. Psychiatric diagnoses were made by a clinician based on the diagnostic criteria stipulated in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. A detailed medical history was obtained for each patient, and their age, gender, education level, parents' age and education level, psychiatric diagnoses, and administered treatments were recorded for further analyses.Results: Based on a review of the relationship between complaints at presentation and polypharmacy, irritability was more prevalent among polypharmacy users, while domestic problems were more prevalent in those who did not use polypharmacy. Based on our regression analysis; conduct disorder (CD) diagnosis (B=2.405, Exp [B]=11.079, p<0.001), age (B=0.127, Exp [B]=1.136, p=0.008), and any psychiatric comorbidity (B=4.761, Exp [B]=116.874, p<0.001) were the variables most frequently and significantly associated with polypharmacy independent of other variables.Conclusion: This study's results indicate that the presence of CD, age, and comorbid psychiatric diagnosis significantly increase the risk of polypharmacy. A better understanding of the factors that pave the way toward polypharmacy is critical to reduce unnecessary medication use in children and adolescents.","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":" ","pages":"979-988"},"PeriodicalIF":1.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144966576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0